Chronic Myeloid Leukemia: Part II—Cost of Care Among Patients in Advanced Phases or Later Lines of Therapy in Chronic Phase in the United States from a Commercial Perspective by Ehab L. Atallah, Rodrigo Maegawa, Dominick Latremouille-Viau, Carmine Rossi, Annie Guérin

“…Despite advances in therapy, there remains a proportion of patients with CML-CP that are refractory/intolerant to TKIs, and these patients cycle through multiple lines of therapy. …”
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The effectiveness of Transcranial Photobiomodulation therapy (tPBM) on reducing anxiety, depression, and opioid craving in patients undergoing methadone maintenance treatment: a double-blind, randomized, controlled trial by Helya Helali, Nastaran Samani, Faraj Tabeie, Shiva Eiliaei, Ali Kheradmand

“…The purpose of this study was to evaluate the impact of tPBMT on reducing anxiety, depression, and opioid craving in patients undergoing MMT. Methods This randomized controlled clinical trial included two groups of substance-dependent patients undergoing MMT. …”
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MiR-25-3p regulates pulmonary arteriovenous malformation after Glenn procedure in patients with univentricular heart via the PHLPP2-HIF-1α axis by Junpei Kawamura, Munekazu Yamakuchi, Kentaro Ueno, Teruto Hashiguchi, Yasuhiro Okamoto

“…Serum miRNAs that showed ≥ 2-fold higher levels in patients with G-PAVMs than in other patients were selected. …”
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Corrigendum to “Negative Video Capsule Endoscopy Had a High Negative Predictive Value for Small Bowel Lesions, but Diagnostic Capability May Be Lower in Young Patients with Overt Bleeding” by Sipawath Khamplod, Julajak Limsrivilai, Uayporn Kaosombatwattana, Nonthalee Pausawasdi, Phunchai Charatcharoenwitthaya, Supot Pongprasobchai, Somchai Leelakusolvong

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Dynamics of Somatic and Comorbid Mental Disorders (Distress, Anxiety, Somatisation and Depression) in Patients with Irritable Bowel Syndrome during Therapy with Alimemazine: Results of an Non-Interventional Observational Programme (“Terra”) by V. T. Ivashkin, O. Z. Okhlobystina, M. V. Mayevskaya, O. S. Shifrin, Z. A. Mamieva, Yu. E. Azimova

“…Most of the patients tolerated alimemazine at a dose of 15 mg/day. …”
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Exploration of the quantitative-effectiveness association between acupuncture temporal parameters and chemotherapy-induced peripheral neuropathy in cancer patients: a dose-response meta-analysis of randomized controlled trials by Hao Tian, Qin Luo, Liuyang Huang, Liuyang Huang, Liuyang Huang, Guang Chen, Mingsheng Sun, Fanrong Liang

“…The identified time-dose-response relationship suggests that tailoring acupuncture frequency and duration can to optimize pain relief in CIPN patients. Future high-quality studies and large-scale multicenter clinical trials are needed to validate these findings.…”
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The pattern of antibiotic utilisation among intensive care unit patients hospitalised in a Gauteng (South African) provincial tertiary hospital: Comparing findings before and during COVID-19 by L Spinickum, Z Booth, S Leigh-de Rapper

“…A retrospective cross-sectional data analysis was undertaken of 335 medical files of ICU patients hospitalised in a GPTH between January 2017 and December 2021. …”
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Weight Change and Predictors of Weight Change Among Patients Initiated on Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide or Bictegravir/Emtricitabine/Tenofovir Alafenamide: A Real-World Retrospective Study by Bruno Emond, Carmine Rossi, Aurélie Côté-Sergent, Keith Dunn, Patrick Lefebvre, Marie-Hélène Lafeuille, Prina Donga

“…**Background:** Recent evidence suggests that integrase strand transfer inhibitors are associated with greater weight gain than protease inhibitors in patients with human immunodeficiency virus (HIV-1). …”
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Discordance between 90Y-PET/CT(MR)-estimated activity and dose calibrator measured administered activity: an international study in SIRT patients treated with resin and glass microspheres by Thomas Carlier, Silvano Gnesin, Justin K. Mikell, Maurizio Conti, John O. Prior, Niklaus Schaefer, Maria del Sol Pérez Lago, Clément Bailly, Yuni K. Dewaraja, Thiago V. M. Lima

“…The objective of this work was to investigate whether these discrepancies were also seen in patients. Methods We analysed patient 90Y-PET reconstructions (99 glass and 15 resin microspheres) from 4 different institutions and 4 different systems. …”
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A multicenter retrospective study of early cardiac toxicity in operable breast cancer patients receiving concurrent dual or mono anti-HER2 therapy with postoperative radiation therapy by Jing Yang, Meng-Yun Zhou, Bo Yu, Qing Lin, Yuan Yao, Hua-Ling Wu, Qi-Wei Zhu, Ming Ye, Hua-Ying Xie, Jian-Wei Wu, Gang Cai, Rong Cai, Wei-Xiang Qi, Jia-Yi Chen, Lu Cao

“…Results: In total, 681 patients were enrolled in the analysis, of whom 567 were treated with trastuzumab-alone and 124 patients received dual anti-HER2 therapy. …”
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Diagnostic Accuracy of Next Generation Sequencing Panel using Circulating Tumor DNA in Patients with Advanced Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis by Mariana M. Sebastião, Rodrigo S. Ho, João Paulo V. de Carvalho, Micha Nussbaum

“…**Background/Objectives:** Until now, no meta-analysis has been published to evaluate the diagnostic performance of next-generation sequencing (NGS) panel using circulating tumor (ctDNA) in patients with advanced non-small cell lung cancer (aNSCLC). …”
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Evaluating the effectiveness of integrated traditional Chinese and Western treatment based on symptom grading: a study protocol for a multi-center, randomized controlled trial of patients with depressive disorder by Jiaxi Mai, Tingwei Zhou, Tingwei Zhou, Tingwei Zhou, Chen Wang, Chen Wang, Junrong Ye, Junrong Ye, Jiao Chen, Jiao Chen, Jiao Chen, Wen Wang, Wen Wang, Wen Wang, Yuanxin Pan, Yuanxin Pan, Yuanxin Pan, Yanheng Wei, Yanheng Wei, Lexin Yuan, Lexin Yuan, Hang Yang, Hang Yang, Shengwei Wu, Shengwei Wu, Jianxiong Guo, Jianxiong Guo, Jianxiong Guo, Aixiang Xiao, Aixiang Xiao, Aixiang Xiao

“…Primary outcome measurements include the Patient Health Questionnaire (PHQ-9), the Hamilton Depression Rating Scale (HAMD-17), and the Self-Rating Depression Scale (SDS). …”
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Ultrasonographic Assessment of Intima-Media Thickness (IMT), as a Surrogate of Future Atherosclerosis and Cardiac Diseases in Patients with Hashimoto’s Thyroiditis and Concomitant Celiac Disease: A Case-Control Study by Maryam Alaei, Mohamad Ghazanfari Hashemi, Seyedeh Nooshin Miratashi Yazdi, Mohammad Ali Kaviani, Ali Asadifar, Sahand Adib Moradi, Khazar Adibmoradi Langaroudi, Helia Helali, Mina Mahboudi, Aynaz Gerami

“…Materials and Methods: A total of 191 patients including 89 patients with only Hashimoto’s thyroiditis, 11 patients with Hashimoto’s thyroiditis and concomitant Celiac disease, and 91 healthy control subjects underwent ultrasound evaluation of intima-media thickness of carotid artery. …”
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Determination of the MEC90 of Oxycodone for Preventing Perioperative Shivering in Pregnant Patients Undergoing Caesarean Delivery with Neuraxial Anaesthesia: A Biased-Coin up-and-Down Sequential Allocation Trial by Lu X, Chen K, Xuan Y, Shen M, Lei W, Huang Y, Sun J

“…The 2-h and 6-h postoperative VAS scores were 3 (2– 3) and 4 (3– 5), respectively. The patient’s anaesthesia satisfaction score was 5 (4– 5). …”
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Supporting primary care clinicians in caring for patients with alcohol use disorder: study protocol for Records for Alcohol Care Enhancement (RACE), a factorial four-arm randomized trial by Kara M. Magane, Richard Saitz, Sarah Fielman, Marc R. LaRochelle, Christopher W. Shanahan, Christine A. Pace, Michael LaValley, Kaley Penington, Skylar Karzhevsky, Emily Hurstak

“…The primary outcome will be the percent of patients engaged in AUD treatment among those with a new AUD diagnosis on a PCP’s panel. …”
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Effects of community family doctors-led intervention for self-management and medication adherence in type 2 diabetes mellitus patients: study protocol of a cluster randomised controlled trial by Yue Chen, Biqi Ren, Ningsheng Wang, Shuang Lei, Shuzhi Lin, Lianye Liu, Yufang Xiang, Bianling Feng

“…The development of community-based type 2 diabetes management in China has not yet reached an ideal state, and the most suitable management methods for diabetic patients are still being explored. Few studies have used community-based family doctors to perform interventions of appropriate intensity. …”
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Moderate Hypofractionated Post-Prostatectomy Radiotherapy (MYSTERY) Versus Conventionally Fractionated Post-Prostatectomy Radiotherapy (COPORT) for the Patients With Localized Prostate Cancer: The Protocol of a Prospective, Randomized Trial by Yiyin Liang MD, Weiwei Zhang MD, Xianzhi Zhao MD, Huojun Zhang MD, PhD

“…Introduction A few studies have examined whether the safety and efficacy of moderate hypofractionated post-prostatectomy radiotherapy (moderate HYPORT, also called MYSTERY) are equal to those of conventionally fractionated post-prostatectomy radiotherapy (COPORT) in patients with localized prostate cancer. Therefore, this study aims to compare the safety and efficacy of MYSTERY and COPORT in patients with postoperative prostate cancer. …”
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Effect of arm-ergometry versus treadmill supervised exercise on health-related quality of life and mental health in patients with peripheral artery disease: secondary outcomes from the ARMEX trial by Sandra Magalhães, Mário Santos, Sofia Viamonte, Fernando Ribeiro, Joana Martins, Cristine Schmidt, Henrique Cyrne-Carvalho

“…Journal of Patient-Reported Outcomes…”
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Study protocol of the METAPANC trial - intensified treatment in patients with local operable but oligometastatic pancreatic cancer - multimodal surgical treatment versus chemotherapy alone: a randomized controlled trial by Michael Ghadimi, Uwe Pelzer, Marc G. Besselink, Jens Siveke, Ralph Telgmann, Rickmer Braren, Hanneke Wilmink, Marie Crede, Alexander Koenig, Ute Koenig, Sven Thorsten Liffers, Kai Antweiler, Bas Uijterwijk, Hanna Seppanen, Arno Nordin, Pauli Puolakkainen, Olav F. Dajani, Knut Jørgen Labori, Mia Johansson, Svein Olav Bratlie, Tim Friede, Peter Jo

“…Abstract Background Based on current guidelines, surgical treatment of hepatic oligometastases in patients with pancreatic ductal adenocarcinoma (PDAC) is not primarily recommended. …”
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The incidence rate of caries on individual tooth surfaces and its distribution by age and gender in clinic patients of Hawler Medical University/College of Dentistry: a retrospective cross-sectional study. by Niaz Hamaghareeb Hamasaeed, Eman Kanabi Mohammed, Kazhin Mahmood Omer, Rayan Amir Bapir

“…Methods: This cross-sectional study was conducted among clinic patients of Hawler Medical University/College of Dentistry in Erbil Governorate, Kurdistan, Iraq, over a span of four months in 2021. …”
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