The zinc receptor, ZnR/GPR39, modulates taste sensitivity by regulating ion secretion in mouse salivary gland
Summary: Reduced saliva secretion, dry mouth, and loss of taste are debilitating symptoms associated with zinc deficiency. A mechanism for zinc regulation of these processes is lacking. Here, we identified the Zn2+ sensing receptor ZnR/GPR39 as a mediator of ion transport in salivary gland epitheliu...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225001725 |
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| author | Moran Melamed Hila Asraf Noa Livne Milos Bogdanovic Anil Shendge Gilad Shamir Maayan Mero Omer Adir Avi Schroeder Israel Sekler Michal Hershfinkel |
| author_facet | Moran Melamed Hila Asraf Noa Livne Milos Bogdanovic Anil Shendge Gilad Shamir Maayan Mero Omer Adir Avi Schroeder Israel Sekler Michal Hershfinkel |
| author_sort | Moran Melamed |
| collection | DOAJ |
| description | Summary: Reduced saliva secretion, dry mouth, and loss of taste are debilitating symptoms associated with zinc deficiency. A mechanism for zinc regulation of these processes is lacking. Here, we identified the Zn2+ sensing receptor ZnR/GPR39 as a mediator of ion transport in salivary gland epithelium. By monitoring transport of NH4+, a surrogate for K+, we revealed that Zn2+ upregulates the Na+/K+ ATPase pump activity in parotid and submandibular salivary gland epithelium from wildtype (WT), but not from ZnR/GPR39 knockout (KO), mice. Since Na+/K+ ATPase activity is crucial for solute transport, we compared saliva composition in WT and ZnR/GPR39 KO mice and found impaired ionic concentration and reduced saliva secretion in ZnR/GPR39 KO mice. Moreover, mice deficient in ZnR/GPR39 exhibited decreased sensitivity to appetitive Na+ concentrations. Altogether, we demonstrate that salivary ZnR/GPR39 activity controls saliva ion composition and secretion, and provides a target for therapeutic approaches for dry mouth and taste disorders. |
| format | Article |
| id | doaj-art-fea2e69e3ec244d1b0b64a815f053cc2 |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-fea2e69e3ec244d1b0b64a815f053cc22025-02-11T04:35:21ZengElsevieriScience2589-00422025-02-01282111912The zinc receptor, ZnR/GPR39, modulates taste sensitivity by regulating ion secretion in mouse salivary glandMoran Melamed0Hila Asraf1Noa Livne2Milos Bogdanovic3Anil Shendge4Gilad Shamir5Maayan Mero6Omer Adir7Avi Schroeder8Israel Sekler9Michal Hershfinkel10Department of Physiology and Cell Biology, School of Bio Medical Research, and the Zelman School of Brain Sciences and Cognition, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, IsraelDepartment of Physiology and Cell Biology, School of Bio Medical Research, and the Zelman School of Brain Sciences and Cognition, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, IsraelDepartment of Physiology and Cell Biology, School of Bio Medical Research, and the Zelman School of Brain Sciences and Cognition, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, IsraelDepartment of Physiology and Cell Biology, School of Bio Medical Research, and the Zelman School of Brain Sciences and Cognition, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, IsraelDepartment of Physiology and Cell Biology, School of Bio Medical Research, and the Zelman School of Brain Sciences and Cognition, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, IsraelDepartment of Physiology and Cell Biology, School of Bio Medical Research, and the Zelman School of Brain Sciences and Cognition, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, IsraelDepartment of Physiology and Cell Biology, School of Bio Medical Research, and the Zelman School of Brain Sciences and Cognition, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, IsraelThe Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion, Haifa, IsraelThe Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion, Haifa, IsraelDepartment of Physiology and Cell Biology, School of Bio Medical Research, and the Zelman School of Brain Sciences and Cognition, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, IsraelDepartment of Physiology and Cell Biology, School of Bio Medical Research, and the Zelman School of Brain Sciences and Cognition, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel; Corresponding authorSummary: Reduced saliva secretion, dry mouth, and loss of taste are debilitating symptoms associated with zinc deficiency. A mechanism for zinc regulation of these processes is lacking. Here, we identified the Zn2+ sensing receptor ZnR/GPR39 as a mediator of ion transport in salivary gland epithelium. By monitoring transport of NH4+, a surrogate for K+, we revealed that Zn2+ upregulates the Na+/K+ ATPase pump activity in parotid and submandibular salivary gland epithelium from wildtype (WT), but not from ZnR/GPR39 knockout (KO), mice. Since Na+/K+ ATPase activity is crucial for solute transport, we compared saliva composition in WT and ZnR/GPR39 KO mice and found impaired ionic concentration and reduced saliva secretion in ZnR/GPR39 KO mice. Moreover, mice deficient in ZnR/GPR39 exhibited decreased sensitivity to appetitive Na+ concentrations. Altogether, we demonstrate that salivary ZnR/GPR39 activity controls saliva ion composition and secretion, and provides a target for therapeutic approaches for dry mouth and taste disorders.http://www.sciencedirect.com/science/article/pii/S2589004225001725Natural sciencesBiological sciencesBiochemistryPhysiology |
| spellingShingle | Moran Melamed Hila Asraf Noa Livne Milos Bogdanovic Anil Shendge Gilad Shamir Maayan Mero Omer Adir Avi Schroeder Israel Sekler Michal Hershfinkel The zinc receptor, ZnR/GPR39, modulates taste sensitivity by regulating ion secretion in mouse salivary gland iScience Natural sciences Biological sciences Biochemistry Physiology |
| title | The zinc receptor, ZnR/GPR39, modulates taste sensitivity by regulating ion secretion in mouse salivary gland |
| title_full | The zinc receptor, ZnR/GPR39, modulates taste sensitivity by regulating ion secretion in mouse salivary gland |
| title_fullStr | The zinc receptor, ZnR/GPR39, modulates taste sensitivity by regulating ion secretion in mouse salivary gland |
| title_full_unstemmed | The zinc receptor, ZnR/GPR39, modulates taste sensitivity by regulating ion secretion in mouse salivary gland |
| title_short | The zinc receptor, ZnR/GPR39, modulates taste sensitivity by regulating ion secretion in mouse salivary gland |
| title_sort | zinc receptor znr gpr39 modulates taste sensitivity by regulating ion secretion in mouse salivary gland |
| topic | Natural sciences Biological sciences Biochemistry Physiology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225001725 |
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