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341
Improvement of Helicobacter pylori eradication efficacy at stomach and duodenum peptic ulcers
Published 2016-08-01“…All patients underwent quantitative serological test for H. pylori-specific IgG antibodies, stool test for H. pylori antigen, fibrogastroscopy with stomach mucosa (SM) biopsy and rapid urease test, microscopic examination of SM biopsy specimens, polymerase chain reaction for H. pylori DNA in SM biopsy specimens. Results. Efficacy of H. pylori eradication at modified sequential therapy was 95,8%, at standard, also combined with bismuthate tripotassium dicitrate, - 86,4%. …”
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342
Gastrochilus obovatifolius (Orchidaceae, Aeridinae), a new species from the Daba Mountains of Chongqing, China
Published 2025-02-01“…The results of molecular phylogenetic analysis, based on nuclear ribosome internal transcribed spacer (nrITS) and four chloroplast DNA fragments (matK, psbA–trnH, psbM–trnD, and trnL–F) of 55 Gastrochilus species, support the inclusion of G. obovatifolius in G. sect. …”
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343
A review of leishmaniasis: current knowledge and future directions of heterocyclic molecules
Published 2024-09-01“…These mechanisms include disruption of cellular processes within the parasite, interference with DNA replication, and modulation of host immune responses. …”
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344
LASSO–MOGAT: a multi-omics graph attention framework for cancer classification
Published 2024-08-01“…This article introduces Least Absolute Shrinkage and Selection Operator–Multi-omics Gated Attention (LASSO–MOGAT), a novel graph-based deep learning framework that integrates messenger RNA, microRNA, and DNA methylation data to classify 31 cancer types. …”
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345
Functionalized oligonucleotides, synthetic catalysts as enzyme mimics
Published 2024-04-01“…These additional handles (located on the base or the sugar moiety) were carefully chosen to enhance the rather limited repertoire of DNA to develop FuONs that display enzyme-like properties such as catalysis and recognition. …”
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346
PaleoProPhyler: a reproducible pipeline for phylogenetic inference using ancient proteins
Published 2023-11-01“…In contrast to the field of ancient DNA - where several computational methods exist to process and analyze sequencing data - few tools exist for handling ancient protein sequence data. …”
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347
Isolation and characterization of cadmium-resistant Bacillus cereus strains from Cd-contaminated mining areas for potential bioremediation applications
Published 2025-02-01“…Morphological analysis and 16S rDNA sequencing identified both strains as Bacillus cereus. …”
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348
Human microbiome, applied to clinical practice
Published 2018-08-01“…The Human Genome Project assumes: development of the human genome variations database (HapMap; Human Variome Project), interpretation of human phenotype differences (Encyclopedia Of DNA Elements), modeling of human phenomenon (RECON), interpretation of epigenetic variants and hereditary changes in phenotypical manifestations. …”
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349
Performance and limitations of linkage-disequilibrium-based methods for inferring the genomic landscape of recombination and detecting hotspots: a simulation study
Published 2023-03-01“…Population genomic approaches offer an attractive way to infer the population-scaled recombination rate ρ=4Ner using the linkage disequilibrium information contained in DNA sequence polymorphism data. Such methods have been used in a broad range of plant and animal species to build genome-wide recombination maps. …”
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350
Harlequin Ichthyosis: Case Series
Published 2024-04-01“…Some risk factors include preterm births and consanguinity. Prenatal DNA testing for the ABCA12 mutation aids in diagnosis. …”
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351
Metabolic rate and insulin-independent glucose uptake increase in a TDP-43Q331K mouse model of amyotrophic lateral sclerosis
Published 2025-02-01“…Here, we investigated energy balance and glucose control in TAR DNA-binding protein 43 (TDP-43)Q331K mice, a model of ALS, at both the early and late symptomatic stages of disease. …”
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352
Research Progress of ROS-Mitochondrial Pathway on Cardiovascular Protection of Tea Polyphenols
Published 2025-02-01“…From the perspective of ROS-mitochondrial pathway, the article elucidates how tea polyphenols behaved the beneficial effects against cardiovascular diseases by modulating the expression of mitochondrial fusion and fission proteins, reducing the opening of mitochondrial membrane permeability transition pore, maintaining cellular calcium homeostasis, mitigating mitochondrial DNA damage and regulating mitochondrial apoptosis signaling pathways. …”
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353
Development and characterization of a reverse genetics system for the lineage II Chicava strain of Machupo virus in a guinea pig model.
Published 2025-01-01“…<h4>Methods</h4>We report the development of a reverse genetics system for the MACV lineage II Chicava strain, using a pRF42 plasmid encoding the L and S segment genomic RNA under the transcriptional control of a murine DNA-dependent RNA polymerase I promoter sequence. …”
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354
The impact of PD-L1 polymorphisms on the efficacy of immune checkpoint inhibitors depends on the tumor proportion score: a retrospective study
Published 2025-02-01“…Method Patients treated with immune checkpoint inhibitor monotherapy for non-small cell lung cancer at Kyoto University Hospital until January 2023, with TPS data and biological specimens available for SNP measurement, were eligible for this study. Genomic DNA was extracted from peripheral blood leukocytes. …”
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355
Widespread mutagenesis and chromosomal instability shape somatic genomes in systemic sclerosis
Published 2024-10-01“…We hypothesize that the inflammation and immune response associated with systemic sclerosis can trigger DNA damage, leading to elevated somatic mutagenesis, a hallmark of pre-cancerous tissues. …”
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356
Antibiotic resistance gene occurrence in poultry farms in northeast Brazil
Published 2025-02-01“…A total of 14 chicken litter samples were collected from twelve farms and subjected to total DNA extraction. The presence of ARGs in the obtained material was tested by Polymerase Chain Reaction (PCR) using primers for selected ARGs. …”
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357
Molecular pathways in reproductive cancers: a focus on prostate and ovarian cancer
Published 2025-02-01“…Epigenetic alterations, including DNA methylation and histone modifications, are also prevalent in both cancer types. …”
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358
Physiological value of intestinal microflora
Published 2011-09-01“…In the last years in clinical practice chemical methods, in particular gas chromatography (GC) in combination to mass spectrometry (GC-MS) are actively developed, the method of fluorescent DNA hybridization in situ (FISH) is applied, polymerase chain reaction (PCR-diagnostics) became quite widespread method of microorganisms assessment. …”
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359
Decoding vascular aging: implications for atherosclerosis progression and clinical intervention
Published 2024-08-01“…The promising therapeutic targets reviewed include the angiotensin (1–7)/MAS axis, the gut microbiome, histone deacetylases, DNA repair systems, noncoding RNAs, β3/dopamine adrenoceptors, senescence and inflammation checkpoints.…”
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360
Efficacy of CLT4A variants as immunoregulatory molecules among Vitiligo patients in Saudi Arabia
Published 2025-02-01“…The recruitment was based on the sample size calculation and based on it, we have recruited 300 Saudi individuals who were evenly divided into vitiligo cases and controls. Extracted genomic DNA was utilized to amplify rs231775 and rs3087243 SNPs in the CTLA4 gene, which were subsequently digested and verified using Sanger sequencing. …”
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