Challenges in the diagnosis of heart failure with preserved ejection fraction in individuals with obesity
Abstract The rising prevalence of obesity and its association with heart failure with preserved ejection fraction (HFpEF) highlight an urgent need for a diagnostic approach tailored to this population. Diagnosing HFpEF is hampered by the lack of a single non-invasive diagnostic criterion. While this...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12933-025-02612-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823863325876813824 |
|---|---|
| author | Bas M. van Dalen Jie Fen Chin Praveen A. Motiram Anneke Hendrix Mireille E. Emans Jasper J. Brugts B. Daan Westenbrink Rudolf A. de Boer |
| author_facet | Bas M. van Dalen Jie Fen Chin Praveen A. Motiram Anneke Hendrix Mireille E. Emans Jasper J. Brugts B. Daan Westenbrink Rudolf A. de Boer |
| author_sort | Bas M. van Dalen |
| collection | DOAJ |
| description | Abstract The rising prevalence of obesity and its association with heart failure with preserved ejection fraction (HFpEF) highlight an urgent need for a diagnostic approach tailored to this population. Diagnosing HFpEF is hampered by the lack of a single non-invasive diagnostic criterion. While this makes a firm diagnosis of HFpEF already notoriously difficult in the general population, it is even more challenging in individuals with obesity. The challenges stem from a range of factors, including the use of body mass index as a conceptually suboptimal indicator of health risks associated with increased body mass, symptom overlap between HFpEF and obesity, limitations in physical examination, difficulties in electrocardiographic and echocardiographic evaluation, and reduced diagnostic sensitivity of natriuretic peptides in individuals with obesity. In this review, we examine these diagnostic challenges and propose a diagnostic algorithm specifically tailored to improve the accuracy and reliability of HFpEF diagnosis in this growing patient demographic. Graphical abstract Proposed obesity-adjusted HFpEF score. HFpEF, Heart failure with preserved ejection fraction. Created with BioRender.com. |
| format | Article |
| id | doaj-art-ff6819230bc6430484265bb8314709a3 |
| institution | Kabale University |
| issn | 1475-2840 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj-art-ff6819230bc6430484265bb8314709a32025-02-09T12:11:00ZengBMCCardiovascular Diabetology1475-28402025-02-0124111210.1186/s12933-025-02612-zChallenges in the diagnosis of heart failure with preserved ejection fraction in individuals with obesityBas M. van Dalen0Jie Fen Chin1Praveen A. Motiram2Anneke Hendrix3Mireille E. Emans4Jasper J. Brugts5B. Daan Westenbrink6Rudolf A. de Boer7Thorax Center, Department of Cardiology, Cardiovascular Institute, Erasmus MCThorax Center, Department of Cardiology, Cardiovascular Institute, Erasmus MCThorax Center, Department of Cardiology, Cardiovascular Institute, Erasmus MCDepartment of Cardiology, Franciscus Gasthuis & VlietlandDepartment of Cardiology, Ikazia ZiekenhuisThorax Center, Department of Cardiology, Cardiovascular Institute, Erasmus MCDepartment of Cardiology, University Medical Center Groningen, University of GroningenThorax Center, Department of Cardiology, Cardiovascular Institute, Erasmus MCAbstract The rising prevalence of obesity and its association with heart failure with preserved ejection fraction (HFpEF) highlight an urgent need for a diagnostic approach tailored to this population. Diagnosing HFpEF is hampered by the lack of a single non-invasive diagnostic criterion. While this makes a firm diagnosis of HFpEF already notoriously difficult in the general population, it is even more challenging in individuals with obesity. The challenges stem from a range of factors, including the use of body mass index as a conceptually suboptimal indicator of health risks associated with increased body mass, symptom overlap between HFpEF and obesity, limitations in physical examination, difficulties in electrocardiographic and echocardiographic evaluation, and reduced diagnostic sensitivity of natriuretic peptides in individuals with obesity. In this review, we examine these diagnostic challenges and propose a diagnostic algorithm specifically tailored to improve the accuracy and reliability of HFpEF diagnosis in this growing patient demographic. Graphical abstract Proposed obesity-adjusted HFpEF score. HFpEF, Heart failure with preserved ejection fraction. Created with BioRender.com.https://doi.org/10.1186/s12933-025-02612-zObesityHeart failure with preserved ejection fractionDiagnosisEchocardiographyNatriuretic peptides |
| spellingShingle | Bas M. van Dalen Jie Fen Chin Praveen A. Motiram Anneke Hendrix Mireille E. Emans Jasper J. Brugts B. Daan Westenbrink Rudolf A. de Boer Challenges in the diagnosis of heart failure with preserved ejection fraction in individuals with obesity Cardiovascular Diabetology Obesity Heart failure with preserved ejection fraction Diagnosis Echocardiography Natriuretic peptides |
| title | Challenges in the diagnosis of heart failure with preserved ejection fraction in individuals with obesity |
| title_full | Challenges in the diagnosis of heart failure with preserved ejection fraction in individuals with obesity |
| title_fullStr | Challenges in the diagnosis of heart failure with preserved ejection fraction in individuals with obesity |
| title_full_unstemmed | Challenges in the diagnosis of heart failure with preserved ejection fraction in individuals with obesity |
| title_short | Challenges in the diagnosis of heart failure with preserved ejection fraction in individuals with obesity |
| title_sort | challenges in the diagnosis of heart failure with preserved ejection fraction in individuals with obesity |
| topic | Obesity Heart failure with preserved ejection fraction Diagnosis Echocardiography Natriuretic peptides |
| url | https://doi.org/10.1186/s12933-025-02612-z |
| work_keys_str_mv | AT basmvandalen challengesinthediagnosisofheartfailurewithpreservedejectionfractioninindividualswithobesity AT jiefenchin challengesinthediagnosisofheartfailurewithpreservedejectionfractioninindividualswithobesity AT praveenamotiram challengesinthediagnosisofheartfailurewithpreservedejectionfractioninindividualswithobesity AT annekehendrix challengesinthediagnosisofheartfailurewithpreservedejectionfractioninindividualswithobesity AT mireilleeemans challengesinthediagnosisofheartfailurewithpreservedejectionfractioninindividualswithobesity AT jasperjbrugts challengesinthediagnosisofheartfailurewithpreservedejectionfractioninindividualswithobesity AT bdaanwestenbrink challengesinthediagnosisofheartfailurewithpreservedejectionfractioninindividualswithobesity AT rudolfadeboer challengesinthediagnosisofheartfailurewithpreservedejectionfractioninindividualswithobesity |