Pantoprazole – safety in drug-drug interaction by E. V. Shikh, D. A. Sychev

“…To carry out comparative analysis of metabolic pathways of proton pump inhibitors (PPI), to determine the agent with lowest effect on activity of cytochrome CYP2C19 isoenzyme for improvement of safety of combined treatment by pharmaceuticals metabolized by this isoenzyme.Key points. …”
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Up-to-date approaches to treatment of the functional constipation at children by V. F. Privorotsky, N. Ye. Luppova

“…In the literature there are data indicating safety and high performance of this pharmaceutical agent.Conclusion. Rome criteria of IBS are applicable only in relation to children of middle and senior school age. …”
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Research Progress on Enzymatic Preparation and Functional Properties of Bioactive Peptides in Hairtail by Yuanyuan WU, Kewei ZHENG, Wenzhu LI, Cheng LI, Xiaojun YAN, Qingbao MA, Wei JIANG

“…The simple preparation process and diverse bioactivity of hairtail-derived bioactive peptides present broad application prospects in the food industry, health products, and pharmaceuticals.…”
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Physician Perspectives on the Potential Benefits and Risks of Applying Artificial Intelligence in Psychiatric Medicine: Qualitative Study by Austin M Stroud, Susan H Curtis, Isabel B Weir, Jeremiah J Stout, Barbara A Barry, William V Bobo, Arjun P Athreya, Richard R Sharp

“…ResultsPhysicians highlighted multiple potential benefits of AI tools, including potential support for optimizing pharmaceutical efficacy, reducing administrative burden, aiding shared decision-making, and increasing access to health services, and were optimistic about the long-term impact of these technologies. …”
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Nuclear receptors in regulation of bile acids transport and metabolism by A. F. Sheptulina, Ye. N. Shirokova, V. T. Ivashkin

“…Accumulation of data on metabolism and transport of BA under physiological and cholestatic conditions allows not only to explain the mechanism of action of the drugs empericaly utilized for treatment of cholestasis for many years, but also to develop new, probably, more effective pharmaceuticals. So, it is supposed, that application of nuclear receptor ligands will help to boost hepatocyte protection mechanisms, and, hence, to slow down or arrest progression of disease.…”
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Significance, pharmacological properties, and industrial applications of bael (Aegle marmelos): A review of current knowledge by Farina Mujeeb, Ahamad Faiz Khan, Vinay Kumar Pandey, Ashapurna Sinha, Mukul Machhindra Barwant, Sarvesh Rustagi, Béla Kovács, Ayaz Mukarram Shaikh

“…One way to replicate the therapeutic capabilities of Bael across a wide range of illnesses in the pharmaceutical industry is to formulate bioactive compounds derived from Bael extracts and compounds into medicines for the treatment of diabetes, gastrointestinal problems, or skin ailments. …”
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The Lignicolous Fungus Hericium erinaceus (Lion’s Mane Mushroom): A Promising Natural Source of Antiradical and DPPH Inhibitory Agents by Akbar Jahedi, Saeideh Ahmadifar, Rahman Mohammadi, Ebrahim Mohammadi Goltapeh

“…Nowadays, the importance of the genus Hericium is increasing due to its nutraceutical and pharmaceutical properties. The main idea of this study is to ingenious management of these wastes to achieve the highest performance of nutrients, minerals, and antioxidant properties using enriched agricultural waste. …”
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Editorial: Exploring small molecule inhibitors in cardiovascular and cerebrovascular diseases by Basveshwar Gawali, Shweta Shrivastava, R. Uday Kumar, Satyendra Kumar Rajput, Manish Kumar Jeengar

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Multimodal lung cancer theranostics via manganese phosphate/quercetin particle by Chong Qiu, Fei Xia, Qingchao Tu, Huan Tang, Yinan Liu, Hongda Liu, Chen Wang, HaiLu Yao, Linying Zhong, Yuanfeng Fu, Pengbo Guo, Weiqi Chen, Xinyu Zhou, Li Zou, Licheng Gan, Jiawei Yan, Yichong Hou, Junzhe Zhang, Huanhuan Pang, Yuqing Meng, Qiaoli Shi, Guang Han, Xijun Wang, Jigang Wang

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Risk Factors for the Occurrence of Depressive Disorders in Pediatric Patients With Tuberculosis by Mihailov OM, Stavar Matei L, Tocu G, Ciubara A, Mihailov R

“…Oana Mariana Mihailov,1,2 Loredana Stavar Matei,2 George Tocu,3 Anamaria Ciubara,2 Raul Mihailov4 1Children Pneumology Department, Pneumophthisiology Hospital “Sfântul Spiridon” of Galati, Galați, 800198, Romania; 2Clinical Medicine Department, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University of Galati, Galați, 800008, Romania; 3Pharmaceutical Science Department, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University of Galati, Galați, 800008, Romania; 4Clinical Surgery department, Faculty of Medicine and Pharmacy, “dunărea de Jos” University of Galati, Galați, 800008, RomaniaCorrespondence: George Tocu, Pharmaceutical science department, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University of Galati, Galați, 800008, Romania, Tel +40773819438, Email [email protected]: Tuberculosis (TB) is one of the oldest and most persistent infectious diseases, continuing to pose a significant public health challenge worldwide. …”
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A Rare Case of Spontaneous Heterotopic Pregnancy at 12 weeks of Gestation Following Natural Conception With Literature Review by Wang F, Xu Y, Dong X, Jiang P, Yu QQ

“…Fei Wang,1,* Yuting Xu,1,* Xin Dong,2 Pei Jiang,3 Qing-Qing Yu4 1Department of Gynecology, Jining No.1 People’s Hospital, Jining, People’s Republic of China; 2Department of Ultrasonography, Jining No.1 People’s Hospital, Jining, People’s Republic of China; 3Translational Pharmaceutical Laboratory, Jining NO.1 People’s Hospital Jining, People’s Republic of China; 4Clinical Research Center, Jining NO.1 People’s Hospital, Jining, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qing-Qing Yu, Clinical Research Center, Jining No.1 People’s Hospital, Jining, People’s Republic of China, 272011, Email [email protected] Pei Jiang, Translational Pharmaceutical Laboratory, Jining No.1 People’s Hospital, Jining, 272011, People’s Republic of China, Email [email protected]: Spontaneous heterotopic pregnancy is an uncommon and possibly serious problem characterized by maternities at unique implantation sites, with only one occurring in the intrauterine cavity. …”
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ENO1/Hsp70 Interaction Domains: In Silico and In Vitro Insight for a Putative Therapeutic Target in Cancer by Maria Rita Gulotta, Ugo Perricone, Patrizia Rubino, Angela Bonura, Salvatore Feo, Agata Giallongo, Giovanni Perconti

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Principles of management of patient with asymptomatic elevation of serum aminotransferases by Ye. N. German, M. V. Mayevskaya, Ye. O. Lyusina, V. T. Ivashkin

“…According to past history it was known: the patient is non-smoker, absolutely denies use of pharmaceuticals and alcohol abuse. At physical examination excessive body weight (BMI of 31 kg/m2) drew attention. …”
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Investigation of new exopolysaccharides produced by strains of donkey milk by Arevik Israyelyan, Tsovinar Balabekyan, Lara Aleksanyan, Inesa Sahakyan, Anna Gasparyan, Flora Тkhruni

“…Conclusion: The obtained results were shown that strains isolated from fermented donkey milk that are capable of synthesizing two substances of different nature with high antimicrobial properties during the growth process are promising for further research and application for their use as probiotics and biopreparations in pharmaceuticals. …”
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A split intein and split luciferase-coupled system for detecting protein-protein interactions by Zhong Yao, Jiyoon Kim, Betty Geng, Jinkun Chen, Victoria Wong, Anna Lyakisheva, Jamie Snider, Marina Rudan Dimlić, Sanda Raić, Igor Stagljar

“…Recently, PPIs have started to be exploited for drug discovery purposes and have thus attracted much attention from both the academic and pharmaceutical sectors. We previously developed a sensitive method, Split Intein-Mediated Protein Ligation (SIMPL), for detecting binary PPIs via irreversible splicing of the interacting proteins being investigated. …”
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XGBoost-enhanced ensemble model using discriminative hybrid features for the prediction of sumoylation sites by Salman Khan, Sumaiya Noor, Tahir Javed, Afshan Naseem, Fahad Aslam, Salman A. AlQahtani, Nijad Ahmad

“…The model’s reliability and high performance make it a valuable resource for researchers, with strong potential for applications in pharmaceutical development.…”
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Ultrasonic preparation, structural characterization and functional enhancement of thyme essential oil-loaded microcapsules based on mannosylerythritol lipid-A by Shunjie Kang, Qihe Chen, Haorui Ma, Jiwei Ding, Changchun Hao, Qin Shu, Yongfeng Liu

“…Mannosylerythritol lipid-A (MEL-A) is a kind of novel biosurfactant and has great potential to apply into food and pharmaceutical field with its outstanding physicochemical and biological property. …”
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Exploring the Evolution and Diverse Applications of Immobilized Glucose Oxidase: A Comprehensive Review by G. Sreenivasulu, R.Ramakoteswara Rao

“…The widespread applications of glucose oxidase have garnered significant attention across diverse industries such as chemical, pharmaceutical, food and beverage, clinical chemistry, biotechnology, and others. …”
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Efficient voltammetric platform combining a molecularly imprinted polymer and silver-nanoparticle-decorated black phosphorus nanosheets for selective determination of Gatifloxacin by Jingtao Wu, Yonghui Xia, Tianyu Wang, Yafeng Zhang, Guangli Li

“…The applicability of MIP/BPNS-AgNP/GCE toward the detection of GAT in pharmaceutical formulations, milk, and human serum was verified with satisfactory results.…”
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Determination of Calcium Carbonate Content in Eggshells of Different Types (White and Brown Egg shells). by Namutebi, Joweria

“…This study was designed to evaluate the calcium carbonate in different hens' eggshells because it has a potential application in the development of a new option for pharmaceutical excipients. Egg shells are a rich source of mineral salts, mainly calcium carbonate, which is probably the best natural source of calcium and it is about 90% absorbable. …”
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