Within- and between-day test–retest reliability of responses to rapid bilateral anterolateral magnetic phrenic nerve stimulation in healthy humans (ReStim) by Kyle G. P. J. M. Boyle, Andrea A. Beglinger, Heinrich Häusler, Anna Stahel, Esther I. Schwarz, Esther I. Schwarz, Christina M. Spengler, Christina M. Spengler

“…An ordinal regression was used to determine changes of sensory ratings within and between days.ResultsAt all stimulator outputs, within-day Pdi,mean displayed “good” reliability (ICC range 0.78–0.89). …”
Get full text

Crinum jagus (J. Thomps. Dandy): Antioxidant and protective properties as a medicinal plant on toluene-induced oxidative stress damages in liver and kidney of rats by Mariama, Salihu, Gaber, El-Saber Batiha, Keneth Iceland, Kasozi, George D., Zouganelis, Souty M.Z., Sharkawi, Eman, Ibrahim Ahmed, Ibe Michael, Usman, Halima, Nalugo, Juma J., Ochieng, Ibrahim, Ssengendo, Olatayo Segun, Okeniran, Theophilus, Pius, Kyobe Ronald, Kimanje, Eric Simidi, Kegoye, Ritah, Kenganzi, Fred Ssempijja

“…The study assessed the protective effects and changes in oxidative stress indices due to C. jagus leaf extracts on the toluene-induced liver and kidney injuries in rats. …”
Get full text

The anticancer properties, cell-cycle cytotoxicity and apoptosis of cissus rotundifolia, trema orientalis, and buddleja polystachya with ocular applications by Ali Hendi Alghamdi, Aimun A.E. Ahmed, Mahadi bashir, Haidar abdalgadir, Asaad khalid, Ashraf N. Abdalla, Mohamed E. elzubier, Riyad almaimani, Bassem refaat, Khalid alzahrani, Saleh MS. alghamdi, Sheraz gul

“…Additionally, a clonogenic assay was performed to measure tumor cell survival and subsequent proliferative capacity after drug exposure was conducted for the most active extract(s) and finally western blotting was used to determine the expression change of the two selected proteins (survivin and CCND1) in order to determine the exact mechanistic features of the most promising plant extract. …”
Get full text

The anti-circumsporozoite antibody response to repeated, seasonal booster doses of the malaria vaccine RTS,S/AS01E by M. Sanni Ali, Lisa Stockdale, Issaka Sagara, Issaka Zongo, Rakiswendé Serge Yerbanga, Almahamoudou Mahamar, Frédéric Nikièma, Amadou Tapily, Frédéric Sompougdou, Modibo Diarra, Duncan Bellamy, Samuel Provstgaard-Morys, Charles Zoungrana, Djibrilla Issiaka, Alassane Haro, Koualy Sanogo, Abdoul Aziz Sienou, Mahamadou Kaya, Seydou Traore, Oumar M. Dicko, Youssouf Kone, Hama Yalcouye, Ismaila Thera, Kalifa Diarra, Paul Snell, Opokua Ofori-Anyinam, Chris Ockenhouse, Cynthia Lee, Katie Ewer, Halidou Tinto, Abdoulaye Djimde, Jean-Bosco Ouedraogo, Alassane Dicko, Daniel Chandramohan, Brian Greenwood

“…Although anti-CSP antibody titres declined after repeated booster doses of RTS,S/AS01E a high, although declining, level of efficacy was sustained suggesting that there may have been changes in the characteristics of the anti-CSP antibody following repeated booster doses. …”
Get full text

CD4 T cell dynamics shape the immune response to combination oncolytic herpes virus and BRAF inhibitor therapy for melanoma by Victoria Jennings, Kevin Harrington, Hardev Pandha, Alan Melcher, Adel Samson, Fiona Errington-Mais, Victoria Roulstone, Eva Crespo-Rodriguez, Galabina Bozhanova, Shane Foo, Emmanuel C Patin, Martin McLaughlin, Malin Pedersen, Richard Vile, Joan Kyula, Jehanne Hassan, Lizzie Appleton, Charleen ML Chan Wah Hak, Gabby Baker, Edward Armstrong, Matthew Chiu, Masahiro Ono

“…Dual therapy results in changes in T cell dynamics within tumors, with relatively maintained antigen signaling in Treg compared with conv CD4+. …”
Get full text

The Use of L-Menthol in Endoscopic Transpapillary Interventions. Prospective Randomized Dual-Center Study by M. A. Anishchenko, M. A. Nazmeev, S. G. Shapovalyants, S. A. Budzinsky, A. V. Rogov, R. R. Zaynutdinov, A. S. Melnikova, E. D. Fedorov, E. N. Platonova

“…Three minutes post-irrigation, the suppression of peristaltic waves was noted in the experimental group “L”: 0 points — 63 (90 %) patients, 1 point — 6 (8.6 %) patients, compared to the control, with no change in peristalsis (p < 0.05). Successful selective cannulation was achieved in 64 (91.4 %) patients of group “L” and in 41 (73.2 %) — of the control group (p < 0.05). …”
Get full text

Multi-omics uncovers immune-modulatory molecules in plasma contributing to resistance exercise-ameliorated locomotor disability after incomplete spinal cord injury by Ren Zhou, Jibao Chen, Yunhan Tang, Chuijin Wei, Ping Yu, Xinmei Ding, Li’ao Zhu, Jiajia Yao, Zengqiang Ouyang, Jing Qiao, Shumin Xiong, Liaoliao Dong, Tong Yin, Haiqing Li, Ye Feng, Lin Cheng

“…We integrated the analysis of plasma proteomics and peripheral blood mononuclear cells (PBMC) transcriptomics to explore the molecular and cellular changes induced by resistance exercise. Subsequently, we established a weight-loaded ladder-climbing mouse model to mimic the physiological effects of resistance exercise, and we analyzed the plasma proteome and metabolome, as well as the transcriptomes of PBMC and muscle tissue. …”
Get full text

Low-activity [18F]-somatostatin receptor (SSTR) imaging using [18F]SiTATE on a long axial field-of-view PET/CT scanner by Nils F. Trautwein, Eduardo Calderón, Pia M. Linder, Gerald Reischl, Philippe Driessen, Wenhong Lan, Andreas S. Brendlin, Thorben Groß, Helmut Dittmann, Martina Hinterleitner, Christian la Fougère, Fabian P. Schmidt, Lena S. Kiefer

“…Despite a reduction to 1 MBq/kg of [18F]SiTATE all lesions were still detected while at 0.25 MBq/kg lesion detectability decreased to 70% (HS) and 93% (UHS). Only minor changes in SUVmean and TLR were detected with reduced activity. …”
Get full text

Impaired creatinine-based estimated glomerular filtration rate in Thai individuals switching to dolutegravir: illustrating the role of cystatin C testing to aid clinical decision m... by Carlo Sacdalan, Curtis Austin, Aswathy Varma, Suteeraporn Pinyakorn, Eugène Kroon, Donn J. Colby, Phillip Chan, Orlanda Goh, Krittaporn Pornpaisakul, Jintana Intasan, Tassanee Luekasemsuk, Merlin L. Robb, Nitiya Chomchey, Nittaya Phanuphak, Jintanat Ananworanich, Sandhya Vasan, Denise Hsu, the SEARCH 010/RV254 study group

“…Random-effect linear regression model was used to assess changes in eGFRcre over 96 weeks from starting ART, and from switching to DTG. …”
Get full text

Effectiveness of ertugliflozin during Ramadan fasting in patients with type 2 diabetes mellitus: a real-world study (ErtuRamadan study) by Md Faruque Pathan, Nazma Akter, Marufa Mustari, M. Saifuddin, Mirza Sharifuzzaman, Mohammad Motiur Rahman, Mohammed Ripon, S. M. Mohiuddin, A. B. M. Kamrul-Hasan, Mohammad Abdul Hannan, Muhammad Shah Alam, Samira Mahjabeen, Faria Afsana, Muhammed Abu Bakar, Tahniyah Haq, Afsar Ahammed, Samir Kumar Talukder, Sourav Sarkar, Shahjada Selim

“…The primary endpoints were changes in HbA1c levels, body weight, body mass index (BMI), and the incidence of hypoglycemia during Ramadan fasting.ResultsThe mean age of the study participants was 50.37 ± 11.14 (SD) years, with 40.6% male and 58.7% female. …”
Get full text

Supported biopsychosocial self-management for back-related leg pain: a randomized feasibility study integrating a whole person perspective by Brent Leininger, Roni Evans, Carol M. Greco, Linda Hanson, Craig Schulz, Michael Schneider, John Connett, Francis Keefe, Ronald M. Glick, Gert Bronfort

“…Providers were trained to address participants’ individualized needs and use behavior change and motivational communication techniques to develop a therapeutic alliance to facilitate self-management. …”
Get full text

Targeting aldose reductase using natural African compounds as promising agents for managing diabetic complications by Miriam E. L. Gakpey, Shadrack A. Aidoo, Toheeb A. Jumah, George Hanson, Siyabonga Msipa, Florence N. Mbaoji, Omonijo Bukola, Palesa C. Tjale, Mamadou Sangare, Hedia Tebourbi, Olaitan I. Awe

“…Molecular dynamics simulations and MM-PBSA analysis confirmed that the compounds bound to AR exhibited high stability and less conformational change to the AR-inhibitor complex.ConclusionThis study highlighted the potential inhibitory activity of 5 compounds that belong to the African region: (+)-Pipoxide, Zinc000095485961, Naamidine A, (−)-Pipoxide, and 1,6-di-o-p-hydroxybenzoyl-beta-d-glucopyranoside. …”
Get full text

Review: A systematic review of dairy cow health, welfare, and behaviour in year-round loose range housing by W.J. Harvey, L. Petrokofsky, M.W. Jordon, G. Arnott, L.W. von Walter, A. Malik, T. Carter, L.S. Wade, G. Petrokofsky

“…For future research, data collected should be made freely available in a disaggregated form to enable robust meta-analysis to be conducted. In order to change policies and practices, based on evidence, more standardised primary research studies, measuring welfare indicators, including behaviour, are necessary.…”
Get full text

Call for Papers: Constitutions and Intergenerational Justice by IF and FRFG

“…Are they the guardians of earlier regulations and therefore opponents of constitutional change? • Are eternity clauses (clauses which prohibit changes to certain or all provisions of a constitution) generationally fair? …”
Get full text

Indicators of Esophageal pH-Impedance Monitoring and High-Resolution Manometry in Patients with Various Forms of Gastroesophageal Reflux Disease by I. V. Maev, E. V. Barkalova, M. A. Ovsepyan, D. N. Andreev, Yu. A. Kucheryavyi

“…The aim of the study is to analyze the regularities of changes in the basic indicators of esophageal pH-impedance monitoring and high-resolution manometry in patients with non-erosive reflux disease (NERD), erosive reflux disease (ERD) and Barrett’s esophagus (BE) in comparison with healthy individuals.Materials and methods.  69 patients were examined, including 19 patients with NERD, 16 patients with ERD, 14 patients with BE and 20 individuals comprising the control group (CG). …”
Get full text

An optimized approach for predicting water quality features and a performance evaluation for mapping surface water potential zones based on Discriminant Analysis (DA), Geographical... by Abhijeet Das

“…Surface water resources are running low as a result of things like severe climate change and overexploitation. Estimating water output and locating possible surface water zones are therefore crucial. …”
Get full text

The Identification of FN1 as an Early Diagnostic Marker for Recurrent Abortion by Single-Exosome Profiling by Wang C, Lu Z, She G, Chen K, Zhou H, Zhan X, Yu H, Pi L, Zuo L, Che D

“…Among these, FN1 was the most significantly differentially expressed gene in exosomes, with FN1 | log2 (fold change) |> 1.5 and an AUC of 0.7414. In addition, exosome subpopulation analyses showed that cluster 11 accounted for the largest proportion of the total 16 subpopulations, and FN1 was the marker with the highest concentration of cluster 11.Conclusion: Single-exosome profiling and exosome subpopulations of RA by PBA yielded significant differential gene FN1, which provides new possibilities for diagnostic screening of RA.Keywords: recurrent abortion, exosomes, FN1, PBA…”
Get full text

The role of Nazi organizations in German repatriation from the Baltic states (1939-1941) by Ingrida Jakubavičienė

“…The number of Germans increased because of Nazi agitation, then Lithuanians changed their nationality into German. In Latvia in 1930, there lived about 70 thousand, and in Estonia—16 thousand Germans. …”
Get full text

Dexmedetomidine versus Dexamethasone as Perineural Adjuvants in Supraclavicular Brachial Plexus Block: An Interventional Study by Charmi Hitenbhai Shah, Jinesh Pareshbhai Kothari, Nilesh Vrajmohan Shah, Rajsi Rajan Shah, Sara Mary Thomas

“…The onset and duration of sensory and motor blocks, haemodynamic changes {variations in pulse, blood pressure, and oxygen saturation (SpO2)}, duration of rescue analgesia, side-effects, and complications were evaluated. …”
Get full text

Clinical significance of Helicobacter pylori infection in iron-deficiency anemia: features of comprehensive treatment approach by I. V. Mayev, S. A. Kochetov

“…At control examination in 28 days after iron supplementation onset positive changes were observed, that were more prominent in the subgroup 1a: Hb 117,8 g/l, RBC 3,9×1012, RBC color index 0,83, serum iron 17,7 µmol/l, TIBC 74,4 µmol/l, transferrin saturation percent 20,8 %, ferritin of 20,7 µg/l; in the subgroup 1B: 104,2 g/l, 3,6×1012, 0,81, 12,6 µmol/l, 79,2 µmol/l, 16,6 %, 17,9 µg/l respectively. …”
Get full text