The impact of HPV/HIV co-infection on immunosuppression, HPV genotype, and cervical cancer biomarkers
Abstract Background Human papillomavirus (HPV) and human immunodeficiency virus (HIV) co-infection present a significant impact on women's health globally, especially in immunocompromised individuals. HIV-induced immunosuppression promotes the persistence of high-risk HPV infection and increase...
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BMC
2025-02-01
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| Online Access: | https://doi.org/10.1186/s12885-025-13516-2 |
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| author | Terkimbi Dominic Swase Ilemobayo Victor Fasogbon Ifie Josiah Eseoghene Ekom Monday Etukudo Solomon Adomi Mbina Chebet Joan Reuben Samson Dangana Chinyere Anyanwu Comfort Danchal Vandu A. B Agbaje Tijjani Salihu Shinkafi Ibrahim Babangida Abubarkar Patrick Maduabuchi Aja |
| author_facet | Terkimbi Dominic Swase Ilemobayo Victor Fasogbon Ifie Josiah Eseoghene Ekom Monday Etukudo Solomon Adomi Mbina Chebet Joan Reuben Samson Dangana Chinyere Anyanwu Comfort Danchal Vandu A. B Agbaje Tijjani Salihu Shinkafi Ibrahim Babangida Abubarkar Patrick Maduabuchi Aja |
| author_sort | Terkimbi Dominic Swase |
| collection | DOAJ |
| description | Abstract Background Human papillomavirus (HPV) and human immunodeficiency virus (HIV) co-infection present a significant impact on women's health globally, especially in immunocompromised individuals. HIV-induced immunosuppression promotes the persistence of high-risk HPV infection and increased the progression to cervical cancer. The aim of this systematic review was to assessed the impact of HPV/HIV co-infection on the prevalence and distribution of HR-HPV genotypes, the level of immunosuppression and expression of cervical cancer biomarkers. Method The article selection method for this review was based on the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards. The total of eighty-four (84) articles from standard electronic databases mainly Web of Science, PubMed, and Scopus were extracted and reviewed. The articles were published in English between 2008 and 2024 and comprised a total of 80023 participants. Results The HR-HPV genotypes reported across various studies include HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 54, 56, 58, 59, 66, 68, 70, 73, and 82. Among HIV positive individuals, the most common circulating HR-HPV genotypes were HPV16, 18, 45, 35, and 58, accounted for 11%, 10%, 9%, 8%, and 8% of cases, respectively. Approximately 29.1% and 30.0% of patients had CD4 counts of 200–400 cells/L and 300–400 cells/L, respectively. The most commonly reported cervical cancer biomarkers were p16INK4a and Ki-67, according to the analysis. Conclusion The findings indicate high prevalence of multiple HR-HPV genotypes among HIV positive individuals, indicating the impact of HPV/HIV co-infection on immunosuppression and persistence of HPV infection. The expression of cervical cancer biomarker such as p16INK4a and Ki-67 emphasized target screening and early detection strategy in high-risk population. However, there was no direct impact of HPV/HIV co-infection reported on these biomarkers and required to be studied more especially in people living with HIV. |
| format | Article |
| id | doaj-art-fd9aead156de447f8d44ae02f498cb57 |
| institution | Kabale University |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj-art-fd9aead156de447f8d44ae02f498cb572025-02-09T12:41:28ZengBMCBMC Cancer1471-24072025-02-0125111510.1186/s12885-025-13516-2The impact of HPV/HIV co-infection on immunosuppression, HPV genotype, and cervical cancer biomarkersTerkimbi Dominic Swase0Ilemobayo Victor Fasogbon1Ifie Josiah Eseoghene2Ekom Monday Etukudo3Solomon Adomi Mbina4Chebet Joan5Reuben Samson Dangana6Chinyere Anyanwu7Comfort Danchal Vandu8A. B Agbaje9Tijjani Salihu Shinkafi10Ibrahim Babangida Abubarkar11Patrick Maduabuchi Aja12Department of Biochemistry, Faculty of Biomedical Science, Kampala International University Western CampusDepartment of Biochemistry, Faculty of Biomedical Science, Kampala International University Western CampusDepartment of Biochemistry, Faculty of Biomedical Science, Kampala International University Western CampusDepartment of Anatomy, Kampala International UniversityDepartment of Biochemistry, Faculty of Biomedical Science, Kampala International University Western CampusDepartment of Biochemistry, Faculty of Biomedical Science, Kampala International University Western CampusDepartment of Biochemistry, Faculty of Biomedical Science, Kampala International University Western CampusDepartment of Microbiology, Faculty of Biomedical Science, Kampala International University Western CampusDepartment of Medical Laboratory Science, Faculty of Allied Science, Kampala International University Western CampusDepartment of Microbiology, Faculty of Biomedical Science, Kampala International University Western CampusDepartment of Biochemistry, Faculty of Biomedical Science, Kampala International University Western CampusDepartment of Biochemistry, Faculty of Biomedical Science, Kampala International University Western CampusDepartment of Biochemistry, Faculty of Biomedical Science, Kampala International University Western CampusAbstract Background Human papillomavirus (HPV) and human immunodeficiency virus (HIV) co-infection present a significant impact on women's health globally, especially in immunocompromised individuals. HIV-induced immunosuppression promotes the persistence of high-risk HPV infection and increased the progression to cervical cancer. The aim of this systematic review was to assessed the impact of HPV/HIV co-infection on the prevalence and distribution of HR-HPV genotypes, the level of immunosuppression and expression of cervical cancer biomarkers. Method The article selection method for this review was based on the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards. The total of eighty-four (84) articles from standard electronic databases mainly Web of Science, PubMed, and Scopus were extracted and reviewed. The articles were published in English between 2008 and 2024 and comprised a total of 80023 participants. Results The HR-HPV genotypes reported across various studies include HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 54, 56, 58, 59, 66, 68, 70, 73, and 82. Among HIV positive individuals, the most common circulating HR-HPV genotypes were HPV16, 18, 45, 35, and 58, accounted for 11%, 10%, 9%, 8%, and 8% of cases, respectively. Approximately 29.1% and 30.0% of patients had CD4 counts of 200–400 cells/L and 300–400 cells/L, respectively. The most commonly reported cervical cancer biomarkers were p16INK4a and Ki-67, according to the analysis. Conclusion The findings indicate high prevalence of multiple HR-HPV genotypes among HIV positive individuals, indicating the impact of HPV/HIV co-infection on immunosuppression and persistence of HPV infection. The expression of cervical cancer biomarker such as p16INK4a and Ki-67 emphasized target screening and early detection strategy in high-risk population. However, there was no direct impact of HPV/HIV co-infection reported on these biomarkers and required to be studied more especially in people living with HIV.https://doi.org/10.1186/s12885-025-13516-2Human papillomavirusHuman immunodeficiency virusImmunosuppressionCervical cancer BiomarkersGenotypes |
| spellingShingle | Terkimbi Dominic Swase Ilemobayo Victor Fasogbon Ifie Josiah Eseoghene Ekom Monday Etukudo Solomon Adomi Mbina Chebet Joan Reuben Samson Dangana Chinyere Anyanwu Comfort Danchal Vandu A. B Agbaje Tijjani Salihu Shinkafi Ibrahim Babangida Abubarkar Patrick Maduabuchi Aja The impact of HPV/HIV co-infection on immunosuppression, HPV genotype, and cervical cancer biomarkers BMC Cancer Human papillomavirus Human immunodeficiency virus Immunosuppression Cervical cancer Biomarkers Genotypes |
| title | The impact of HPV/HIV co-infection on immunosuppression, HPV genotype, and cervical cancer biomarkers |
| title_full | The impact of HPV/HIV co-infection on immunosuppression, HPV genotype, and cervical cancer biomarkers |
| title_fullStr | The impact of HPV/HIV co-infection on immunosuppression, HPV genotype, and cervical cancer biomarkers |
| title_full_unstemmed | The impact of HPV/HIV co-infection on immunosuppression, HPV genotype, and cervical cancer biomarkers |
| title_short | The impact of HPV/HIV co-infection on immunosuppression, HPV genotype, and cervical cancer biomarkers |
| title_sort | impact of hpv hiv co infection on immunosuppression hpv genotype and cervical cancer biomarkers |
| topic | Human papillomavirus Human immunodeficiency virus Immunosuppression Cervical cancer Biomarkers Genotypes |
| url | https://doi.org/10.1186/s12885-025-13516-2 |
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