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261
An Update on African Trypanocide Pharmaceutics and Resistance.
Published 2023“…In AAT, quinapyramine sulfate interferes with DNA synthesis and suppression of cytoplasmic ribosomal activity in the mitochondria. …”
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262
Wilson and Walker's Principles and Techniques of Biochemistry and Molecular Biology /
Published 2018Table of Contents: “…Biochemical and molecular biological methods in life sciences studies -- Basic principles -- Cell culture techniques -- Recombinant DNA techniques and molecular cloning -- Preparative protein biochemistry -- Electrophoretic techniques -- Immunochemical techniques -- Flow cytometry -- Radioisotope techniques -- Principles of clinical biochemistry -- Microscopy -- Centrifugation and ultracentrifugation -- Spectroscopic techniques -- Basic techniques probing molecular structure and interactions -- Mass spectrometric techniques -- Fundamentals of bioinformatics -- Fundamentals of chemoinformatics -- The python programming language -- Data analysis -- Fundamentals of genome sequencing and annotation -- Fundamentals of proteomics -- Fundamentals of metabolomics -- Enzymes and receptors -- Drug discovery and development.…”
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263
Genetically Modified Food
Published 2014-11-01“… A food is considered genetically modified when its genetic makeup is altered in some way as a result of the use of recombinant DNA biotechnological procedures. These changes result in the expression of attributes not found in the original. …”
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264
Predicting the evolution of bacterial populations with an epistatic selection-mutation model
Published 2024-06-01“…It incorporates two recently noticed phenomena related to mutations: (i) the fact that the marginal improvement from a beneficial mutation declines with increasing fitness or diminishing returns epistasis and (ii) for some hypermutator variants, the mutation rate for the bacterial DNA undergoes a sudden increase by at least one order of magnitude. …”
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265
Weak solutions of unconditionally stable second-order difference schemes for nonlinear sine-Gordon systems
Published 2024-12-01“…This paper presents the existence and uniqueness of the weak solution for the nonlinear system of sine-Gordon equations which describes DNA dynamics. An unconditionally stable second order difference scheme generated by the unbounded operator A2 corresponding to the system of sine-Gordon equations is considered. …”
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266
Genetically Modified Food
Published 2014-11-01“… A food is considered genetically modified when its genetic makeup is altered in some way as a result of the use of recombinant DNA biotechnological procedures. These changes result in the expression of attributes not found in the original. …”
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267
Epigenetic and gene regulatory functions of small RNAs
Published 2023-12-01“…I also discuss new emerging paradigms, highlighting the role of RNA in heritable information similar to the well-known DNA function.…”
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268
Exome sequencing in Nigerian children with early‐onset epilepsy syndromes
Published 2025-02-01“…Venous blood samples were collected, and genomic DNA was isolated and purified. Molecular analysis included DNA fragmentation, ligation, target enrichment, library preparation, and whole‐exome sequencing. …”
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269
STING agonist-based treatment promotes vascular normalization and tertiary lymphoid structure formation in the therapeutic melanoma microenvironment
Published 2021-02-01“…In vitro assays were performed on CD11c+ BMDCs treated with 2.5 µg/mL ADU S-100 or CD11c+ DCs isolated from tumor digests and associated transcriptional changes analyzed via qPCR or profiled using DNA microarrays. For T cell repertoireβ-CDR3 analyses, T cell CDR3 was sequenced from gDNA isolated from splenocytes and enzymatically digested tumors.Results We report that activation of STING within the TME leads to slowed melanoma growth in association with increased production of antiangiogenic factors including Tnfsf15 (Vegi) and Cxcl10, and TLS-inducing factors including Ccl19, Ccl21, Lta, Ltb and Light. …”
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270
SETD2 loss-of-function uniquely sensitizes cells to epigenetic targeting of NSD1-directed H3K36 methylation
Published 2025-02-01“…Its role in regulating cellular processes such as RNA splicing, DNA repair, and spurious transcription initiation underlies its broader tumor suppressor function. …”
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271
Blockades of effector T cell senescence and exhaustion synergistically enhance antitumor immunity and immunotherapy
Published 2022-10-01“…Induction of ataxia-telangiectasia mutated protein (ATM)-associated DNA damage is the cause for T cell senescence induced by both mouse tumor cells and Treg cells, which is also regulated by mitogen-activated protein kinase (MAPK) signaling. …”
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272
Genomic analysis of the SMN1 gene region in patients with clinically diagnosed spinal muscular atrophy: a retrospective observational study
Published 2025-02-01“…Methods This retrospective observational study conducted in Japan used pre-collected DNA samples from patients with clinically diagnosed SMA. …”
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273
Advances in personalized gastroenterology and hepatology 2016
Published 2016-08-01“…On the other hand, using high throughput array and other technologies, it is possible to simultaneously analyze thousands of genes (DNA) or gene products (RNA and proteins), resulting in an individual gene or gene expression profile (‘signature’) or to characterize the individual microbiome and its pathogenetic potential. …”
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274
Clinical significance of exosomal noncoding RNAs in hepatocellular carcinoma: a narrative review
Published 2025-01-01“…Exosomes, which are characterized by their cargos of stable intracellular messengers, such as DNA, RNA, proteins, and lipids, play a crucial role in regulating cell differentiation and HCC development. …”
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275
Les traces de Denis Papin dans la poussière de l’histoire
Published 2024-11-01“…However, these devices apparently had no practical application at the time.In this article, we explore Papin’s efforts to create practical devices and the subsequent imprints he left in the literature, which can be considered a cultural artifact containing part of the “DNA” of human society. We employ bibliometric techniques to analyze the published literature (books, manuscripts, patents, etc.) from the 17th to the 21st century to quantitatively trace Papin’s impressive influence on science and technology.…”
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276
INTESTINAL MICROBIOME - A LEADING FACTOR IN HUMAN HEALTH AND DISEASES
Published 2018-08-01“…On the other hand, high throughput array and other technologies made it possible to simultaneously analyze thousands of genes (DNA) or gene products (RNA and proteins), resulting in an individual gene or gene expression profile (‘signature’) or to characterize the individual microbiome and its pathogenetic potential. …”
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277
Natural selection and evolution: evolving concepts
Published 2024-05-01“…Current evolutionary models incorporate different adaptive and non-adaptive processes based on molecular genetic changes and how DNA is modified over time in unicellular species, or in germline versus somatic cells in metazoan species. …”
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278
Role of aspirin in cancer prevention
Published 2024-01-01“…In recent years, studies have found that the potential mechanism of aspirin in the prevention and treatment of cancer may lie in immune regulation, the role of DNA repair pathways, the regulation of cell metabolism, anti-inflammatory effects and antiplatelet effects.…”
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279
Clinical and molecular analysis of JCPyV and BKPyV infection and associated risk of urothelial carcinoma development in the upper tract
Published 2025-02-01“…Nested polymerase chain reaction and DNA sequencing were used to detect viral DNA and genotypes. …”
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280
Molecular characterization of pregnancy-associated breast cancer and insights on timing from GEICAM-EMBARCAM study
Published 2025-02-01“…., DEPDC1, CCNA2, PSAT1, CDKN3, and FAM83D), enriched in DNA repair and cell proliferation pathways. Through the PPI network, we also identified a cluster of cell-cycle regulation genes like MYC, FOXM1, or PTEN. …”
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