Systemic Lupus Erythematosus Presenting as Anorexia Nervosa in a Middle‐Aged Woman: A Rare Case Report and Literature Review
ABSTRACT Background Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multisystemic involvement and unclear etiology. Although SLE could be linked to multiple neuropsychiatric manifestations, the co‐occurrence of anorexia nervosa was only described through a few case reports th...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Immunity, Inflammation and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/iid3.70083 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832087077918867456 |
|---|---|
| author | Maen Nizam Baroudi Anwar I. Joudeh Mohammed Kays Alattiya Abdo Qaid Ahmed Lutf Hassan Abuzaid Salah Mahdi |
| author_facet | Maen Nizam Baroudi Anwar I. Joudeh Mohammed Kays Alattiya Abdo Qaid Ahmed Lutf Hassan Abuzaid Salah Mahdi |
| author_sort | Maen Nizam Baroudi |
| collection | DOAJ |
| description | ABSTRACT Background Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multisystemic involvement and unclear etiology. Although SLE could be linked to multiple neuropsychiatric manifestations, the co‐occurrence of anorexia nervosa was only described through a few case reports that mainly affected children and adolescents. Case Presentation a 40‐year‐old Filipina woman presented to hospital with a 3‐day history of agitation, anorexia and auditory hallucinations. She also had restrictive dietary habits with substantial weight loss and excessive fear of weight gain for the past several months. Her medical history was also noticeable for a 3‐month history of erythematous non‐itchy skin rash. On examination, the patient was pale and underweight. She had angular stomatitis, bilateral exophthalmos, and diffuse goiter. Skin examination revealed diffuse scaly and erythematous rash over the neck and upper torso with post‐inflammatory skin discoloration. Laboratory investigations showed pancytopenia, high serum creatinine, and +1 proteinuria. Further workup confirmed thyrotoxicosis due to Graves disease as well as having multiple positive autoantibodies including antinuclear antibody (ANA) which were suggestive for SLE. A subsequent kidney biopsy demonstrated class IV diffuse lupus nephritis. The patient was treated successfully with intravenous pulse steroid therapy, rituximab, and antithyroid medications with no residual symptoms or laboratory abnormalities. Conclusions The concurrence of anorexia nervosa with SLE and the complete resolution of anorexia nervosa symptoms with immunosuppressive therapy suggest common autoinflammatory pathogenesis for both conditions. Further research is needed to elucidate any potential association between SLE and anorexia nervosa. |
| format | Article |
| id | doaj-art-fe853fd5ffc34a7f8c1a7107439e611e |
| institution | Kabale University |
| issn | 2050-4527 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj-art-fe853fd5ffc34a7f8c1a7107439e611e2025-02-06T07:50:39ZengWileyImmunity, Inflammation and Disease2050-45272025-01-01131n/an/a10.1002/iid3.70083Systemic Lupus Erythematosus Presenting as Anorexia Nervosa in a Middle‐Aged Woman: A Rare Case Report and Literature ReviewMaen Nizam Baroudi0Anwar I. Joudeh1Mohammed Kays Alattiya2Abdo Qaid Ahmed Lutf3Hassan Abuzaid4Salah Mahdi5Department of Internal Medicine Al‐Khor Hospital, Hamad Medical Corporation Doha QatarDepartment of Internal Medicine Al‐Khor Hospital, Hamad Medical Corporation Doha QatarDepartment of Internal Medicine Al‐Khor Hospital, Hamad Medical Corporation Doha QatarDepartment of Internal Medicine Al‐Khor Hospital, Hamad Medical Corporation Doha QatarDepartment of Internal Medicine Al‐Khor Hospital, Hamad Medical Corporation Doha QatarDepartment of Internal Medicine Al‐Khor Hospital, Hamad Medical Corporation Doha QatarABSTRACT Background Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multisystemic involvement and unclear etiology. Although SLE could be linked to multiple neuropsychiatric manifestations, the co‐occurrence of anorexia nervosa was only described through a few case reports that mainly affected children and adolescents. Case Presentation a 40‐year‐old Filipina woman presented to hospital with a 3‐day history of agitation, anorexia and auditory hallucinations. She also had restrictive dietary habits with substantial weight loss and excessive fear of weight gain for the past several months. Her medical history was also noticeable for a 3‐month history of erythematous non‐itchy skin rash. On examination, the patient was pale and underweight. She had angular stomatitis, bilateral exophthalmos, and diffuse goiter. Skin examination revealed diffuse scaly and erythematous rash over the neck and upper torso with post‐inflammatory skin discoloration. Laboratory investigations showed pancytopenia, high serum creatinine, and +1 proteinuria. Further workup confirmed thyrotoxicosis due to Graves disease as well as having multiple positive autoantibodies including antinuclear antibody (ANA) which were suggestive for SLE. A subsequent kidney biopsy demonstrated class IV diffuse lupus nephritis. The patient was treated successfully with intravenous pulse steroid therapy, rituximab, and antithyroid medications with no residual symptoms or laboratory abnormalities. Conclusions The concurrence of anorexia nervosa with SLE and the complete resolution of anorexia nervosa symptoms with immunosuppressive therapy suggest common autoinflammatory pathogenesis for both conditions. Further research is needed to elucidate any potential association between SLE and anorexia nervosa.https://doi.org/10.1002/iid3.70083anorexia nervosacase reportGraves's diseaseneuropsychiatric lupussystemic lupus erythematosus |
| spellingShingle | Maen Nizam Baroudi Anwar I. Joudeh Mohammed Kays Alattiya Abdo Qaid Ahmed Lutf Hassan Abuzaid Salah Mahdi Systemic Lupus Erythematosus Presenting as Anorexia Nervosa in a Middle‐Aged Woman: A Rare Case Report and Literature Review Immunity, Inflammation and Disease anorexia nervosa case report Graves's disease neuropsychiatric lupus systemic lupus erythematosus |
| title | Systemic Lupus Erythematosus Presenting as Anorexia Nervosa in a Middle‐Aged Woman: A Rare Case Report and Literature Review |
| title_full | Systemic Lupus Erythematosus Presenting as Anorexia Nervosa in a Middle‐Aged Woman: A Rare Case Report and Literature Review |
| title_fullStr | Systemic Lupus Erythematosus Presenting as Anorexia Nervosa in a Middle‐Aged Woman: A Rare Case Report and Literature Review |
| title_full_unstemmed | Systemic Lupus Erythematosus Presenting as Anorexia Nervosa in a Middle‐Aged Woman: A Rare Case Report and Literature Review |
| title_short | Systemic Lupus Erythematosus Presenting as Anorexia Nervosa in a Middle‐Aged Woman: A Rare Case Report and Literature Review |
| title_sort | systemic lupus erythematosus presenting as anorexia nervosa in a middle aged woman a rare case report and literature review |
| topic | anorexia nervosa case report Graves's disease neuropsychiatric lupus systemic lupus erythematosus |
| url | https://doi.org/10.1002/iid3.70083 |
| work_keys_str_mv | AT maennizambaroudi systemiclupuserythematosuspresentingasanorexianervosainamiddleagedwomanararecasereportandliteraturereview AT anwarijoudeh systemiclupuserythematosuspresentingasanorexianervosainamiddleagedwomanararecasereportandliteraturereview AT mohammedkaysalattiya systemiclupuserythematosuspresentingasanorexianervosainamiddleagedwomanararecasereportandliteraturereview AT abdoqaidahmedlutf systemiclupuserythematosuspresentingasanorexianervosainamiddleagedwomanararecasereportandliteraturereview AT hassanabuzaid systemiclupuserythematosuspresentingasanorexianervosainamiddleagedwomanararecasereportandliteraturereview AT salahmahdi systemiclupuserythematosuspresentingasanorexianervosainamiddleagedwomanararecasereportandliteraturereview |