A case of neuronal intranuclear inclusion disease (NIID) presenting with hydrocephalus-like clinical features: case report by Yonghong Wang, Yongxiang Li, Wei Pan, Yuezhen Shen, Junxia Li, Ying Liu, Yuhua Peng, Shulai Zhu

“…Physical examination indicated pupillary constriction, and electromyography suggested peripheral neuropathy. Genetic testing revealed 91 GGC repeats in the NOTCH2NLC gene, indicating abnormal expansion. …”
Get full text

Assessment of energy management and power quality improvement of hydrogen based microgrid system through novel PSO-MWWO technique by Hafiz Ghulam Murtza Qamar, Xiaoqiang Guo, Ehab Seif Ghith, Mehdi Tlija, Abubakar Siddique

“…The achieved results and numerical analysis affirm the superiority of the proposed technique compared to other traditional methods like mixed integer linear programming (MILP), HOMER, Variable mesh optimization (VMO), and Cataclysmic genetic algorithm in optimizing component sizing, renewable production, hydrogen production, reliability, cost effective, and overall efficacy. …”
Get full text

Combination of Artificial Neural Network and Particle Swarm Intelligence Algorithm for Diagnosing Diabetes by Cillian Thompson, Oscar Higgins

“…Diabetes is one of the challenges of today's society, which is influenced by important factors such as nutrition, obesity, physical inactivity, and genetic background. Early diagnosis of diabetes reduces the effects of this destructive disease. …”
Get full text

In the coevolution of cotton and pathogenic fungi, resistant cotton varieties lead to an escalation in the virulence of Verticillium dahliae by Yalin Zhang, Lifang Cui, Ruibing Liu, Zili Feng, Hongjie Feng, Jinglong Zhou, Lihong Zhao, Feng Wei, Heqin Zhu

“…Consequently, among the offspring strains, high virulence strains exhibited higher levels of physiological characteristics and genetic diversity compared to moderate and low virulence strains. …”
Get full text

Prospects of Using Microbiota Correction Methods in the Treatment of Inflammatory Bowel Disease by A. I. Akinshina, D. V. Smirnova, A. V. Zagainova, V. V. Makarov, S. M. Yudin

“…In recent years, preference has been given to more accurate and faster molecular genetic methods allowing a more detailed study of the key mechanisms by which microbiota affects the intestine in Crohn’s disease (CD) and ulcerative colitis (UC), as well as of the effect of microbial metabolites on their pathogenesis. …”
Get full text

A Survey of Nature-Inspired Meta-Heuristic Algorithms in Network Alignment by Anagh Awal, Farsuram Pandit

“…It explores a wide range of nature-inspired algorithms, including genetic algorithms, particle swarm optimization, ant colony optimization, and simulated annealing. …”
Get full text

Identification of mitochondrial carrier homolog 2 as an important therapeutic target of castration-resistant prostate cancer by Yankui Liu, Anjie Chen, Yufan Wu, Jiang Ni, Rong Wang, Yong Mao, Ning Sun, Yuanyuan Mi

“…MTCH2 is also upregulated in locally treated CRPC tissue and various primary human CRPC cells. Using genetic silencing via shRNA and knockout (KO) through the CRISPR-sgRNA approach, we showed that the depletion of MTCH2 impaired mitochondrial function, resulting in a reduced oxygen consumption rate, diminished complex I activity, and decreased ATP levels, mitochondrial depolarization, and increased reactive oxygen species production in primary CRPC cells. …”
Get full text

PARP Inhibitors in the Treatment of Ovarian Cancer by Andrzej Paweł Zuzak, Magdalena Cieślik-Porębska, Krzysztof Kułak, Jagoda Niewiadomska

“…Summary PARP inhibitors represent a significant advancement in ovarian cancer treatment, offering improved survival outcomes for patients with specific genetic profiles. Their integration into standard care protocols underscores their importance and efficacy, providing valuable therapeutic options in the fight against ovarian cancer. …”
Get full text

Mendelian randomization study of serum uric acid levels and urate-lowering drugs on pulmonary arterial hypertension outcomes by Xiaoling Yao, Xin Cai, Shaoqin Zhang, Yuzheng Yang, Xiangyan Yang, Wukai Ma, Zong Jiang

“…This study establishes a genetic basis for a causal link between serum uric acid levels and PAH. …”
Get full text

Identification of quantitative trait loci for yield traits and fine-mapping of qGW4 using the chromosome segment substitution line-Z708 and dissected single-segment substitution li... by Kai Zhou, Jinjin Yu, Zhaopeng Yu, Chunyu Chi, Jialin Ren, Zhuowen Zhao, Han Zhang, Yinghua Ling, Changwei Zhang, Fangming Zhao

“…Here, a wide-grain rice chromosome segment substitution line (CSSL), Z708, carrying four substitution segments from Jinhui35 in the genetic background of Xihui18, was used to identify the QTL associated with grain size. …”
Get full text

Probiogenomic analysis of Limosilactobacillus fermentum SD7, a probiotic candidate with remarkable aggregation abilities by Thunchanok Yaikhan, Monwadee Wonglapsuwan, Nuntiya Pahumunto, Natakorn Nokchan, Rawee Teanpaisan, Komwit Surachat

“…These findings provide a comprehensive understanding of the genetic composition of L. fermentum and its potential probiotic properties, identifying L. fermentum SD7 as a promising probiotic candidate for use in the food and healthcare industries.…”
Get full text

Introducing a Markov Chain-Based Energy Awareness Approach for Cloud Data Center Virtual Machine Dynamic Management by Xinbin Huang, Yu Huang, Cecılıa. Mercado

“…The approach integrates genetic algorithms and refrigeration simulation into the migration replacement process, leveraging absorbing Markov chains for predictive analysis. …”
Get full text

Discrete vulnerability to pharmacological CDK2 inhibition is governed by heterogeneity of the cancer cell cycle by Vishnu Kumarasamy, Jianxin Wang, Michelle Roti, Yin Wan, Adam P. Dommer, Hanna Rosenheck, Sivasankar Putta, Alec Trub, John Bisi, Jay Strum, Patrick Roberts, Seth M. Rubin, Costakis Frangou, Karen McLean, Agnieszka K. Witkiewicz, Erik S. Knudsen

“…In cancer models that are genetically independent of CDK2, pharmacological inhibitors suppress cell proliferation by inducing 4N cell cycle arrest and increasing the expressions of phospho-CDK1 (Y15) and cyclin B1. …”
Get full text

Occurrence of macrolides resistance in Legionella pneumophila ST188: Results of the Belgian epidemiology and resistome investigation of clinical isolates by Charlotte Michel, Fedoua Echahidi, Geraldine De Muylder, Max Sewell, Ian Boostrom, Olivier Denis, Owen B. Spiller, Denis Pierard

“…Genotypic screening identified a 23S ribosomal RNA mutation linked to a high-level macrolide resistance in one isolate of ST188, which is genetically closed to resistant isolates from France. …”
Get full text

Another new karst-dwelling rock gecko in the Cnemaspis siamensis group (Reptilia, Gekkonidae) from Kanchanaburi Province, western Thailand by Attapol Rujirawan, Akrachai Aksornneam, Siriporn Yodthong, Parinya Pawangkhanant, Bryan L. Stuart, Anchalee Aowphol

“…Phylogenetically, the new species is recovered as the sister taxon to C. huaseesom, but the two species are separated by 8.3–9.4% uncorrected pairwise genetic divergences in the mitochondrial NADH dehydrogenase subunit 2 gene and flanking tRNAs.…”
Get full text

Case report: A novel 11-bp deletion in exon 11 causing a frameshift in the C-terminal of the ALAS2 gene leading to X-linked sideroblastic anemia—a family study by Salam Al kindi, Salam Al kindi, Altaf Al-Mamari, Shoaib Al-Zadjali, Mohamed Al-Rawahi, Ali Al Madhani, Anil V. Pathare

“…X-linked sideroblastic anemia (XLSA) (MIM 300752) is the most common genetic form of sideroblastic anemia, a heterogeneous group of disorders characterized by iron deposits in the mitochondria of erythroid precursors. …”
Get full text

Security protection method based on mimic defense and Paillier encryption for smart IoT terminals by GU Tiansheng, ZENG Fukang, SHAO Sisi, NIE Yijun, JI Zongkai, ZHENG Yulu, SHI Yuchen, LIU Shangdong, JI Yimu

“…First, a security architecture was constructed based on the mimic defense theory to ensure the reliability and robustness of the system even when the edge domain smart terminal had its own security genetic defects. Then, a secure blind signature with Paillier encryption (SBSPE) algorithm was designed in this architecture to safeguard the data and privacy of the edge-area smart terminals throughout the data processing lifecycle of edge-area smart terminals. …”
Get full text

Early Permian to Middle Triassic Formation petroleum potentials of Sydney Basin, Australia: A geochemical analysis by Garba Terfa Elijah, Mustapha Khairul Azlan, Asiwaju Lanre, Mutari Lawal

“…Still, the molecular signature of some of the coal samples shows prokaryotic organic matter present in the extracts, indicating a thin section of possibly a calcareous lithology interbedded within the coal measure formation. Genetically, the coal extracts of the Permian in the Sydney Basin, Australia, provide a new insight into the generation and expulsion of oil from coal, which might be responsible for the widespread oil and gas shows in the basin. …”
Get full text

Establishment and characterization of ovarian clear cell carcinoma patient-derived xenografts by Joseph J. Caumanns, Shang Li, Gert J. Meersma, Evelien W. Duiker, Ate G. J. van der Zee, G. Bea A. Wisman, Steven de Jong

“…Patient-derived xenografts (PDX) are widely used in vivo models because of their supposedly accurate morphologic and (epi)genetic representation of patient tumors. Here, we established five subcutaneous OCCC PDXs. …”
Get full text

Topical steroids as alternative to systemic hormonal treatment for inflammatory bowel diseases in pediatric practice by E. N. Fedulova, O. V. Shumilova, O. V. Fedorova, O. A. Tutina, G. V. Medyantseva

“…Etiopathogenesis of IBD represents the cascade of self-maintaining pathophysiological reactions: adaptive microcirculational, hypoxicmetabolic, autoimmune inflammatory and dysbiotic disorders emerging on a background of genetic features of the body under the effect of unfavorable environmental factors. …”
Get full text