High-intensity statin therapy in patients with chronic kidney disease: a systematic review and meta-analysis by Jing Wang, Ling Wu, Yu-Ling Yan, Bo Qiu, Song-Bai Deng, Xiao-Dong Jing, Jian-Lin Du, Ya-Jie Liu, Qiang She

“…Objective To evaluate the efficacy and safety of high-intensity statin therapy in patients with chronic kidney disease (CKD).Design A systematic review and meta-analysis.Data sources Randomised controlled trials (RCTs) comparing high-intensity statin therapy (atorvastatin 80 mg or rosuvastatin 20/40 mg) with moderate/mild statin treatment or placebo were derived from the databases (PubMed, Embase, Ovid, the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, and ISI Web of Knowledge).Outcome measure Primary end points: clinical events (all-cause mortality, stroke, myocardial infarction and heart failure); secondary end points: serum lipid, renal function changes and adverse events.Results A total of six RCTs with 10 993 adult patients with CKD were included. …”
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