Polypragmasy at treatment of <i>H. pylori</i> infection in patients with concomitant diseases of other organs and systems. How to prevent side effects related to drug interactions? by S. G. Burkov, N. V. Shornikova

“…As eradication therapy implicates addition to treatment of at least 3 pharmaceuticals of which antibiotics are strictly specified, it is extremely desirable to choose proton pump inhibitor (PPI) with lower affinity to cytochrome Р450. …”
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Daropeptide natural products by Suze Ma, Sijia Guo, Wei Ding, Qi Zhang

“…Cyclophane-containing peptides comprise an important group of macrocyclic peptides with unique structural properties and pharmaceutical relevance. Darobactin A is a ribosomally synthesized and post-translationally modified peptide (RiPP) antibiotic, which features an unusual biscyclophane moiety formed via the class-defining ether crosslink in addition to a carbon-carbon (C-C) crosslink. …”
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Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling by Jeonghyeon Kwon, Haruya Kawase, Kenny Mattonet, Stefan Guenther, Lisa Hahnefeld, Jamal Shamsara, Jan Heering, Michael Kurz, Sina Kirchhofer, Cornelius Krasel, Michaela Ulrich, Margherita Persechino, Sripriya Murthy, Cesare Orlandi, Christian D. Sadik, Gerd Geisslinger, Moritz Bünemann, Peter Kolb, Stefan Offermanns, Nina Wettschureck

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PI3Kδ inhibitor linperlisib combined with gemcitabine and oxaliplatin for relapsed or refractory diffuse large B-cell lymphoma: a multicenter, single-arm phase Ib/II trial by Peng Sun, Hong Cen, Haiyan Yang, Rui Huang, Zhen Cai, Xuekui Gu, Hanying Bao, Zusheng Xu, Zuhong Xu, Zhi-Ming Li

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Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes by Kazuhiro Kakimi, Hirokazu Matsushita, Masaaki Komatsu, Eiryo Kawakami, Mikako Nishida, Nahoko Yamashita, Taisaku Ogawa, Keita Koseki, Eiji Warabi, Tomoyuki Ohue, Katsuyuki Shiroguchi, Heiichiro Udono

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Leveraging AI to optimize vaccines supply chain and logistics in Africa: opportunities and challenges by Sulaiman Muhammad Musa, Usman Abubakar Haruna, Lukman Jibril Aliyu, Mubarak Zubairu, Don Eliseo Lucero-Prisno, Don Eliseo Lucero-Prisno, Don Eliseo Lucero-Prisno

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The South African guidelines on enuresis: 2024 update by A Adam, A Badenhorst, F Claassen, T de Maayer, M Fockema, J Fredericks, E Gottlich, J John, N Lala, J Lazarus, S Leahy, H N Lourens, S Maharaj, K M Mathabe, E M Moshokoa, S B A Mutambirwa, K L Petersen, M B Radzuma, A van der Merwe, I van Heerden, C A Zietsman, F Alyami, A Deshpande, G H H Smith

“…These options include behavioural modification, urotherapy, pharmaceutical therapy, alarm therapy, alternative therapies, neuromodulation, psychological support and biofeedback. …”
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Discussion of irritable bowel syndrome issue and functional constipations in reports of the 21st United European Gastroenterological Week (Berlin, 2013) by A. A. Sheptulin, M. A. Vizye-Khripunova

“….), that may progress under a mask of the functional intestinal disorders is required. The range of pharmaceuticals has been replenished by new agents (linaclotide, prucalopride), increasing efficacy of IBS and CFC treatment.Conclusion. …”
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Safety profiles of sevoflurane in pediatric patients: a real-world pharmacovigilance assessment based on the FAERS database by Chuang Yang, Bangjian Deng, Qiang Wen, Pei Guo, Xiang Liu, Chen Wang

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Energy transfer aspects of chemically reactive Casson fluid between a conical gap of cone-disk system with multiple rotations by M. Qamar, M. Khan, A.S. Alqahtani, M.Y. Malik

“…Casson fluids have been widely used in engineering and biotechnology including, energy systems, polymer fluids, pharmaceuticals, chocolate, automotive industries, blood, and honey. …”
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Comparison of clinical and pharmacodynamic features of proton pump inhibitors efficacy in gastroesophageal reflux disease by O. A. Storonova, A. S. Trukhmanov

“…PPI are the most effective pharmaceuticals for treatment of acid-related diseases (ARD). …”
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Alcohol, alcoholism and related consequences by M. V. Mayevskaya

“…Successful campaign against alcoholism is possible only at application of all resources: strategy of the state, involvement of internist doctors in problem decision (application of motivational conversation technic), pharmaceutical therapy directed on reduction of amount alcoholic drinks.…”
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Control of atropoisomerism: an access to valuable compounds by Choppin, Sabine, Wencel-Delord, Joanna, Colobert, Françoise

“…Atropoisomerism is well-known in biaryls, however this phenomenon is encountered in many pharmaceutically relevant compounds such as heterobiaryl, diarylamines, benzamides and anilides.Currently four FDA-approved drugs are atropostable and many others are in clinical trials. …”
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Drug-induced liver injuries (Part 1) by S. F. Galimova

“…DILI can progress under the mask of all known acute and chronic liver diseases. Pharmaceuticals act as one of the leading causes of development of fulminant liver failure in many countries of the world. …”
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Efficacy of silymarinum at chronic diffuse liver diseases by A. V. Matvieiev, E. I. Konyaeva, N. V. Matvieieva

“…Analysis of literary data demonstrated, that silymarinum is a safe pharmaceutical and, despite of a plenty of clinical and experimental publications, its efficacy at alcoholic liver disease and primary biliary cirrhosis requires further studying as series of systematic reviews and metaanalyses are subject for discussion due to the absence of uniform methodological approaches, application of drugs with different pharmakokinetics and because of ignoring of evidencebased medicine requirements.Conclusion. …”
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Metabolomic profiles as a new understanding of disease processes by O. Yu. Zolnikova, M. S. Reshetova, M. N. Ivanova, V. T. Ivashkin

“…These results define new potential therapeutic strategies, making metabolomics useful for a wide range of biomedical and pharmaceutical research.Conclusion. Metabolomic profile changes in different types of diseases will help to improve understanding of the pathogenesis. …”
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The need for Open Labs for fostering interdisciplinarities in Modern Chemistry. Biocatalysis: a necessary tool for synthetic chemists by Martin, Juliette

“…However, enzymatic catalysis is a mature technology, and this should encourage more chemists to take further ownership and expand applications in modern chemistry.In the industrial sector, some pharmaceutical companies have been pioneers in the use and acceptance of biocatalysis for the unique properties that enzymes can deliver. …”
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Some Bioactivities of Limonium meyeri Extracts and their Separated Compounds by Masum Sami, Esen Sezen Karaoğlan, Hayrunisa Hancı, Cavit Kazaz

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Natural compounds from medicinal plants against COVID-19 by Anton Kolodnitsky, Nikita Ionov, Irina Gravel, Vladimir Poroikov

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A multicenter, cross‐sectional analysis to assess the safety and usage pattern of brivaracetam in the management of partial‐onset seizure with BAEs—BREEZE study: A post‐hoc analysi... by Arvind Sharma, Krishnaprasad Korukonda, Amit Haldar, Usha Kant Misra, R. V. Anand, Yakshdeep Dave, Girish Kulkarni

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