Infection <i>Helicobacter pylori</i> and stomach cancer: state-of-the-art by A. A. Sheptulin

“…Nowadays it is indicated for patients with high risk of SC (having atrophic gastritis, postgastrectomy patients for early SC, first-degree relatives of patients with SC).Conclusion. Pathophysiological and clinical aspects of interrelations between Н. pylori infection and SC require the further studies.…”
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Critical evaluation of pathogenic factors of primary biliary cirrhosis by A. F. Sheptulina, M. V. Mayevskaya, V. T. Ivashkin

“…Despite of sufficient progress in studying of main pathophysiological mechanisms of PBC, etiology of disease remains obscure. …”
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Discussion of irritable bowel syndrome issue and functional constipations in reports of the 21st United European Gastroenterological Week (Berlin, 2013) by A. A. Sheptulin, M. A. Vizye-Khripunova

“…The range of pharmaceuticals has been replenished by new agents (linaclotide, prucalopride), increasing efficacy of IBS and CFC treatment.Conclusion. Pathophysiological and clinical aspects of IBS and CFC require further investigation.…”
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Exploring nutraceutical approaches linking metabolic syndrome and cognitive impairment by Rebecca Sonnino, Gea Ciccarelli, Simona Moffa, Laura Soldovieri, Gianfranco Di Giuseppe, Michela Brunetti, Francesca Cinti, Eleonora Di Piazza, Antonio Gasbarrini, Enrico C. Nista, Alfredo Pontecorvi, Andrea Giaccari, Teresa Mezza

“…This review examines clinical and translational evidence on commonly used nutraceuticals targeting shared pathophysiological mechanisms of MetS and MCI. By addressing inflammation, oxidative stress, and metabolic dysfunction, these supplements may offer a valuable approach to mitigating the progression and consequences of both conditions. …”
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Methods of risk prediction and monitoring of treatment response rate of bleedings from esophageal varices in patients with liver cirrhosis by D. V. Garbuzenko

“…Optimization of known methods of assessment of portal hypertension, and development of new, pathophysiologically based methods, allows to increase efficacy of VEV bleedings prophylaxis in patients with liver cirrhosis.…”
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Gastroesophageal reflux disease and the functional diseases of gastro-intestinal tract: are there any interrelations? by A. A. Sheptulin, M. A. Vize-Khripunova

“…It can be caused by common pathophysiological mechanisms of these diseases. Within the framework of non-erosive form of GERD it is possible to define 2 subgroups of patients, at which: 1)correlation of clinical symptoms to episodes of physiological gastroesophageal reflux (GER) is present – patients with hypersensitive esophagus or 2) clinical symptoms are not related to GER at all – patients with functional heartburn, which can be considered within the framework of functional pathology. …”
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Leading causes of fever in patients with liver function disorders by V. T. Ivashkin, M. A. Morozova, M. V. Mayevskaya

“…Article presents pathophysiological mechanisms of development of fever. The algorithm of assessment of patient with disorder of liver function and fever is submitted.Original positions. …”
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Application of Refill, Recoil, Rebound (3R) as a Novel Chest Compression Technique in Cardiopulmonary Resuscitation; Report of Two Cases by Georgia Tsoungani, Sayed Nour

“…It seems that, 3R/CPR adapts the pathophysiological conditions of CA victims promoting a less traumatic return of spontaneous circulation (ROSC), making it worthy of further investigation and study. …”
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New options for targeting TRPV1 receptors for cancer treatment: odorous Chinese herbal medicine by Minghui Zhang, Minghui Zhang, Zongao Wang, Zongao Wang, Shaojun Liu, Shaojun Liu, Yuxuan Li, Yuxuan Li, Yanting Gong, Yanting Gong, Min Liu, Min Liu

“…Vanilloid1 (TRPV1), a subfamily of transient receptor channels, is one of the non-selective calcium channels, which is a bridge between cellular response and extracellular environmental networks, and is involved in a variety of pathophysiological processes. It is also involved in the process of cancer occurrence and progression, and researchers are revealing its role in cancer. …”
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Circulatory shock in adults in emergency department by Ashok Kumar Pannu

“…The review emphasizes prompt shock identification with tissue hypoperfusion, knowledge of the underlying pathophysiological mechanism, initial fluid resuscitation with balanced crystalloids, norepinephrine as the preferred vasopressor in septic and profound cardiogenic shock, and tailored intervention addressing specific etiologies. …”
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INTESTINAL MICROBIOME - A LEADING FACTOR IN HUMAN HEALTH AND DISEASES by E. Blum Hubert

“…Aim: to present the modern concept of physiological and pathophysiological impact of microbiome. Summary: Major advances in molecular and cell biology significantly improved our understanding of disease pathogenesis as well as in novel strategies for the diagnosis, therapy and prevention of human diseases. …”
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Vascular malformations of the lungs and the liver at patient with hereditary hemorrhagic teleangiectasia by M. S. Zharkova, A. V. Lapshin, Ye. N. German, M. V. Mayevskaya, I. A. Sokolina, V. T. Ivashkin

“…To show a rare case of pulmonary and hepatic vascular malformations development, to discuss pathophysiological mechanisms of revealed changes and clinical symptoms of disease.Features of clinical case. …”
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Controversy About Management of Osteoarthritis with Disease-modifying Anti-rheumatic Drugs by CUI Hanshu, LIU Bin

“…It leads to pain, stiffness, deformation and even disability in the patients, and increases the risk of comorbidities. As its pathophysiological mechanisms are not well understood, it is hard to identify the specific targets of OA and standardize its pharmacological treatments. …”
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Application of Low Intensity Ultrasound in the Treatment of Alzheimer’s Disease by Hong Fei, Xu Fei

“…According to the current known pathological studies, AD biomarker TAU protein, phosphorylated tau and amyloid-β (Aβ) play an important role in the pathophysiological changes of AD. For pathological research, the development of low-intensity ultrasound (LIUS) provides another idea for the mechanism of AD treatment, which can better treat AD, regulate various factors specifically, and effectively treat AD by stimulating synapses and improving neurons. …”
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Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis by Fenli Shao, Qianqian Liu, Yuyu Zhu, Zhidan Fan, Wenjun Chen, Shijia Liu, Xiaohui Li, Wenjie Guo, Gen-Sheng Feng, Haiguo Yu, Qiang Xu, Yang Sun

“…Here we discovered spontaneous kyphosis, arthritis and bony fusion in mature CD4-Cre;Ptpn11 f/f mice, which present the pathophysiological features of AS. A population of CD4-Cre-expressing proliferating chondrocytes was SHP2 deficient, which could differentiate into pre-hypertrophic and hypertrophic chondrocytes. …”
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Exploring the Ancient Persian/Unani Theory of Connection between Gastrointestinal and Respiratory Tracts: Current Evidence and Future Directions by Shahin Saeidinejat, Syed Mohd Abbas Zaidi, Alireza Ranjbar, Alireza Derakhshan

“…Numerous epidemiologic, pathophysiologic and clinical evidence confirm the interrelationship and integrated functioning of the respiratory and gastrointestinal tracts. …”
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Targeting adipocyte ESRRA promotes osteogenesis and vascular formation in adipocyte-rich bone marrow by Tongling Huang, Zhaocheng Lu, Zihui Wang, Lixin Cheng, Lu Gao, Jun Gao, Ning Zhang, Chang-An Geng, Xiaoli Zhao, Huaiyu Wang, Chi-Wai Wong, Kelvin W. K. Yeung, Haobo Pan, William Weijia Lu, Min Guan

“…Abstract Excessive bone marrow adipocytes (BMAds) accumulation often occurs under diverse pathophysiological conditions associated with bone deterioration. …”
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Parathyroid carcinoma and pheochromocytoma in a patient with neurofibromatosis type 1: a rare association by Jardelina Brena Rocha Leite, Nicole Ramalho De Freitas, Rafaella Nelice de Holanda Cardoso, Erik Trovão Diniz, Gabriel Rodrigues de Assis Ferreira, Fernão Henrique Costa e Alvim, Camila Ribeiro Coutinho Madruga, Ana Carolina Thé Garrido, Luciano Albuquerque, Patricia Sampaio Gadelha, Ruy Lyra, Lucio Vilar

“…Further investigation into the underlying mechanisms linking these conditions is warranted to elucidate their pathophysiological interplay and inform optimal therapeutic strategies for affected individuals. …”
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PRKD2 as a novel target for targeting the diabetes–osteoporosis nexus by Rongjin Chen, Chenhui Yang, Hefang Xiao, Ao Yang, Changshun Chen, Fei Yang, Bo Peng, Bin Geng, Yayi Xia

“…Abstract Diabetes mellitus (DM) and osteoporosis (OP) co-morbidity (DMOP) pose major health challenges owing to their complex pathophysiological interactions. The aim of this study was to identify and validate key genes implicated in the pathogenesis of both conditions. …”
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Liver diseases: epidemiology, causes, trends and predictions by Can Gan, Yuan Yuan, Haiyuan Shen, Jinhang Gao, Xiangxin Kong, Zhaodi Che, Yangkun Guo, Hua Wang, Erdan Dong, Jia Xiao

“…While sharing common features, liver diseases exhibit distinct pathophysiological, clinical, and therapeutic profiles. …”
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