Patients Walking Faster After Anterior Cruciate Ligament Reconstruction Have More Gait Asymmetry by Rachel J. Knobel, Naoaki Ito, Elanna K. Arhos, Jacob J. Capin, Thomas S. Buchanan, Lynn Snyder-Mackler

“… # Study Design Secondary analysis of a clinical trial. # Methods Athletes 24±8 weeks after primary ACLR walked at self-selected speeds as kinematics, kinetics, and electromyography data were collected. …”
Get full text

A randomized controlled trial to compare the effect of oxycodone and sufentanil on postoperative analgesia and immune function for laparoscopic resection of colorectal cancer by Chunmei Lin, Zhiqiao Xu, XinLiang, Hong Wei, Xiaoping Wang

“…Trial registration Chinese Clinical Trial Registry (ChiCTR2400089072).…”
Get full text

Methods to address functional unblinding of raters in CNS trials by Steven D. Targum, William P. Horan, Vicki G. Davis, Alan Breier, Stephen K. Brannan

“…These methods may have utility across all clinical trials.…”
Get full text

Effects of neutrophil granule proteins on sepsis-associated lymphopenia and their relationship with CD4+ T-cell pyroptosis by Jia-yu Mao, Ya-wen Xie, Xian-li Lei, Jia-hui Zhang, Wei Cheng, Na Cui

“…Furthermore, neutrophil granule proteins were significantly correlated with CD4+ T cell and its pyroptosis [MPO and CD4+ T cells (r = −0.4039, p < 0.0001), CD4+NLRP3 (r = 0.4868, p < 0.0001), NE and CD4+ T cells (r = −0.5140, p < 0.0001), and CD4+NLRP3 (r = 0.6513, p < 0.0001)].ConclusionIncreased levels of neutrophil granule proteins were significantly associated with SAL incidence, and a significant relationship between neutrophil granule proteins and the pyroptosis pathway of CD4+ T cells was revealed.Clinical trial registrationchictr.org.cn identifier ChiCTR-ROC-17010750.…”
Get full text

The Effects of Foot Reflexology Massage on the Sleep Quality of Nurses Working in the Selected Hospitals of Sabzevar University of Medical Sciences by Mojgan Gholitabar Omrani, mohammad Reza Ghasemi, Mohammad Gholizadeh Gerdrodbari, Roghayeh Javan, Neda Mahdavifar

“…Therefore, this study aimed to evaluate the effects of foot reflexology massage on the sleep quality of nurses. This controlled clinical trial was conducted on 80 nurses working in the selected hospitals of Sabzevar University of Medical Sciences. …”
Get full text

Integrated malaria vector control strategies and their effectiveness in sub-Saharan Africa: a systematic review protocol for interventional studies by Diederick E Grobbee, Lihanimpo Djalogue, Marianne van der Sande, Patrice Ngangue, Gountante Kombate, Kamba Andre-Marie Soubeiga

“…This systematic review is designed to assess the effectiveness of integrated vector control versus single vector control interventions on malaria incidence and prevalence to guide decisions on controlling malaria vectors in sub-Saharan Africa.Methods and analyses We will systematically retrieve published and grey literature from electronic databases and clinical trial registries. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines will guide us in applying a systematic approach to screening, reviewing and extracting data. …”
Get full text

The effect of dienogest and gonadotropin-releasing hormone agonist on pelvic pain after laparoscopic surgery for endometriosis: An RCT by Fatemeh Davari Tanha, Azam Rasti, Hamideh Pakniat, Shohreh Salimi Setudeh

“…Materials and Methods: In this randomized clinical trial study, 104 women with endometriosis who were referred to the Department of Reproductive Medicine of Yas hospital, Tehran, Iran, between April 2022 and March 2023 were studied. …”
Get full text

Exploring the Effects of Sub-Dissociative Doses of Ketamine on Sedation Quality in Bronchoscopy: A Double-Blind Clinical Study by Hamidreza Shetabi, Samira Rostami

“…Methods: This research utilized randomized clinical trial design involving three cohorts, each consisting of 30 participants. …”
Get full text

Annual Zoledronic Acid for the Treatment of Osteoporosis: A Randomized Controlled Trial by Asif Hussain, Sushil Kumar Saini, Jaydeep Patel, Chandra Prakash Pal, Hemant Singh Chahar, Rohit Yadav

“…Methods: This is a blinded randomized clinical trial conducted at a government hospital. Patients aged 50–89 years with bone mineral density (BMD) T score < −2.5 or < −1.5 with 2 mild vertebral fractures or 1 moderate vertebral fractures were randomized to receive placebo versus zoledronic acid. …”
Get full text

Effects of a Groin Pain Prevention Program in Male High School Soccer Players: A Cluster-Randomized Controlled Trial by Kazuki Fujisaki, Kiyokazu Akasaka, Takahiro Otsudo, Hiroshi Hattori, Yuki Hasebe, Toby Hall

“… # Design Randomized Controlled Clinical Trial. # Methods A cluster randomized controlled trial spanning 16 weeks was conducted on 202 high school soccer players from seven high schools in a Japanese under 18 Soccer League. …”
Get full text

A systematic review of Aspilia africana (Pers.) C.D. adams traditional medicinal uses, phytoconstituents, bioactivities, and toxicities by Gang, Roggers, Okello, Denis, Yeongjun, Ban, Kang, Youngmin

“…Additionally, toxicity and clinical trial data for A. africana are limited with most toxicological assessments being acute in nature. …”
Get full text

Long-term real-world evidence of CPX-351 of high-risk patients with AML identified high rate of negative MRD and prolonged OS by Thomas Cluzeau, Fabio Guolo, Edmond Chiche, Paola Minetto, Ramy Rahme, Sarah Bertoli, Luana Fianchi, Jean-Baptiste Micol, Michele Gottardi, Pierre Peterlin, Sara Galimberti, Xavier Thomas, Giuliana Rizzuto, Olivier Legrand, Michela Rondoni, Emmanuel Raffoux, Giambattista Bertani, Alexis Caulier, Michelina D’Argenio, Caroline Bonmati, Atto Billio, Caroline Lejeune, Barbara Scappini, Arnaud Pigneux, Patrizia Zappasodi, Christan Recher, Francesco Grimaldi, Lionel Ades, Roberto M. Lemoli

“…These data provide the rationale for the 2 ongoing studies evaluating CPX-351 vs 7+3 in non–MRC-AML and non–t-AML using MRD as the primary end point for ALFA-2101 phase 2 clinical trial and event-free survival for AMLSG 30-18 phase 3 clinical trial.…”
Get full text

Experiences of working as a clinical nurse while pregnant during the coronavirus disease-2019 pandemic: a qualitative study by Lin Ye Wu, Wing Fai Yeung, Yao Lin Pei, Ling Xi Chen, Meng Qi Li, Jia Yin Ruan

“…Moreover, research on moral stigma and bullying in nursing during pregnancy deserves further exploration. Clinical trial number Not applicable.…”
Get full text

Oral health status, behavior and impact profile among naval personnel in the Malaysian naval armed forces by Nik Madihah Nik Azis, Raja Noreihan Raja Abdullah, Mohamad Nur Adzmi Mohamad Ayub, Badiah Baharin

“…These findings highlight the need for tailored oral health interventions within the naval setting to enhance deployment readiness, improve oral health outcomes, and elevate the quality of life for naval personnel. Clinical trial number Not applicable.…”
Get full text

Bupivacaine–fentanyl isobaric spinal anesthesia reduces the risk of ICU admission in elderly patients undergoing lower limb orthopedic surgery by Wenxun Liu, Shuzhen Bao, Jiaxin Chen, Yan Li, Yinghua Gu, Qingshan Ye, Kerong Hai

“…Trial registration: This study has been registered in the Chinese Clinical Trial Registry (ChiCTR2000033411).…”
Get full text

Assessing the relationship between nursing process competency and work environment among clinical nurses: a cross-sectional correlational study by Reza Nemati-Vakilabad, Ehsan Kamalifar, Mobina Jamshidinia, Alireza Mirzaei

“…Additionally, targeted training programs should be provided to focus on the nursing process and skills enhancement, thereby boosting both confidence and competency. Clinical trial number Not applicable.…”
Get full text

Persistence with Early-Line Abatacept versus Tumor Necrosis Factor-Inhibitors for Rheumatoid Arthritis Complicated by Poor Prognostic Factors by Xue Han, Francis Lobo, Michael S. Broder, Eunice Chang, Sarah N. Gibbs, David J. Ridley, Irina Yermilov

“…Gathering data on treatment patterns outside of a clinical trial setting can provide useful context for clinicians. …”
Get full text

Phase 1 study of novel anti-platelet agent to overcome pharmacogenomic limitations of clopidogrel by Anil Pareek, Nitin Chandurkar, Vivek Raut, Kumar Naidu

“…It can be further developed in clinical studies for the unmet medical needs in management of CVDs and overcome the pharmacogenomic limitations of Clopidogrel.Trial registration number Clinical Trial Registry-India URL: http://ctri.nic.in. …”
Get full text

Effect of Dynamic Neuromuscular Stabilization Exercises on Activity of External Oblique Muscle in Low Back Pain by Hediyeh Hosseini, Abbas Rahimi, Khodabakhsh Javanshir, Mohammad Taghipour, Aliyeh Daryabor, Sedigheh Sadat Naimi

“…Materials and Methods: In a randomized clinical trial, 44 people with chronic NSLBP were randomly assigned to the experimental and the control groups, with 22 participants in each group. …”
Get full text

Effectiveness of a Foam Roller Warm-Up in Professional Basketball Players: A Randomized Controlled Trial by Daniel Casado, Ivan Nacher, Juan Pardo, Javier Reina

“… # Level of Evidence 3\. Registered as a clinical trial at ClinicalTrials.gov with registration number: NCT05971316.…”
Get full text