Frk positively regulates innate antiviral immunity by phosphorylating TBK1 by Xiaomei Zhang, Ying You, Tingrong Xiong, Tingrong Xiong, Xiaokai Zhang, Haibo Wang, Jinxia Geng, Miao Wang, Yanyan Xu, Shanshan Gao, Shanshan Gao, Xiaoyan Wu, Yue Zheng, Xianhua Wen, Haoyu Yang, Yu Wang, Yu Wang, Xiaohua Wen, Congcong Zhao

“…Type I interferons (IFN-I) are crucial for the initial defense against viral infections. TBK1 serves as a key regulator in the production of IFN-I, with its phosphorylation being essential for the regulation of its activity. …”
Get full text

Grain sizes of sand substrates significantly influence the growth, survival, digestive enzyme profiles, and gut histology of sandfish (Holothuria scabra Jaeger 1833) juveniles duri... by Sari Budi Moria Sembiring, Rarastoeti Pratiwi, Suwarno Hadisusanto, Ketut Mahardika, Haryanti Haryanti, Jhon Harianto Hutapea

“…Twelve containers, 59 cm× 47 cm x 37 cm, and 30 juveniles were put into each as experimental animals. The initial mean wet weight of juveniles was 2.22 ± 0.43 g. …”
Get full text

Liver diseases: epidemiology, causes, trends and predictions by Can Gan, Yuan Yuan, Haiyuan Shen, Jinhang Gao, Xiangxin Kong, Zhaodi Che, Yangkun Guo, Hua Wang, Erdan Dong, Jia Xiao

“…We also highlight the multifaceted mechanisms underlying the initiation and progression of liver diseases, spanning molecular and cellular levels to organ networks. …”
Get full text

Integrating comprehensive surgical, intensive, and emergency care systems into the Pan American Health Organization’s health agenda by Maria Jose Garcia Fuentes, Ayla Gerk, Leticia Campos, Alejandro Torres, Taylor Wurdeman, Nikathan Kumar, Ruth Jimbo-Sotomayor, Juan Carlos Salamea, Luiz Fernando dos Reis Falcão, Guido Parquet, John G. Meara, Tarsicio Uribe-Leitz, Alfredo Borrero Vega

“…By focusing on vulnerable groups and leveraging collaboration, this initiative can reduce health inequities across the Americas, reinforcing universal health coverage and access to safe, timely, and affordable surgical care.…”
Get full text

Dual functional hydrogel of osteoclastic-inhibition and osteogenic-stimulation for osteoporotic bone defect regeneration by Lei Yu, Wentao Wang, Chang Lv, Qian Chen, Peng Yang, Zhenrong Qi, Haomiao Yu, Ruiqi Cao, Wenhao Li, Yi Qin, Gaoran Ge, Peilai Liu, Lixin Zhu, Houyi Sun, Dechun Geng, Liang Zhang

“…This system, loaded with the osteogenesis-promoting peptide DWIVA (D5) and the osteoclastogenesis-inhibiting drug alendronate (ALN), is gelled using a light initiator and 405 nm wavelength light. The MBG@D5-Gel complex enables the controlled spatiotemporal release of these agents, markedly enhancing bone regeneration in osteoporotic conditions within ovariectomized rats by inhibiting osteoclastogenesis and bone resorption while promoting osteogenic differentiation and mineralization. …”
Get full text

Replication-IDentifier links epigenetic and metabolic pathways to the replication stress response by Sophie C. van der Horst, Leonie Kollenstart, Amandine Batté, Sander Keizer, Kees Vreeken, Praveen Pandey, Andrei Chabes, Haico van Attikum

“…Mechanistically, we show that Lge1 affects replication initiation and/or fork stability by promoting Bre1-dependent H2B mono-ubiquitylation. …”
Get full text

Case study of a neuroendocrine tumor of uncertain origin: single-cell transcriptomics unravels potential primary location by Frolova Tatyana, Ekaterina Avsievich, Diana Salimgereeva, Zoia Antysheva, Alesia Maluchenko, Denis Maksimov, Ilia Feidorov, Mark Voloshin, Olga Glazova, Natalia Bodunova, Nikolay Karnaukhov, Pavel Volchkov, Julia Krupinova

“…This study explores the histogenesis of a retroperitoneal, non-functional NET localized between the duodenum and pancreatic head, utilizing advanced molecular diagnostics to elucidate its probable primary source. Methods Initial diagnostic methods, including imaging and histopathology, failed to resolve the tumor’s origin. …”
Get full text

EBOLA AND COVID-19 EPIDEMICS: A DISCOURSE ON NIGERIA’S FOREIGN POLICY RESPONSES by BARILEDUM KIA, CALISTUS N DUMLE

“…These include setting up of screening and monitoring Centre at the nation’s Airports, facilitated the setting up of a regional solidarity fund, in which countries made contributions, initiated actions that adjudged Ebola epidemic as not only national and regional but also international emergency, donated huge sum to worst affected states like Guinea, Sierra Leone and Liberia. …”
Get full text

The Impact of diabetes on long-term prognosis in non-ST elevation acute coronary syndrome by Farouk BOUKERCHE, Leila HAMMOU, Nadia LAREDJ

“…Results -Of the 296 patients initially included, 274 completed the 5-year follow-up (7.4% lost at follow-up). …”
Get full text

Assessing the impact of educational methods on influenza vaccine uptake and patient knowledge and attitudes: a randomised controlled trial by Pei Lin Hu, Eileen Yi Ling Koh, Jolene Shi Han Tay, Valerie Xin-Bei Chan, Shermin Shi Min Goh, Sinead Zhen Wang

“…Performing vaccination at the initial point of contact improves actual uptake rates.…”
Get full text

Sustainability Reporting and Assurance: A New Challenge for the Audit Profession in Europe by Darko DACHEVSKI, Barry ACKERS

“…Implications for the European audience: For the European audience, the study underscores the significance of collaborative training initiatives led by academia and professional audit associations to equip external auditors with the requisite skills necessary for delivering assurance services on sustainability reporting of satisfactory quality. …”
Get full text

Simultaneous cardiocerebral infarctions: a five-year retrospective case series reviewing natural history by Cheryl Zhiya Chong, Benjamin Yong-Qiang Tan, Ching-Hui Sia, Thet Khaing, Leonard Leong Litt Yeo

“…In this series, IV tPA at stroke doses appeared to be the preferred initial step for its treatment, with subsequent coronary or cerebral endovascular therapy, if necessary.…”
Get full text

Theologie der heiligen Pilgerstätten – biblische und pastorale Aspekte by Maciej Ostrowski

“…Gott schafft mit seiner Initiative einen günstigen Platz für ein näheres Treffen mit dem Menschen. …”
Get full text

Treatment and outcomes of high-risk neuroblastoma in Southeast Asia: a single-institution experience and review of the literature by Anselm Chi-Wai Lee, Chan Hon Chui, Robert Kwok, Kim Shang Lee, Chee Meng Fong, Wilfred Hing-Sang Wong

“…Their five-year overall survival rate compared to patients whose initial chemotherapy was done elsewhere was 81.6% versus 41.1% (P = 0.011), and that of event-free survival was 69.7% versus 36.1% (P = 0.032). …”
Get full text

Mudharabah, musyarakah, financing risk, and performance of Islamic banks: Empirical evidence from Indonesia by Radhita Asfarina Annizar, Eddy Junarsin

“…Findings – We find that mudharabah is negatively related to financing risk and positively (in the initial stage) linked to Islamic bank performance. …”
Get full text

The Effect of Transobturator Tape Surgery on Female Sexual Functions: A Systematic Review by Engin Yildirim, Nuriye Buyukkayaci Duman, Umit Gorkem, Ozgur Kan

“…It is of high importance that before initiating surgical treatments, clinicians should give the patients a detailed medical examination in terms of both urinary and sexual functions. …”
Get full text

Narrative Literature Review of Potential Atrial Fibrillation Mechanism of Action Induced by Discontinuation of Benzodiazepines by Agnė Okulevičiūtė, Gabija Laubner Sakalauskienė

“…Discussion: Benzodiazepines (BZDs) were synthesized in 1955 and initially considered less toxic than barbiturates. …”
Get full text

Repeated gastroscopies at impendent relapse of bleeding from gastroduodenal ulcers by V. A. Stupin, S. V. Siluyanov, M. B. Sokhikyan, R. Yu. Tronin, R. Sh. Sardarov

“…Repeated gastroscopies were caused by: relapse of bleeding – in 21 (17,2%) patient, of them in 81% of cases it developed within first 3 days after primary examination, non-informative initial EGDS – in 12 (9,8%), control gastroscopy in dynamics – in 89 (73%). …”
Get full text

DIGITAL HUMANISM IN THE AGE OF THE INTERNET AND ARTIFICIAL INTELLIGENCE: CHALLENGES, OPPORTUNITIES, AND PROSPECTS FOR DEVELOPMENT by Mykyta Slyusar, Vitaliia Nikitenko, Valentyna Voronkova

“…The study also highlights the European Digital Humanism Initiative and the methodology of informationalism, which illuminate the challenges and opportunities of digital humanism. …”
Get full text