Autoimmune Hepatitis in Children: The Current State of the Problem by G. V. Volynets, A. I. Khavkin, T. A. Skvortsova, V. V. Matkash

“…., those formulated by the main group of the European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) members.Conclusion. …”
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Functional Evaluation of Open Carpal Tunnel Release in Carpal Tunnel Syndrome Patients by Swagat Mahapatra, Devta Singh, Prakhar Mishra, Jaydeep Patel, Madhusudan Mishra, Animesh Gupta

“…The decompression of the median nerve is the main target of the treatment, and carpal tunnel syndrome can usually be treated effectively through surgical methods. …”
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Verbascoside Inhibits the Activation of NLRP3 Inflammasome and Improves BV-2 Cell Inflammatory Damage by Wenjing HUANG, Fang CHENG, Min DU, Jiayi CHEN, Wei XIANG, Ke SHI, Xingliang XIE, Yanmei SHENG

“…Objective: To investigate the main component verbascoside (VB) in Osmanthus fragrans which inhibits NLRP3 inflammasome activation to improve inflammatory damage in BV-2 cells and its related mechanisms. …”
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Adipose tissue-derived microRNA-450a-5p induces type 2 diabetes mellitus by downregulating DUSP10 by Jiaojiao Zhu, Yanting Hou, Wei Yu, Jingzhou Wang, Xiaolong Chu, Xueting Zhang, Huai Pang, Dingling Ma, Yihan Tang, Menghuan Li, Chenggang Yuan, Jianxin Xie, Cuizhe Wang, Jun Zhang

“…Moreover, the adipose Dicer-knockout mouse model was constructed to identify adipose tissue as the main source of microRNA-450a-5p. microRNA-450a-5p could inactivate the insulin signal pathway by targeting the inhibited Dual Specificity Phosphatase 10 (DUSP10) and inducing IR and glucose metabolism disorders in vitro cultured hepatocytes and adipocytes. …”
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New Technological Knowledge Integration in Industries with Long-Wave Innovation: Case Study of Iran Mining and Mineral Industry by akbar Mohammadi, Nima Garosi Mokhtarzade, Ahmad Jafar nejad

“…These activities and initiatives are introduced in three main stages of identification and transfer of new technological knowledge (including three sub-sections of identifying new technological knowledge, identifying suitable knowledge sources, and transferring new technological knowledge), combining new technological knowledge with the firm's knowledge base (including three sub-sections of external new technological knowledge interpretation, external new technological knowledge sharing, and external new technological knowledge consolidation), and exploitation of new technological knowledge (including two sub-sections of implementation and reconfiguration).   …”
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Association between mixed exposure of non-persistent pesticides and liver fibrosis in the general US population: NHANES 2013–2016 by Shuge Shu, Yuan Li, Xiangyu Yu, Xinting Chen, Ummara Abdullah, Yongquan Yu

“…The results of Posterior Inclusion Probability (PIP) further showed that GLYP, TCPY, and PNP were the main contributors to the overall effects of pesticides mixture, and the corresponding PIPs were 1.000 (1.000), 1.000 (0.914) and 0.972 (0.819) for FIB-4 (HFS) liver fibrosis, respectively. …”
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GelMA@LNP/AST Promotes eNOS-Dependent Angiogenesis Through Autophagy Activation for the Treatment of Hind Limb Ischemia by Lai L, Wu H, Peng L, Zhang Z, Wu X, Zheng S, Su Z, Chu H

“…The changes in angiogenesis markers, autophagy markers, and eNOS levels were detected using qPCR and Western blotting. 3-MA was used to assess the role of autophagy in the activation of eNOS mediated by AST and its subsequent angiogenic effects.Results: GelMA@LNP/AST significantly promoted blood flow recovery in mice with hind limb ischemia. This effect was mainly attributed to the enhanced migration and angiogenic capabilities of endothelial cells mediated by AST. …”
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TAB2 deficiency induces dilated cardiomyopathy by promoting mitochondrial calcium overload in human iPSC-derived cardiomyocytes by Wenrui Sun, Jianchao Zhang, Shuang Li, Wanrong Fu, Yangyang Liu, Mengduan Liu, Jianzeng Dong, Xiaoyan Zhao, Xiaowei Li

“…Paradoxically, TAB2 knockout cell lines showed abnormal calcium handling after 40 days, later than reduced contractility, suggesting that the main cause of impaired contractility was abnormal energy production due to mitochondrial damage. …”
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Characteristics and Source-specific Health Risks of Ambient PM2.5-bound PAHs in an Urban City of Northern Taiwan by Yu-Chieh Ting, Chun-Hung Ku, Yu-Xuan Zou, Kai-Hsien Chi, Jhy-Charm Soo, Chin-Yu Hsu, Yu-Cheng Chen

“…Abstract Polycyclic aromatic hydrocarbons (PAHs) with highly toxic compounds mainly exist in small-sized particles and can induce considerable human health risks. …”
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Top health service concerns: a data mining study of the Shanghai health hotline by Lili Shi, Tong Zhao, Shimiao Shi, Tianyu Tan, Aksara Regmi, Yuyang Cai

“…Using text mining, we examined various aspects of the calls, including duration, purpose, and topics discussed, to identify patterns and themes that emerged.ResultsThe calls were categorized into four main groups: complaints, suggestions, inquiries, and requests for assistance. …”
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Spatiotemporal Variations of Particulate Matter and their Association with Criteria Pollutants and Meteorology in Malaysia by Anis Asma Ahmad Mohtar, Mohd Talib Latif, Doreena Dominick, Maggie Chel Gee Ooi, Azliyana Azhari, Nor Hafizah Baharudin, Norfazrin Mohd Hanif, Jing Xiang Chung, Liew Juneng

“…Further statistical analyses, such as Spearman’s Rank Correlation and Principal Component Analysis (PCA), were conducted to study the associations between PM2.5 and PM10 with other main criteria air pollutants, as well as meteorological parameters. …”
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3,5,6,7,8,3’,4’- Heptamethoxyflavonoid inhibits TGF-β1-induced epithelial–mesenchymal transition by regulating oxidative stress and autophagy through MEK/ERK/PI3K/AKT/mTOR signalin... by Yiting Wang, Zhiheng Ma, Weiwen Peng, Qinglian Yu, Wenjie Liang, Liu Cao, Zhuqiang Wang

“…Abstract Epithelial–mesenchymal transition (EMT) is a crucial pathological process in the pathogenesis of fibrosis. 3,5,6,7,8,3′,4′-hepmethoxyflavone (HMF), the main active ingredient extracted from the Chinese herb Breynia fruticosa (L.) …”
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Microbiota governs host chenodeoxycholic acid glucuronidation to ameliorate bile acid disorder induced diarrhea by Zishen Lin, Yue Feng, Jinping Wang, Zhaoyue Men, Xi Ma

“…Fecal microbiota transplantation and various cell experiments further indicated that chenodeoxycholic acid (CDCA) metabolic disorder produced CDCA-3β-glucuronide, which is the main cause of BA disorder diarrhea. Non-targeted metabolomics uncovered the inhibition of the BA glucuronidation by Lactobacillus reuteri (L. reuteri) is through deriving indole-3-carbinol (I3C). …”
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Effect of cover crops on phosphorus and trace metal leaching in agricultural soils by Vishawjot Sandhu, Jasmeet Lamba, Preetika Kaur, Kritika Malhotra, Thomas R. Way, Kipling S. Balkcom, Rishi Prasad

“…The cover crop, a mixture of cereal rye and crimson clover, was planted in the late fall in the field. The main crop, planted the following spring, was strip-tillage cotton. …”
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Prioritas Investasi Keamanan Informasi Menggunakan Analytic Network Process (ANP) Bagi Pemerintah Daerah Provinsi Kalimantan Tengah by Ruby Haris, Alva Hendi Muhammad, Asro Nasiri

“…Although there have been initiatives from the Central Government, such as the Information Security Index (KAMI) introduced by the National Cyber and Crypto Agency (BSSN), implementation at the regional level still faces various challenges. The main obstacles encountered are limited budgets, a shortage of qualified human resources, and a lack of awareness about the importance of information security. …”
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Serum cytokines in ulcerative colitis of various clinical activity by Ye. A. Konovich, I. L. Halif, M. V. Shapina, K. E. Shirokikh

“…Expansion of circulating cytokines spectrum, mainly IL-6, IL-8 and IL-10 profile in combination to 1–3 of the other studied cytokines (GM-CSF, IFN-γ, TNF-α) is typical for resistant form of disease.…”
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Evaluation of Ecosystem Services and Tradeoff and Synergy in the Alpine and Canyon Region of Southwest China Based on Multi-source Geographic Data by LIU Jing, XIANG Jiayi, ZHANG Donghai, LAN Mengyao, GUAN Yinghui

“…These synergies were mainly located in the southeastern Tibetan alpine canyon ecological maintenance zone and the eastern Tibetan-western Sichuan alpine canyon ecological maintenance and water retention zone. …”
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Chemical Composition Characteristics and Source Apportionment of PM2.5 in Ceramic Industrial Base during Winter by Xiang Tu, Xiaozhen Fang, Hansun Fang, Changlin Ye, Zugen Liu, Xuehui Jia, Dan He, Jinliang Wang, Hong Huang, Changwei Zou, Chenglong Yu

“…Furthermore, source apportionment using the CMB model indicated that a ceramic industry source was the main contributor to the PM2.5 mass, which accounted for about 27.9%, and this was followed by secondary formation dust sources, and gasoline/diesel vehicle exhaust emissions and motor vehicle non-exhaust emissions. …”
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Chronic lower back pain among occupational workers: effect of relaxation technique on quality of working life, pain and disability level with nurse-led intervention by Nabila ELSayed Sabola, Kamal Wifaq, Musaad M. Alruwaili, Rasha Kamal Mohamed Sweelam, Sabah Hassan El-Amrosy, Amal Yousef Abdelwahed

“…Abstract Background Lower back pain (LBP) is the main cause of workplace impairment and a significant contributor to absenteeism. …”
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DIGITAL TOOLS FOR MATCHING QUALIFICATIONS TO THE LEVELS OF THE NATIONAL QUALIFICATIONS FRAMEWORK by Volodymyr Kovtunets, Sergiy Londar, Serhii Melnyk, Oles Kovtunets

“…Therefore, a user should be capable of forming at most four matrices of judgments and computing the main eigenvectors with some level of accuracy. The maximal dimension of matrices is four (for example it's true for the Ukrainian case). …”
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