Understanding cancer predisposition in Singapore: what’s next by Jianbang Chiang, Tarryn Shaw, Joanne Ngeow

“…Knowledge of an underlying genetic predisposition to cancer allows the use of personalised prognostic, preventive and therapeutic strategies for the patient and carries clinical implications for family members. …”
Get full text

Requiring durations of therapy at the time of antibiotic order entry reduces antibiotic use by Megan R. Wright, Jessica Gillon, Sophie E. Katz, Ritu Banerjee

“…Requiring ordering clinicians to enter stop dates at the time of antibiotic order entry decreased DOT/1000 patient days for orders with empiric indication from 154 to 119 (–34.9 (–55.7 to –14)).…”
Get full text

A rare case of vision loss caused by leptomeningeal metastasis of lung adenocarcinoma: a case report and literature review by Zhihua Li, Jian Chu, Wennan Shen, Junnan Chen, Yuemei Dong, Manze Zhang, Nan Zhao, Wei Zhao, Haoran Zha, Ning Wang, Yalin Han, Zhaoxia Li

“…Leptomeningeal metastasis (LM) is a fatal complication with increasing incidence in patients with non-small cell lung cancer. Herein, we present the case of a patient who presented with complete vision loss due to LM and achieved a survival benefit from treatment with trametinib. …”
Get full text

Protein restriction in CKD: an outdated strategy in the modern era by Abdullah Bawazir, Joel M Topf, Swapnil Hiremath

“…Important advances in CKD treatment, including ACE inhibitors, SGLT2 inhibitors, and GLP-1 receptor agonists, are discussed to propose a comprehensive strategy that optimizes patient outcomes.…”
Get full text

Simultaneous Coronary Artery Bypass Grafting and Anterior Rectum Resection: The First Clinical Case in Kazakhstan by Anuar Abdikarimov, Serik Aitaliyev, Vladimir Dikolayev

“… In this case report, we describe the experience of a patient who was initially admitted for rectal cancer treatment. …”
Get full text

A Rare Case of Solitary Fibrous Tumor of the Breast in a Healthy 40-Year-Old Woman by Marissa Yaldo, Arif Musa, Michael Aulicino, Brigitte Berryhill

“…This rarity is underscored by its classification as a SFT and its unusual location within the breast tissue as well as this patient’s young age. This case emphasizes the importance of a thorough evaluation with both imaging and histopathology for diagnosing SFTs. …”
Get full text

Synthesis and Biological Activities of Some Benzimidazoles Derivatives by Hamdan S Al-Ebaisat

“…The biological activity of these compounds as fungicides was tested against three commercially known fungicides (C. albicans, patient isolate C. glabrata and C. krusei).The biological activity of two compounds was found to be comparable to that of the commercially available fungicides (6 and 9). …”
Get full text

Scapular Osteochondroma: A Unique Site in 50 Years Old: An Unusual Case by Ravi Sauhta, Dheeraj Makkar

“…We describe a 50-year-old patient who presented with a ventral scapular osteochondroma that limited her shoulder movement and induced paresthesia during sleep. …”
Get full text

Decoding the Genetics of Recurrent Molar Pregnancy by Sumita Mehta, Sunita Bijarnia Mahay, Abhishek Satapathy, Kiran Arora

“…Accordingly, the woman was counselled regarding assisted reproduction with oocyte donation for a normal pregnancy outcome. At present, the patient has an ongoing 5-month pregnancy through oocyte donation.…”
Get full text

Męczeństwo formą samobójstwa? by Marcin Cholewa

“…The article focuses on key elements of martyrdom (conscious and voluntary acceptance of death, dying for the faith, virtues pertaining to God, bearing witness to truth and love, patient endurance until death, externalised defending the truth of faith, a persecutor as opposed to the martyr, no pursuit of martyrdom, the pursuit of martyrdom not for its glory) and altruistic suicide (conscious and voluntary acceptance of death, death for the sake of others, society, bearing witness to the values, God, honour, friendship, freedom, desire for death without reward, death as a personal act, not harming innocent people, exceptions are acts of terrorism and suicide acts during wars). …”
Get full text

Intracardiac Ectopic Thyroid Tissue: A Case Report by Hira Nasir, Azra Bashir, Faria Waqar Khan, Aribah Atiq, Akhtar Sohail Chughtai

“…The results revealed benign thyroid tissue with no evidence of malignancy. The patient was symptom-free on follow up after 6 months. …”
Get full text

Guidance for the gastrointestinal evaluation and management of iron deficiency in Sub-Saharan Africa by W M Simmonds, Y Awuku, C Barrett, M Brand, K Davidson, D Epstein, E Fredericks, S Gabriel, S Grobler, C Gounden, L Katsidzira, V J Louw, V Naidoo, C Noel, E Ogutu, N Ramonate, N Seabi, M Setshedi, J Van Zyl, G Watermeyer, C Kassianides

“…The current drive towards patient blood management in sub-Saharan Africa (SSA)prescribes that we regulate not only the use of blood transfusion but also the management of patients in whom the cause of iron loss or inadequate iron absorption is sought. …”
Get full text

Assessing the comparative effectiveness of ECHO and coaching implementation strategies in a jail/provider MOUD implementation trial by Todd Molfenter, Jessica Vechinski, Jee-Seon Kim, Jingru Zhang, Lionel Meng, Jessica Tveit, Lynn Madden, Faye S. Taxman

“…For sites with low coaching without ECHO, new patient counts for combined MOUD were predicted to increase by 47.44% during the intervention phase and 7.30% during the sustainability phase. …”
Get full text

Budget Impact of Rivaroxaban for the Prevention of Thromboembolic Events after Hip or Knee Replacement in Spain by Xavier Granero Xiberta, Antonio Murcia, José Ricardo Troncoso Durán, Claudio Gómez Zubeldia, Aleix Llorac Moix, Ruth Graefenhain De Codes, Maria Giovana Ferrario, Luis Lizán

“…**Background:** Anti-thrombotic prophylaxis is routinely used in patients undergoing elective total hip or knee replacement (THR or TKR) to reduce the risk of venous thromboembolism (VTE). …”
Get full text

A prognostic signature of Glutathione metabolism-associated long non-coding RNAs for lung adenocarcinoma with immune microenvironment insights by Junxi Hu, Junxi Hu, Shuyu Tian, Shuyu Tian, Qingwen Liu, Qingwen Liu, Jiaqi Hou, Jiaqi Hou, Jun wu, Jun wu, Xiaolin Wang, Xiaolin Wang, Yusheng Shu, Yusheng Shu

“…The model effectively forecasted patient survival, and the nomogram, incorporating additional clinical risk factors, satisfied clinical needs adequately. …”
Get full text

Recommendations of the Russian Gastroenterological Association on Clinical Use of High-Resolution Manometry in Diagnosis of Esophageal Disorders by V. T. Ivashkin, I. V. Mayev, A. S. Trukhmanov, O. A. Storonova, S. A. Abdulkhakov, D. N. Andreev, D. S. Bordin, E. R. Valitova, I. L. Klyaritskaya, V. V. Krivoy, Yu. A. Kucheryavyi, T. L. Lapina, S. V. Morozov, O. A. Sablin, E. V. Semenikhina, Yu. P. Uspenskiy, A. A. Sheptulin

“…In 2018, a joint meeting of the Russian Gastroenterological Association and Russian Neurogastroenterology and Motility Group approved unified terminology and classification of esophageal motor function disorders for high-resolution manometry diagnosis.Gastrointestinal patient complaints typically concern esophageal disorders such as dysphagia, regurgitation, heart-burn, chest pain or belching. …”
Get full text

Real-world enrollment for a prospective clinico-genomic database using a pragmatic technology-enabled platform by Alexia Exarchos, Ariel B. Bourla, Maneet Kaur, Katja Schulze, Sophia Maund, Yi Cao, Yihua Zhao, Elizabeth H. Williams, Sarah C. Gaffey, Richard Zuniga, Shaily Lakhanpal, Vladan Antic, Michelle Doral, Johanna Sy, Neal J. Meropol, Anne C. Chiang

“…Results: Between December 2019 and May 2021, 944 patients enrolled, representing ≈25 % of eligible patients. …”
Get full text

Changes in Internet Activities and Influencing Factors for Problematic Internet Use During the COVID-19 Pandemic in Korean Adolescents: Repeated Cross-Sectional Study by Sol I Kim, Jae-Chan Jin, Seo-Koo Yoo, Doug Hyun Han

“…ResultsThere were significant differences in the depression scale (Patient Health Questionnaire 9). The Patient Health Questionnaire 9 scores for 2018, 2019, and 2023 decreased compared to those in 2020, 2021, and 2022 (F5=3.07; P=.007). …”
Get full text

Robotic Assistance in Simultaneous Bilateral Medial Unicompartmental Knee Arthroplasty: A Retrospective Cohort Study of 126 Knees Demonstrating Enhanced Radiographic Accuracy and C... by Valentina Rossi, MD, Constant Foissey, MD, Andreas Fontalis, MD, MSc, MRCS, Gabriel Gaggiotti, MD, Stefano Gaggiotti, MD, Elvire Servien, MD, PhD, Sébastien Lustig, MD, PhD

“…Background: One-stage bilateral unicompartmental knee arthroplasty (BUKA) is a promising option for patients with bilateral medial knee osteoarthritis. …”
Get full text

Construction and validation of a prognostic model for NK/T-cell lymphoma based on random survival forest algorithm by HUANG Zhen, HUANG Zhen, WU Yazhou

“…The patients were divided into a training cohort (n=471) and a validation cohort (n=203) in a 7∶3 ratio. …”
Get full text