Abuse and misuse of tramadol in patients with non-oncologic pain in a region of Southern Europe by M. Perelló, K. Rio-Aigé, G. Cereza, P. Rius, F. J. Pérez-Cano, M. Rabanal

“…To estimate the potential abuse and misuse of tramadol by patients visiting community pharmacy, and to establish the demographic characteristics of the tramadol users, a validated questionnaire based on the Finch criteria was designed. A total of 251 cases were registered.Results Data show that women were more involved (56.6%) and the highest proportion was found in the age interval of 46-65 years (42.6%). …”
Get full text

Efficacy of osmotic laxative polyethylene glycol 4000 in treatment of constipation in pediatrics by S. I. Erdes, B. O. Matsukatova, S. A. Revyakina, Ye. V. Casanave

“…With the help of specifically designed original questionnaire dynamics of clinical symptoms of constipation, and changes of scores of electrical activity of various regions of gastro-intestinal tract (GIT) by PEGEG was estimated. …”
Get full text

Extreme-phenotype genome-wide association study (XP-GWAS) of powdery mildew race 2 W tolerance in the USDA Citrullus germplasm collection by Sandra E. Branham, Venkata Rao Ganaparthi, W. Patrick Wechter, Younghoon Park, Todd Wehner, Angela Davis, Antonia Tetteh, Laura Massey, Sue Hammar, Rebecca Grumet, Shaker Kousik, Amnon Levi

“…Kompetitive Allele-Specific PCR (KASP) markers were designed for sixteen SNPs across the three genomic regions. …”
Get full text

Best practice mechanisms for biodiversity conservation law and policy by Callum Brockett, Katie Woolaston, Felicity Deane, Fran Humphries, Ethan Kumar, Amanda Kennedy, Justine Bell-James

“…Around the world, countries have introduced laws and policies designed to prevent species extinction. While there have been some success stories, overall, these laws and policies are routinely failing. …”
Get full text

Multi-layered electrospun grafts for surgical repair: Biomimicking physiological ascending aortic compliance by Julia Krammer, Maximilian Pichlmaier, Jan Stana, Christian Hagl, Sven Peterss, Maximilian Grab, Linda Grefen

“…Three groups (G 1–3 ; n  = 5) with varying layer designs were evaluated regarding the main mechanical properties of vascular grafts such as suture retention strength, permeability and static and dynamic compliance. …”
Get full text

Clinical and Radiographic Evaluation of Bone Profile Around Dental Implants Placed in the Esthetic Zone by Alssum L, Al-Kattan R, Al-Shibani N, Al Ali H, Aldossari F, Allam E

“…Patient satisfaction was assessed by using a specially designed questionnaire. The Oral Health Impact Profile (OHIP)-14 was used to assess the quality of life. …”
Get full text

Segmentasi Wilayah Terdampak Bencana Berdasarkan Fitur Geo-Posisi by Ade Sutedi, Indri Tri Julianto, Leni Fitriani

“…Abstract   This research introduces a prototype Disaster-affected Area Segmentation Application (DAS-Apps) designed to perform segmentation of disaster-affected areas based on latitude and longitude features (geo-positioning). …”
Get full text

Resetting the Hsc70-mediated lysosomal degradation of PD-L1 via a supramolecular meso peptide for the restoration of acquired anti-tumor T cell immunity by Yujia Zhao, Dan Liu, Wenguang Yang, Wangxiao He, Jin Yan, Leiqing Yao

“…To overcome this issue, a meso chimeric peptide PEPPDL1 was designed to specifically bind the PD-1 binding domain of PD-L1 instead of the Hsc70/CMTM6 binding domain, while also binding to Hsc70 to facilitate the dragging of PD-L1 into Hsc70-mediated chaperone-mediated autophagy (CMA), thereby achieving lysosomal degradation. …”
Get full text

Analyzing frequency spectrum and Total Harmonic Distortion for high switching frequency operation of GaN-based filter-less multilevel cascaded H-bridge inverter by Ramkrishna Mishan, Xingang Fu, Chanakya Hingu, Poria Fajri

“…Despite the advantageous electrical properties of GaN switches for switching operation, their assimilation into high multilevel CHB inverter designs at MHz frequencies poses considerable challenges regarding efficiency, control, and the minimization of THD. …”
Get full text

Vagal nerve stimulation dynamically alters anxiety-like behavior in rats by A.G. Butler, J.K. Bassi, A.A. Connelly, M.R. Melo, A.M. Allen, S.J. McDougall

“…Background: Electrical vagal nerve stimulation (VNS), at currents designed to target sensory, interoceptive neurons, decreases anxiety-like behavior. …”
Get full text

Entrepreneurship in Medical Education: Evaluation of the Entrepreneurship in Healthcare Seminar Series by Amanda Mac, Hayley McKee, Michael Balas, Aazad Abbas, Aida Ahrari, Pawandeep Sandhu, Dante Morra, Sarah McClennan, Alison Freeland

“…We created the Entrepreneurship in Healthcare Seminar Series (EHSS), a novel initiative designed to teach medical students about developing innovations and launching entrepreneurial ventures. …”
Get full text

ASSESSING THE EFFICACY OF CLOUD SERVICES FOR DEVELOPING EDUCATIONAL PRESENTATIONS by Tetiana V. Bondarenko, Nadia M. Stetsenko, Volodymyr P. Stetsenko, Halyna V. Tkachuk

“…The evaluation methodology proposed within this study holds potential for application to other cloud services designed for educational content creation. By fostering effective organization of educational activities across diverse subject domains, this approach contributes to the enhancement of the educational process as a whole. …”
Get full text

Using Deep Learning to Identify High-Risk Patients with Heart Failure with Reduced Ejection Fraction by Zhibo Wang, Xin Chen, Xi Tan, Lingfeng Yang, Kartik Kannapur, Justin L. Vincent, Garin N. Kessler, Boshu Ru, Mei Yang

“…For DL models to predict HF hospitalizations and worsening HF events, we utilized two study designs: with and without a buffer window. For comparison, we also tested multiple traditional machine learning models including logistic regression, random forest, and eXtreme Gradient Boosting (XGBoost). …”
Get full text

Investigation Report and Analysis Knowledge, attitudes and vaccination status regarding HPV vaccines among female healthcare workers at vaccination clinics in Beijing city: a surve... by Haikun QIAN, Wenyan JI, Luodan SUO

“…MethodsIn June 2023, a self-designed online questionnaire was distributed through work groups to female healthcare workers involved in HPV vaccination services at all Beijing immunization clinics providing HPV vaccines. …”
Get full text

Models for predicting risk of endometrial cancer: a systematic review by Bea Harris Forder, Anastasia Ardasheva, Karyna Atha, Hannah Nentwich, Roxanna Abhari, Christiana Kartsonaki

“…Results Twenty studies describing 19 models were included. Ten were designed for the general population and nine for high-risk populations. …”
Get full text

A qualitative investigation of the influences of gender among low-socioeconomic status students’ motivations to study biology by Svetlana Masjutina, Elizabeth Stearns

“…Understanding this gendered dynamic and interplay between these motivational types is essential for designing programs and policies that aim to increase the representation of LSES students in biology, a field critical to environmental conservation and societal welfare.…”
Get full text

The evolving roles of geophysics in environmental assessment, monitoring, and management of landfill leachate contaminant plumes: An overview by Joseph Omeiza Alao

“…Future research should focus on developing advanced data interpretation techniques, integrating geophysical data with other environmental monitoring data, and exploring the use of artificial intelligence for automated analysis and prediction of LLP behaviour, which ultimately aiding the environmental decision-makers in addressing ecological challenges and designing/managing landfill sites.…”
Get full text

Fine-tuning GBS data with comparison of reference and mock genome approaches for advancing genomic selection in less studied farmed species by Daniel Fischer, Miika Tapio, Oliver Bitz, Terhi Iso-Touru, Antti Kause, Ilma Tapio

“…Results DdRAD data generation was designed for a reliable estimation of relatedness and is scalable to up to 384 samples. …”
Get full text

Delayed-release prednisone improves fatigue and health-related quality of life: findings from the CAPRA-2 double-blind randomised study in rheumatoid arthritis by Frank Buttgereit, Rieke Alten, Amy Grahn, Robert J Holt, Patricia Rice

“…Delayed-release (DR) prednisone is designed for evening administration (approximately 22:00) and releases 4 h later to coincide with the rise of nocturnal inflammatory cytokines associated with development of morning stiffness. …”
Get full text

Two chromatographic methods for analyzing paracetamol in spiked human plasma with its toxic metabolite, N-acetyl parabenzoquinone imine and its antidote, N-acetyl-l-cysteine by Omar M El-Abassy, Michael Gamal Fawzy, Ebraam B. Kamel

“…Additionally, the achievement of the eco-friendliness profile of the designed procedures was assessed. Both techniques passed the ICH validation tests.…”
Get full text