High risk for life-threatening adverse events of fluoroquinolones in young adults: a large German population-based cohort study by Julia Wicherski, Jonas Peltner, Cornelia Becker, Katrin Schüssel, Gabriela Brückner, Andreas Schlotmann, Helmut Schröder, Winfried V. Kern, Britta Haenisch

“…Abstract Background Fluoroquinolone antibiotics have a high potential for serious adverse drug reactions, but real-world evidence in European patient cohorts is lacking. Therefore, we aim to examine the association between fluoroquinolone exposure and potentially life-threatening adverse events stratified by age and gender in Germany. …”
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Development of an artificial intelligence-based application for the diagnosis of sarcopenia: a retrospective cohort study using the health examination dataset by Chang-Won Jeong, Dong-Wook Lim, Si-Hyeong Noh, Sung Hyun Lee, Chul Park

“…Studies have proposed using the T-score and patient information as key diagnostic factors. However, these techniques have either been time-consuming or have required separate calculation processes after collecting each parameter. …”
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An initial benchmark of the quality of the diagnosis and surgical treatment of breast cancer in South Africa by S Nietz, H Cubasch, I Buccimazza, S Čačala, B Phakathi, M Joffe, W C C Chen, S Norris, P Ruff

“…Ten quality indicators were evaluated for 3 545 breast cancer patients across four SA surgical breast units using a shared electronic patient record system. …”
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Leveraging Comprehensive Echo Data to Power Artificial Intelligence Models for Handheld Cardiac Ultrasound by D.M. Anisuzzaman, PhD, Jeffrey G. Malins, PhD, John I. Jackson, PhD, Eunjung Lee, PhD, Jwan A. Naser, MBBS, Behrouz Rostami, PhD, Grace Greason, BA, Jared G. Bird, MD, Paul A. Friedman, MD, Jae K. Oh, MD, Patricia A. Pellikka, MD, Jeremy J. Thaden, MD, Francisco Lopez-Jimenez, MD, MSc, MBA, Zachi I. Attia, PhD, Sorin V. Pislaru, MD, PhD, Garvan C. Kane, MD, PhD

“…Objective: To develop a fully end-to-end deep learning framework capable of estimating left ventricular ejection fraction (LVEF), estimating patient age, and classifying patient sex from echocardiographic videos, including videos collected using handheld cardiac ultrasound (HCU). …”
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Insights into simulation-based learning: student and faculty experiences in a PharmD program in Saudi Arabia by Reem Binsuwaidan, Najla A. Altwaijry, Alnada A. Ibrahim, Rawan A. Alghamdi, Razan Bin Humaid, Alaa A. AlSharif, Alaa A. AlHubaishi, Elshaymaa I. Elmongy, Lina I. Alnajjar, Ghadah H. Alshehri

“…This study gathered data on three simulation activity formats: computerized, mannequin, and standardized patient role-play simulations. The sample size was calculated with a 5% margin of error, 95% confidence interval for a target population. …”
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Care coordination across healthcare systems: development of a research agenda, implications for practice, and recommendations for policy based on a modified Delphi panel by Aneesa Motala, Susanne Hempel, Michelle Wong, Maria Bolshakova, Ning Fu, David Ganz, Sonali Saluja, Timothy Kim, Carolyn Turvey, Kristina Cordasco, Aashna Basu, Tonya Page, Reshma Mahmood, Jenny Barnard, Isomi M Miake-Lye

“…Objective For large, integrated healthcare delivery systems, coordinating patient care across delivery systems with providers external to the system presents challenges. …”
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Patent Ductus Arteriosus Stenting via Percutaneous Common Carotid Artery Access for Ductus Dependent Pulmonary Blood Flow in Newborns and Infants: Experience in Latvia by Zanda Grīnberga, Elizabete Zaharāne, Pauls Sīlis, Valts Ozoliņš, Normunds Sikora, Elīna Ligere

“…In two cases, early restenting was necessary, while other patients had no procedure-associated complications. …”
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Characterization of the genomic landscape of canine diffuse large B-cell lymphoma reveals recurrent H3K27M mutations linked to progression-free survival by Anna Darlene van der Heiden, Raphaela Pensch, Sophie Agger, Heather L. Gardner, William Hendricks, Victoria Zismann, Shukmei Wong, Natalia Briones, Bryce Turner, Karin Forsberg-Nilsson, Cheryl London, Kerstin Lindblad-Toh, Maja Louise Arendt

“…We focused on identifying genes that were significantly or recurrently mutated with coding point mutations, copy number aberrations, and their associations with patient outcomes. We identified 26 recurrently mutated genes, 18 copy number gains, and 8 copy number losses. …”
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Analytical Accuracy of a Continuous Glucose Monitor in Adult Diabetic KetoacidosisTake-Home Points by Nathan L. Haas, MD, Lynn Ang, MD, Nazanene H. Esfandiari, MD, Ahsan M. Khan, MBBS, James A. Cranford, PhD, Ashley Cohen, MD, Jordan Sell, MD, Mostafa Abdel-Hamid, MD, Kevin E. Romanchik, BSN, RN, Frederick K. Korley, MD, PhD

“…Future interventional trials can assess the impact of CGM-guided DKA management on patient outcomes, patient experience, and resource use.…”
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Effect of crystalline lens decentration and tilt on visual performance in eyes implanted with bifocal or extended depth of focus intraocular lenses by Yu Zhang, Jiaqing Zhang, Chen Liang, Yifan Xu, Jiaying Wu, Junming Wu, Yifan Zhang, Aixia Jin, Xuhua Tan, Lixia Luo

“…Results Eighty‑seven patients with ZMB00 IOL and 76 patients with ZXR00 IOL were included. …”
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Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening by Anand Ramani, Giovanni Pasquini, Niklas J. Gerkau, Vaibhav Jadhav, Omkar Suhas Vinchure, Nazlican Altinisik, Hannes Windoffer, Sarah Muller, Ina Rothenaigner, Sean Lin, Aruljothi Mariappan, Dhanasekaran Rathinam, Ali Mirsaidi, Olivier Goureau, Lucia Ricci-Vitiani, Quintino Giorgio D’Alessandris, Bernd Wollnik, Alysson Muotri, Limor Freifeld, Nathalie Jurisch-Yaksi, Roberto Pallini, Christine R. Rose, Volker Busskamp, Elke Gabriel, Kamyar Hadian, Jay Gopalakrishnan

“…Hi-Q brain organoids displayed a reproducible invasion pattern for a given patient-derived glioma cell line. This enabled a medium-throughput drug screen to identify Selumetinib and Fulvestrant, as inhibitors of glioma invasion in vivo. …”
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Rescue of common and rare exon 2 skipping variants of the GAA gene using modified U1 snRNA by Paolo Peruzzo, Natascha Bergamin, Martina Bon, Sara Cappelli, Alessandra Longo, Elisa Goina, Cristiana Stuani, Emanuele Buratti, Andrea Dardis

“…The effect on endogenously expressed GAA transcript and GAA enzymatic activity was assessed by transfecting patient-derived fibroblasts bearing the common c.-32-13T>G with the best performing modified U1 snRNA. …”
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Asymptomatic Post-Traumatic Rupture of the Right Diaphragm Dome by E. A. Losik, M. V. Fadeeva, V. V. Shchegelsky, R. T. Rzaev, A. V. Stepanov, K. B. Puzakov, M. R. Skhirtladze

“…In the right thoracic cavity, anterior to the liver, were the loops of the intestine and the outlet of the stomach.More than 30 years before, the patient had experienced an explosive trauma, which might have caused a rupture in the right dome of the diaphragm. …”
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A Case Report on Kimura Disease by Biswajit Adhikari, Sarmila Sen, Somnath Saha

“…The swelling was first noticed by the patient about 3.5 years back. The swelling was gradually progressive in size. …”
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The first experience of laser scalpel «LS-0,97» application at endoscopic ablation of rectal polyps by V. S. Rubtsov, Yu. V. Chalyk

“…Totally 16 polyps of the rectum at 11 patients over 45 years old were removed by laser ablation.Results. …”
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A Rare Coexistence in an Infertile Woman: Ligneous Disease in Cervix and Conjunctiva by Murat Özekinci, Mehmet Sakıncı, Cem Yaşar Sanhal, Elif Pestereli, Münire Erman Akar, İnanç Mendilcioğlu

“…We present a case of a patient who admitted to our clinic with the complaints of dyspareunia, postcoital bleeding and infertility. …”
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Mosaic Turner Variant Adult Female Presenting with XO/XY Karyotype by Sigin George, Vikas Karamchand Dagar, N. Nagaraja, Barun Kumar Chakrabarty

“…We describe a rare case of an adult female patient detected as mosaic Turner variant with the presence of Y chromosome and reconfirmed by an aneuploidy FISH probe.…”
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Bladder Stone 6 Years after Intravaginal Slingplasty: A Case Report and Review of Literature by Fulya Dökmeci, Şerife Esra Çetinkaya, Vugar Bayramov, Kaan Aydos

“… We present a 42 year-old patient with a history of intravaginal slingplasty operation performed 6 years ago admitted with persistent lower urinary tract symptoms, dyspareunia and chronic pelvic pain for almost four years. …”
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Biological therapy for inflammatory bowel disease: cyclical rather than lifelong treatment? by Christian Philipp Selinger, Konstantina Rosiou, Marco V Lenti

“…Consequently, a large proportion of patients with IBD receive advanced therapies for a long time. …”
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Ectopic Pancreas in Duodenal Wall Putatively Causal for Gastrointestinal Bleeding by O. V. Khlynova, L. G. Girfanova, A. A. Cheremin

“…Asymptomatic EP often leads to its casual diagnosis due to background complications or concomitant gastrointestinal disorders. A 57 years-old patient was urgently admitted to a surgery unit with signs of gastrointestinal bleeding. …”
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