Engineering a phi15-based expression system for stringent gene expression in Pseudomonas putida by Eveline-Marie Lammens, Daniel C. Volke, Alison Kerremans, Yannick Aerts, Maarten Boon, Pablo I. Nikel, Rob Lavigne

“…In conclusion, the phi15 RNAP, promoter, lysozyme and growth-decoupler provide a valuable plug-and-play set of genetic parts for the P. putida toolbox.…”
Get full text

Using the clustering method to find the final environmental parameters coefficients in road construction projects by Eshagh Rasouli Sarabi, Ramin Vafaei Poursorkhabi, Mehdi Ravanshadnia

“…In the first phase, the Genetic Optimization Algorithm was implemented to determine convenient coefficients for the relevant parameters. …”
Get full text

Arrhythmogenic right ventricular cardiomyopathy - What Is New since 2023 European Society of Cardiology Guidelines? Current Knowledge, Literature Review by Magdalena Balwierz

“… Introduction: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetically conditioned disease, characterized by gradual fibro-fatty replacement of myocardium and tendency to ventricular arrhythmias and heart failure. …”
Get full text

Recombinant AAV batch profiling by nanopore sequencing elucidates product-related DNA impurities and vector genome length distribution by Florian Dunker-Seidler, Kathrin Breunig, Magdalena Haubner, Florian Sonntag, Markus Hörer, Rebecca C. Feiner

“…During production, recombinant adeno-associated virus (rAAV) capsids are equipped with heterogeneous genetic payloads including undesired DNA impurities as well as truncated vector genomes. …”
Get full text

Red Army Soldiers from Kalmykia in the Battles for Belarus: a Historical and Statistical Study by Sergey G. Ershov

“…When writing the article, a complex of various general scientific and special methods was used, including historical-genetic, historical-comparative, historical-typological, historical-systemic, and statistical methods. …”
Get full text

Genome-wide association study reveals major loci for resistance to septoria tritici blotch in a Tunisian durum wheat collection. by Maroua Ouaja, Bikash Ghimire, Bochra Amina Bahri, Medini Maher, Sahbi Ferjaoui, Sripada Udupa, Sonia Hamza

“…Tunisian durum wheat landraces are reported to be valuable genetic resources for resistance to STB and should prominently be deployed in breeding programs to develop new varieties resistant to STB disease. …”
Get full text

A 15-year pheochromocytoma and paraganglioma experience in a single centre: a Singapore perspective by Yingshan Lee, Leon Yuan Rui Tan, Shaikh Abdul Kader Kamaldeen Abdul Shakoor

“…Disease recurrences and metastasis occurred in up to one-fifth of the patients. Genetic screening should be offered to patients with PCC and PGL.…”
Get full text

Correlation of Vitamin B12 Levels with Clinical and Laboratory Features in Patients of Dengue Fever by Asma Abdul Razzak

“…The creation of DNA, the genetic information-carrying molecules found inside cells, as well as the metabolism of cells, neuron function, and red blood cell development all depend on vitamin B-12.6 Measurements of serum or plasma vitamin B12 levels are commonly used to determine vitamin B12 status. …”
Get full text

Characterization of environmental and clinical surveillance inputs to support prospective integrated modeling of the polio endgame. by Kamran Badizadegan, Kimberly M Thompson

“…In addition, the development and expansion of genetic testing technologies create new opportunities for poliovirus surveillance system designs. …”
Get full text

Recent Advances in Biopesticide Research and Development with a Focus on Microbials [version 4; peer review: 3 approved, 1 approved with reservations] by Dennis Ndolo, Jing Ge, Debbie Muir, Lawrence Malinga, Kahsay Tadesse Mawcha

Get full text

Challenges Faced by Nurses in Transitioning Pediatric Sickle Cell Disease Patients to Adult Care by Gifty Enyonam Amoaku, Delali Adwoa Wuaku, Vivian Efua Senoo-Dogbey

“…Background Sickle-cell disease is a common genetic red blood cell disorder with global concern. …”
Get full text

Rett syndrome complicated by diabetes mellitus type 1 by Yasutaka Kuniyoshi, Satoru Takahashi

“…A review of her history revealed normal early developmental milestones, including the onset of stereotypical hand movements at 3 years, communication impairment and seizures at 4 years and a diagnosis of autism spectrum disorder. At 10 years of age, genetic testing revealed a pathogenic MECP2 mutation. …”
Get full text

Zero-day exploits detection with adaptive WavePCA-Autoencoder (AWPA) adaptive hybrid exploit detection network (AHEDNet) by Ahmed A. Mohamed, Abdullah Al-Saleh, Sunil Kumar Sharma, Ghanshyam G. Tejani

“…Additionally, a novel “Meta-Attention Transformer Autoencoder (MATA)” for enhancing feature extraction which address the subtlety issue, and improves the model’s ability and flexibility to detect new security threats, and a novel “Genetic Mongoose-Chameleon Optimization (GMCO)” was introduced for effective feature selection in the case of addressing the efficiency challenges. …”
Get full text

Circadian rhythm related genes signature in glioma for drug resistance prediction: a comprehensive analysis integrating transcriptomics and machine learning by Junbo Liao, Yingxing Duan, Xiangwang Xu, Yaxue Liu, Chaohong Zhan, Gelei Xiao

“…The studies of immune cell infiltration, genetic variations, differential gene expression pattern, and single cell analysis were performed for exploring the mechanisms of chemotherapy resistance in glioma. …”
Get full text

Blue elixir of youth and wellness: The multicomponent-multitarget paradigm of Curcuma caesia Roxb by Sabrina Burattini, Federico Gianfanti, Francesco Onesimo, Sabrina Donati Zeppa, Barbara Canonico, Mariele Montanari, Giovanna Panza, Daniele Lopez, Giosuè Annibalini, Fabiana Fanelli, Roberta Saltarelli, Michele Mari, Michele Retini, Riham Osman, Aghna Mariam, Matteo Micucci, Giovanni Caprioli, Agnese Santanatoglia, Deborah Agostini, Michela Battistelli

“…Aging is a complex biological process influenced by genetic, environmental, and lifestyle factors, including diet and exercise. …”
Get full text

Integrating MAPK pathway inhibition into standard-of-care therapy for pediatric low-grade glioma by Erin E. Crotty, Aimee A. Sato, Aimee A. Sato, Mohamed S. Abdelbaki

“…Pediatric low-grade gliomas (pLGG) are a group of tumors largely driven by alterations in a single genetic pathway, known as the RAS-RAF-mitogen-activated protein kinase (MAPK) pathway. …”
Get full text

Structures and strategies for retaining an international pediatric cohort from birth: Lessons from The Environmental Determinants of Diabetes in the Young (TEDDY) study by Patricia Gesualdo, Jessica Melin, Rachel Karban, Claire Crouch, Michael Killian, Diane Hopkins, Annika Adamsson, Joanna Stock, Suzanne Bennett Johnson, Judith Baxter

“…The aim of this report is to describe the structures and strategies used to retain participants in The Environmental Determinants of Diabetes in the Young (TEDDY) Study, an observational study of children at increased genetic risk for type 1 diabetes followed in an intensive protocol from birth until age 15. …”
Get full text

‘You Choose No Time to Live and Die’: Dinmukhamed A. Kunayev and His Time by Ziyabek Y. Kabuldinov, Konstantin V. Cherepanov, Didar B. Kassymova

“…The article employs the historical-genetic and historical-comparative methods, addresses the concept of biographic approach and theory of ethnic mobilization to reconstruct some episodes of D. …”
Get full text

FTO effects the proliferation, invasion, and glycolytic metabolism of colon cancer by regulating PKM2 by Kongyan Zhang, Fei Zhang, Jiahe Wang

“…The Fat mass and obesity-associated protein (FTO), a genetic variant associated with obesity, significantly impact the energetic metabolism of mechanical tumors. …”
Get full text

A novel high-throughput screen identifies phenazine-1-carboxylic acid as an inhibitor of African swine fever virus replication in primary porcine alveolar macrophages by Jing Lan, Rui Luo, Di Liu, Changxing Qi, Xin Song, Zhanhao Lu, Ruojia Huang, Yuying Yang, Yuan Sun, Yonghui Zhang, Tao Wang, Hua-Ji Qiu

“…Furthermore, analysis of Gluc activities, fluorescence, and next-generation sequencing indicated that rASFV-Gluc/EGFP maintains good genetic stability after 20 consecutive passages in PAMs. …”
Get full text