Effect of icatibant on sweating-induced dermal pain by Shunsuke Takahagi, Shunsuke Takahagi, Daiki Matsubara, Emi Murakami, Yumi Aoyama, Shinya Imamura, Atsushi Fukunaga, Atsushi Fukunaga, Yoshiko Oda, Hiroyuki Murota, Michihiro Hide, Michihiro Hide

“…The role of bradykinin in the dermal pain varies among patients.Clinical trial registrationhttps://jrct.niph.go.jp/, identifier jRCTs061210021.…”
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Development of a machine learning model related to explore the association between heavy metal exposure and alveolar bone loss among US adults utilizing SHAP: a study based on NHAN... by Jiayi Chen

“…In the future, more advanced algorithms should be developed to validate these results and related parameters can be tuned to improve the accuracy of the model. Clinical trial number not applicable.…”
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Rapid Verbal Persuasion to increase influenza vaccine uptake: protocol for a randomized hybrid type 2 effectiveness -implementation trial by Siyuan Liu, Lan Gao, Yingying Jin, Jiangyun Chen, Dadong Wu, Yiyuan Cai, Tao Wang, Sanhao Huang, Ciling Yan, Run Wang, Dong Roman Xu

“…Trial registration Chinese Clinical Trial Registry. Trial identifier: ChiCTR2400091302 (Registration Date: October 25, 2024); ChiCTR2400091324 (Registration Date: October 25, 2024).…”
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Clinical Profile and Prescription Patterns in Culture-proven Enteric Fever in Children by Divya Priyadharshini, Mobill Clinton, Nandini Sethuraman, Mathrubootham Sridhar, Vidya Krishna

“…Future areas of research interest will include an effective vaccine for paratyphoid fever and a randomized clinical trial on single vs combination therapy in enteric fever.…”
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Abdominal fat distribution and its relationship to brain changes: the differential effects of age on cerebellar structure and function: a cross-sectional, exploratory study by Yvonne Böttcher, Michael Stumvoll, Kees Straatman, Matthias Raschpichler, Matthias Leopold Schroeter, Katrin Arelin, Haiko Schlögl, Dominik Fritzsch, Meinhard Mende, André Pampel, Arno Villringer, Karsten Mueller

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Effect of arm-ergometry versus treadmill supervised exercise on health-related quality of life and mental health in patients with peripheral artery disease: secondary outcomes from... by Sandra Magalhães, Mário Santos, Sofia Viamonte, Fernando Ribeiro, Joana Martins, Cristine Schmidt, Henrique Cyrne-Carvalho

“…Methods This was an ancillary study of the ARMEX trial, a single-center, single-blinded, parallel group, randomized clinical trial, enrolling symptomatic PAD patients referred to a cardiovascular rehabilitation program (CRP). …”
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Prescription pattern, glycemic control status, and predictors of poor glycemic control among diabetic patients with comorbid chronic kidney disease in Ethiopia: a facility-based cr... by Oumer Sada Muhammed, Minimize Hassen, Samuel Mamusha

“…With only 4.4% of participants achieving optimal HbA1c levels, the findings underscore a critical public health concern regarding the management of diabetes in this vulnerable population. Clinical trial number Not applicable.…”
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Youth experiencing homelessness at risk for suicide: psychosocial risk factors and service use patterns by Laura J. Chavez, Kelly J. Kelleher, Alicia Bunger, Xin Feng, Margaret Fitzpatrick, Jodi L. Ford, Allen B. Mallory, Arielle H. Sheftall, Tansel Yilmazer, Alexis Pizzulo, Jesse L. Hawke, Mattina A. Davenport, Natasha Slesnick

“…Methods A cross-sectional analysis of youth enrolled in a supportive housing randomized clinical trial. We categorized suicide risk into three groups (low-, moderate-, and high-risk) based on suicidal ideation and past-year suicide attempt. …”
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Validating a digital depression prevention program for adolescents in Jordan: cultural adaptation and user testing in a randomized controlled trial by Latefa Ali Dardas, Obada Al-leimon, Tracy Gladstone, Abd Arrahman Dabbas, Insaf Alammouri, Benjamin Van Voorhees

“…Future implementations should consider strategies to actively engage parents to foster a supportive environment that promotes the well-being of adolescents.Clinical trial registrationhttps://doi.org/10.1186/ISRCTN14751844, identifier ISRCTN14751844.…”
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An investigator-blinded, 24-month, parallel-group, non-inferiority study to compare aesthetic restorations in primary anterior teeth in a paediatric dental clinic: study protocol f... by Ana Paula Taboada Sobral, Elaine Marcilio Santos, Marcela Leticia Leal Gonçalves, Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Sandra Kalil Bussadori, Elza Padilha Ferri, Juliana Maria Altavista Sagretti Gallo, Thais Gimenez, José Carlos Pettorossi Imparato

“…Thus, this project aims to evaluate the effectiveness of restorative treatment of anterior primary teeth with monochromatic composite resin in single insertion through polyvinyl crowns, after selective removal of carious tissue compared with the effectiveness of conventional restoration.Methods and analysis This study proposes to conduct a randomised clinical trial, composed of a sample of 194 deciduous central and lateral incisors with active cavitated lesions, simplified International Caries Detection and Assessment System (ICDAS) C+ score (active and extensive stage caries: ICDAS 5 and 6), with involvement of more than two surfaces. …”
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Multicentre, 26-week, open-label phase 2 trial of the JAK inhibitor filgotinib in Behçet’s disease, idiopathic inflammatory myopathies and IgG4-related disease: DRIMID study protoc... by Sander W Tas, Joost Raaphorst, Paco M J Welsing, Jacob M van Laar, Rogier M Thurlings, Robbert J Goekoop, César Magro Checa, Jan A M van Laar, Bettina C Geertsema-Hoeve, Nicolle H Rekers, Erik Present

“…Introduction Research into novel therapies for rare, immune-mediated inflammatory diseases (IMIDs) faces significant challenges, including small patient populations, complex clinical trial design and difficulties in patient recruitment. …”
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Anti-inflammatory treatment using alpha melanocyte stimulating hormone (α-MSH) does not alter osteoblasts differentiation and fracture healing by Johanna Graue, Melanie Timmen, Katharina Schmitz, Daniel Kronenberg, Markus Böhm, Kishor K. Sivaraj, M. Gabriele Bixel, Richard Stange

“…We can conclude from our results, that treatment of inflammatory diseases using α-MSH does not interfere significantly with bone regeneration in a murine fracture model and therefore treatment with α-MSH could be continued without negative effects on bone formation and bone regeneration in patients. Clinical trial number Not applicable.…”
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Pregnant Women, a Potential Reservoir for Onchocerca volvulus? A Cross Sectional Study in Maridi County, South Sudan by Chiara Trevisan, Amber Hadermann, Stephen Raimon Jada, Raphael A. Abong, Yak Yak Bol, Joseph N. Siewe Fodjo, Katja Polman, Robert Colebunders

“…Pregnant women in South Sudan are a reservoir for parasite transmission. A clinical trial evaluating the potential beneficial effect of treating O. volvulus infected pregnant women with IVM should be considered, as our preliminary results and the literature suggest that IVM intake might not affect the newborn.…”
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Auricular acupressure for minimizing adverse reactions to colonoscopic bowel preparation in hospitalized patients: A randomized controlled trial by Jiahui Zhang, Chang Liu, Guodong Ruan, Haiyan Zhang, Beiping Zhang, Xuejun Hu, Cailing Zhong

“…Methods: This was a prospective, assessor-blinded, randomized controlled clinical trial implemented at Guangdong Provincial Hospital of Chinese Medicine. …”
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Disproportionality analysis of upadacitinib-related adverse events in inflammatory bowel disease using the FDA adverse event reporting system by Shiyi Wang, Xiaojian Wang, Jing Ding, Xudong Zhang, Hongmei Zhu, Yihong Fan, Changbo Sun

“…The most commonly reported AEs were acne, product residue present, haematochezia, frequent bowel movements, flatulence, blood cholesterol increased, aligning with clinical trial outcomes. Notably, significant but unexpected AEs, such as rosacea, proctalgia, polyp, were also reported. …”
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Reference values for the 1-minute sit-to-stand test to assess functional capacity and short-term mortality in people with idiopathic pulmonary fibrosis and fibrotic connective tiss... by Meng-Yun Tsai, Kuo-Tung Huang, Chiann-Yi Hsu, Yi-Hsuan Yu, Pin-Kuei Fu

“…Conclusions The findings suggest that ≤ 23 repetitions in the 1MSTS can serve as an indicator of functional impairment, demonstrate a good correlation with 6MWT distance, and effectively predict 18-month mortality in patients with F-ILD. Clinical trial number Not applicable.…”
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Machine learning reveals sex differences in distinguishing between conduct-disordered and neurotypical youth based on emotion processing dysfunction by Gregor Kohls, Erik M. Elster, Peter Tino, Graeme Fairchild, Christina Stadler, Arne Popma, Christine M. Freitag, Stephane A. De Brito, Kerstin Konrad, Ruth Pauli

“…However, the data also underscore the heterogeneity of CD, namely that only a subset of those affected are likely to have emotion dysfunction and that other neurocognitive domains (not tested here) probably also contribute to CD etiology. Clinical trial number Not applicable.…”
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Under-five mortality and its associated factors in sub-Saharan Africa: a multilevel analysis of recent demographic and health surveys data based on Bayesian approach by Atalay Liknaw Birhanie, Zemenu Tadesse Tessema, Bekalu Endalew, Koku Sisay Tamirat

“…The adjusted odds ratio (AOR) and its 95% credible interval (CrI) were reported for significant factors associated with under-five mortality. Clinical trial number: not applicable. Results The prevalence of under-five mortality in sub Saharan Africa was 62 per 1000 live births (95%CI (56.29, 68.29). …”
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Effectiveness of Continuous Glucose Monitoring on Short-Term, In-Hospital Mortality Among Frail and Critically Ill Patients With COVID-19: Randomized Controlled Trial by Jiawei Shang, Ziming Yuan, Zuoyan Zhang, Quanhong Zhou, Yan Zou, Wei Wang

“…Trial RegistrationChinese Clinical Trial Registry ChiCTR2200059733; https://www.chictr.org.cn/showproj.html?…”
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Assessing Sedation Depth with PSI in Elderly ERCP Patients: A Prospective Cohort Study by Huang L, Liu LL, Lu YD, Zhuang MY, Dou W, Liu H, Ji FH, Peng K

“…Our results showed a significant correlation between the PSI values and MOAA/S scores and suggested a PSI value of 50 with a range of 48 to 52 for maintaining adequate sedation.Trial Registration: Chinese Clinical Trial Registry (ChiCTR2400079859).Keywords: endoscopic retrograde cholangiopancreatography, depth of sedation, elderly patients, Modified Observer’s Assessment of Alertness/Sedation, patient state index…”
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