Parathyroid carcinoma and pheochromocytoma in a patient with neurofibromatosis type 1: a rare association by Jardelina Brena Rocha Leite, Nicole Ramalho De Freitas, Rafaella Nelice de Holanda Cardoso, Erik Trovão Diniz, Gabriel Rodrigues de Assis Ferreira, Fernão Henrique Costa e Alvim, Camila Ribeiro Coutinho Madruga, Ana Carolina Thé Garrido, Luciano Albuquerque, Patricia Sampaio Gadelha, Ruy Lyra, Lucio Vilar

“…Surgical intervention confirmed the presence of pheochromocytoma and parathyroid carcinoma. Genetic analysis corroborated NF1 with a pathogenic variant in the NF1 gene. …”
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Characterization and phylogenetic analysis of the chloroplast genome of endangered Impatiens chishuiensis by LAN Wenxiang, MO Qing, HUANG Haiquan, HUANG Meijuan

“…[Objective] The chloroplast genome structure and phylogenetic location of Impatiens chishuiensis were studied in order to provide scientific basis for the conservation of plant germplasm resources, genetic diversity, and phylogeny of I. chishuiensis. …”
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The intestinal microbiome as a separate organ by Yu. O. Shulpekova

“…Intestinal microbiome encompasses about 1014 microorganisms, over 99% of microbiome genetic material belong to bacteria. In healthy people three basic enterotypes (according to the type of dominating species) are defined. …”
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Case report of familial hypercholesterolemia with internal carotid neck swelling by Sudesh Kumar, Prajna Ray, Ranita Sahana

“…This case highlights the significance of conscious and proactive genetic screening for familial hypercholesterolemia especially in consanguineous marriage, to diagnose, treat and prevent mortality with premature coronary artery disease.…”
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In-service teachers' self-efficacy to practice inclusive education at public primary schools in the Amhara region: Implications for teacher education by Tsegie Genet Zegeye, Solomon Kassie Alem, Ayetenew Abie

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Psoriasis: Unraveling Disease Mechanisms and Advancing Pharmacological and Nanotechnological Treatments by Miao M, Yan J, Sun Y, Liu J, Guo S

“…The identification of age, gender, and genetic factors contributing to these complex conditions has been pivotal in developing novel pharmacological and technological treatments. …”
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Impacts of Climate Change on the Plant Water Interactions by Turyasingura, Benson, Ayiga, Natal

“…It was also found that drought was one of the most significant biotic challenges faced by plants, with considerable genetic variation in water deficit responses. There is a need for research on climate change to ease biodiversity conservation.…”
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Comprehensive analysis of the mechanisms conferring resistance to phenamacril in the Fusarium species by Alexander Dumbai Joe, Runze Liu, Xiao Luo, Ruqiya Syed, Farhan Aslam, Zhenying Luo, Zhitian Zheng

“…We examine the molecular, genetic, and environmental factors contributing to this resistance. …”
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Quantum computational infusion in extreme learning machines for early multi-cancer detection by Anas Bilal, Muhammad Shafiq, Waeal J. Obidallah, Yousef A. Alduraywish, Haixia Long

“…This study presents a hybrid model integrating Extreme Learning Machine (ELM) with FuNet transfer learning, applied on a multi-cancer dataset and optimized using the Quantum-Genetic Binary Grey Wolf Optimizer (Q-GBGWO). This model leverages a diverse feature fusion strategy, enhancing the extraction of critical imaging features, while Q-GBGWO optimizes ELM parameters to achieve superior classification performance. …”
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RTEL1 is upregulated in gastric cancer and promotes tumor growth by Chunyu Yang, Suzeng Wang, Ge Gao, Peiwen Xu, Mengyuan Qian, Yuan Yin, Surui Yao, Zhaohui Huang, Zehua Bian

“…GC is a highly heterogeneous disease and its progression is associated with complex interplay between genetic and environmental factors. Identifying novel genes and pathways involved in GC development is crucial for improving the therapeutic outcome. …”
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Structural basis for RNA-guided DNA degradation by Cas5-HNH/Cascade complex by Yanan Liu, Lin Wang, Qian Zhang, Pengyu Fu, Lingling Zhang, Ying Yu, Heng Zhang, Hongtao Zhu

“…Abstract Type I-E CRISPR (clustered regularly interspaced short palindromic repeats)–Cas (CRISPR-associated proteins) system is one of the most extensively studied RNA-guided adaptive immune systems in prokaryotes, providing defense against foreign genetic elements. Unlike the previously characterized Cas3 nuclease, which exhibits progressive DNA cleavage in the typical type I-E system, a recently identified HNH-comprising Cascade system enables precise DNA cleavage. …”
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The Determination of Fetal Gender with Gestational Sac Volume Maternal Age and Body Mass Index by Aytekin Aydın, Mustafa Öztürk, Murat Gökhan Kinaş

“… OBJECTIVE: In this study, we aimed to examine the effects of fetal gender on Gestational Sac Volume (GSV), maternal age and Body Mass Index (BMI) between 10 and 12 gestational weeks in order to detect the fetal gender in diseases being transferred genetically with x by using non-invasive methods. STUDY DESIGN: 37 pregnant women who came for routine antenatal controls between 10 and 12 gestational weeks were incorporated in study. …”
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Causal relationship between educational attainment and the occurrence of venous thromboembolism by Sitong Guo, Sitao Tan, Shiran Qin, Dandan Xu, Henghai Su, Xiaoyu Chen

“…Use the MR-Egger method for pleiotropy analysis and leave one method for sensitivity analysis to verify the reliability of the data. Results Genetically predicted decreased EA was associated with a decreased risk of VTE in both the FinnGen consortium and UK Biobank (FinnGen-VTE: OR = 0.848; 95% CI 0.776—0.927; P = 2.84 × 10–4; UKB-VTE OR = 0.996; 95% CI 0.994—0.999; P = 0.008) under a multiplicative random-effects IVW model. …”
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Combined Parental Thrombophilia Gene Mutation Defects in Couples with Repeated Pregnancy Loss by Mehdi Kashifard, Zahra Basirat, Fatemeh Ramezani, Faeze Ghofrani, Masoumeh Golsorkhtabaramiri

“…Background: Several genetic mutations in female thrombotic defects have recently been shown to affect recurrent pregnancy loss (RPL); however, it is unclear which common parental mutations are involved in thrombosis-associated repeated pregnancy loss RPL. …”
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Engineered Bacillus subtilis WB600/ZD prevents Salmonella Infantis-induced intestinal inflammation and alters the colon microbiota in a mouse model by Wei Li, Xue Wang, Keyuan Chen, Yaohong Zhu, Guiyan Yang, Yipeng Jin, Jiufeng Wang

“…However, the intrinsic instability associated with the in vivo delivery of AMPs constitutes a substantial impediment to their therapeutic efficacy in treating infections. In this study, we genetically modified Bacillus subtilis (B. subtilis) WB600 to express Zophobas atratus defensin (ZD), an antimicrobial peptide with broad-spectrum activity isolated from Zophobas atratus, for oral administration. …”
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The Science of Memory Loss: Insights into Alzheimer’s Disease by Agnieszka Starzyk, Piotr Charzewski

“…Since the 2016 Seminar, substantial progress has been made in understanding AD’s complex pathogenesis, identifying genetic risk and protective factors, and developing novel diagnostic biomarkers and therapeutic strategies. …”
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Synthetic wheat as a new source of flour quality under drought conditions: Associations with solvent retention capacity. by Niloofar Mokhtari, Mohammad Mahdi Majidi, Aghafakhr Mirlohi

“…Correlation analysis indicated that genetic improvement for high-yielding varieties can be achieved by producing more damaged starch, higher water absorption, hardness, and lower gluten strength, and zeleny (ZEL). …”
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Machine Learning with Tunicate Swarm Optimization for Improved Disc Herniation Prediction by Theofilos Gofas, Argyros Maris

“…The many variables that contribute to disc herniation are examined in this study, including age-related deterioration, genetic predispositions, lifestyle choices, and traumatic experiences. …”
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A lethal disease of the European bison – posthitis is conditionally determined by its genomics by Sazia Kunvar, Sylwia Czarnomska, Cino Pertoldi, Astrid V. Stronen, Iwona Ruczyńska, Małgorzata Tokarska

“…Studies indicated the disease could have a genetic background after tools developed for cattle (Bos taurus) revealed genomic regions that could be associated with its occurrence. …”
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Brazilian Thoracic Association recommendations for the management of lymphangioleiomyomatosis by Bruno Guedes Baldi, Paulo Henrique Ramos Feitosa, Adalberto Sperb Rubin, Alexandre Franco Amaral, Carolina Salim Gonçalves Freitas, Cláudia Henrique da Costa, Eliane Viana Mancuzo, Ellen Caroline Toledo do Nascimento, Mariana Sponholz Araujo, Marcelo Jorge Jacó Rocha, Martina Rodrigues de Oliveira, Tatiana Senna Galvão, Pedro Paulo Teixeira e Silva Torres, Carlos Roberto Ribeiro Carvalho

“…In recent decades, a number of advances have been made in the understanding of the pathophysiology and management of LAM, leading to improvements in its prognosis: identification of the main genetic aspects and the role of the mechanistic target of rapamycin (mTOR) pathway; relationship with hormonal factors, mainly estrogen; characterization of pulmonary and extrapulmonary manifestations in imaging studies; identification and importance in the diagnosis of VEGF-D; a systematic diagnostic approach, often without the need for lung biopsy; use of and indications for the use of mTOR inhibitors, mainly sirolimus, for pulmonary and extrapulmonary manifestations; pulmonary rehabilitation and the management of complications such as pneumothorax and chylothorax; and the role of and indications for lung transplantation. …”
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