deutetrabenazine for the treatment of chorea associated with Huntington’s disease by Harshit Gupta, Wil Perkins, Cain Stark, Sathya Kikkeri, Juyeon Kakazu, Adam D. Kaye, Alan D. Kaye

“…Thus, management is primarily focused on symptom management with the use of a variety of pharmaceutical agents. Chorea is one of the many manifestations that significantly alter the quality of life of many patients. …”
Get full text

Case report: Bevacizumab-induced cerebrovascular events: a case series report and literature review by Ke Chen, Boyang Jiang, Boyang Jiang, Huiping Yan, Huiping Yan, Liu Yang, Liu Yang, Zheling Chen, Zheling Chen

“…In clinical use, bevacizumab has improved the overall survival (OS) and progression-free survival (PFS) of malignant solid tumors, and the safe use of bevacizumab has gradually become the mainstream direction of clinical, nursing and pharmaceutical research. Bevacizumab is a humanized anti-VEGF drug. …”
Get full text

Advanced Techniques for Glucose Oxidase Immobilization: Evolution, Computational Integration, and Biomedical Applications by G Sreenivasulu, R. Ramakoteswara Rao

“…Glucose oxidase is a crucial enzyme used in industries such as chemicals, pharmaceuticals, food, and biotechnology due to its ability to oxidize glucose into hydrogen peroxide and gluconic acid (C6H12O7). …”
Get full text

Deciphering the Immune Subtypes and Signature Genes: A Novel Approach Towards Diagnosing and Prognosticating Severe Asthma Through Interpretable Machine Learning by Yue Hu, Yating Lin, Bo Peng, Chunyan Xiang, Wei Tang

“…While many manage their symptoms through pharmaceutical interventions and self-care, a significant subset grapples with severe asthma, posing therapeutic challenges. …”
Get full text

Advancements in 3D printing technologies for personalized treatment of osteonecrosis of the femoral head by Tingting Chen, Lincong Luo, Jiaying Li, Jiamin Li, Tao Lin, Mingrui Liu, Hang Sang, Xinyu Hong, Jiahao Pu, Wenhua Huang

“…Three-dimensional (3D) printing technology has shown significant promise in the medical field, particularly in orthopedics, prosthetics, tissue engineering, and pharmaceutical preparations. This review focuses on the innovative application of 3D printing in addressing the challenges of osteonecrosis of the femoral head (ONFH). …”
Get full text

Anti-TNBC effects of Lappaol F by targeting epithelial-mesenchymal transition via regulation of GSK-3β/YAP/β-catenin and PI3K/AKT pathways by Qiqi Meng, Qiqi Meng, Zhiping Li, Xiaofeng He, Yuanhao Hu, Guiyun Wu, Jiawen Huang, Zhuohui Luo, Zhuohui Luo, Yingjie Hu, Xiaoling Shen

Get full text

AxiWorm: a new tool using YOLOv5 to test antiparasitic drugs against Trichinella spiralis by Javier Sánchez-Montejo, Miguel Marín, María Alejandra Villamizar-Monsalve, María del Carmen Vieira, Belén Vicente, Rafael Peláez, Julio López-Abán, Antonio Muro

Get full text

Safety and efficacy of switching from adalimumab to sarilumab in patients with rheumatoid arthritis in the ongoing MONARCH open-label extension by Gerd R Burmester, Mark C Genovese, Vibeke Strand, Gregory St John, Andrea Rubbert-Roth, Howard Amital, Tatiana Raskina, Antonio Gómez-Centeno, Claudia Pena-Rossi, Leon Gervitz, Karthinathan Thangavelu, Susan Boklage

Get full text

Global disparities in cancer supportive care: An international survey by Alexandre Chan, Lawson Eng, Changchuan Jiang, Mary Dagsi, Yu Ke, Mary Tanay, Cristiane Bergerot, Niharika Dixit, Ana Cardeña Gutiérrez, Ana I. Velazquez, Farhad Islami, Enrique Soto‐Perez‐de‐Celis

Get full text

Biodistribution of 89Zr-Radiolabeled Nanoassemblies for Monoclonal Antibody Delivery Revealed through In Vivo PET Imaging by Ana M. López-Estévez, Amaia Carrascal-Miniño, Dolores Torres, María José Alonso, Rafael T. M. de Rosales, Juan Pellico

Get full text

Резолюция Экспертного совета «Диагностика и лечение больных со сладжем в желчном пузыре» by V. T. Ivashkin, Alexey V. Okhlobystin, Dmitry S. Bordin, M. F. Osipenko, E. Ya. Seleznyova, Yu. O. Shulpekova, S. R. Abdulkhakov, O. P. Alexseyeva, I. G. Bakulin, L. G. Vologjhanina, V. B. Grinevich, N. V. Bakulina, T. A. Kolesova, N. V. Korochanskaya, I. V. Putintseva, A. S. Sarsenbayeva, N. S. Yazenok

“…Selective antispasmodic medications (e.g. hymecromone) will be one of the basic pharmaceutical agents in this case, indications to endoscopic treatment should be evaluated, typically - by means of endoscopic ultrasound investigation). …”
Get full text

Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women by Katja Graf, José Martin Murrieta-Coxca, Tobias Vogt, Sophie Besser, Daria Geilen, Tim Kaden, Tim Kaden, Anne-Katrin Bothe, Diana Maria Morales-Prieto, Behnam Amiri, Behnam Amiri, Stephan Schaller, Ligaya Kaufmann, Martin Raasch, Ramy M. Ammar, Ramy M. Ammar, Christian Maass, Christian Maass

“…BackgroundPregnant women represent a vulnerable group in pharmaceutical research due to limited knowledge about drug metabolism and safety of commonly used corticosteroids like prednisone due to ethical and practical constraints. …”
Get full text

Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases by Jialian Lv, Xinyue Song, Zixin Luo, Duoqin Huang, Li Xiao, Kang Zou

“…These challenges can be addressed by modifying the chemical structure and enhancing pharmaceutical formulations. We summarized the research advancements in improving the solubility and bioavailability of luteolin, as well as the effects of luteolin on various pulmonary diseases and their related mechanisms, with the aim of providing new ideas for researchers.…”
Get full text

Management of adult patients with alcoholic liver disease: clinical guidelines of the Russian Scientific Liver Society by V. T. Ivashkin, M. V. Mayevskaya, Ch. S. Pavlov, Yu. P. Sivolap, V. D. Lunkov, M. S. Zharkova, R. V. Maslennikov

“…Short therapeutic interventions practice helps to cope with alcoholic issue at any stage, gives the chance to motivate the patient, including the treatment of addiction to alcohol, intake of drugs. Specific pharmaceutical therapy is carried out at alcoholic hepatitis in relation to severity and alcoholic liver cirrhosis. …”
Get full text

Treatment compliance at initial and maintenance therapy at gastroesophageal reflux disease by V. I. Simanenkov, S. V. Tikhonov, N. B. Lischuk

“…Treatment compliance was established according to duration of study participation, along with that patients self-estimated it on 2, 3, 4 and 5 visits by Morisky-Green test and 5-score analog scales of pharmaceutical treatment compliance and lifestyle verification. …”
Get full text

One-pot green synthesis of BSA-capped O-CQDs as an effective fluorescent sensing platform for sensitive and selective detection of promethazine drug by S. Viji, A. Dinesh, K. Radhakrishnan, L. Srimathi Priya, C. Sivasankari, Madhappan Santhamoorthy, Manikandan Ayyar, V. Mohanavel, Mohamed Hashem, Hassan Fouad, G. Ramachandran, S. Santhoshkumar

“…The primary advantages of this technique include simplified sample preparation together with economic advantages which make it a critical instrument for public health monitoring as well as cutting-edge pharmaceutical research. Sustainable O-CQDs demonstrate the potential for creating environmentally friendly biosensors.…”
Get full text

Pervasive systemic disparities: medical-related gaslighting, trauma, and distrust among LGBTQ+ people in the United States by Dustin Z. Nowaskie, Dehandra Blackwood, Frank Garcia

“…Likewise, LGBTQ+ people conveyed significantly less trust (ORs 0.46–0.53) in primary care providers (59.8% vs. 74.1%), medical specialists (56.5% vs. 71.7%), pharmaceutical companies (17% vs. 28%), insurance companies (15.9% vs. 29.3%), and U.S. healthcare systems (17.8% vs. 30.4%).DiscussionMedical-related gaslighting, trauma, and distrust are pervasive systemic disparities among LGBTQ+ people. …”
Get full text

Ideologization and commercialization in pandemic management by Anđelković Maja, Radosavljević Milan, Radosavljević Dragana

“…The crisis of the pandemic and the fight against it is aggravated by migration, environmental, economic and other crises, which means that these are integrated crises to which an integrated or holistic response should be given. Medical and pharmaceutical science and the profession found themselves in a delicate situation, to respond to the challenges of mass infection with the C-19 virus, and both were not prepared to respond to the pandemic, and this disorientation caused "cracks" that led to undermined public confidence in medicine and the subordination of the medical profession to politics. …”
Get full text

Solubility of gemcitabine (an anticancer drug) in supercritical carbon dioxide green solvent: Experimental measurement and thermodynamic modeling by Gholamhossein Sodeifian, Masturah Markom, Jarinah Mohd Ali, Muhammad Zulhaziman Mat Salleh, Reza Derakhsheshpour

“…Abstract In order to develop supercritical fluid (SCF) processes for the micro or nanosizing of solid solute components, such as pharmaceuticals, it is essential to assess their solubility in solvents including supercritical carbon dioxide (SC–CO2). …”
Get full text

Evaluation and testing of polymethylmetacrylic (PMMA) bone cements with admixed Amphotericin B by Florian A. Frank, Barbara Krampitz, Julia Steiner, Rainer Strathausen, Mario Morgenstern, Martin Clauss, Klaus-Dieter Kühn

“…PMMA mixed with such pharmaceutical Amphotericin B formulations colored the cement orange. …”
Get full text