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301
Evolution by natural selection is a scientific law and not just a theory
Published 2024-02-01“…The developing knowledge of prokaryotic microorganisms and the discovery of DNA or RNA as the fundamental basis of inheritance in all living organisms, together with Mendel’s laws, now provide the four basic conditions for evolution by natural selection, namely reproduction that is stable, but allows for variation that can increase fitness in the broadest sense. …”
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302
Protocol for the purification and analysis of nuclear UFMylated proteins
Published 2025-03-01“…Summary: Protein UFMylation regulates numerous cellular processes including ribosome quality control and nuclear DNA repair. Here, we present a technique to isolate nuclei and purify UFMylated proteins under denaturing non-reducing conditions from commonly used mammalian cell line models such as hTERT-RPE1, HEK293, U2OS, and HCT116 cells. …”
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303
Axon regeneration: an issue of translation
Published 2024-12-01“…However, it is now well described that mRNA and protein levels correlate only partially in cells, and that the transcription process (from DNA to mRNA) may not directly reflect protein expression. …”
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304
Mutual Effect of <i>NAT2</i> rs1799930 (590G>A) Polymorphism and Alcohol Abuse on Risk of Acute Pancreatitis
Published 2020-12-01“…Estimation of the contribution of rs1799930 (590G>A) polymorphism of gene NAT2 to the development of acute alcoholic pancreatitis.Materials and methods. DNA samples were obtained from 547 unrelated patients with acute alcoholic pancreatitis and 573 unrelated individuals without gastrointestinal diseases. …”
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305
Examining the epigenetic transmission of risk for chronic pain associated with paternal post-traumatic stress disorder: a focus on veteran populations
Published 2025-02-01“…Numerous overlapping neurological pathways are implicated in both PTSD and chronic pain; many of which are susceptible to epigenetic modification, such as DNA methylation, histone modifications, and RNA regulation. …”
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306
Mineral Plastics and Gels from Multi‐Arm Ionomers
Published 2025-02-01“…This concept of synthesizing multi‐arm polymers with improved characteristics from building blocks of traditionally linear structures may be applicable to other mineral and bioplastic materials including acrylates, polysaccharides, and DNA.…”
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307
Polycystic ovary syndrome (PCOS): progress towards a better understanding and treatment of the syndrome
Published 2024-04-01“…However, the underlying mechanisms of its transmission remain unknown, thus limiting the development of effective therapeutic strategies.This article highlights how an altered fetal environment (prenatal exposure to high levels of anti-Müllerian hormone) can contribute to the onset of PCOS in adulthood and lead to the transgenerational transmission of neuroendocrine and metabolic traits through alterations in the DNA methylation process.The originality of the translational findings summarized here involves the identification of potential biomarkers for early diagnosis of the syndrome, in addition to the validation of a promising therapeutic avenue in a preclinical model of PCOS, which can improve the management of patients suffering from the syndrome.…”
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308
Comprehensive transcriptome and proteome analysis revealed the molecular mechanisms of melatonin priming and waterlogging response in peach
Published 2025-02-01“…Transcriptome analysis implicated genes related to ‘DNA-binding transcription factor activity’, such as AP2/ERF, HSF and WRKY transcription factors, in response to waterlogging. …”
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309
Early life gut microbiome and its impact on childhood health and chronic conditions
Published 2025-12-01“…Some of these challenges are technical, such as lack of standardized stool collection protocols, inconsistent DNA extraction methods, and outdated sequencing technologies. …”
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310
Nucleoside analogues in treatment of liver cirrhosis as an outcome of chronic hepatitis B
Published 2009-02-01“…Terms of lamivudine treatment for patients with liver cirrhosis should be no less than 22 months, and clearance HBV DNA is achieved in 93,9 % of patients. Sustained virologic response (it was assessed in 4 years after termination of treatment course) is estimated as 39%. …”
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311
The role of Airbnb creating a “new”-old city centre: facts, problems and controversies in Porto
Published 2019-12-01“…We make use of qualitative and quantitative methods and draw on the official AirDNA database to analyse the relation between Airbnb and urban transformation, and the governance context. …”
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312
Short tandem repeats delineate gene bodies across eukaryotes
Published 2024-12-01“…Recently, it has been shown that a broad range of transcription factors (TFs) are affected by STRs near or in the DNA target binding site. Despite this, the distribution of STR motif repetitiveness in eukaryote genomes is still largely unknown. …”
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313
Commentary on "Preliminary Species Hypotheses" in Entomological Taxonomy: A Global Data and FAIR Infrastructure Perspective
Published 2025-02-01“…In response to the need for rapid, scalable biodiversity monitoring, Buckley introduces preliminary species hypotheses (PSH) as a bridge between quick identification tools and the rigorous Linnaean system, leveraging DNA barcoding and AI-assisted image recognition to produce provisional classifications that can later be validated. …”
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314
The biodiversity survey of the Cape (BioSCape), integrating remote sensing with biodiversity science
Published 2025-02-01“…In situ biodiversity observations of plant and animal communities, estuaries, kelp, and plankton were made using traditional field methods as well as novel approaches like environmental DNA and acoustic surveys. Biodiversity observations were accompanied by an unprecedented combination of airborne imaging spectroscopy and lidar measurements acquired across 45,000 km2. …”
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315
Understanding cancer from an evolutionary perspective: high-risk reprogramming of genome-damaged stem cells
Published 2024-01-01“…Oxygen-sensitive germline and stem cells suffer DNA double-strand breaks due to stress and oxygen ranges reminiscent of ancestral hyperoxia, leading to cell senescence. …”
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316
Integrating Legal Protection Strategies for Wife and Children Due to Rejection of Marriage Isbat Application
Published 2024-12-01“…Normatively, the way that can be taken is by integrating several aspects such as aspects of the law, law enforcement, and facilities or facilities that can support the application of law, such as human resources and sophisticated tools such as tools to find out a person's DNA. Meanwhile, sociologically, two aspects of social problems are crucial to carrying out an integrated improvement strategy, namely aspects such as aspects of a religious-type society and a negative patriarchal culture. …”
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317
An Obstetrics Index for the Assessment of Risk Levels of “High Risk Pregnancy” Groups
Published 2015-04-01“…STUDY DESIGN: This study is consisted of 3 groups of patients; 1) Pregnancies without MTHFR polymorphisms (n=65), 2) Pregnancies with methylenetetrahydrofolate reductase (MTHFR; homozygous or compound heterozygous) polymorphisms (n=140), 3) Pregnancies with “autoimmune antibody positivity” without any other type of hereditary thrombophilia (Anti-dsDNA, anti-phospholipid Ig G/M, anti-cardiolipin Ig G/M, ASMA, APA, ENA, anti-mitochondrial antibodies) (n=76). …”
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318
A new crustin-like gene from the redclaw crayfish Cherax quadricarinatus and its response to decapod iridescent virus 1 (DIV1) challenge
Published 2025-01-01“…In this study, a novel crustin-like gene, Cqcarc1, was characterized from the redclaw crayfish Cherax quadricarinatus. The full-length cDNA sequence was 488 bp, and the open reading frame encoded 101 amino acids with a signal peptide in the N-terminus and a conserved WAP domain in the C-terminus. …”
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319
Leveraging genomic insights from the neglected malaria parasites P. malariae and P. ovale using selective whole genome amplification (SWGA) approach
Published 2025-02-01“…Furthermore, leveraging the long DNA fragments generated by SWGA, we achieved high-quality genome assemblies for P. malariae and P. ovale using PacBio long reads sequencing technology. …”
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320
Detection of gene mutation in a case of Nagashima-type palmoplantar keratoderma
Published 2025-01-01“…[Methods] Clinical data of the patient were collected. Genomic DNA was extracted from the patient′s peripheral blood sample. …”
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