Complex regulation of Cav2.2 N-type Ca2+ channels by Ca2+ and G-proteins. by Jessica R Thomas, Jinglang Sun, Juan De la Rosa Vazquez, Amy Lee

“…Studies of these forms of regulation generally employ Ba2+ as the permeant ion, despite that Ca2+ -dependent pathways may impinge upon G-protein modulation. To address this possibility, we compared tonic G-protein inhibition of currents carried by Ba2+ (IBa) and Ca2+ (ICa) in HEK293T cells transfected with Cav2.2. …”
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Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling by Jeonghyeon Kwon, Haruya Kawase, Kenny Mattonet, Stefan Guenther, Lisa Hahnefeld, Jamal Shamsara, Jan Heering, Michael Kurz, Sina Kirchhofer, Cornelius Krasel, Michaela Ulrich, Margherita Persechino, Sripriya Murthy, Cesare Orlandi, Christian D. Sadik, Gerd Geisslinger, Moritz Bünemann, Peter Kolb, Stefan Offermanns, Nina Wettschureck

“…Abstract Macrophages express numerous G protein-coupled receptors (GPCRs) that regulate adhesion, migration, and activation, but the function of orphan receptor GPRC5B in macrophages is unknown. …”
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Supplementation of Arjun (Terminalia arjuna) bark powder prevented oxidative stress and enhanced antioxidants in kidneys on isoproterenol-treated Swiss albino mice model by Rashedul Haque, Sajib Paul, Md. Tipu Sultan, Faizul Islam Chowdhury, Md. Kawser, Shariful Islam Nayan, S.M. Hafiz Hassan, Afsana Kabir Chowdhury, Raiyana Huda, Sauda Sumaya Dina, Sheikh Zahir Raihan

“…Catalase plasma (ISO- 15.90 U/min, ISO + Arjun 2.5%- 19.75 U/min, P = 0.0070) and in catalase kidney (ISO- 381.6 U/min/g protein, ISO + Arjun 2.5%- 581.9 U/min/g protein, P = 0.0082). …”
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Rapid expansion and specialization of the TAS2R bitter taste receptor family in amphibians. by Kathleen W Higgins, Akihiro Itoigawa, Yasuka Toda, Daniel Winston Bellott, Rachel Anderson, Roberto Márquez, Jing-Ke Weng

“…TAS2Rs are a family of G protein-coupled receptors that function as bitter taste receptors in vertebrates. …”
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Delta opioid receptors engage multiple signaling cascades to differentially modulate prefrontal GABA release with input and target specificity by Ryan P.D. Alexander, Kevin J. Bender

“…We found that DORs regulate inhibition from these interneuron classes using different G-protein signaling pathways that both converge on presynaptic calcium channels but regulate distinct aspects of calcium channel function. …”
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Novel risk loci encompassing genes influencing STAT3, GPCR, and oxidative stress signaling are associated with co-morbid GERD and COPD. by Ava C Wilson, Alison Rocco, Joe Chiles, Vinodh Srinivasasainagendra, Wassim Labaki, Deborah Meyers, Bertha Hidalgo, Marguerite R Irvin, Surya P Bhatt, Hemant Tiwari, Merry-Lynn McDonald

“…The co-heritability of GERD and COPD was 39.7% (h2 = 0.397, SE = 0.074) and we identified several ancestry-independent loci associated with co-morbid GERD and COPD (within LINC02493 and FRYL) known to be involved in oxidative stress and G protein-coupled receptor (GPCR) signaling mechanisms. …”
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A ribosome-associating chaperone mediates GTP-driven vectorial folding of nascent eEF1A by Ibrahim M. Sabbarini, Dvir Reif, Kibum Park, Alexander J. McQuown, Anjali R. Nelliat, Charlotte Trejtnar, Volker Dötsch, Eugene I. Shakhnovich, Andrew W. Murray, Vladimir Denic

“…Our work shows that an ATP-independent chaperone can drive vectorial folding of nascent chains by co-opting G protein nucleotide binding.…”
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High-power ultrasound pretreatment for enhanced protein extraction from lupin flour: Impact on yield, anti-technological and anti-nutritional factors, and techno-functional propert... by Paola Navarro-Vozmediano, Esperanza Dalmau, Jose Benedito, Jose V. Garcia-Perez

“…Ultrasonic field was characterized by computing acoustic pressure from frequency spectra analysis.In general terms, pretreatment reduced noticeably ANF and ATF in both LF and protein isolate (LPI), while also producing a protein concentrate (LPC, avg. 65 g protein/100 g) with low ANF and ATF content. Total protein yield, adding LPC and LPI, was increased by 15 % due to the pretreatment, which also enhanced the techno-functional properties of LPI, such as water absorption index (avg. 26 %) and foaming (avg. 8 %) and emulsifying properties (avg. 14 %). …”
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Quality Control of Fetal Wharton’s Jelly Mesenchymal Stem Cells-Derived Small Extracellular Vesicles by Krishnan I, Ng CY, Kee LT, Ng MH, Law JX, Thangarajah T, Zainuddin AA, Mahmood Z, Rajamanickam S, Subramani B, Lokanathan Y

“…Quantitatively, the protein and particle concentrations revealed that all the sEV preparations were “impure” with < 1.5 × 109 particles/μg protein. Albumin was co-isolated in all the sEV preparations.Conclusion: In short, all characterized and standardized individual and pooled sEV preparations were deemed “impure” due to albumin co-isolation using the TFF method. …”
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Binding of HCN channels to GABAB receptors in dopamine neurons of the VTA limits synaptic inhibition and prevents the development of anxiety by Enrique Pérez-Garci, Kateryna Pysanenko, Giorgio Rizzi, Florian Studer, Daniel Ulrich, Thorsten Fritzius, Simon Früh, Alessandra Porcu, Valérie Besseyrias, Adolf Melichar, Martin Gassmann, Tania Rinaldi Barkat, Rostislav Tureček, Kelly R. Tan, Bernhard Bettler

“…During GABAergic synaptic transmission, G protein-coupled GABAB receptors (GBRs) activate K+ channels that prolong the duration of inhibitory postsynaptic potentials (IPSPs). …”
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Integrative bioinformatic approach reveals novel melatonin-related biomarkers for Alzheimer’s disease by Hua-xiong Zhang, Dilmurat Hamit, Qing Li, Xiao Hu, San-feng Li, Fu Xu, Ming-yuan Wang, Guo-qing Bao, Hong-yan Li

“…After overlapping with 3,490 DEGs and 550 MRGs in GSE5281, four genes were found to be causally related to AD, namely, G protein-coupled receptor, family C, group 5, member B (GPRC5B), Methyltransferase-like protein 7 A (METTL7A), NF-κB inhibitor alpha (NFKBIA) and RAS association domain family 4(RASSF4). …”
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Optimasi Data Tidak Seimbang pada Interaksi Drug Target dengan Sampling dan Ensemble Support Vector Machine by Nabila Sekar Ramadhanti, Wisnu Ananta Kusuma, Annisa Annisa

“…Metode ini sudah diuji pada dataset Nuclear Receptor, G-Protein Coupled Receptor dan Ion Channel dengan rasio ketidakseimbangannya sebesar 14.6%, 32.36%, dan 28.2%. …”
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Identification of a guanine nucleotide exchange factor for Arf3, the yeast orthologue of mammalian Arf6. by Alison K Gillingham, Sean Munro

“…Small G proteins of the Arf and Rab families are fundamental to the organisation and activity of intracellular membranes. …”
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