Multi-locus CRISPRi targeting with a single truncated guide RNA by Molly M. Moore, Siddarth Wekhande, Robbyn Issner, Alejandro Collins, Anna J. Cruz, Yanjing V. Liu, Nauman Javed, Salvador Casaní-Galdón, Jason D. Buenrostro, Charles B. Epstein, Eugenio Mattei, John G. Doench, Bradley E. Bernstein, Noam Shoresh, Fadi J. Najm

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Opportunities for promoting open data in the Caribbean through biobanks by Sushant Saluja, Simon G. Anderson

“…The UK Biobank project is a large-scale study with deep genetic and phenotypic data from about 500 000 participants in the United Kingdom. …”
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The emerging role of glycine receptor α2 subunit defects in neurodevelopmental disorders by Sean D. Fraser, Sean D. Fraser, Robert J. Harvey, Robert J. Harvey

“…This review will focus on newly-emerging genetic forms of NDDs resulting from variants in the glycine receptor (GlyR) α2 subunit gene. …”
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The causal relationship of cigarette smoking to metabolic disease risk and the possible mediating role of gut microbiota by Jingda Zhang, Lin Hou, Shanxiang Lei, Yan Li, Guogang Xu

“…In the MVMR model, the genetic connection between cigarette smoking, gut microbiota, and type 2 diabetes remained significant. …”
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Optimizing fully-efficient two-stage models for genomic selection using open-source software by Javier Fernández-González, Julio Isidro y Sánchez

“…Genomic selection (GS) predicts genomic breeding values (GEBV) using dense genetic markers. Single-stage models predict GEBVs from phenotypic observations in one step, fully accounting for the entire variance-covariance structure among genotypes, but face computational challenges. …”
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Florida Cow-Calf and Stocker Beef Safety and Quality Assurance Handbook: Quality Control Points by Todd A. Thrift, Matt J. Hersom, Max Irsik

“…It describes management approaches for five areas of quality concern: breeding and genetic selection, utilization of animal health products and practices, processing/cattle handling, nutrition, and culling management. …”
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Soil pH Management for Optimum Commercial Fruit Production in Florida by Guodong Liu, Rao Mylavarapu, Ed Hanlon, Wei Chieh Lee

“…The crop response to soil pH varies due to crop genetic diversity. Soil pH determines nutrient bioavailability and hence fruit growth, yield, and quality. …”
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Addressing the limitations of the regulatory landscape in South Africa regarding advanced cell and gene therapies and related sectors involving human cells, tissues and organs by I M Viljoen, M S Pepper

“…However, South Africa (SA)’s regulatory frameworks for medicines, human biological materials and genetically modified organisms have not kept pace with scientific and technological developments, leaving regulatory gaps. …”
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Infantile undifferentiated sarcomas: a diagnostic and therapeutic challenge – two case reports and literature review by Aleksandra Stanio, Jakub Czarny, Sandra Rutkowska, Katarzyna Adamczewska-Wawrzynowicz, Łukasz Młynarczyk, Agnieszka Stróżyk, Katarzyna Jończyk-Potoczna, Alicja Bartkowska-Śniatkowska, Jacek Wachowiak, Katarzyna Derwich, Olga Zając-Spychała

“…Background: Soft tissue undifferentiated sarcomas (STUS) are an ultra-rare and heterogenous group of mesenchymal neoplasms often lacking known genetic abnormalities with a marked vulnerability towards intensive therapy such as invasive surgery and high dose chemotherapy. …”
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Tropical and Subtropical Fruit Propagation by Jeff Wasielewski, Carlos F. Balerdi

“…While sexual propagation (by seed) results in plants that are not genetically the same as the mother plant, asexual propagation (cuttings, division, air-layers, and grafting) creates offspring that are clones of the mother plant. …”
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Floridians’ Perceptions of GMOs: GMOs and Florida Citrus by Nicole M. W. Dodds, Laura M. Gorham, Joy N. Rumble

“…This 4-page fact sheet is intended to help Extension faculty understand public perceptions regarding the use of genetic engineering to combat citrus greening. Extension faculty can use this understanding of public perceptions as they develop and deliver programming for clientele. …”
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Critical evaluation of pathogenic factors of primary biliary cirrhosis by A. F. Sheptulina, M. V. Mayevskaya, V. T. Ivashkin

“…Etiological factors increasing risk of PBC development include genetic factors, immunologic disorders, and environmental features. …”
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Chronic wounds and adaptive Pseudomonas aeruginosa: A phenotypic and genotypic characterization by Kasandra Buchholtz, Rie Jønsson, Rasmus L. Marvig, Biljana Mojsoska, Karen Angeliki Krogfelt

“…Phenotypic and genetic diversity is found in varying prevalence in clinical populations where beneficial adaptations enable the bacteria to avoid recognition and eradication by the host immune system. …”
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Cryo-electron tomography pipeline for plasma membranes by Willy W. Sun, Dennis J. Michalak, Kem A. Sochacki, Prasanthi Kunamaneni, Marco A. Alfonzo-Méndez, Andreas M. Arnold, Marie-Paule Strub, Jenny E. Hinshaw, Justin W. Taraska

“…The pipeline allows for angstrom-scale structure determination with subtomogram averaging and employs a genetically encodable rapid chemically-induced electron microscopy visible tag for marking specific proteins within the complex cellular environment. …”
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The treatment of irritable bowel syndrome from the modern views on the disease pathogenesis by Ye. A. Poluektova, S. Yu. Kuchumova, A. A. Sheptulin, V. T. Ivashkin

“…The data received in the recent years provide evidence about the fact that in the development of IBS the genetic factors, the inflammatory changes of the intestinal mucosa and the violation of the balance of the gut microflora play the important role. …”
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'Micro-Tina' and 'Micro-Gemma' Miniature Dwarf Tomatoes by John W. Scott, Brent K. Harbaugh, E. A. Baldwin

“…These companion releases provide tomato cultivars that are genetically smaller (plant, fruit, leaves, and stems) than are normal dwarf cultivars. …”
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Median Mandibular Cleft in SAMS Syndrome – A Rare Case Report by S. M. Balaji, Preetha Balaji, Chris Joseph, Sachin Nishanth, Varsha Christy Balaji

“…Rationale: SAMS syndrome is a rare genetic disorder characterized by midline facial clefting, skeletal anomalies, and other defects. …”
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Cardiac achalasia: modern concepts on etiology, pathogenesis, clinical presentation and diagnostics by Yu. V. Yevsyutina, O. A. Storonova, A. S. Trukhmanov, V. T. Ivashkin

“…Esophageal manometry which allows to evaluate resting pressure and relaxation phenomenon of the lower esophageal sphincter and peristaltic activity of distal part of the esophagus is the «gold standard» of diagnostics. Genetic, autoimmune and infectious theories are considered for disease etiology.Conclusion. …”
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Progress in the Management of Retinal Detachment Associated With Morning Glory Syndrome by Wu S, Wang W, Liu L, Wang W, Jiang K, Peng C, Sun H, Zhang J

“…The etiology of MGS is not fully understood but has been associated with genetic factors, particularly mutations in the PAX6 and PAX2 genes, which play critical roles in eye development. …”
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The optimization of calcareous soil cation exchange capacity via the feather hydrolysate and N-P fertilizers integration by Doaa A. Goda, Eman H. El-Gamal, Mohamed Rashad, Yasser R. Abdel-Fattah

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