FusOn-pLM: a fusion oncoprotein-specific language model via adjusted rate masking by Sophia Vincoff, Shrey Goel, Kseniia Kholina, Rishab Pulugurta, Pranay Vure, Pranam Chatterjee

“…We introduce FusOn-pLM, a fine-tuned pLM trained on a newly curated, comprehensive set of fusion oncoprotein sequences, FusOn-DB. …”
Get full text

Aduhelm, a novel anti-amyloid monoclonal antibody, for the treatment of Alzheimer’s Disease: A comprehensive review by Hannah W. Haddad, Garett W. Malone, Nicholas J. Comardelle, Arielle E. Degueure, Salomon Poliwoda, Rachel J. Kaye, Kevin S. Murnane, Adam M Kaye, Alan D. Kaye

“…Cholinesterase inhibitors and N-methyl-D-aspartate receptor antagonists have historically been the most widely used pharmacologic therapies for patients with AD; however, these drugs are not curative. The present investigation describes the epidemiology, pathophysiology, risk factors, presentation, and current treatment of AD followed by the role of the novel monoclonal antibody, Adulhelm, in the treatment of AD. …”
Get full text

Acoustic Characteristics of Coconut Leaf Beetle, Brontispa Longissima (Coleoptera: Chrysomelidae) by Ganeshwari Selvaraj, Johari Jalinas

“…Furthermore, this acoustic study is critical to understanding the behavior of destructive insects and helps develop more curative and sustainable methods to control B. longissima. …”
Get full text

Phylogenomics of North American cybaeid spiders (Araneae, Cybaeidae), including the description of new taxa from the Klamath Mountains Geomorphic Province by Marshal Hedin, Martín J. Ramírez, Rodrigo Monjaraz-Ruedas

“…We also conduct analyses of traditional Sanger loci, allowing curation of some previously published data. Our UCE phylogenomic results support the monophyly of recognized cybaeids, with strongly supported internal relationships, and evidence for five primary molecular subclades. …”
Get full text

Improving access to suicide prevention services through the National Suicide Prevention Framework implementation: The community level evidence-based recommendations by J C Y Nyasulu, D A Siddiqi, S Seedat, J Bantjies, M Udedi, S Gondwe, S Kambale, M Mkandawire, N Silungwe, L A Hendricks, I Maposa, J Vumu, D Skinner

Get full text

NASSDA as a Data-Collaborative Network to Enhance Social Science Research in East Asia by Pei-Shan Liao, Shuai Wang, Hiroshi Ishida, Hearan Koo, Won-ho Park

“…Although the advantages of sharing social science data has been recognized, challenges persist, particularly for data repositories focusing on curation and dissemination. In this article, we introduce the establishment of the Network of Asian Social Science Data Archives (NASSDA), a collaborative network among social science data depositories in East Asia. …”
Get full text

A BIBLIOMETRIC ANALYSIS OF VIDEO-BASED FEEDBACK IN HIGHER EDUCATION (2003-2022): TRENDS, GAPS AND FUTURE DIRECTIONS by Nagaletchimee Annamalai, Arathai Din Eak

“…Data was systematically curated from the Dimensions database. Out of an initial 25,747 publications, 1,532 publications were selected for final analysis after refining the keyword search to ensure relevance to the subject. …”
Get full text

SHASI-ML: a machine learning-based approach for immunogenicity prediction in Salmonella vaccine development by Ottavia Spiga, Ottavia Spiga, Ottavia Spiga, Anna Visibelli, Francesco Pettini, Bianca Roncaglia, Annalisa Santucci, Annalisa Santucci, Annalisa Santucci

“…The model was trained and validated using a curated dataset of experimentally verified immunogenic and non-immunogenic proteins. …”
Get full text

Validity assessment of the POLARS score tool in the prediction of post rectal cancer surgery LARS score in a population-based Swedish cohort by Asif Johar, Pernilla Lagergren, Boglarka Rethy, Caroline Nordenvall, Emil Pieniowski, Gabriella Jansson-Palmer, Mirna Abraham-Nordling

“…The aim of this study was to analyse how accurately the POLARS score could predict LARS scores when compared with actual patient-reported LARS (PR-LARS) scores in a population-based Swedish cohort.Design This retrospective cohort study included patients who underwent curative rectal cancer surgery between 2007 and 2013 in Stockholm County and were identified using the Swedish Colorectal Cancer Registry (SCRCR). …”
Get full text

Recent updates of centromere proteins in hepatocellular carcinoma: a review by Zhongyuan Yang, Wenjiao Chen, Yunhui Liu, Yuxin Niu

“…Owing to the atypical early symptoms and characteristics of HCC, over 80% of HCC patients cannot receive curative treatment. The treatment of HCC is facing a bottleneck, and new treatment methods are urgently needed. …”
Get full text

Study protocol of the METAPANC trial - intensified treatment in patients with local operable but oligometastatic pancreatic cancer - multimodal surgical treatment versus chemothera... by Michael Ghadimi, Uwe Pelzer, Marc G. Besselink, Jens Siveke, Ralph Telgmann, Rickmer Braren, Hanneke Wilmink, Marie Crede, Alexander Koenig, Ute Koenig, Sven Thorsten Liffers, Kai Antweiler, Bas Uijterwijk, Hanna Seppanen, Arno Nordin, Pauli Puolakkainen, Olav F. Dajani, Knut Jørgen Labori, Mia Johansson, Svein Olav Bratlie, Tim Friede, Peter Jo

“…Discussion METAPANC is the first international, randomized, controlled, open-label, multicentre, phase III clinical trial for curative intended surgical therapy of oligometastatic pancreatic cancer in Europe and America. …”
Get full text

Nephroprotective effects of Foeniculum vulgare mill (Apiaceae Family) hydromethanol leaf extract against cisplatin-induced nephrotoxicity on Swiss albino mice by Kibur Hunie Tesfa, Chernet Desalegn Gebeyehu, Tiget Ayelgn Mengstie, Hiwot Tezera Endale

“…Therefore, it is mandatory to seek effective, affordable, and safe drugs for the prevention and curative effects of kidney toxicity caused by cisplatin. …”
Get full text

Sporoderm-Removed Spore Powder May Suppress the Proliferation, Migration, and Invasion of Esophageal Squamous Cell Carcinoma Cells Through PI3K/AKT/mTOR and Erk Pathway by Jingyan Liu Master degree, Tao Zeng Doctor degree

“…Tumor metastasis is a key factor of therapeutic failure in tumor patients, but the underlying molecular mechanism remains to be explored and novel effective curative strategies are urgently required. Emerging evidence suggests that sporoderm-removed Ganoderma lucidum spore powder can suppress tumor growth and metastasis. …”
Get full text

Breast cancers with neuroendocrine differentiation: Retrospective case studies series from a single institution based on the 2019 WHO classification by Youngkyung Jeon, Ji-Yeon Kim, Jin Seok Ahn, Young-Hyuck Im, Kyuehee Choi, Sun Young Jeong, Yeji Jung, Jaeyeon Jang, Dae-Ho Choi, Joohyun Hong, Hyo Jung Kim, Soo Youn Cho, Yeon Hee Park

“…All patients were treated with curative intent surgery; five patients received neoadjuvant chemotherapy, twelve patients received radiotherapy, six patients received adjuvant chemotherapy, and eight patients received hormone therapy. …”
Get full text

Efficacy analysis of folic acid in chronic atrophic gastritis with Helicobacter pylori infection: a systematic review and meta-analysis by Hui Li, Jincheng Li, Mingyu Lai

“…Gastric mucosal protective agents can improve the curative effect and can be selected according to the condition of patients with obvious adverse reactions. …”
Get full text

Analysis of clinical and pathological prognostic factors of survival in rectal adenocarcinoma treated with preoperative radiochemotherapy by Sarhan Sydney Saad, Nora Forones, Gaspar Lopes Filho, Jaques Waisberg, Elesiario Caetano Júnior, Ricardo Artigiani-Neto, Delcio Matos

“…Methods: We studied 70 patients from the Discipline of Surgical Gastroenterology at Escola Paulista de Medicina from 2000 to 2019, with rectal cancer located up to 10 cm from the anal verge and with stages II or III, submitted to preoperative RCT and curative surgery (R0) and with follow-up of at least 12 months. …”
Get full text

Evaluation of treatment strategies for patients with stage IIIA non-small cell lung cancer in the immunotherapy era by Amy Alabaster, Jeffrey B. Velotta, Haley I. Tupper, Mark S. Walker, Yanina Natanzon

“…Data was from ConcertAI's curated EHR Patient360™ NSCLC real-world care product. …”
Get full text

Real world study on combining local interventions with systemic therapy in unresectable hepatocellular carcinoma by Zhaosong Xue, Ming Yao, Kang Chen, Taiyun Huang, Jianjun Li, Jian Chen, Fei Huang, Yubin Huang, Xiaoyong Cai, Yihe Yan

“…Notably, patients without extrahepatic disease and those who exhibited a radiographic response to triple therapy were more likely to be eligible for curative resection. Importantly, hepatectomy independently associated with a favorable overall survival (HR, 0.388; 95% CI, 0.177–0.847; P = 0.017). …”
Get full text

Outcomes after Surgery for Malignant Pancreatic Neuroendocrine Tumors by Omar Hama Ghalib Azeez Hawramy, Karzan Seerwan Abdullah, Barham M.M. Salih, Qalandar Hussein A. Kasnazani, Dana Taib Gharib, Dara Ahmed Mohammed

“…The aim of the study is to declare the role of surgery in potentially curative malignant pancreatic neuroendocrine tumors, in term of prognosis, survival and complications after the surgical procedures. …”
Get full text