Anti-VEGF therapy improves EGFR-vIII-CAR-T cell delivery and efficacy in syngeneic glioblastoma models in mice by Dai Fukumura, Rakesh K Jain, Jun Ren, Xinyue Dong, Zohreh Amoozgar, Somin Lee, Meenal Datta, Sylvie Roberge, Mark Duquette

“…Here, we tested the hypothesis that anti-VEGF therapy can improve the delivery and efficacy of CAR-T cells in immunocompetent mice bearing orthotopic GBM tumors. We engineered two syngeneic mouse GBM cell lines (CT2A and GSC005) to express EGFRvIII—one of the most common neoantigens in human GBM—and CAR T cells to recognize EGFRvIII. …”
Get full text

The Potential Applications of Stem Cell Conditioned Medium Secretome in Knee Cartilage Regeneration: A Systematic Review by I Gusti Ngurah Wien Aryana, Febyan Febyan, Nyoman Gede Grenata Nanda Ustriyana

“…The search, encompassing PubMed, MEDLINE, the Cochrane Library, Scopus, Web of Science, and Science Direct from January 10, 2023, to July 27, 2023, was conducted utilizing Google Chrome as the search engine. Studies with outcomes based on OARSI or ICRS scores, as well as any additional outcomes related to MSC secretome utilization, cartilage regeneration, and proliferation, were included. …”
Get full text

TMEM45A enhances palbociclib resistance and cellular glycolysis by activating AKT/mTOR signaling pathway in HR+ breast cancer by Cui Chen, Zehong Chen, Jinze Zhao, Xinyun Wen, Hanming Yao, Zijin Weng, Huiping Xiong, Zongheng Zheng, Juekun Wu

“…Additionally, the use of engineered exosomes loaded with siRNA targeting TMEM45A presents a promising strategy for enhancing CDK4/6 inhibitor sensitivity without observable toxic side effects in a patient-derived xenograft (PDX) model. …”
Get full text

MONITORING AND ANALYSIS OF STUDENTS' PERFORMANCE DURING SOFTWARE DEVELOPMENT by Oleksandr Sharyhin, Vasyl Fedorets, Oksana Klochko

“…The primary focus is on the development of novel performance metrics that effectively capture the level of control required from the Team Leader and the quality of work assessed by the QA Engineer. The introduced metrics, namely Relative Control Degree and Relative Quality Assurance Degree, offer a robust framework for evaluating and understanding students’ performance across project, company, and industry levels. …”
Get full text

ZBiotics ameliorates T2DM-induced histopathological damage in liver, kidney and adipose tissues by modulating the NOD-like receptor signaling in Wistar rats by Mohammed Esawie, Marwa Matboli, Mariam Sameh Bushra, Amany H. Hasanin, Eman Kamal Habib, Reham Hussein Mohamed, Hebatalla Said Ali

“…In the present study, we explored the beneficial impact of ZBiotics, an engineered probiotic, on T2DM Wistar rats. In silico analysis was performed to construct a genetic-epigenetic network linked to STING-NOD pathway and autophagy signaling. …”
Get full text

Nitrogen Dioxide (NO2) Level Changes during the Control of COVID-19 Pandemic in Thailand by Tin Ko Oo, Noppol Arunrat, Praeploy Kongsurakan, Sukanya Sereenonchai, Can Wang

“…The concentrations of tropospheric NO2 were extracted from the Sentinel-5P satellite data. The Google Earth Engine JavaScript API was used to retrieve and calculate the NO2 data. …”
Get full text

EARice10: a 10 m resolution annual rice distribution map of East Asia for 2023 by M. Song, M. Song, M. Song, L. Xu, L. Xu, J. Ge, J. Ge, J. Ge, H. Zhang, H. Zhang, H. Zhang, L. Zuo, L. Zuo, J. Jiang, J. Jiang, J. Jiang, Y. Ding, Y. Ding, Y. Ding, Y. Xie, Y. Xie, Y. Xie, F. Wu, F. Wu

“…Therefore, to acquire the latest rice distribution of the EA, this study proposed a novel rice distribution mapping method based on the Google Earth Engine (GEE) platform, producing a 10 m resolution annual rice distribution map (EARice10) of EA for 2023. …”
Get full text

The Japanese encephalitis virus NS1' protein facilitates virus infection in mosquitoes. by Yuwei Liu, Yutian Huang, Ruidong Li, Chang Miao, Yi He, Changhao Xu, Xi Zhu, Bowen Li, Rui Wu, Qin Zhao, Yiping Wen, Xiaobo Huang, Qi-Gui Yan, Yi-Fei Lang, Shan Zhao, Yiping Wang, Yajie Hu, San-Jie Cao, Senyan Du

“…<h4>Methodology/principal findings</h4>In this study, an NS1'-defective virus (rG66A) was engineered, and its effect on the infection of mosquito cells was investigated. …”
Get full text

Assessing the Impact of Sustainable Construction Practices on Project Performance. by Niwahereza, Blair

“…Questionnaire surveys were conducted across stakeholders that included site engineers, consultants and contractors. The research categorized the proposed strategies to the implementation of sustainable construction practices using relative importance index (RII) as a basis of analysis. …”
Get full text

Assessing the Hydraulic Performance of Ntungamo Town Piped Water Distribution System. by Ahimbisibwe, James

“…A water supply system comprises engineered hydrologic and hydraulic components designed to deliver water for various purposes. …”
Get full text

Efficacy of Herbicide Active Ingredients against Aquatic Weeds by Stephen F. Enloe, Ben Sperry, James Leary, Jay Ferrell

Get full text

Off-the-shelf CAR-NK cells targeting immunogenic cell death marker ERp57 execute robust antitumor activity and have a synergistic effect with ICD inducer oxaliplatin by Jichao Sun, Dinglan Wu, Liuhai Zheng, Huifang Wang, Jihao Zhou, Guangwei Shi, Jingbo Ma, Yuke Jiang, Zhiyu Dong, Jiexuan Li, Yuan-Qiao He, Chengchao Xu, Zhijie Li, Jigang Wang

“…Background Chimeric antigen receptor natural killer (CAR-NK) therapy holds great promise for treating hematologic tumors, but its efficacy in solid tumors is limited owing to the lack of suitable targets and poor infiltration of engineered NK cells. Here, we explore whether immunogenic cell death (ICD) marker ERp57 translocated from endoplasmic reticulum to cell surface after drug treatment could be used as a target for CAR-NK therapy.Methods To target ERp57, a VHH phage display library was used for screening ERp57-targeted nanobodies (Nbs). …”
Get full text

Evaluation of filling ability of Guttaflow Bioseal sealer to the simulated lateral canal by scanning electron microscope by Hero Mohammed Zahid, Niaz Hama Ghareeb

“…Three lateral canals were prepared in the coronal, middle and apical thirds in each root (at 3, 6, and 9 mm) using #15 engine-driven reamer. The specimens were divided into three groups (n = 10), according to the filling material, (I): Guttaflow Bioseal seal, (II): AH Plus sealer, (III): Endosequence Bioceramic sealer. …”
Get full text

Design of an Inhalation Chamber and Metrology Assessment to Study Tungsten Aerosol Neurotoxic Effects by Léo Macé, Chrystelle Ibanez, Thomas Gelain, Cécile Bodiot, Laure Juhel, François Gensdarmes

“…Then, we simultaneously measured the resultant aerosol, which was generated in an inhalation chamber, using three pairs of instruments—a Dekati® Low Pressure Impactor (DLPI; 30 L min−) and a gravimetric filter holder, a DLPI and a TSI® Aerodynamic Particle Sizer (APS; Model 3321), a TSI Engine Exhaust Particle Sizer (EEPS; Model 3090) and an APS—and symmetrical sampling lines. …”
Get full text

Acute and transient psychotic disorders: A review of Indian research by Sandeep Grover, Sanjana Kathiravan

“…Methodology: A combination of search terms “Acute and Transient Psychosis,” “acute psychosis,” “non-affective psychosis,” “non-affective psychotic disorder,” “reactive psychosis,” “first-episode psychosis,” and “India” were searched on various search engines like PUBMED, Medknow, Hinari, and Google Scholar. …”
Get full text

Analysis of a mouse germ cell tumor model establishes pluripotency-associated miRNAs as conserved serum biomarkers for germ cell cancer detection by Amanda R. Loehr, Dennis M. Timmerman, Michelle Liu, Ad J. M. Gillis, Melia Matthews, Jordana C. Bloom, Peter K. Nicholls, David C. Page, Andrew D. Miller, Leendert H. J. Looijenga, Robert S. Weiss

“…We previously developed a genetically engineered mouse model featuring malignant mixed TGCTs consisting of pluripotent embryonal carcinoma (EC) and differentiated teratoma that, like the corresponding human malignancies, originate in utero and are highly chemosensitive. …”
Get full text

Dealing with post-excavation data: the Omeka S TiMMA web-database by Rueff, Bastien

“…The TiMMA project also faces the limitations of Omeka S, such as the lack of efficiency of the search engine, which makes the use of web-semantic vocabularies difficult, a few bugs, and the absence of convenient functionalities in archaeological projects (e.g. the automatic creation of primary keys, a statistic dashboard, cells’ automatic filling). …”
Get full text

Easy, fast and reproducible Stochastic Cellular Automata with chouca by Génin, Alexandre, Dupont, Guillaume, Valencia, Daniel, Zucconi, Mauro, Ávila-Thieme, M. Isidora, Navarrete, Sergio A., Wieters, Evie A.

“…Besides providing better reproducibility and accessibility, a fast engine for SCA unlocks novel, computationally intensive statistical approaches, such as simulation-based inference of ecological interactions from field data, which represents by itself an important avenue for research. …”
Get full text

Electricity Generation from Cow Dung Biogas by J. Akpojaro, G. Ofualagba, M.A. Akpojaro

“…We successfully modified the internal combustion engine, which works smoothly without any sign of audible knocking during the entire experimentation. …”
Get full text

THrombosis AETiology of Aviation-Related Travel: The THETA θ study by B F Jacobson, S Louw, E Schapkaitz, F Laher

“…Venous blood and urine samples were collected prior to departure and immediately after flying in an unpressurised twin-engine airplane. D-dimer levels, thromboelastography (TEG) parameters, von Willebrand factor (VWF) activity and urine osmolality were measured. …”
Get full text