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A microscale thermophoresis-based enzymatic RNA methyltransferase assay enables the discovery of DNMT2 inhibitors
Published 2025-02-01“…Abstract RNA methyltransferases (MTases) have recently become increasingly important in drug discovery. Yet, most frequently utilized RNA MTase assays are limited in their throughput and hamper this rapidly evolving field of medicinal chemistry. …”
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A dextrorotatory residues-incorporated bioactive dodecapeptide against enterohemorrhagic Escherichia coli
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Distinguishing classes of neuroactive drugs based on computational physicochemical properties and experimental phenotypic profiling in planarians.
Published 2025-01-01“…Organismal behavioral testing is needed to fill the gap, but mammalian studies are too time-consuming and cost-prohibitive for the early stages of drug discovery. Behavioral medium-throughput screening (MTS) in small organisms promises to address this need and complement in silico and in vitro HTS to improve the discovery of novel neuroactive compounds. …”
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Precision nanoparticles for drug delivery, cell therapy tracking, and theranostics
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Multi-organ frailty is enhanced by periodontitis-induced inflammaging
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Advancing Alzheimer's Therapy: Computational strategies and treatment innovations
Published 2025-06-01“…A comprehensive analysis of recent literature was conducted to elucidate the broad scope of Alzheimer's etiology and the limitations of conventional drug discovery approaches. Our findings underscore the critical role of computational models in elucidating disease mechanisms, identifying therapeutic targets, and expediting drug discovery. …”
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Wilson and Walker's Principles and Techniques of Biochemistry and Molecular Biology /
Published 2018Table of Contents: “…Biochemical and molecular biological methods in life sciences studies -- Basic principles -- Cell culture techniques -- Recombinant DNA techniques and molecular cloning -- Preparative protein biochemistry -- Electrophoretic techniques -- Immunochemical techniques -- Flow cytometry -- Radioisotope techniques -- Principles of clinical biochemistry -- Microscopy -- Centrifugation and ultracentrifugation -- Spectroscopic techniques -- Basic techniques probing molecular structure and interactions -- Mass spectrometric techniques -- Fundamentals of bioinformatics -- Fundamentals of chemoinformatics -- The python programming language -- Data analysis -- Fundamentals of genome sequencing and annotation -- Fundamentals of proteomics -- Fundamentals of metabolomics -- Enzymes and receptors -- Drug discovery and development.…”
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Wilson and Walker's Principles and Techniques of Biochemistry and Molecular Biology /
Published 2018Table of Contents: “…Biochemical and molecular biological methods in life sciences studies -- Basic principles -- Cell culture techniques -- Recombinant DNA techniques and molecular cloning -- Preparative protein biochemistry -- Electrophoretic techniques -- Immunochemical techniques -- Flow cytometry -- Radioisotope techniques -- Principles of clinical biochemistry -- Microscopy -- Centrifugation and ultracentrifugation -- Spectroscopic techniques -- Basic techniques probing molecular structure and interactions -- Mass spectrometric techniques -- Fundamentals of bioinformatics -- Fundamentals of chemoinformatics -- The python programming language -- Data analysis -- Fundamentals of genome sequencing and annotation -- Fundamentals of proteomics -- Fundamentals of metabolomics -- Enzymes and receptors -- Drug discovery and development.…”
View in OPAC
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31
Chimie des substances naturelles et pharmacie : à la croisée des chemins
Published 2024-04-01“…An overview of the importance of natural products in pharmacy and drug discovery is provided herein. This “account” article seeks to shed light on current issues and challenges, through a critical analysis ranging from bioprospecting to the marketing of new drugs.…”
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Molecular optimization using a conditional transformer for reaction-aware compound exploration with reinforcement learning
Published 2025-02-01“…Abstract Designing molecules with desirable properties is a critical endeavor in drug discovery. Because of recent advances in deep learning, molecular generative models have been developed. …”
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A multiplex method for rapidly identifying viral protease inhibitors
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ISLRWR: A network diffusion algorithm for drug-target interactions prediction.
Published 2025-01-01“…Machine learning techniques and computer-aided methods are now widely used in the pre-discovery tasks of drug discovery, effectively improving the efficiency of drug development and reducing the workload and cost. …”
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Unlocking biological complexity: the role of machine learning in integrative multi-omics
Published 2024-11-01“…By integrating machine learning in multi-omics, we can enhance our understanding of drug discovery, disease, pathway, and network analysis. …”
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Molecular techniques for cancer diagnostics
Published 2024-01-01“…Recent advancements in describing genetic alterations in human cancers are a tempting reason for scientists to develop more effective, personalized therapies as the next level of cancer treatment. However, the drug discovery process is tedious, and getting approval from various regulatory authorities may be more frustrating for a steady developmental pace. …”
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Screening of multi deep learning-based de novo molecular generation models and their application for specific target molecular generation
Published 2025-02-01“…Moreover, we evaluated the performance of these NLP-based generation models and another new model architecture based on a selective state space and selected the best approach jointing a transfer learning strategy for de novo drug discovery to target L858R/T790M/C797S-mutant EGFR in non-small cell lung cancer.…”
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