A cross-tissue transcriptome-wide association study identified susceptibility genes for age-related macular degeneration by Hongfan Yang, Haofei Huang, Kunlin Pu

“…Abstract Age-related macular degeneration (AMD) is a complex multifactorial disease with a significant genetic component. Despite extensive research efforts, the underlying molecular mechanisms remain elusive, necessitating innovative approaches to identify specific genes involved in the pathogenesis of AMD and to elucidate their functional mechanisms. …”
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The Borrachudos Granitic Suite: Paleo- to Mesoproterozoic A-type Magmatism in the Southeastern São Francisco Craton (SE Brazil) by IVO ANTONIO DUSSIN, MARIO LUIZ S.C. CHAVES, TANIA MARA DUSSIN, PHILLIPPE ROSSI, JACQUES CHARVET

“…To investigate the nature of this magmatism, mineralogical, geochemical, Nd-Sr isotopic studies in the BGS and genetically related metarhyolites inside the fold belt were carried out. …”
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Subgenome asymmetry of gibberellins-related genes plays important roles in regulating rapid growth of bamboos by Ling Mao, Cen Guo, Liang-Zhong Niu, Yu-Jiao Wang, Guihua Jin, Yi-Zhou Yang, Ke-Cheng Qian, Yang Yang, Xuemei Zhang, Peng-Fei Ma, De-Zhu Li, Zhen-Hua Guo

“…Rapid growth is an innovative trait of woody bamboos that has been widely studied. However, the genetic basis and evolution of this trait are poorly understood. …”
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Travelogs of Journeys to Lithuania in Early 15th–19th Century: The Problem of Egodocumentality and Typology by Arvydas Pacevičius

“…The attempt at a typology of travel egodocumentation revealed a gap between a genetic taxonomy based on the notion of the personal archive as a treasure trove of memory and a literary classification based on contemporary genres of travel writing. …”
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East Asian Gene flow bridged by northern coastal populations over past 6000 years by Juncen Liu, Yichen Liu, Yongsheng Zhao, Chao Zhu, Tianyi Wang, Wen Zeng, Bo Sun, Fen Wang, Hui Han, Zhenguang Li, Xiaotian Feng, Peng Cao, Fengshi Luan, Feng Liu, Qingyan Dai, Junfeng Guo, Zimeng Wang, Chengmin Wei, Qiaowei Wei, Ruowei Yang, Weihong Hou, Wanjing Ping, Fan Bai, Bo Miao, Wenjun Wang, Melinda A. Yang, Qiaomei Fu

“…In the ShanDong region, we observed gene flow from populations to the north and south of this region by at least ~7700 BP, and two waves of gene flow associated with the inland Yellow River populations into the ShanDong region during the DaWenKou cultural period (6000-4600 BP) and in the early dynastic period (3500-1500 BP). Reconstructing the genetic history of the Neolithic, Bronze, and Iron Age populations of coastal northern East Asia shows gene flow on both a north-south and an east-west (inland-coastal-island) scale.…”
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Immunopathogenesis of inflammatory bowel diseases by Ye. A. Konovich, I. L. Khalif, M. V. Shapina

“…To present analysis of data on immunopathogenesis of inflammatory bowel diseases.Key points. At genetically sensitive animals inflammatory bowel diseases (IBD) develop at various effects on innate and adaptive systems of immune defense (knock-out and transgenic mice), causing changes of expression of significant immunologic factors with distortion of pro- and anti-inflammatory cells and molecules ratio at their contact to microbiota structures. …”
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Tumor-initiating and metastasis-initiating cells of clear-cell renal cell carcinoma by Dinh-Xuan Pham, Tien Hsu

“…MICs result from various genetic changes during subclonal evolution, while TICs reside in the stem of the ccRCC phylogenetic tree of clonal development. …”
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Inotersen to Treat Polyneuropathy Associated with Hereditary Transthyretin (hATTR) Amyloidosis by Christopher Robinson, Cynthia Pham, Alec M. Zamarripa, Chase S. Dugay, Christopher A. Lee, Amnon A. Berger, Avi Landman, Elyse M. Cornett, Hisham Kassem, Alan D. Kaye, Ivan Urits, Omar Viswanath, Latha Ganti

“…The use of RNA interference (RNAi) opens the door to the treatment of hereditary diseases by targeting them at the genetic level.…”
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The Role of the Pathoanatomical Diagnosis «Chronic Gastritis» in the System of Personified Cancer Prevention by A. V. Kononov

“…Biopsy diagnosis of chronic gastritis combined with the evaluation of gene structure (genetic polymorphism) and epigenomic mechanisms (microRNA) allows the risk of gastric cancer to be ranked in a particular patient even with early precancerous changes in the gastric mucosa. …”
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Systematic analysis of the pharmacogenomics landscape towards clinical implementation of precision therapeutics in Greece by George P. Patrinos, Kariofyllis Karamperis, Margarita-Ioanna Koufaki, Maria Skokou, Zoe Kordou, Eirini Sparaki, Margarita Skaraki, Christina Mitropoulou

“…Abstract Pharmacogenomics (PGx) aims to delineate a patient’s genetic profile with differences in drug efficacy and/or toxicity, particularly focusing on genes encoding for drug-metabolizing enzymes and transporters. …”
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Neurosurgical aspects of marble bone disease: treatment modalities and outcome by Mahmoud Mohammed Gamal, Roshdy Elkhayat, Hassan Mohammed Hassan

“…Osteopetrosis has 3 types of genetic inheritance either malignant autosomal recessive (ARO) which occur in childhood, intermediate ARO which occur in adolescence, and benign autosomal dominant osteopetrosis which occur in adults. …”
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Toll-like receptors in atopic dermatitis: pathogenesis and therapeutic implications by Ahmad Vafaeian, Fateme Rajabi, Nima Rezaei

“…The dysregulation of proinflammatory and immunomodulatory effects of TLRs can be attributed to their ligand structures, receptor heterodimerization, the relative frequency of each TLR, interactions with other receptors/signalling pathways, cytokine milieu, and genetic polymorphisms. Current AD treatments like vitamin-D analogs, tacrolimus, and cyclosporine partially work through TLR modulation. …”
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Evaluation of acitretin side effects on Iraqi psoriatic patients by Ahmed H. Kadhim‎, Dhia'a A. Hassan‎, Amer H. Chyad‎, Abdulstaar M. Khudyar‎

“…There is other  important factors should be consider before evaluation the physiological changes may be caused by acitretin like smoking , alcohol intake , obesity and genetic association between psoriasis and other physiological change. …”
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Molecular pathways in reproductive cancers: a focus on prostate and ovarian cancer by Ayodeji Folorunsho Ajayi, Mega Obukohwo Oyovwi, Oyedayo Phillips Akano, Grace Bosede Akanbi, Florence Bukola Adisa

“…This review aims to provide an overview of the molecular pathways implicated in prostate and ovarian cancers, highlighting key genetic alterations, signaling cascades, and epigenetic modifications. …”
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How energy determines spatial localisation and copy number of molecules in neurons by Cornelius Bergmann, Kanaan Mousaei, Silvio O. Rizzoli, Tatjana Tchumatchenko

“…Abstract In neurons, the quantities of mRNAs and proteins are traditionally assumed to be determined by functional, electrical or genetic factors. Yet, there may also be global, currently unknown computational rules that are valid across different molecular species inside a cell. …”
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Seasonal recurrence and modular assembly of an Arctic pelagic marine microbiome by Taylor Priest, Ellen Oldenburg, Ovidiu Popa, Bledina Dede, Katja Metfies, Wilken-Jon von Appen, Sinhué Torres-Valdés, Christina Bienhold, Bernhard M. Fuchs, Rudolf Amann, Antje Boetius, Matthias Wietz

“…Furthermore, the structuring of genetic diversity within functions over time indicates that environmental selection pressure acts heterogeneously on microbiomes across seasons. …”
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Looking outside the box with a pathology aware AI approach for analyzing OCT retinal images in Stargardt disease by Parisa Khateri, Tiana Koottungal, Damon Wong, Rupert W. Strauss, Lucas Janeschitz-Kriegl, Maximilian Pfau, Leopold Schmetterer, Hendrik P. N. Scholl

“…Abstract Stargardt disease type 1 (STGD1) is a genetic disorder that leads to progressive vision loss, with no approved treatments currently available. …”
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Prevalence of CagA-positive Helicobacter pylori strain and H. pylori-associated gastritis activity in Tuva schoolchildren of different age groups by Tamara V. Polivanova, Vitaly A. Vshivkov

“…The received results demonstrate that development, course and progression of CagA-positive H. pylori associated gastritis is affected by genetic (ethnic) features of the host.…”
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Multigenerational effects of cultivating transgenic maize straw on earthworms: A combined laboratory and field experiment by Li Zhang, Wenjing Shen, Zhixiang Fang, Laipan Liu, Ruizong Jia, Jingang Liang, Biao Liu

“…The cultivation of genetically modified (GM) maize has aroused notable public concern related to the potential risks to soil fauna caused by the release of foreign proteins. …”
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Construction of a multienzyme cascade reaction system and its application in D-tagatose biosynthesis by Xiaoxiao Zhang, Jie Chu, Yuanqiang Lv, Xuan Li, Aijiao Yin, Yanhua Huang

“…In this study, Escherichia coli BL21 was used as the starting strain to express the β-galactosidase (β-Gal) gene—BgaB—derived from Bacillus stearothermophilus and the L-arabinose isomerase (L-AI) gene—araA—derived from Thermus sp., yielding the genetically engineered strains E. coli BL21-pET28a-BgaB and E. coli BL21-pET28a-araA. …”
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