Fluoroalkenes as biomolecules isosteres; preparation and application: a personal account
Fluoroalkenes have been known for decades, but their preparation is still a hot topic. Indeed, the olefination reactions of carbonyl compounds with fluorinated derivatives are not trivial. For that reason, new tools have been developed to efficiently access tri- and tetrasubstituted alkenes. We repo...
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| Language: | English |
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Académie des sciences
2024-09-01
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| Series: | Comptes Rendus. Chimie |
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| Online Access: | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.337/ |
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| author | Lequeux, Thierry Pfund, Emmanuel |
| author_facet | Lequeux, Thierry Pfund, Emmanuel |
| author_sort | Lequeux, Thierry |
| collection | DOAJ |
| description | Fluoroalkenes have been known for decades, but their preparation is still a hot topic. Indeed, the olefination reactions of carbonyl compounds with fluorinated derivatives are not trivial. For that reason, new tools have been developed to efficiently access tri- and tetrasubstituted alkenes. We report our contribution in this field and their interest will be illustrated by the preparation of dipeptide isosteres and acyclonucleoside analogues. |
| format | Article |
| id | doaj-art-fd5da2cb68bb4ec6a4c1f92e75d1a27e |
| institution | Kabale University |
| issn | 1878-1543 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus. Chimie |
| spelling | doaj-art-fd5da2cb68bb4ec6a4c1f92e75d1a27e2025-02-07T13:39:46ZengAcadémie des sciencesComptes Rendus. Chimie1878-15432024-09-0127G120521510.5802/crchim.33710.5802/crchim.337Fluoroalkenes as biomolecules isosteres; preparation and application: a personal accountLequeux, Thierry0https://orcid.org/0000-0003-3783-4458Pfund, Emmanuel1https://orcid.org/0000-0003-1896-0109Laboratoire de Chimie Moléculaire et Thioorganique LCMT UMR 6507 ENSICAEN, UNICAEN, CNRS, Normandie Université, 6 Bd. du Maréchal Juin, 14050 Caen, FranceLaboratoire de Chimie Moléculaire et Thioorganique LCMT UMR 6507 ENSICAEN, UNICAEN, CNRS, Normandie Université, 6 Bd. du Maréchal Juin, 14050 Caen, FranceFluoroalkenes have been known for decades, but their preparation is still a hot topic. Indeed, the olefination reactions of carbonyl compounds with fluorinated derivatives are not trivial. For that reason, new tools have been developed to efficiently access tri- and tetrasubstituted alkenes. We report our contribution in this field and their interest will be illustrated by the preparation of dipeptide isosteres and acyclonucleoside analogues.https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.337/MonofluoroalkenesOlefinationDipeptidesAcyclonucleosides |
| spellingShingle | Lequeux, Thierry Pfund, Emmanuel Fluoroalkenes as biomolecules isosteres; preparation and application: a personal account Comptes Rendus. Chimie Monofluoroalkenes Olefination Dipeptides Acyclonucleosides |
| title | Fluoroalkenes as biomolecules isosteres; preparation and application: a personal account |
| title_full | Fluoroalkenes as biomolecules isosteres; preparation and application: a personal account |
| title_fullStr | Fluoroalkenes as biomolecules isosteres; preparation and application: a personal account |
| title_full_unstemmed | Fluoroalkenes as biomolecules isosteres; preparation and application: a personal account |
| title_short | Fluoroalkenes as biomolecules isosteres; preparation and application: a personal account |
| title_sort | fluoroalkenes as biomolecules isosteres preparation and application a personal account |
| topic | Monofluoroalkenes Olefination Dipeptides Acyclonucleosides |
| url | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.337/ |
| work_keys_str_mv | AT lequeuxthierry fluoroalkenesasbiomoleculesisosterespreparationandapplicationapersonalaccount AT pfundemmanuel fluoroalkenesasbiomoleculesisosterespreparationandapplicationapersonalaccount |