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TEFM facilitates transition from RNA synthesis to DNA synthesis at H-strand replication origin of mtDNA
Published 2025-02-01“…Transition from RNA synthesis to DNA synthesis at OH is crucial for balancing replication with transcription, yet the mechanism remains unclear. …”
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Real-time analysis of initiation regulation systems during the progression of the reconstituted chromosomal replication cycle
Published 2025-02-01“…The oriC sequestration system involves SeqA binding to hemimethylated oriC—generated during nascent DNA synthesis to prevent reinitiation. SeqA inhibited RCR, but the addition of Dam methylase relieved this inhibition. …”
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Association of HLA-B27 Gene and Rheumatoid Arthritis: Analysis of Potential Role as a Predictive Biomarker
Published 2024-10-01“…Samples of human blood from RA patients and healthy individuals were collected, and RNA extraction, cDNA synthesis and qPCR were carried out to detect relative expression of HLA-B27. …”
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Reassessing Nutritional Supplementation Program: The Impact of Maternal Vitamin B12 Levels on Feto-Maternal Outcomes
Published 2023-12-01“…Vit B12 is an important cofactor for enzymatic reactions related to DNA synthesis, folate, and cell metabolism. While folate deficiency has been acknowledged in not only the prevention of neural tube defects and other adverse pregnancy outcomes, the effects of low vit B12 status have not been well defined. …”
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Seed priming and abiotic stress tolerance in carrot: Unraveling the mechanisms of improved germination.
Published 2025-01-01“…Additionally, we investigated the impact of inhibitors (actinomycin D-inhibitor of transcription, cycloheximide-inhibitor of translation, hydroxyurea-inhibitor of DNA synthesis, cytochalasin-inhibitor of actin polymerization) on seed germination under stress conditions. …”
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A ribodepletion and tagging protocol to multiplex samples for RNA-seq based virus detection: application to the cassava virome
Published 2025-02-01“…Results Here, we develop a high-throughput sequencing protocol, named Ribo-M-Seq, that combines plant rRNA ribodepletion, cDNA synthesis, tagging with a 96 multiplexing scheme and Illumina sequencing. …”
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An Update on African Trypanocide Pharmaceutics and Resistance.
Published 2023“…In AAT, quinapyramine sulfate interferes with DNA synthesis and suppression of cytoplasmic ribosomal activity in the mitochondria. …”
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