MAEMC-NET: a hybrid self-supervised learning method for predicting the malignancy of solitary pulmonary nodules from CT images by Tianhu Zhao, Tianhu Zhao, Yong Yue, Hang Sun, Jingxu Li, Yanhua Wen, Yudong Yao, Wei Qian, Yubao Guan, Shouliang Qi, Shouliang Qi

“…A generative self-supervised task of reconstructing masked axial CT patches containing lesions was designed to learn intra- and inter-slice image representations. …”
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Master your practice! A quantitative analysis of Device and system handling training to enable competent interactions with intelligent voice assistants by Maximilian Baumann, André Markus, Jan Pfister, Astrid Carolus, Andreas Hotho, Carolin Wienrich

“…Since higher knowledge of device and system handling is fundamental for positive interaction quality and self-determined use of IVAs, this study examines how training can contribute to the promotion of variables such as usage aspects, social perception, and self-determined interaction and how such training can be designed. Based on an established competence framework and the principles of learning psychology and media didactics, three online training modules were developed to strengthen the user's device and system handling competence, and their effects on the parameters of competent AI interaction were investigated. …”
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Agroecology and the limits to resilience: extending the adaptation capacity of agroecosystems to drought by Miguel A. Altieri, Clara I. Nicholls, Rene Montalba, Lorena Vieli, Luis L. Vazquez

“…Although an overwhelming number of studies demonstrate that these agroecological designs and practices are associated with greater farm-level resilience, it is important to recognize the limits of resilience. …”
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A Comprehensive Resource for Exploring Antiphage Defense: DefenseFinder Webservice,Wiki and Databases by Tesson, Florian, Planel, Rémi, Egorov, Artyom A, Georjon, Héloïse, Vaysset, Hugo, Brancotte, Bryan, Néron, Bertrand, Mordret, Ernest, Atkinson, Gemma Catherine, Bernheim, Aude, Cury, Jean

“…DefenseFinder is a bioinformatic program designed for the systematic identification of known antiphage defense mechanisms. …”
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Vitamin D deficiency and intracranial aneurysms: Systematic Review by Lívio Pereira de Macêdo, Glaudir Donato, Maria Eduarda d’Almeida Lins Regis, Isabela Fernandes de Melo Pereira, Gustavo Rodrigues Paulo, Kamilla Azevedo Bringel, Gabriel Carvalho Andrade Gadelha, Fábio Antônio Serra de Lima Júnior, Yally Dayanne Oliveira Ferreira, Renata de Castro Tavares, Arlindo Ugulino Netto, Kauê Franke, Pierre Vansant Oliveira Eugênio, Auricélio Batista Cezar-Junior, Igor Vilela Faquini, Eduardo Vieira de Carvalho Júnior, Nivaldo Sena de Almeida, Francisco Alfredo Bandeira e Farias, Marcelo Moraes Valença, Hildo Rocha Cirne Azevedo-Filho

“…Discussion: Among the limitations of the papers, the following are noteworthy: sample size and selection, recording flaws inherent to retrospective designs, failure to consider confounding variables, and heterogeneity of data produced among the researches, making a quantitative analysis of the evidence unfeasible. …”
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Thermally tunable add-drop filter based on valley photonic crystals for optical communications by Sun Lu, Li Xingfeng, Hu Pan, Wang Hongwei, Zhang Yong, Tang Guojing, He Xintao, Dong Jianwen, Su Yikai

“…A diamond-shaped microloop resonator is designed to confine the light and enhance its interaction with the thermal field generated by the microheater, leading to a relatively low power of 23.97 mW needed for switching the output signal from one port to the other. …”
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Comprehensive landscape and oncogenic role of extrachromosomal circular DNA in malignant biliary strictures by Zhuo Cheng, Xuanmei Luo, Wenzheng Liu, Xiaofang Lu, Hong Chang, Yingchun Wang, Wei Zheng, Xiue Yan, Yonghui Huang

“…For functional exploration, a simple and efficient workflow was designed to synthesize large eccDNA particularly containing multiple regions. …”
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Comprehensive Analysis of DDoS Anomaly Detection in Software-Defined Networks by Abdinasir Hirsi, Mohammed A. Alhartomi, Lukman Audah, Adeb Salh, Nan Mad Sahar, Salman Ahmed, Godwin Okon Ansa, Abdullahi Farah

“…The paper concludes by synthesizing key findings, identifying unresolved challenges, and outlining future research directions to advance DDoS detection mechanisms in SDN. This roadmap is designed to guide researchers in addressing security vulnerabilities and enhancing SDN resilience against evolving DDoS threats.…”
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Establishment of Sensory Evaluation Method for Wolfberry Tea and Exploration of the Main Characteristic Aroma Substances by Yuanchao LI, Qinji LI, Yuqiong GUO, Zhilong HAO, Shan JIN

“…To establish the sensory evaluation method for wolfberry tea made from wolfberry buds and leaves, sensory evaluation experiments were designed with multi-variables, including brewing time and tea amount, by using two brewing methods with covered bowl and column cup, respectively. …”
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Chinese nurses’ perspectives on child-friendly healthcare practice assessment: a qualitative study by Wei Xiao Huang, Mei Chan Chong, Li Yoong Tang, Xiao Xia Liu, Mei Fang, Yun Yun Shen, Xiao Li Guo

“…The four categories were identified: services designed for children’s interests, tailoring the environment adapted for children, facilitating social interactions, and promoting childhood development. …”
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Personalized prediction of anticancer potential of non-oncology drugs through learning from genome derived molecular pathways by Xiaobao Dong, Huanhuan Liu, Ting Tong, Liuxing Wu, Jianhua Wang, Tianyi You, Yongjian Wei, Xianfu Yi, Hongxi Yang, Jie Hu, Haitao Wang, Xiaoyan Wang, Mulin Jun Li

“…Herein we present CHANCE, a supervised machine learning model designed to predict the anticancer activities of non-oncology drugs for specific patients by simultaneously considering personalized coding and non-coding mutations. …”
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Comparison of CRISPR-Cas13b RNA base editing approaches for USH2A-associated inherited retinal degeneration by Lewis E. Fry, Lauren Major, Ahmed Salman, Lucy A. McDermott, Jun Yang, Andrew J. King, Michelle E. McClements, Robert E. MacLaren

“…We develop and characterize a mouse model of Usher syndrome carrying the c.11840 G > A mutation designed for the evaluation of base editors for inherited retinal disease. …”
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Multimodal lung cancer theranostics via manganese phosphate/quercetin particle by Chong Qiu, Fei Xia, Qingchao Tu, Huan Tang, Yinan Liu, Hongda Liu, Chen Wang, HaiLu Yao, Linying Zhong, Yuanfeng Fu, Pengbo Guo, Weiqi Chen, Xinyu Zhou, Li Zou, Licheng Gan, Jiawei Yan, Yichong Hou, Junzhe Zhang, Huanhuan Pang, Yuqing Meng, Qiaoli Shi, Guang Han, Xijun Wang, Jigang Wang

“…Here, we present a multifunctional pH-sensitive core-shell nanoparticle containing quercetin (QCT), termed AHA@MnP/QCT NPs, designed for the simultaneous diagnosis and treatment of non-small cell lung cancer. …”
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A qualitative analysis of unintended effects of a digital conditional cash transfer intervention to encourage healthcare utilization in Southern Madagascar by Mara Anna Franke, Anne Neumann, Kim Nordmann, Daniela Suleymanova, Onja Gabrielle Ravololohanitra, Samuel Knauss, Julius Valentin Emmrich

“…The three key negative consequences we identified were i) facility overcrowding, ii) an increase in costs of care, and iii) cases of hospital imprisonment. Conclusions Designers and implementers of future (digital) cash transfer interventions should carefully consider and proactively seek to leverage the positive and mitigate the negative unintended consequences of cash transfer interventions for healthcare such as those highlighted in our work.…”
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Digital twins as global learning health and disease models for preventive and personalized medicine by Xinxiu Li, Joseph Loscalzo, A. K. M. Firoj Mahmud, Dina Mansour Aly, Andrey Rzhetsky, Marinka Zitnik, Mikael Benson

“…However, widespread implementation faces several challenges: (1) characterizing dynamic molecular changes across multiple biological scales; (2) developing computational methods to integrate data into DTs; (3) prioritizing disease mechanisms and therapeutic targets; (4) creating interoperable DT systems that can learn from each other; (5) designing user-friendly interfaces for patients and clinicians; (6) scaling DT technology globally for equitable healthcare access; (7) addressing ethical, regulatory, and financial considerations. …”
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Antiviral activity of natural compounds extracted from Mediterranean medicinal plants against SARS-CoV-2 by Stephanie Ghio, Jean-Pierre Brincat, Yuksel Cetin, Frederick Lia

“…Phytocompounds can serve as a foundation for designing new antiviral therapies.…”
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Defect Detection in Concrete Structures Based on Characteristics of Hammer Reaction Force and Apparent Stiffness of Concrete by Koki Shoda, Jun Younes Louhi Kasahara, Qi An, Atsushi Yamashita

“…To address this challenge, we propose a novel method that enhances defect discrimination accuracy by integrating statistical processing and physical property analysis within a machine learning framework designed for force signal characteristics. Our method employs wavelet transformation to convert short-duration force signals into high-resolution time-frequency features, capturing their non-stationary behavior in detail. …”
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Six events that shaped antibody approvals in oncology by Suman Paul, Suman Paul, Shibin Zhou, Shibin Zhou

“…In the last three years, the EMA and FDA greenlighted eighteen antibodies, the majority of them designed in the formats of antibody-drug conjugates (ADC) and bispecific antibodies (BsAb). …”
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Perceived MOOC satisfaction: A review mining approach using machine learning and fine-tuned BERTs by Xieling Chen, Haoran Xie, Di Zou, Gary Cheng, Xiaohui Tao, Fu Lee Wang

“…These insights offer valuable guidance for educators, course designers, and platform developers, contributing to the optimization of MOOC offerings to better meet the evolving needs of learners.…”
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Therapeutic Effect of Zataria Multiflora Essential Oil on Burn Wound Infected by Pseudomonas aeruginosa by Maryam Zare, Elahe Sattarinezhad, Ali Karimi Akhormeh, Maryam Motevasel, Marzieh Ashrafmansouri, Maral Mokhtari, Omid Koohi Hosseinabadi, Aida Iraji, Azar Purkhosrow

“…Due to the rapid increase in resistance to the currently used antimicrobial agents, finding new antibiotics is one of the research priorities. This study was designed to investigate antibacterial and wound healing effects of Zataria multiflora essential oil (ZMEO) on burn wounds infected with P. aeruginosa in Sprague-Dawley rats. …”
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