PROTACs: Mechanism and Bioavailability enhancement strategies by nanotechnology, RNA viral infections (vaccine strategy) and Prodrug development by Sanaul Mustafa, Md Sabir Hussain Siddiquee

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A nucleoside-modified mRNA vaccine prevents enterovirus A71 infection in mouse model by Fengyu Chi, Fengyu Chi, Xu Zhang, Xu Zhang, Dong Zhang, Dong Zhang, Airu Zhu, Zhen Zhuang, Zhaoyong Zhang, Zhenjie Zhang, Chuansong Quan, Kaixiao Nie, Juan Li, Chunhong Yin, Jie Tong, Yuming Li, Yuming Li, Yuming Li

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Experience in the Treatment of Irritable Bowel Syndrome Developed after a New Coronavirus Infection (COVID-19) by R. G. Myazin

Subjects: “…coronavirus infection…”
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Potential links between human bloodstream infection by Salmonella enterica serovar Typhimurium and international transmission to Colombia. by Yan Li, Caisey V Pulford, Paula Díaz, Blanca M Perez-Sepulveda, Carolina Duarte, Alexander V Predeus, Magdalena Wiesner, Darren Heavens, Ross Low, Christian Schudoma, Angeline Montaño, Neil Hall, Jaime Moreno, Jay C D Hinton

“…Salmonella enterica serovar Typhimurium is a prevalent food-borne pathogen that is usually associated with gastroenteritis infection. S. Typhimurium is also a major cause of bloodstream infections in sub-Saharan Africa, and is responsible for invasive non-typhoidal Salmonella (iNTS) disease. …”
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Elective incisional hernia repair: lower risk of postoperative wound infection with laparoscopic versus open repair by Serene Si Ning Goh, Kaushal Amitbhai Sanghvi, Aaryan Nath Koura, Jaideepraj Krishnaraj Rao, Aung Myint Oo

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Metabolic deficiencies underlie reduced plasmacytoid dendritic cell IFN-I production following viral infection by Trever T. Greene, Yeara Jo, Carolina Chiale, Monica Macal, Ziyan Fang, Fawziyah S. Khatri, Alicia L. Codrington, Katelynn R. Kazane, Elizabeth Akbulut, Shobha Swaminathan, Yu Fujita, Patricia Fitzgerald-Bocarsly, Thekla Cordes, Christian Metallo, David A. Scott, Elina I. Zúñiga

“…Abstract Type I Interferons (IFN-I) are central to host protection against viral infections, with plasmacytoid dendritic cells (pDC) being the most significant source, yet pDCs lose their IFN-I production capacity following an initial burst of IFN-I, resulting in susceptibility to secondary infections. …”
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Preoperative Hemoglobin Level Predicts Surgical Site Infections in Trauma Orthopedic Surgery: A Cohort Study by Williams Walana, Fredrick Gyilbagr, Alexis D. B. Buunaaim

“…Conclusion: In conclusion, our study demonstrates that preoperative hemoglobin level is a useful hematological parameter for predicting surgical site infection following trauma orthopedic surgery. These inexpensive and common hematological parameters could assist in guiding preventive efforts to reduce surgical site infections and improve outcomes for vulnerable patients undergoing trauma orthopedic surgery. …”
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Retrospective Analysis of RSV Infection in Pediatric Patients: Epidemiology, Comorbidities, Treatment, and Costs in Dubai (2014-2023) by Jean Joury, Nawal Al Kaabi, Sara Al Dallal, Bassam Mahboub, Mostafa Zayed, Mohamed Abdelaziz, Jennifer Onwumeh-Okwundu, Mark A. Fletcher, Subramanyam Kumaresan, Badarinath C. Ramachandrachar, Mohamed Farghaly

“…**Background:** Infections attributable to respiratory syncytial virus (RSV) are a major cause of hospitalization among young children worldwide. …”
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Aetiopathogenesis, clinico-epidemiological and diagnostic aspects of human ocular trematode infections: a scoping review protocol by Harshi Weerakoon, Kosala Weerakoon, Piyumi Kodithuwakku, Anjana Silva, Susiji Wickramasinghe

“…Introduction Human ocular trematode infections, caused by parasitic flatworms, are a significant public health concern worldwide. …”
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Extrapulmonary manifestations and complications of severe acute respiratory syndrome coronavirus-2 infection: a systematic review by Jiacai Cho, Joanne Lee, Ching-Hui Sia, Chieh Sian Koo, Benjamin YQ Tan, Weizhen Hong, Ellie Choi, Xueying Goh, Louis Chai, Nisha Suyien Chandran, Horng Ruey Chua, Bernard PL Chan, Mark Muthiah, Ting Ting Low, Eng Soo Yap, Manjari Lahiri

“…Conclusion: Although the systemic manifestations of SARS-CoV-2 infection are variegated, they are deeply interwoven by shared mechanisms. …”
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Correction: The salivary microbiota of patients with acute lower respiratory tract infection-A multicenter cohort study. by Matthew B Rogers, Ashley Harner, Megan Buhay, Brian Firek, Barbara Methé, Alison Morris, Octavia M Peck Palmer, Susan B Promes, Robert L Sherwin, Lauren Southerland, Alexandre R Vieira, Sachin Yende, Michael J Morowitz, David T Huang

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Targeting AI-2 quorum sensing: harnessing natural products against Streptococcus suis biofilm infection by Shuji Gao, Shuo Yuan, Yingying Quan, Wenjie Jin, Yamin Shen, Rishun Li, Baobao Liu, Yuxin Wang, Li Yi, Shaohui Wang, Xiaogai Hou, Yang Wang

“…Finally, the efficacy of SAA and RH against S. suis infection was validated in Galleria mellonella larvae, confirming their significant anti-infection effects.…”
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Digestive Disease Mortality Dynamics During New Coronavirus Infection Pandemic in Different Subjects of Russian Federation by V. T. Ivashkin, A. A. Sheptulin, O. P. Alekseeva, S. A. Alekseenko, A. Yu. Baranovsky, O. Yu. Zolnikova, N. V. Korochanskaya, S. N. Mammayev, I. B. Khlynov, V. V. Tsukanov

Subjects: “…new coronavirus infection…”
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Soap and water cleaning versus bleach-based cleaners for eliminating SARS-CoV-2 infection by Ekong E. Udoh, Ubong A. Udoh, Abiodun Egwuenu, Ekpereonne B. Esu, Aruk Eteng, Faithman E. Ovat, Uduak Okomo, Olabisi Oduwole, Joseph Okebe, Martin Meremikwu

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Research progress on factors influencing suboptimal immune reconstitution in HIV infection: a systematic literature review by Wei CHEN, Qiuyi YANG, Xiaoliang ZENG

“…Acquired immunodeficiency syndrome (AIDS) is an immunodeficiency syndrome caused by infection with the human immunodeficiency virus (HIV). …”
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Molecular genetic factors influencing outcomes of <i>Helicobacter pylori</i> infection at Khakasia republic inhabitants by Ye. S. Ageyeva, O. V. Shtygasheva, N. V. Ryazantseva, V. V. Tsukanov

“…To detect molecular-genetic features of Helicobacter pylori and polymorphism of main immunoregulatory interleukins genes at Khakases, to estimate their effect on outcomes of infection pathogen.Material and methods. Investigation was carried out at native population of Khakasia with H. pyloriassociated diseases: peptic ulcer and chronic gastritis. …”
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Evaluation of cold atmospheric pressure plasma effects on Pseudomonas aeruginosa wound infection in a mouse model by Reyhaneh Shekari, Gholamreza Zarrini, Vahid Siahpoush, Farzam Sheikhzadeh Hesari

“…This study aimed to evaluate the effects of cold plasma on Pseudomonas aeruginosa in a mouse wound infection model. Materials and Methods: The disk diffusion method was used to perform antibiograms after isolating the bacteria. …”
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Economic Evaluation of Boceprevir for the Treatment of Patients with Genotype 1 Chronic Hepatitis C Virus Infection in Hungary by Raymond Odhiambo, Jagpreet Chhatwal, Shannon Allen Ferrante, Antoine El Khoury, Elamin Elbasha

“…**Background:** Recent international, randomized, placebo-controlled clinical trials (SPRINT-2; RESPOND-2) demonstrated that the triple combination of peginterferon (PEG), ribavirin (RBV) and boceprevir (BOC) was more efficacious than the standard dual therapy of PEG and RBV in treatment of patients chronically infected with genotype 1 hepatitis C virus (HCV) infection. …”
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Tailoring management and immunosuppression regimen in kidney transplant recipients with COVID-19 infection: lessons from Singapore by Zi Yun Chang, Paul Anantharajah Tambyah, Lionel Hon Wai Lum, Anantharaman Vathsala, Rachel Zui Chih Teo

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Anti-Malarial Effects of Five Traditional Nigerian Medicinal Plant Extracts on Plasmodium Berghei-Infected Rats by Ugochukwu Vincent, Igbokwe, Ejike, Daniel Eze, Moses Dele, Adams, Karimah Mohammed, Rabiu, Iliya, Ezekiel, Prisca Ojochogu, Ajeka, Peace Ogechukwu, Okpara

“…Group A (negative control) were infected but not treated. Animals in Groups B–E which were infected were given 500 mg/kg body weight (BW) of malanter DS (reference antimalarial drug), 500 mg/kg BW of BL, 250 mg/kg BW each of SL and BL as well as 250 mg/kg BW each of G, PP and UPA. …”
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