Development of an mPBPK machine learning framework for early target pharmacology assessment of biotherapeutics by Krutika Patidar, Nikhil Pillai, Saroj Dhakal, Lindsay B. Avery, Panteleimon D. Mavroudis

“…In the present work, we propose a machine learning-based target pharmacology assessment framework that utilizes minimal physiologically based pharmacokinetic (mPBPK) modeling and machine learning (ML) to infer optimal physicochemical properties of antibodies and their targets. …”
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Epigenetic regulation in female reproduction: the impact of m6A on maternal-fetal health by Peipei Li, Yumeng Lin, Hongyun Ma, Jiao Zhang, Qiaorui Zhang, Ruihua Yan, Yang Fan

“…Epigenetics plays an irreplaceable role in gynecologic diseases. As an important mRNA modification, m6A is involved in the maturation of ovum cells and maternal-fetal microenvironment. …”
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Nonylphenol exposure increases the risk of Hirschsprung’s disease by inducing macrophage M1 polarization by Xuefeng Yang, Chengyan Tang, Daiwei Zhu, Xingrong Xia, Qing Du, Lu Huang, Jianguo Liu, Yuanmei Liu

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Distinct plasmablast developmental intermediates produce graded expression of IgM secretory transcripts by Evelyn P. Sievert, Marissa C. Franke, Kayla B. Thomas, Yoseop Yoon, Yongsheng Shi, Roger Sciammas

“…We developed a dual-fluorescent protein reporter mouse to prospectively study the post-transcriptional-level transition from membrane anchored to secretory immunoglobulin M; μM-PAS and μS-PAS, respectively. We observed (1) graded μS-PAS usage during PC differentiation, (2) IRF4 and Blimp-1 functioned hierarchically to increase μ abundance as well as μS-PAS usage, and (3) graded μS populations did or did not express Blimp-1. …”
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FDFT1 inhibits macrophage M1 polarization and promotes colorectal cancer progression by GAO Yuan, HUANG Yulan, ZHAO Kun

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PERFORMANCE EVALUATION OF ETHERNET TRANSMISSION USING M-ARY PULSE AMPLITUDE MODULATION TECHNIQUES by APENA WALIU OLALEKAN, OLASUNKANMI OMOWUMI GRACE, SALAKO ANUOLUWAPO

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Factors affecting perceived organizational performance with mediation of job satisfaction by Khan Khan Zaman, Haji-Othman Yusuf

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Mechanical forces pattern endocardial Notch activation via mTORC2-PKC pathway by Yunfei Mu, Shijia Hu, Xiangyang Liu, Xin Tang, Jiayi Lin, Hongjun Shi

“…The strong shear stress altered the membrane lipid microdomain structure of endocardial cells, which activated mTORC2 and PKC and promoted Notch1 cleavage even in the absence of strong ligand stimulation. …”
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M. Mayordomo, Argumentiert Paulus logisch? Eine analyse von dem hintergrund antiker logik by C. Stenschke

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Characterization of G2/M checkpoint classifier for personalized treatment in uterine corpus endometrial carcinoma by Yiming Liu, Yusi Wang, Shu Tan, Xiaochen Shi, Jinglin Wen, Dejia Chen, Yue Zhao, Wenjing Pan, Zhaoyang Jia, Chunru Lu, Ge Lou

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Topological 1D gravity, KP hierarchy, and orbifold Euler characteristics of M‾g,n by Zhiyuan Wang, Jian Zhou

“…As an application, we present two types of algorithms to compute the orbifold Euler characteristics of the moduli spaces M‾g,n of stable curves. The first is to use (fat or thin) topological recursion formulas emerging from the Virasoro constraints for Z1D; and the second is to use a formula for the connected n-point functions of a KP tau-function in terms of its affine coordinates on the Sato Grassmannian. …”
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Baltic place in barbarian world's typology (towards the evoliution of M. Schiukin "seven worlds" theory) by Manvydas Vitkūnas

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Semiclassical quantization of M5 brane probes wrapped on AdS3 × S 3 and defect anomalies by M. Beccaria, L. Casarin, A. A. Tseytlin

Subjects: “…M-Theory…”
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Inland Water Body Fraction Map for Canada and Adjacent Regions at 250-m Spatial Resolution by Shaheen Ghayourmanesh, Alexander P. Trishchenko, Calin Ungureanu

“…We present a novel raster dataset of surface inland water body fraction over Canada and neighbouring regions, including the northern parts of the United States, as well as Greenland, Iceland, and the northeastern sector of Russia, at 250-m spatial resolution. It was derived from the Global Surface Water (GSW) dataset (version 5) using a two-step resampling to ensure an accurate replication of the original data and spatial consistency in terms of extent and resolution with the Long-Term Satellite Data Records derived from the Moderate Resolution Imaging Spectroradiometer (MODIS) and the Visible Infrared Imaging Radiometer Suite (VIIRS) sensors. …”
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BOOK REVIEW Bibles in Africa through European eyes by J. Mokhutso

Subjects: “…M. Nyirenda…”
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