Universal capillary screening for chronic autoimmune, metabolic and cardiovascular diseases: feasibility and acceptability of the UNISCREEN study by Sara Angiulli, Aurora Merolla, Elisa Borgonovo, Rebecca De Lorenzo, Serena Spadoni, Barbara Fontana, Giuseppina Manganaro, Elena Rela, Alberto Bongiovanni, Rita Peracino, Chiara Bellino, Giulia Pata, Eleonora Bianconi, Sabina Martinenghi, Francesca Ulivi, Cristina Renzi, Cristina Renzi, Emanuele Bosi, Emanuele Bosi, UNISCREEN Study Group, Sara Angiulli, Aurora Merolla, Alberto Bongiovanni, Rebecca De Lorenzo, Elena Rela, Rita Peracino, Chiara Bellino, Giuseppina Manganaro, Elisa Borgonovo, Sara Critelli, Aldo Fici, Martina Mallus, Giulia Morocutti, Giulia Pata, Clara Soggetti, Chiara Calabrese, Alberico Di Resta, Maria Pia Ruggiero, Antonella Spano’, Francesca Biasco, Manuel Stocchi, Pietro Melodia, Giuseppe Ancona, Andrea Laurenzi

“…The study was registered as ClinicalTrials.gov NCT05841719.ResultsThe study included 1,535 participants (50.1% of local population). …”
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Lost microbes of COVID-19: Bifidobacterium, Faecalibacterium depletion and decreased microbiome diversity associated with SARS-CoV-2 infection severity by Eamonn MM Quigley, Thomas J Borody, Sabine Hazan, Neil Stollman, Huseyin S Bozkurt, Sonya Dave, Andreas J Papoutsis, Jordan Daniels, Brad D Barrows

“…Objective The study objective was to compare gut microbiome diversity and composition in SARS-CoV-2 PCR-positive patients whose symptoms ranged from asymptomatic to severe versus PCR-negative exposed controls.Design Using a cross-sectional design, we performed shotgun next-generation sequencing on stool samples to evaluate gut microbiome composition and diversity in both patients with SARS-CoV-2 PCR-confirmed infections, which had presented to Ventura Clinical Trials for care from March 2020 through October 2021 and SARS-CoV-2 PCR-negative exposed controls. …”
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Transcatheter edge-to-edge mitral valve repair <i>versus</i> medical therapy for secondary mitral regurgitation: a meta-analysis of randomized controlled trials by Emídio Mata, Bárbara Lage Garcia, Mariana Tinoco, Margarida Castro, Luísa Pinheiro, João Português, Francisco Ferreira, Silvia Ribeiro, Bruno Melica, António Lourenço

“… Secondary mitral regurgitation (SMR) is associated with increased hospitalizations and mortality. Clinical trials comparing mitral valve transcatheter edge-to-edge repair (M-TEER) with guideline-directed medical therapy (GDMT) show conflicting results, but the RESHAPE-HF2 trial offers new insights. …”
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Building on and tailoring to: Adapting a cancer caregiver psychoeducational intervention for rural settings by Erin E. Kent, Kelly R. Tan, Zev M. Nakamura, Jesse Kovacs, Mindy Gellin, Allison Deal, Eliza M. Park, Maija Reblin

“…The enCompass intervention is undergoing ongoing single‐arm pilot of rural cancer patient/caregiver dyads targeting caregiver coping self‐efficacy and patient/caregiver distress (Clinical Trials #NCT05828927).…”
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Treatment of Helicobacter pylori infection: mainstream and innovations (Review of the literature and Russian gastroenterological association Advisory council resolution, May 19, 20... by V. T. Ivashkin, I. V. Mayev, T. L. Lapina, A. A. Sheptulin, A. S. Trukhmanov, R. A. Abdulkhakov, S. A. Alekseyenko, N. N. Dekhnich, R. S. Kozlov, I. L. Klyaritskaya, S. A. Kurilovich, M. F. Osipenko, V. I. Simanenkov, I. B. Khlynov

“…To present data of clinical trials, systematic reviews and metaanalyses which allow to optimize eradication therapy of Helicobacter pylori (H. pylori) infection. …”
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Efficacy of Chinese traditional quadruple single pill combination versus valsartan/hydrochlorothiazide for the treatment of hypertension (COSPQ-BP): study protocol for randomised c... by Kai Liu, Yu Yan, Xin Zhang, Yanan Li, Yuanyuan Yao, Lu Liu, Runyu Ye, Si Wang, Xiangyu Yang, Xiaoping Chen, Shanshan Jia, Qingtao Meng, Xianghao Zuo

“…The findings of this study will be disseminated through conference presentations and peer-reviewed publications.Trial registration This study was registered at the Chinese Clinical Trials Registry (ChiCTR2300067920). The COSPQ-BP trial is currently enrolling. …”
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Oncologic oUTcomes of neoadjuvant chemotherapy for obSTructive colon cAncer after steNt decompression (OUTSTAND trial); A study protocol of multicenter non-inferiority randomized c... by Bong-Hyeon Kye, Ji-Hoon Kim, Hyung-Jin Kim, Yoon-Suk Lee, In-Kyu Lee, Won Kyung Kang, Hyeon-Min Cho, Jong-Kyung Park, Chang-Hyeok Ahn, Jae-Im Lee, Seong-Taek Oh, Byung Jo Choi

“…Registration This study is registered on ClinicalTrials.gov Identifier: NCT04889820, registered on May 17, 2021 in clinicaltrials.gov; Protocol ID: XC21MIDI0004.…”
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Donafenib combined with sintilimab for advanced hepatocellular carcinoma: a single arm phase II trial by Xiaoyang Hong, Yongjian Guo, Wenbo Shi, Kangshun Zhu, Licong Liang, Liteng Lin, Ye Chen, Jingwen Zhou, Jingjun Huang, Jiabai Huang, Yaozhu Wu, Wensou Huang, Mingyue Cai

“…Trial registration ClinicalTrials.gov (identifier: NCT05162352; date of registration: December 4, 2021).…”
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Effectiveness of mobile health for exercise promotion on cardiorespiratory fitness after a cancer diagnosis: A systematic review and meta‐analysis by Megan E. Gregory, Weidan Cao, Saurabh Rahurkar, Fadi Haroun, James C. Stock, Sanam M. Ghazi, Daniel Addison

“…Methods Leveraging MEDLINE/PubMed, Scopus, and ClinicalTrials.gov, we identified studies through May 2023. …”
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Can oral caffeine decrease postoperative opioid consumption following posterior spinal fusion in adolescent idiopathic scoliosis? A randomized placebo-controlled trial by Anne Stuedemann, MSN, RN, CPNP, Richard M Schwend, MD FAAP FAOA, Kenneth A. Shaw, MD, Nicolette Saddler, MSN, APRN, FNP-C, Michon Huston, PA-C, Michael Benvenuti, MD, Julia Leamon, MSN, RN, CPN, Ashley K. Sherman, MA, John Anderson, MD

“…This trial's reported mean total oral opioid consumption range of 0.83 to 0.92 MME/kg is lower than the amounts typically observed in clinical trials. This finding could indicate a successful strategy in reducing opioid use, which aligns with current medical efforts for opioid stewardship.…”
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Feasibility of remote robot empowered teleultrasound scanning for radioactive patients by Ying Liang, Lu Wang, Manuel Escobar Amoresa, Zirui Jiang, Bo Yu, Jiami Li, Man Lu

“…In this prospective study (ChineseClinicalTrials.gov identifier, ChiCTR2200057253), 32 radioactive patients were examined by conventional ultrasound and MGIUS-R3 robot-assisted ultrasound from March 2022 to June 2022. …”
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Inosine enhances the efficacy of immune‐checkpoint inhibitors in advanced solid tumors: A randomized, controlled, Phase 2 study by Haiqing Zhao, Wei Zhang, Yuting Lu, Yin Dong, Zhihao He, Hongchao Zhen, Qin Li

“…The trial was registered at ClinicalTrials.gov (NCT05809336). Results Among the 172 participants with advanced malignant solid tumors, 86 each were assigned to the inosine and non‐inosine groups, wherein the median PFS (95% CI) was 7.00 (5.31–8.69) and 4.40 (3.10–5.70) months, respectively (hazard ratio [HR] 0.63; 95% CI 0.44–0.90, p = 0.011), and the ORR was 26.7% and 15.1%, respectively (p = 0.061). …”
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Do preoperative interventions affect patient satisfaction or expectation fulfilment following total hip arthroplasty? A systematic review by April-Rose Matt, Joanne L. Kemp, Andrea B. Mosler, Lucy Salmon, Diogo Almeida Gomes, Alysha De Livera, Erica Hateley, Adam L. Semciw

“…Methods: MEDLINE, EMBASE, Cochrane Register of Clinical Trials, CINAHL and Sports Discus were searched from inception to May 2023. …”
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Comparable outcomes after busulfan- or treosulfan-based conditioning for allo-HSCT in children with ALL: results of FORUM by Krzysztof Kalwak, Laura M. Moser, Ulrike Pötschger, Peter Bader, Katharina Kleinschmidt, Roland Meisel, Jean-Hugues Dalle, Akif Yesilipek, Adriana Balduzzi, Gergely Krivan, Evgenios Goussetis, Raquel Staciuk, Petr Sedlacek, Herbert Pichler, Peter Svec, Melissa Gabriel, Tayfun Güngör, Ernest Bilic, Jochen Buechner, Marleen Renard, Kim Vettenranta, Marianne Ifversen, Cristina Diaz-de-Heredia, Jerry Stein, Jacek Toporski, Marc Bierings, Christina Peters, Marc Ansari, Franco Locatelli

“…This trial was registered at www.ClinicalTrials.gov as #NCT01949129.…”
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Study protocol of a pilot randomised controlled trial assessing the feasibility and acceptability of RecoverEsupport: a digital health intervention to enhance recovery in women und... by Christopher Oldmeadow, Mitch J Duncan, Penny Reeves, Priscilla Viana da Silva, Rebecca Wyse, Helen Moore, Alison Zucca, Sancha Robinson, Stephen Ridley Smith, Emma Sansalone, Owen Morris, Rebecca Chenery, Lara Riley, Anna Palazzi-Parsons

“…Trial outcomes will be disseminated via peer-reviewed publications and conference presentations.Trial registration number Australian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12624000417583.…”
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Adrenal aldosterone synthase (CYP11B2) histopathology and its association with disease-induced sudden death: a cross-sectional studyResearch in context by Antero Ylänen, Juhani Isojärvi, Antti Virtanen, Helena Leijon, Tiina Vesterinen, Aapo L. Aro, Heini Huhtala, Eeva Kokko, Ilkka Pörsti, Marianna Viukari, Pasi I. Nevalainen, Niina Matikainen

“…This trial was registered at ClinicalTrials.gov (NCT05446779). Findings: Adrenal histopathology revealed changes in 31 (7.7%) subjects of the cohort. …”
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Radiological abnormalities persist following COVID-19 and correlate with impaired health-related quality of life: a prospective cohort study of hospitalised patients by Rhian M Touyz, Ninian N Lang, Kevin G Blyth, Naveed Sattar, Patrick B Mark, Stefan Siebert, Colin Berry, Iain McInnes, Giles Roditi, Neil Basu, David Corcoran, Kenneth Mangion, Alex McConnachie, David Carrick, Jaclyn Carberry, Stuart Watkins, Paul Welsh, Sabrina Nordin, Katherine Scott, Christian Delles, Bernard Kelly, Fraser Goldie, John GF Cleland, Sharon Kean, Peter Kellman, David J Lowe, Andrew J Morrow, Antonia Ho, Rosemary Woodward, Tracey Hopkins, Ryan Wereski, Massimo Palmarini, Alasdair McIntosh, Campbell Rogers, Ammani Brown, Catherine Bagot, Kathryn Scott, Robert Sykes, Colin Church, Claire Rooney, Nicola Ryan, Clare Orange, Dirk Husmeier, Xiaoyu Luo, PETER W MACFARLANE, Heerajnarain Bulluck, Iain Findlay, Evonne McLennan, Michael Briscoe, Oliver Peck, Alastair J Rankin, Gruschen Veldtman, Varun Sharma, Kathryn McLaren, Elaine Butler, Sarah Mullen, Andrew Morrow, Patrick Mark, Daniel Doherty, Alexander Payne, Jennifer S Lees, Kaitlin J Mayne, Louise Inglis, Anna Kamdar, Hannah Bayes, Vivienne B Gibson, Lynsey Gillespie, Douglas Grieve, Pauline Hall Barrientos, Christopher McGinley, Connor Mckee, Sarah Allwood-Spiers, Sarah Weeden, Laura Knox, Lynn Abel, David Stobo, Andrew Dougherty, Liam Peng, David Barrie Stobo, Sylvia Wright, Stephen Dobbin, Keith Gillis, Sarah A Spiers, Ian Fergus, Kirsty Fallon, Lesley Gilmour, Chloe Cowan, Jurgen Van-Melckebeke, Kim Moran-Jones, Debra Stuart, Maureen Travers, Laura Dymock, Fiona Savage, Nicola Tynan, Sau Lee Chang, Mhairi Dupre, Lindsey Norton, George Bruce, Rosario Gonzalez-Lopez, Rebecca Stace, Dionne Russell, Jean Watt, Shahid Latif, Nick Hill, Amy Collinsworth, Ross McGeoch Vera Lennie, Robin P Weir

“…We present a prospective, observational, multicentre cohort study using multimodality imaging to describe the pulmonary sequelae of patients hospitalised with COVID-19, predictors of persistent abnormal radiology and implications on health status.Methods In survivors of COVID-19, we performed convalescent CT pulmonary angiogram and high-resolution CT imaging as part of the CISCO-19 study (ClinicalTrials.gov ID NCT04403607). This included serial blood biomarkers and patient-reported outcomes 28–60 days following discharge from hospital.Results Of the COVID-19 cohort, 88 (56%) patients of the COVID-19 cohort (n = 159; mean age, 55 years; 43% female) had persisting radiological abnormalities at 28–60 days postdischarge. …”
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Concomitant abdominal organ transplantation alongside lung transplantation: An ISHLT transplant database analysis by Renita Wilson, BS, J. Asher Jenkins, MD, Juan Maria Farina, MD, Blake Langlais, MS, Bashar Aqel, MD, Ashraf Omar, MD, Jonathan D’Cunha, MD, PhD, Pedro Reck dos Santos, MD, PhD

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Use of Anabolic-Androgenic Steroids and Male Fertility: A Systematic Review and Meta-analysis by Prashant Motiram Mulawkar, Pankaj N. Maheshwari, Vineet Gauhar, Sumeet Gopal Agrawal, Taofiq Olayinka Mohammed, Abhishek Gajendra Singh, Gopal Ramdas Tak, Utsav Shailesh Shah, Deepali Parthsarthi Shukla, Deepali Mamankar

“…Information sources - A systematic literature search was performed using PubMed, MEDLINE, EMBASE, Google Scholar and World of Science. Controlled clinical trials randomised or nonrandomised (if available), case series with or without matched controls, case reports, cross-sectional surveys, reports on follow-up of subjects caught in doping test and their fertility parameters when reported. …”
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Refining management strategies for Lennox–Gastaut syndrome: Updated algorithms and practical approaches by Stéphane Auvin, Alexis Arzimanoglou, Mercè Falip, Pasquale Striano, J. Helen Cross

“…The resulting consensus document is based on current evidence from clinical trials and clinical practice and the panel's expert opinion, focusing on new ASMs with novel mechanisms of action, such as highly purified cannabidiol and fenfluramine. …”
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