Methylprednisolone substituted lipid nanoparticles deliver C3 transferase mRNA for combined treatment of spinal cord injury by Haoru Dong, Zongxing He, Shiyi Cai, Haiqiang Ma, Lili Su, Jianfeng Li, Huiying Yang, Rong Xie

“…The novel formulation, MP-LNP-C3, is designed for direct administration to the injury site during decompression surgery, offering a targeted therapeutic modality for SCI. …”
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Effect of a bimetal Mn/Zn catalyst supported on activated carbon for selective oxidation of ethyl lactate to ethyl pyruvate by G. Madhanagopal, K. Premalatha, P.N. Poovizhi, V. Sumithra, S. Mahalingam, L. Guganathan, S. Sivakumar, A. Subramani, P. Tamizhdurai

“…This success is attributed to the well-designed structure incorporating zinc into the AC-supported manganese. …”
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Optimising Access Surgery in Senior Haemodialysis Patients (OASIS): study protocol for a multicentre randomised controlled trial by Patrick WHE Vriens, Edith M Willigendael, Maarten A Lijkwan, Friedo W Dekker, Chava L Ramspek, Michiel W de Haan, Çaĝdaş Ünlü, Boudewijn DC Heggen, Koen E A van der Bogt, Marc H Hemmelder, Mickaël J C Hiligsmann, Magda M van Loon, Joris I Rotmans, Jan H M Tordoir, Geert Willem H Schurink, Maarten G J Snoeijs, Marijke J Molegraaf, Philippe WM Cuypers, Denise Nio, Cora H Arts, Jacobien C Verhave, Goos D Laverman, Aron S Bode, Marcel C Weijmer, Bas Govaert, Aaltje Y Adema, Gijs MJM Welten, Michel MPJ Reijnen, Marc JH Groeneveld, Hans S Brink, Jeroen B van der Net, Arno Kuijper, Hilde PE Peters, Roos C van Nieuwenhuizen, Rombout R Kruse, Yvonne C Schrama, Karina A de Groot, Karima Farhat

“…In addition, long-term complications associated with arteriovenous grafts and central venous catheters may be less relevant when considering the limited life expectancy of these patients. Therefore, we designed the Optimising Access Surgery in Senior Haemodialysis Patients (OASIS) trial to determine the best strategy for vascular access creation in elderly haemodialysis patients.Methods and analysis OASIS is a multicentre randomised controlled trial with an equal participant allocation in three treatment arms. …”
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Immune dysfunction revealed by digital spatial profiling of immuno-oncology markers in progressive stages of renal cell carcinoma and in brain metastases by Wei Wei, Michael Hurwitz, Sabina Signoretti, Lucia Jilaveanu, Toni K Choueiri, David L Rimm, Adebowale Adeniran, Sandra Martínez, Harriet M Kluger, David A Schoenfeld, Myrto Moutafi, Dijana Djureinovic, Ross D Merkin, David A Braun, Fabio Parisi

“…Our findings may have important implications for designing future biomarker and treatment studies and may aid in development of brain metastases-specific therapies.…”
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Maternal neonicotinoid pesticide exposure impairs glucose metabolism by deteriorating brown fat thermogenesis by Wenwen Zhu, Jiali Fang, Chenbo Ji, Hong Zhong, Tianying Zhong, Xianwei Cui

“…Background: Neonicotinoids (NEOs) are well-designed highly selective pesticides that target nicotinic acetylcholine receptors. …”
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Leveraging genomic insights from the neglected malaria parasites P. malariae and P. ovale using selective whole genome amplification (SWGA) approach by Fathia Ben-Rached, Amit Kumar Subudhi, Chang Li, Mariah Alawi, Rohit Satyam, Sui Xu, Guoding Zhu, Raeece Naeem, Sara Mfarrej, Di Liu, Zenaida Stead, Caroline Askonas, Yaobao Liu, Jun Cao, Arnab Pain

“…Results We applied SWGA using specifically designed primer sets targeting the pathogen genome to enrich parasite DNA from clinical samples. …”
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Antimicrobial and ADME properties of methoxylated, methylated and nitrated 2-hydroxynaphthalene-1 carboxanilides by Lucia Vrablova, Tomas Gonec, Tereza Kauerova, Michal Oravec, Izabela Jendrzejewska, Peter Kollar, Alois Cizek, Josef Jampilek

“…Experimental approach: This study includes a series of twenty-seven mono-, di- and trisubstituted 2-hydroxynaphthalene-1-carboxanilides designed as multitarget agents. The compounds are substituted with methoxy, methyl, and nitro groups, as well as additionally with chlorine, bromine, and trifluoromethyl at various positions. …”
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Genomic characterization of Achromobacter genogroup 20 and identification of a potential species-specific marker by Mariana Papalia, Rocio Stucchi, Valeria Alexander, Liliana Clara, Mariángeles Visus, Gabriel Gutkind, Marcela Radice

“…The genome included coding sequences for three putative β-lactamases (one new OXA type-class D β -lactamase and two new class C), 32 efflux pump proteins, two aminoglycoside-modifying enzymes and a dihydropteroate synthase; also, substitutions in parC and parE were detected. The OXA enzyme, designated OXA-1238 (PP446293), differs from OXA-114a by 85 amino acids, with 69% identity. …”
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Citizen engagement in public food procurement, a novel choose-your-own-adventure canteen campaign case study by Luke John Schafer, Anna Gundorph, Carla Mingolla, Christian Bugge Henriksen, Marin Lysak, Reni Todorova Boncheva, Maarten Crivits

“…Existing in-person canteen user-group workshops were re-purposed and coupled with an adapted online survey designed in a ‘Choose-Your-Own-Adventure' style. This approach embedded the FoodSHIFT Citizen Empowerment Scheme, merging interactive engagement with flexible digital participation to enhance user input. …”
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Re-annotation of SARS-CoV-2 proteins using an HHpred-based approach opens new opportunities for a better understanding of this virus by Brézellec, Pierre

“…To avoid "false positive predictions" as much as possible, we designed a robustness procedure to evaluate the HHpred results. …”
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Advancing the Indian cattle pangenome: characterizing non-reference sequences in Bos indicus by Sarwar Azam, Abhisek Sahu, Naveen Kumar Pandey, Mahesh Neupane, Curtis P Van Tassell, Benjamin D Rosen, Ravi Kumar Gandham, Subha Narayan Rath, Subeer S Majumdar

“…Among these, 2,312 NUIs encompassing ~ 2 Mb, were commonly found in 98 samples of the 5 breeds and designated as Bos indicus Common Insertions (BICIs) in the population. …”
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Analysis of community older adult care facility construction and demand differentiation based on residential area and population attribute differences by Yanzhe Liu, Yaolei Wang, Guiping Guo, Tubao Yang, Tubao Yang, Yupeng Liu, Hongmei Gao, Tiejian Jiang, Xiangmin Li

“…Based on the indicator system, a survey questionnaire was designed, and validity analysis was conducted using Kaiser Meyer Olkin test and Bartlett sphericity test. 490 survey questionnaires were distributed to 22 communities in Wuhan, and 447 valid questionnaires were collected, with a response rate of 91.22%. …”
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Hispanic Patients Undergoing Spinal Fusion for Neuromuscular Scoliosis Sustain Health Inequalities by Armando S. Martinez, David Momtaz, Travis Kotzur, Alexandra McLennan, Abdullah Ghali, Farhan Ahmad, Ebubechi Adindu, Alan C. Santiago-Rodriquez, Ali Seifi, Brian Smith

“…In addition to ANOVA, Chi-Squares, and t-tests, multiple-linear and multiple-logistic regression models were designed and run to generate adjusted odds ratios. …”
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Is surgery superior for distal ulna fractures? a comprehensive systematic review and meta-analysis by Zakaria Chabihi, Brahim Demnati, Mohamed Moussadiq, Tariq Aalil, Yassine Fath El Khir, El Mehdi Boumediane, Mohamed Amine Benhima, Imad Abkari

“…Future research should focus on standardizing study designs to improve the quality of evidence in the management of distal ulna fractures. …”
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Community-Based Assessment of Knowledge, Attitudes, and Practices Towards COVID-19: an Epidemiological Survey in Kurdistan Region, Iraq by Zhino Rawf Ali, Bayan Omar Sharif, Aram Salih Mohammed Amin Kamali, Varin Tofiq Abbas, Azad Karim Ahmed, Shaho Osman Mahmood, Chiman Jamal ahmed, Sarwat Ahmed Abdulqader

“…A self- constructed questionnaire was used for data collection and it was designed according guidelines, literatures, and articles concerning COVID-19; which consisted of 40 variables. …”
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Evaluasi Usability Aplikasi Elektronik-Kesehatan Ibu dan Anak (e-KIA) by Fitra Abdurrachman Bachtiar, Retno Indah Rokhmawati, Fajar Pradana, Intan Yusuf Habibie

“…Usability testing started by taking the literature review followed by evaluator selection and evaluation briefing. The next step is designing an evaluation instrument and evaluation scenario. …”
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Artificial Intelligence–Powered Training Database for Clinical Thinking: App Development Study by Heng Wang, Danni Zheng, Mengying Wang, Hong Ji, Jiangli Han, Yan Wang, Ning Shen, Jie Qiao

“…MethodsThe “XueYiKu” app was designed as a contactless, self-service, trial-and-error system application based on actual complete hospital medical records and natural language processing technology to comprehensively assess the “clinical competence” of residents at different stages. …”
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Pengembangan Sistem Monitoring Pendataan Aplikasi Berbasis Web pada Kementerian Pekerjaan Umum dan Perumahan Rakyat by Salma Nada Safira, Yusi Tyroni Mursityo, Mochamad Chandra Saputra

“…This application is designed using the Rational Unified Process (RUP) method. …”
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Cognitive behavior therapy for academic burnout, procrastination, self-handicapping behavior, and test anxiety among adolescents: a randomized control trial by Khizra Khurshid, Rabia Mushtaq, Umara Rauf, Nida Anwar, Qasir Abbas, Sumayah Aljhani, Zoobia Ramzan, Mafia Shahzadi

“…The present study is designed to investigate the impact of cognitive behavioural therapy (CBT) on procrastination, burnout, self-handicapping behaviour, test anxiety, and school functioning among adolescents facing academic problems. …”
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Prediction of drought-flood prone zones in inland mountainous regions under climate change with assessment and enhancement strategies for disaster resilience in high-standard farml... by Yongheng Shen, Qingxia Guo, Zhenghao Liu, Yanli Shen, Yikun Jia, Yuehan Wei

“…In the final part of the study, management zoning plans were designed for other areas vulnerable to drought and flood disasters, and specific recommendations for enhancing cropland resilience were provided. …”
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