Protocol of an open-label safety and feasibility pilot study of ketamine-assisted psychotherapy for methamphetamine use disorder (the KAPPA trial) by Jonathan Brett, Celia Morgan, Nadine Ezard, Brendan Clifford, Krista J Siefried, Robert May, Liam Acheson, Kathryn Fletcher, Harriet MacDonald, Gillinder Bedi, Alexandre Guerin, Elizabeth Knock, Michael Millard, Jess Doumany

“…Safety and feasibility will be assessed over an 8-week period. Secondary outcomes (changes in methamphetamine use, cravings, withdrawal, quality of life and treatment satisfaction) will be assessed over a 24-week period.Ethics and dissemination This study has been approved by the St Vincent’s Hospital Human Research Ethics Committee, reference 2023/ETH00530. …”
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Time trends in mechanical thrombectomy (2017–2021): do real-world data reflect advances in evidence? by Christoph Riegler, Christoph Riegler, Viktoria Rücker, Regina von Rennenberg, Regina von Rennenberg, Kerstin Bollweg, Kerstin Bollweg, Bastian Cheng, Anna C. Alegiani, Fabian Flottmann, Marlena Schnieder, Marielle Ernst, Waltraud Pfeilschifter, Waltraud Pfeilschifter, Waltraud Pfeilschifter, Christoffer Kraemer, Ruben Mühl-Benninghaus, Steffen Tiedt, Steffen Tiedt, Lars Kellert, Hanna Zimmermann, Felix J. Bode, Felix J. Bode, Gabor C. Petzold, Gabor C. Petzold, Franziska Dorn, Jörg Berrouschot, Albrecht Bormann, Kathleen Bernkopf, Silke Wunderlich, Tobias Boeckh-Behrens, Martina Petersen, Lars Udo Krause, Stephan Lowens, Heinrich J. Audebert, Heinrich J. Audebert, Eberhard Siebert, Peter U. Heuschmann, Peter U. Heuschmann, Peter U. Heuschmann, Christian H. Nolte, Christian H. Nolte, Christian H. Nolte, Christian H. Nolte

“…Our study aimed to evaluate the temporal changes in patients’ characteristics, treatment, and outcomes in clinical practice.MethodsWe used data from the German Stroke Registry, a large national multicentre prospective registry, which includes all patients receiving EVT for ischaemic stroke at its participating centers. …”
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Dupilumab in children with eosinophilic esophagitis: a retrospective multicenter study by Mohammed Hasosah, Ghassan Sukkar, Asharf AlSahafi, Ali Zaidan, Nouf Ghous, Abdulmajed Alshahrani, Ziyad Al Zahrani, Naif Hasosah, Mansour Qurashi, Loie Goronfolah, Ali Alsharief, Nagla Kamal

“…The mean EoE endoscopic reference scoring system scores changed from a baseline of 6.9 (before dupilumab) to 0.3 (after dupilumab). …”
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Ibrutinib disrupts blood-tumor barrier integrity and prolongs survival in rodent glioma model by Sanghee Lim, Minhye Kwak, Jeonghan Kang, Melissa Cesaire, Kayen Tang, Robert W. Robey, William J. E. Frye, Baktiar Karim, Donna Butcher, Martin J. Lizak, Mahalia Dalmage, Brandon Foster, Nicholas Nuechterlein, Charles Eberhart, Patrick J. Cimino, Michael M. Gottesman, Sadhana Jackson

“…Finally, Ibrutinib, combined with doxil, prolonged median survival in rodent glioma models (27 vs. 16 days, p < 0.0001) with brain imaging showing a − 53% versus − 75% volume change with doxil alone versus combination therapy (p < 0.05). …”
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Non-lethal sonodynamic therapy mitigates hypertensive renal fibrosis through the PI3K/AKT/mTORC1-autophagy pathway by DanDan Liu, Hui Wang, Jialong Li, Siqi Sheng, Shu Wang, Ye Tian

“…Pathway-related protein inhibitors (the autophagy-related inhibitor 3-methyladenine (3-MA), chloroquine (CQ), ROS inhibitor N-acetyl-L-cysteine (NAC) were applied, and autophagosome changes were observed under transmission electron microscopy. …”
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Editorial by Ann-Kristin Kölln, Antony Mason, Maria Lenk, Jörg Tremmel, Markus Rutsche

“…In a second book review, Anna Braam writes about Ian Gough’s Heat, Greed and Human Need. Climate Change, Capitalism and Sustainable Wellbeing (2017, Edward Elgar), a recent study which suggests three steps for countries to accomplish staying below a 1.5°C rise above pre-industrial temperatures: eco-efficient production, changing patterns of consumption, and a reduction of absolute consumption. …”
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N-of-1 medicine by Peter Wang, Qiao Ying Leong, Ni Yin Lau, Wei Ying Ng, Siong Peng Kwek, Lester Tan, Shang-Wei Song, Kui You, Li Ming Chong, Isaiah Zhuang, Yoong Hun Ong, Nigel Foo, Xavier Tadeo, Kirthika Senthil Kumar, Smrithi Vijayakumar, Yoann Sapanel, Marlena Natalia Raczkowska, Alexandria Remus, Agata Blasiak, Dean Ho

“…These and other segments are essential to recognise the diversity within these domains to accelerate their respective workflows towards practice-changing healthcare. To emphasise these points, this article elaborates on the concept of digital health and digital medicine-enabled N-of-1 medicine, which individualises combination regimen and dosing using a patient’s own data. …”
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Four Central Nanocavity of Ultra-Sensitive Refractive Index Biosensor for Cancer Detection in Hexagonal Photonic Crystal by William Matsui, Jianqiao Fang

“…In proposed biosensor, four central nanocavities are immersed in the samples and the resonant wavelengths change according to the refractive index. The resonant wavelengths range for the detection of cancer cells is λ0=1.491258µm ~ 1.50588µm. …”
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Pазказът на костните останки: два скелета от вкопано жилище № 10, ранносредновековен комплекс Брестница–Полето, Северозападна България... by Victoria Russeva, Lyuba Manoilova, Stiliyan Ivanov

“…The consequent laboratory analysis presents a detailed report of the individual characteristics of each skeleton starting with age, sex and stature estimation, and a thorough examination of pathological marks and changes, as well as dental and craniometrical indexes where the condition of the bones allowed a reconstruction. …”
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Modification of peroxidase activity and proteome in maize exposed to cadmium in the presence of galactoglucomannan oligosaccharides by Diana Hačkuličová, Eva Labancová, Zuzana Vivodová, Maksym Danchenko, Kristína Holeková, Marko Bajus, Danica Kučerová, Peter Baráth, Karin Kollárová

“…The GGMOs in the presence of Cd did not significantly influence content of peroxidases but modulated their activity, which implies posttranslational regulation. The changes in the content of various proteins (e.g., related to the defence reactions, cell wall structure/metabolism, and activation of plant hormones) caused by GGMOs and Cd indicate possible protective mechanisms that improve the vitality of maize seedlings exposed to metal stress. …”
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Shedding light on evanescent shadows — Exploration of non-anticommuting γ 5 in Dimensional Regularisation by Paul L. Ebert, Paul Kühler, Dominik Stöckinger, Matthias Weißwange

“…Here we present a detailed study of the impact of changing such evanescent details. We leverage this freedom to identify a particularly convenient formulation that simplifies practical calculations. …”
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Environmental selection underlies distinct distribution patterns of closely related European evening primroses by Monika Woźniak-Chodacka, Maciej Kocurek, Maria Pilarska, Ewa Niewiadomska

“…Abstract Understanding of species distribution is becoming a key concern in biogeography, ecology and evolution when to consider the ongoing climate change. This study investigates the distribution patterns of closely related Oenothera species focusing on their adaptations to environmental conditions through morphological traits and photosynthetic adjustments. …”
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Characterization of the sunflower oil-based oleogel developed by the ferulic acid/monoglyceride mixture and its application in chocolate preparation by Sheng Zhang, Sheng Geng, Hanjun Ma, Benguo Liu

“…With the increasing substitution rate (WCBS), the appearance, texture properties and enthalpy change of chocolate gradually deteriorated. But when WCBS ≤ 40 %, the oleogel had no significant effect on the sensory characteristics.…”
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A dataset from the Cryptogamia-Lichenes section of the Herbarium Universitatis Taurinensis (TO) by Rosanna Piervittori, Deborah Isocrono, Enrica Matteucci, Mariagrazia Morando, Luca Dessì, Laura Guglielmone, Heimo Rainer, Stefano Martellos, Andrea Moro, Pier Luigi Nimis, Matteo Conti, Sergio Enrico Favero-Longo

“…With regard to the historical collection, only a set of 59 recently revised specimens is available on the mentioned platforms, but most of the materials are accessible as digital images on the website of the project HERB-TO-CHANGE.…”
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Goji berry (Lycium barbarum) has positive effects on the mucosa and colonic myoenteric innervation of obese rats by Samara Cristina Dossena, Isabela Ramos Mariano Furlan, Maria Montserrat Diaz Pedrosa, Rosângela Fernandes Garcia, Fernando Carlos de Sousa, Maria Raquel Marçal Natali

“…This study investigated the effects of Goji berry supplementation (250 mg/kg) on the intestine of male Wistar rats, from 70 to 130 days (group OGB) or 21 to 130 days (group OPR) of age, with obesity induced by simple carbohydrate-rich diet. The diet did not change the morphology or the thickness of the proximal colon wall but increased the proportion of small neurons in the myoenteric plexus. …”
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Effects of interactions between microorganisms and lipids on inferior volatile compound production during cold storage of grouper (Epinephelus coioides) by Yuanming Chu, Jinfeng Wang, Jing Xie

“…Furthermore, 20 key volatile compounds (VOCs) related to odor changes in the grouper lipid solution were identified using HS-SPME-GC–MS. …”
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Research methodology of youth interpersonal communication based on modern technology by Krstić Milan, Skorup Ana, Gavrić Gordana

“…Modern communication based on ICT has changed the way of communication and has brought numerous benefits for participants of the communication process in several aspects of communication (mass availability, development time, speed of communication, possibilities of combining different multimedia forms, ease of communication, etc.), also including some negative effects in various aspects of communication (protection of privacy, simplification of linguistic content, alienation of people, etc.). …”
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Irritable bowel syndrome: pathophysiological and clinical issues by V. T. Ivashkin, Ye. A. Poluektova

“…At irritable bowel syndrome there are series of structural changes interconnected with each other, built into logic chain, that ends by development of symptoms. …”
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Association of Subjective Cognitive Concerns With Performance on Mobile App–Based Cognitive Assessment in Cognitively Normal Older Adults: Observational Study by Caroline O Nester, Alyssa N De Vito, Sarah Prieto, Zachary J Kunicki, Jennifer Strenger, Karra D Harrington, Nelson Roque, Martin J Sliwinski, Laura A Rabin, Louisa I Thompson

“…Findings suggest that mobile app assessments may be sensitive to subtle cognitive changes, with important implications for early detection and treatment for individuals at risk for dementia.…”
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Correlation pain-quality of life in women after being submitted to surgical treatment of breast cancer by Izabela dos Santos Mendes, Sergio Takeshi Tatsukawa de Freitas, Glaucia de Castro Souza, Mariana Cesar Ribeiro dos Reis, Djenifer Queiroz de Souza, Fernanda Pupio Silva Lima, Adriano Oliveira Andrade, Mario Oliveira Lima

“…Breast cancer, which is more prevalent in the female population, causes physical, functional, and emotional changes that make daily activities difficult, affecting women’s quality of life. …”
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