MICRO RNA: A PROSPECTIVE DIAGNOSTICBIOMARKER IN ALZHEIMER’S DISEASE
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder, characterized by cognitive decline that impairs individuals' ability to perform normal activities independently. Epidemiological data indicates that over 50 million people globally are affected by AD, and no existing dr...
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| Format: | Article |
| Language: | English |
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Baqai University Press
2024-12-01
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| Series: | Baqai Journal of Health Sciences |
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| Online Access: | https://journals.baqai.edu.pk/index.php/CS/article/view/128 |
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| author | Syeda Uroosa Hashmi Ameer Haider Ali |
| author_facet | Syeda Uroosa Hashmi Ameer Haider Ali |
| author_sort | Syeda Uroosa Hashmi |
| collection | DOAJ |
| description |
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder, characterized by cognitive decline that impairs individuals' ability to perform normal activities independently. Epidemiological data indicates that over 50 million people globally are affected by AD, and no existing drugs have successfully reversed its progression. MicroRNAs (miRNAs), small non-coding RNA molecules consisting of approximately 22 nucleotides, play a critical role in modulating intracellular protein expression at the post-translational level through translational degradation. Studies have shown varying concentrations of miRNAs in the peripheral and central nervous tissues of AD patients compared to control groups. This research explores the mechanisms and roles of miRNAs in gene regulation related to AD and highlights their potential as therapeutic agents for neurodegenerative diseases.
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| format | Article |
| id | doaj-art-fd10ef6c13e045d3b76b9b1747eebd08 |
| institution | Kabale University |
| issn | 2312-4423 2312-6884 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Baqai University Press |
| record_format | Article |
| series | Baqai Journal of Health Sciences |
| spelling | doaj-art-fd10ef6c13e045d3b76b9b1747eebd082025-02-11T18:45:30ZengBaqai University PressBaqai Journal of Health Sciences2312-44232312-68842024-12-01252MICRO RNA: A PROSPECTIVE DIAGNOSTICBIOMARKER IN ALZHEIMER’S DISEASESyeda Uroosa Hashmi0Ameer Haider Ali1Third World Center for Science and Technology, H.E.J. Research Institute of Chemistry, University of KarachiDadabhoy Institute of Higher Education Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder, characterized by cognitive decline that impairs individuals' ability to perform normal activities independently. Epidemiological data indicates that over 50 million people globally are affected by AD, and no existing drugs have successfully reversed its progression. MicroRNAs (miRNAs), small non-coding RNA molecules consisting of approximately 22 nucleotides, play a critical role in modulating intracellular protein expression at the post-translational level through translational degradation. Studies have shown varying concentrations of miRNAs in the peripheral and central nervous tissues of AD patients compared to control groups. This research explores the mechanisms and roles of miRNAs in gene regulation related to AD and highlights their potential as therapeutic agents for neurodegenerative diseases. https://journals.baqai.edu.pk/index.php/CS/article/view/128Alzheimer’s diseasemicroRNAsintracellular proteinscognitive declinenon-coding RNA |
| spellingShingle | Syeda Uroosa Hashmi Ameer Haider Ali MICRO RNA: A PROSPECTIVE DIAGNOSTICBIOMARKER IN ALZHEIMER’S DISEASE Baqai Journal of Health Sciences Alzheimer’s disease microRNAs intracellular proteins cognitive decline non-coding RNA |
| title | MICRO RNA: A PROSPECTIVE DIAGNOSTICBIOMARKER IN ALZHEIMER’S DISEASE |
| title_full | MICRO RNA: A PROSPECTIVE DIAGNOSTICBIOMARKER IN ALZHEIMER’S DISEASE |
| title_fullStr | MICRO RNA: A PROSPECTIVE DIAGNOSTICBIOMARKER IN ALZHEIMER’S DISEASE |
| title_full_unstemmed | MICRO RNA: A PROSPECTIVE DIAGNOSTICBIOMARKER IN ALZHEIMER’S DISEASE |
| title_short | MICRO RNA: A PROSPECTIVE DIAGNOSTICBIOMARKER IN ALZHEIMER’S DISEASE |
| title_sort | micro rna a prospective diagnosticbiomarker in alzheimer s disease |
| topic | Alzheimer’s disease microRNAs intracellular proteins cognitive decline non-coding RNA |
| url | https://journals.baqai.edu.pk/index.php/CS/article/view/128 |
| work_keys_str_mv | AT syedauroosahashmi micrornaaprospectivediagnosticbiomarkerinalzheimersdisease AT ameerhaiderali micrornaaprospectivediagnosticbiomarkerinalzheimersdisease |