Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice by Ali Yousefian-Jazi, Suhyun Kim, Jiyeon Chu, Seung-Hye Choi, Phuong Thi Thanh Nguyen, Uiyeol Park, Min-gyeong Kim, Hongik Hwang, Kyungeun Lee, Yeyun Kim, Seung Jae Hyeon, Hyewhon Rhim, Hannah L. Ryu, Grewo Lim, Thor D. Stein, Kayeong Lim, Hoon Ryu, Junghee Lee

“…However, the mechanism behind genetic mutations in the non-coding region of genes that affect epigenetic modifications remains unclear. …”
Get full text

A novel truncated fusion gene ETV6::AC010198.2 in post-MPN acute myeloid leukemia caused by del(12)(p13p11) by Jiao Lu, Jiao Lu, Guanqun Yang, Qiurong Zhang, Man Wang, Man Wang, Lijun Wang, Lijun Wang, Lu Chen, Haoyue Chen, Xin Jiang, Chunhua Liu, Tong Lin, Qiaoyan Han, Zefa Liu, Shi Zhen, Zhao Zeng, Jinlan Pan, Jiannong Cen, Suning Chen, Suning Chen, Zheng Wang, Zheng Wang, Xingxia Zhang, Miao Sun

“…The gene ETV6 has been confirmed to be a genetic susceptibility gene for thrombocytopenia and leukemia. …”
Get full text

Protocol for the purification and analysis of nuclear UFMylated proteins by Pudchalaluck Panichnantakul, Marlene Oeffinger

Get full text

Co-occurrence of a Mullerian anomaly and Kallmann syndrome: A case report by Lea C. George, Rebecca Gendelman, Anat Chemerinski, Pierre Lespinasse, Inessa A. Goldman, Sara Morelli

“…The evaluation of primary amenorrhea requires a thoughtful assessment for hormonal, structural and/or genetic causes. Although most cases of primary amenorrhea are caused by a single pathology, rarely multiple pathologies may be uncovered. …”
Get full text

Measuring Measuring iron concentration in the blood samples of some autistic children from Baghdad City by Ezzuldin sulaiman, Hind Suhail Abdulhay

“…Possible causes for this condition include specific drugs, genetic disorders, or the dietary habits of the ASD. …”
Get full text

Pleiotropic effects of rabeprazole at acid-related diseases by A. V. Zaborovsky, I. V. Mayev, D. N. Andreyev, L. A. Tararina

“…Conclusion. Interleukin genetic polymorphism investigation may be useful at assessment of cytokine status in AP patients to predict the outcomes and to develop the personalized approach to treatment and prophylaxis.…”
Get full text

Contemporary Approaches to the Treatment of Gastroesophageal Reflux Disease by Boris D. Starostin

“…The efficacy of PPI treatment may depend on the genetic polymorphism of the CYP2C19 cytochrome. Rabeprazole is characterized by a predominantly non-enzymatic pathway, providing a more stable pharmacokinetics profile, which is less dependent on the CYP2C19 polymorphism. …”
Get full text

The geographical distribution, trophic modes, and host preferences of Fomitopsis pinicola in Central Europe: a comprehensive review by Gáper Ján, Gáperová Svetlana, Pristaš Peter, Šebesta Martin, Kollárová Patrícia, Gallay Igor, Slobodník Branko

“…In silico analysis of available F. pinicola ITS sequences indicates its genetic homogeneity in Central Europe and the adjacent regions. …”
Get full text

EMT-driven plasticity prospectively increases cell–cell variability to promote therapeutic adaptation in breast cancer by Lauriane Muller, Frédérique Fauvet, Christelle Chassot, Francesca Angileri, Angèle Coutant, Cyril Dégletagne, Laurie Tonon, Pierre Saintigny, Alain Puisieux, Anne-Pierre Morel, Maria Ouzounova, Pierre Martinez

“…Abstract Cellular plasticity enables cancer cells to adapt non-genetically, thereby preventing therapeutic success. …”
Get full text

Relationship between personality traits and spontaneous coronary artery dissection risk: evidence from Mendelian randomization by Kun Zheng, Kun Zheng, Mengdi Wu, Junhua Wang, Junhua Wang, Jinjin Sun, Yuqian Li, Peng Wang, Zhiyue Zhang, Xiuming Pan, Yifeng Yang, Tianqi Li, Yujie Guo

“…These findings were further substantiated by multivariate MR analyses.ConclusionsIn summary, this study identified a significant association between genetically predicted neuroticism scores and an elevated risk of SCAD. …”
Get full text

Molecular techniques for cancer diagnostics by Vimal Kishor Singh, Ramesh Chandra

“…Recent research reported vast genetic and epigenetic heterogeneity, differences in the gene-expression profiles, and signal transduction networks in a broad range of cancers. …”
Get full text

Powdery Mildew of Cucurbits in Florida by Hector G. Nuñez-Palenius, Donald Hopkins, Daniel J. Cantliffe

“…Cantliffe, describes this serious disease of cucurbit crops in Florida, the symptoms and disease development, environmental factors, management, the use of plants with genetic resistance, management using fungicides for susceptible cultivars, the use of biorational and non-harmful chemicals, and biological fungicides. …”
Get full text

Advances in regenerative medicine-based approaches for skin regeneration and rejuvenation by Nathalia Silva Dutra Alves, Gustavo Roncoli Reigado, Mayara Santos, Izabela Daniel Sardinha Caldeira, Henrique dos Santos Hernandes, Bruna Leticia Freitas-Marchi, Elina Zhivov, Felipe Santiago Chambergo, Viviane Abreu Nunes

“…These methods hold promise for treating a range of conditions, from chronic wounds and burns to age-related skin changes and genetic disorders. Challenges remain in optimizing these therapies for broader accessibility and ensuring long-term safety and efficacy.…”
Get full text

Healthy Eating: Folate by Linda B. Bobroff

“…It is involved in the formation of DNA, the genetic material found in all cells of your body. …”
Get full text

ANO7 expression in the prostate modulates mitochondrial function and lipid metabolism by Christoffer Löf, Nasrin Sultana, Neha Goel, Samuel Heron, Gudrun Wahlström, Andrew House, Minna Holopainen, Reijo Käkelä, Johanna Schleutker

“…Abstract Background Prostate cancer (PrCa) is a significant health concern, ranking as the second most common cancer in males globally. Genetic factors contribute substantially to PrCa risk, with up to 57% of the risk being attributed to genetic determinants. …”
Get full text

Unravelling single-cell DNA replication timing dynamics using machine learning reveals heterogeneity in cancer progression by Joseph M. Josephides, Chun-Long Chen

Get full text

Association of CYP11A1 Polymorphisms with Recurrent Pregnancy Loss in the Female Population of Punjab by Amanjot Kaur Rayat, Pallvi Thapar, Mandeep Kaur, Sukhjashanpreet Singh, Anupam Kaur

“…Conclusion: CYP11A1 variants (rs11632698 and rs4077582) may be useful markers in determining the genetic susceptibility to the pathogenesis of RPL. …”
Get full text

The impact of apolipoprotein E, type ∊4 allele on Alzheimer's disease pathological biomarkers: a comprehensive post-mortem pilot-analysis. by Ziyu Wan, Tao Ma

“…The apolipoprotein E type ∊4 allele (ApoE4) is known as the strongest genetic risk factor for Alzheimer's Disease (AD). …”
Get full text

Engineering of SauriCas9 with enhanced specificity by Xiaoqi Zhang, Chen Tao, Miaomiao Li, Sufang Zhang, Puping Liang, Yan Huang, Huihui Liu, Yongming Wang

Get full text

Association of ERCC2/XPD polymorphisms and the risk of head and neck carcinoma: a systematic review, meta-analysis, trial sequential analysis, network analysis, and functional effe... by Mohammad Moslem Imani, Ali Ashabi, Farzad Rezaei, Atefe Saffar Shahroudi, Sadegh Kashkouli, Edris Sadeghi, Masoud Sadeghi

“…Abstract Objectives and aims The combination of genetic and environmental factors may contribute to the carcinogenesis of HNC. …”
Get full text