Pembrolizumab and Pemetrexed for Older Patients With Nonsquamous NSCLC and Programmed Cell Death-Ligand 1 Tumor Proportion Scores of Less Than 50% by Yoshihito Kogure, MD, PhD, Hiroya Hashimoto, PhD, Haruko Daga, MD, PhD, Yasushi Fukuda, MD, Akihiro Bessho, MD, PhD, Tadaaki Yamada, MD, PhD, Yukihiro Toi, MD, Tomoki Kimura, MD, PhD, Hiroshige Yoshioka, MD, PhD, Koichi Azuma, MD, PhD, Naoki Furuya, MD, PhD, Yasutaka Fukui, MD, PhD, Akiko M. Saito, MD, PhD, Nobuyuki Yamamoto, MD, PhD, Hideo Saka, MD, Masashi Kondo, MD, PhD

Subjects: Get full text

Comparative Evaluation of Postoperative Incisional Negative Pressure Wound Therapy with Conventional Dressings in Patients of Proximal Tibia Fracture Managed by Dual Plating by Pranav Kothiyal, Kunal Vij, Puneet Gupta

“…Results: A total of 88 patients were included in the study, and it was found that the rate of minor and major wound site complications was more in the group of patients managed by conventional dressing. …”
Get full text

Features of the Parameters of 24-Hours pH-Impedance and High-Resolution Esophageal Manometry in Patients with Barrett's Esophagus on Proton Pump Inhibitors by I. V. Maev, D. S. Bordin, E. V. Barkalova, M. A. Ovsepyan, E. R. Valitova, N. G. Kalashnikova, D. N. Andreev

“…Аim: to identify predictors of insufficient effectiveness of proton pump inhibitors based on the evaluation of the results of 24-hour pH-impedance and high-resolution esophageal manometry in patients with Barrett's esophagus.Materials and methods. 52 patients with histologically confirmed Barrett's esophagus who are on therapy with proton pump inhibitors were examined. …”
Get full text

CONSTANT MURLEY SCORE ON PATIENTS POST SUPRASPINATUS RECONSTRUCTION WITH MEMBRANE AMNION COMPOSITE AND FAT TISSUE ALLOGENIC MESENCHYMAL STEM CELL AUGMENTATION by Heri Suroto, Bayu Antara Hadi, Goklas Ridwan Ricardo Gultom

“…Background: Rotator cuff tears are the most common cases in nontrauma upper extremities in group patient more than 50 years old. Incidence on rotator cuff can't show the real population. …”
Get full text

Machine learning analysis of pathological images to predict 1-year progression-free survival of immunotherapy in patients with small-cell lung cancer by Hirotaka Matsumoto, Hiroaki Akamatsu, Nobuyuki Yamamoto, Yuki Sato, Daichi Fujimoto, Yoshihiko Taniguchi, Motohiro Tamiya, Yasuhiro Koh, Junya Fukuoka, Hisashi Tanaka, Naoki Furuya, Ryota Shibaki, Tsukasa Nozawa, Akira Sano, Yuka Kitamura, Takashi Kijima, Toshihide Yokoyama, Satoru Miura, Akito Hata, Jun Sugisaka

“…The mean AUC values of patient information, pathological image, and combined models were 0.789 (range 0.571–0.982), 0.782 (range 0.750–0.911), and 0.868 (range 0.786–0.929), respectively. …”
Get full text

Gallbladder Wall Thickness as a Non-Invasive Tool for Prediction of Esophageal Varices in Patients with Hepatitis C Related Chronic Liver Disease by Munir Ahmed, Maliha Aziz, Shahzad Riyaz, Mohammad Salih, Rashed Nazir, Muslim Atiq

“…Results: The median age of patients was 54±10.13 years. 89 patients were male (61.4%), and 56 were female (38.6%). 86.9% of patients had EVs Group 1) and 27.6% had no EVs (Group II). …”
Get full text

Antibiotic resistance among Aerobic Gram-Negative Bacilli isolated from patients with oral inflammatory dysbiotic conditions—a retrospective study by A. Basic, S. Blomqvist, G. Charalampakis, G. Dahlén

“…The aim of the present study was to investigate the identity and antibiotic susceptibility of AGNB isolated from patients in Sweden with mucosal lesions, periodontitis, and peri-implantitis, with special attention to antibiotic resistance and on the presence of phenotypic Extended Spectrum Beta-Lactamase (ESBL) isolates.Materials and methodsMicrobiolgical samples were harvested from 211 patients in total, experiencing mucosal lesions (N = 113), periodontitis (N = 62), or peri-implantitis (N = 36). …”
Get full text

Effectiveness of Caregiver Intervention for Improving Medication Adherence on Level of Medication Adherence and Attitude toward Medications among Nonadherent Patients with Mental Illness by Simrat Kaur, Renju Sussan Baby, Susanta Kumar Padhy

“…Caregivers spend a considerable amount of time with the patients. Therefore, proper training and education for caregivers help to improve treatment outcomes. …”
Get full text

Extending Integration: Interventions Supporting Communication and Collaboration Between Patients with Neurological Diseases, Their Informal Caregivers and Healthcare Staff – a Scoping Review by Eskil Degsell, Lina Al-Adili, Petter Gustavsson, Mats Brommels, Petra Dannapfel

“…Introduction: Addressing challenges due to demographic changes and the quest for improved value in healthcare requires an extended integrated approach to care that fosters collaboration between all stakeholders, especially within collaboration supporting cognitively impaired patients. The aim is to review existing studies on interventions to improve communication and collaboration between such patients, their caregivers and healthcare staff. …”
Get full text

Tough choices: the experience of family members of critically ill patients participating in ECMO treatment decision-making: a descriptive qualitative study by Xiangying Yang, Yao Lin, Amao Tang, Xiaokang Zeng, Weiying Dai, Qian Zhang, Li Ning

“…Abstract Background ECMO treatment for critically ill patients mostly requires family members to make surrogate decisions. …”
Get full text

Association between obstructive sleep apnea hypopnea syndrome and arteriosclerosis in patients with type 2 diabetes mellitus: mediating effect of blood pressure by Xinshui Wang, Xiaolin Huang, Yuexian Xing, Xiaohong Jiang, Fei Hua

“…ObjectiveThis study aims to explore the relationship between Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) and arteriosclerosis in type 2 diabetes mellitus (T2DM) patients and to evaluate the mediating effect of blood pressure in this process.MethodsA total of 411 T2DM patients admitted to the Third Affiliated Hospital of Soochow University from January 2021 to December 2023 were selected and divided into the arteriosclerosis group (n = 299) and the non-arteriosclerosis group (n = 112) based on brachial-ankle pulse wave velocity (ba-PWV). …”
Get full text

Clinical Outcomes in Patients Receiving Originator Follitropin Alfa and Follitropin Alfa Biosimilars in Real-world Clinical Practice: A Retrospective Study by Nayana Hitesh Patel, Niket H. Patel, Molina Niket Patel, Harsha K. Bhadarka, Kairavi Sunilkumar Vyas

“…Aims: To compare the ART outcomes in patients receiving originator follitropin (Gonal-f®) and its biosimilars in clinical setting. …”
Get full text

First-in-human exploratory trial assessing safety, feasibility, and efficacy of artificial protein (silk-elastin) in promoting healing in patients with meniscus injuries by Masakazu Ishikawa, Shunya Tsuji, Goki Kamei, Kyohei Nakata, Akinori Nekomoto, Naofumi Hashiguchi, Tomoyuki Nakasa, Atsuo Nakamae, Naosuke Kamei, Keiichiro Inoue, Shingo Kawabata, Keiko Ueda, Nobuo Adachi

“…MRI findings indicated one patient with grade 1 healing, three with grade 2, and four with grade 3 (unhealed). …”
Get full text

Healthcare Resource Utilization and Costs Among Patients With Gastroesophageal Reflux Disease, Barrett’s Esophagus, and Barrett’s Esophagus-Related Neoplasia in the United States by Prateek Sharma, Gary W. Falk, Menaka Bhor, A. Burak Ozbay, Dominick Latremouille-Viau, Annie Guerin, Sherry Shi, Margaret M. Elvekrog, Paul Limburg

“…As patients progressed to more advanced stages, there was substantially higher disease-related resource utilization, with associated costs being 16 times higher in patients with EAC than those with NDBE. …”
Get full text

Efficacy of non-surgical mechanical debridement with and without adjunct antimicrobial photodynamic therapy in the treatment of peri-implantitis among patients undergoing chemotherapy by Asma Saleh Almeslet, Malak Mohammed ALOsaimi, Chitra Jhugroo, Abdullah Faraj Alshammari, Darshan Devang Divakar, Cristalle Soman

“…The objective was to assess the efficacy of MD with and without adjunct aPDT in treating peri‑implantitis among patients undergoing chemotherapy. Methods: Patients with peri‑implantitis were included. …”
Get full text

The Role of E-Cadherin in the Assessment of Esophageal Mucosal Damage in Patients with Gastroesophageal Reflux Disease Associated with Obstructive Sleep Apnea/Hypopnea Syndrome by Y. Ya. Shaukovich

“…Group 1 (n = 29) consisted of GERD patients, group 2 (n = 35) of patients with GERD in combination with OSAHS, group 3 (n = 30) of patients with OSAHS, group 4 (n = 26) was the comparison group. …”
Get full text

A Study to Assess the Prevalence of Depression among Alcoholics, among Patients, Admitted to Christian Institute of Health Sciences and Research, Dimapur, Nagaland by Nukshijungla Ao

“…The CAGE questionnaire was used to screen out the patients for level of dependence. The tool used is the Patient Health Questionnaire-9 (PHQ-) to assess the prevalence. …”
Get full text

Irritable Bowel Syndrome: What Are the Reasons for Dissatisfaction with the Treatment of Patients and Doctors? (Based on the Experience of Medical Institutions of the Northwestern Federal District of Russia) by A. Yu. Baranovsky, T. V. Reshetova, I. S. Sakeyan

“…Аim: analyze the results of an anonymous survey of patients with irritable bowel syndrome (IBS) to assess the degree of their satisfaction with the results of the therapy and, on this basis, determine the most optimal approaches to treatment. …”
Get full text

Efficacy of hepatitis B vaccination in patients awaiting liver transplantation in prophylaxis of <i>de novo</i> HBV-infection of a graft by V. Ye. Syutkin, O. I. Andreytseva, A. A. Saliyenko, A. V. Chzhao

“…Results of vaccination against hepatitis B in 41 patients with liver cirrhosis included into the Waiting list for orthotopic liver transplantation (OLT), and dynamics of HBV seromarkers in 72 patients before and after liver transplantation were analyzed.Results. …”
Get full text

Risk factors analysis and prediction model establishment of acute kidney injury after heart valve replacement in patients with normal renal function by Xiaofan Huang, Xiaofan Huang, Xiangyu Sun, Jiangang Song, Yongqiang Wang, Jindong Liu, Jindong Liu, Yu Zhang, Yu Zhang

“…BackgroundThe study aimed to develop a risk prediction model through screening preoperative risk factors for acute kidney injury (AKI) after heart valve replacement in patients with normal renal function.MethodsA total of 608 patients with normal renal function who underwent heart valve replacement from November 2013 to June 2022 were analyzed retrospectively. …”
Get full text