Methylprednisolone substituted lipid nanoparticles deliver C3 transferase mRNA for combined treatment of spinal cord injury by Haoru Dong, Zongxing He, Shiyi Cai, Haiqiang Ma, Lili Su, Jianfeng Li, Huiying Yang, Rong Xie

“…Our findings reveal several significant advantages of this approach: Firstly, the incorporation of C3 transferase mRNA into MP-LNPs does not compromise the structural integrity of the nanoparticles, ensuring efficient mRNA expression within the spinal cord. …”
Get full text

Identification of m6A methyltransferase-related WTAP and ZC3H13 predicts immune infiltrates in glioblastoma by Liyun Gao, Jiaxin Gao, Jiayin He, Wenyan Fan, Xiangxin Che, Xin Wang, Tao Wang, Chunhua Han

Subjects: Get full text

USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation by Na Shao, Lei Xi, Yangfan Lv, Muhammad Idris, Lin Zhang, Ya Cao, Jingyi Xiang, Xi Xu, Belinda X. Ong, Qiongyi Zhang, Xu Peng, Xiaoyan Yue, Feng Xu, Chungang Liu

“…Here, we report that USP5 interacts with YTHDF1, stabilizing it by removing K11-linked polyubiquitination. Insulin activates mTORC1, phosphorylating USP5 and promoting its dimerization, which binds to and protects YTHDF1 from degradation. …”
Get full text

Mettl3-m6A-NPY axis governing neuron–microglia interaction regulates sleep amount of mice by Qihang Sun, Jinpiao Zhu, Xingsen Zhao, Xiaoli Huang, Wenzheng Qu, Xia Tang, Daqing Ma, Qiang Shu, Xuekun Li

“…Collectively, our study has revealed the critical function of Mettl3-m6A-NPY axis in regulating sleep behavior.…”
Get full text

Mechanical Thrombectomy in Medium Vessels Occlusion (MeVOs): An Institutional Experience with M2 Divisions of Middle Cerebral Artery by Bheru Dan Charan, Shailesh B Gaikwad, Savyasachi Jain, Ajay Garg, Leve Joseph Devarajan Sebastian, M V Padma Srivastava, Rohit Bhatia, Awadh Kishore Pandit, Shashank Sarad Kale

“…The primary outcome of our study was the mTICI recanalisation status, categorised as successful recanalisation (mTICI = 2b or mTICI = 3) and unsuccessful recanalisation (mTICI = 1 or mTICI = 2a) and mRS at 6 months. …”
Get full text

Commentary: Sodium levels and immunotherapy efficacy in mRCC patients with bone metastases: sub analysis of the Meet-Uro 15 study by Martina Catalano, Sara Elena Rebuzzi, Giuseppe Fornarini, Giandomenico Roviello

Get full text

RESEARCH IN THE FIELD OF TECHNICAL EXPERTISE AND TRACK REHABILITATION FOR A COAL MINING MACHINE TYPE M4A T2052-78 by Liviu Marius CÎRȚÎNĂ, Constanța RĂDULESCU

“…Thus, between the University "Constantin Brâncuși" of Târgu Jiu and the Company Complexul Energetic Oltenia S.A. there are data contained in Contract no.2490 /CEOSE/15.11.2016, entitled: Elaboration of documentation for the "Rehabilitation and modernization of the M4A Coal Mining Machine - including the track" - Rovinari S.E.. …”
Get full text

The RNA M5C methyltransferase NSUN2 promotes progression of hepatocellular carcinoma by enhancing PKM2-mediated glycolysis by Qin Qi, Rui Zhong, Yan Huang, Yong Tang, Xiao-wen Zhang, Chang Liu, Chun-fang Gao, Lin Zhou, Jian Yu, Lu-yi Wu

“…NSUN2 overexpression significantly promoted HCC growth and metastasis, whereas NSUN2 knockdown had the opposite effect. m5C RNA immunoprecipitation sequencing (m5C-RIP-Seq) revealed that m5C hypermethylation correlates with mRNA overexpression and that NSUN2-mediated m5C hypermethylation promotes metabolism in HCC patients. …”
Get full text

A comparative study of mitoxantrone hydrochloride injection and technetium-99 m for tracing axillary sentinel nodes in patients with breast cancer by Dechuang Jiao, Xiuchun Chen, Xianfu Sun, Zhenduo Lu, Hao Dai, Chengzheng Wang, Chongjian Zhang, Lianfang Li, Jianghua Qiao, Zhenzhen Liu

Subjects: Get full text

Author Correction: GATA4 binding to the Sox9 enhancer mXYSRa/Enh13 is critical for testis differentiation in mouse by Yuya Ogawa, Iku Tsuchiya, Shogo Yanai, Takashi Baba, Ken-Ichirou Morohashi, Takehiko Sasaki, Junko Sasaki, Miho Terao, Atsumi Tsuji-Hosokawa, Shuji Takada

Get full text

Comorbidity Networks From Population-Wide Health Data: Aggregated Data of 8.9M Hospital Patients (1997–2014) by Elma Dervić, Katharina Ledebur, Stefan Thurner, Peter Klimek

Get full text

Human Resource Management Practices and Performance of Small and Medium Enterprises (S.M.Es) in Uganda: A case of Ntungamo Municipality. by Atyanga, Patrick

Subjects: Get full text