RECK as a Potential Crucial Molecule for the Targeted Treatment of Sepsis by Qin Y, Liao S, Sun J, Ye H, Li J, Pan J, He J, Xia Z, Shao Y

“…Yuting Qin,1,* Shuanglin Liao,1,* Jianbo Sun,2 Huiyun Ye,1 Jiafu Li,1 Jiahui Pan,1 Junbing He,3 Zhengyuan Xia,4,5 Yiming Shao1,6 1Dongguan Key Laboratory of Sepsis Translational Medicine, The Intensive Care Unit, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, Guangdong, People’s Republic of China; 2Dongguan Key Laboratory of Chronic Inflammatory Diseases, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, Guangdong, People’s Republic of China; 3The Key Laboratory of Organ Dysfunction and Protection Translational Medicine, Jieyang Medical Research Center, Jieyang People’s Hospital, Jieyang, Guangdong, People’s Republic of China; 4Department of Anesthesiology and Perioperative Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, People’s Republic of China; 5State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, People’s Republic of China; 6The Key Laboratory of Sepsis Translational Medicine, Guangdong Medical University, Zhanjiang, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yiming Shao, Dongguan Key Laboratory of Sepsis Translational Medicine, the Intensive Care Unit,The First Dongguan Affiliated Hospital, Guangdong Medical University, Jiaoping Road 42, Tangxia Town, Dongguan, Guangdong Province, 523710, People’s Republic of China, Tel +86 18826690188, Email [email protected] Zhengyuan Xia, Department of Anesthesiology and Perioperative Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, People’s Republic of China, Tel +852-68798794, Email [email protected]: Reversion inducing cysteine rich protein with kazal motifs (RECK), a Kazal motif-containing protein, regulates pro-inflammatory cytokines production, migration of inflammatory cells, vascular endothelial growth factor (VEGF) and Wnt pathways and plays critical roles in septic inflammatory storms and vascular endothelial dysfunction. …”
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Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors by Alessandro Papale, Ilaria Maria Morella, Marzia Tina Indrigo, Rick Eugene Bernardi, Livia Marrone, Francesca Marchisella, Andrea Brancale, Rainer Spanagel, Riccardo Brambilla, Stefania Fasano

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A patient-centered interactive voice response system for supporting self-management in kidney transplantation: design and field testing by Raheleh Ganjali, Raheleh Ganjali, Mahin Ghorban Sabbagh, Mahin Ghorban Sabbagh, Saeid Eslami, Saeid Eslami

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Economic and Clinical Impact of Stroke and Warfarin Use for Patients with Non-valvular Atrial Fibrillation by Li Wang, Elyse Fritschel, Onur Baser

“…For all groups, demographic, clinical, and pharmaceutical characteristics were analyzed descriptively. …”
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Efficacy in Japanese adults with growth hormone deficiency receiving weekly somapacitan or daily growth hormone: results from phase 3 REAL 1 trial by Fumio Otsuka, Michael Højby Rasmussen, Takaaki Endo, Claus Sværke, Shigeyuki Tahara, Gudmundur Johannsson

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Quzhou Aurantii Fructus Flavonoids Ameliorate Inflammatory Responses, Intestinal Barrier Dysfunction in DSS-Induced Colitis by Modulating PI3K/AKT Signaling Pathway and Gut Microbi... by Wang H, Huang W, Pan X, Tian M, Chen J, Liu X, Li Q, Qi J, Ye Y, Gao L

“…Haiou Wang,1 Wenkang Huang,1 Xiaoya Pan,1 Meizi Tian,1 Jiahui Chen,1 Xiaotong Liu,1 Qin Li,1 Jianhua Qi,2 Yiping Ye,1 Lijuan Gao1 1School of Pharmacy, Hangzhou Medical College, Hangzhou, 310013, People’s Republic of China; 2College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, People’s Republic of ChinaCorrespondence: Lijuan Gao; Yiping Ye, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou, Zhejiang, 310013, People’s Republic of China, Email [email protected]; [email protected]: To explore the protective effect and underlying mechanism of Quzhou Aurantii Fructus flavonoids (QAFF) on Ulcerative colitis (UC).Methods: The constituents of QAFF were accurately determined by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). …”
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ASSESSMENT OF THE REGION'S INVESTMENT ENVIRONMENT AND POLICY INSTRUMENTS FOR THE IMPLEMENTATION OF ITS INVESTMENT POTENTIAL IN WARTIME by Ruslan Boiko, Roman Martsenyuk, Arsen Protsykevych

“…It is substantiated that effective instruments of regional investment policy in the context of critical instability are: military risk insurance and diversification; use of concession agreements; private and public investments in the defence industry and critical infrastructure industries/sectors (energy, transport and logistics, medicine and pharmaceuticals, natural resources); support for innovative and technological startups in the areas of security, the real economy and infrastructure; stimulation of investments in human resources; support for investments in business projects of demobilised persons, war veterans and other combatants; encouragement of investments in the development of export potential to maintain the country's financial security.…”
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Long-term results of irritable bowel syndrome treatment by A. I. Ulyanin, Yu. M. Poluektov, Ye. A. Poluektova, Ch. S. Pavlov, V. T. Ivashkin

“…In 30 days secession of pharmaceutical therapy 73.3% of patients with IBS-D who received probiotic therapy during relapse maintained clinical remission, 75% of patients often motility regulator treatment and 60% of those who received antispasmodic medications. …”
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Penerapan Model Enterprise Architecture Cube Pada Perencanaan Strategi Sistem Dan Teknologi Informasi by Delia Apriana, Sawali Wahyu

“…Abstrack   Afdhal Pharmacy is an enterprise engaged in the pharmaceutical sector as a drug provider. In carrying out its business processes there are problems at Afdhal Pharmacy, namely ordering goods to suppliers still relying on bookkeeping for recording goods data resulting in errors in goods data collection such as lagging data on goods that should be recorded and delays in ordering goods. …”
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Presenting a Leadership Empowerment Model through Sense-making by Using the Cognitive and Behavioral Scripts by Hamid Zare, Aliasghar Pourezzat, Hasan Zareei Matin, Arezoo Salmani

“…In this extensive study, a total of 111 randomly selected groups operating at various organizational levels within companies active in the pharmaceutical industry were meticulously examined to gather a broad spectrum of insights. …”
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Optimizing Risk-based Stock Return Prediction in Tehran Stock Exchange industries: A Data Envelopment Analysis by Hamidreza Akhbari, Heydar Mohammadzadeh Salteh, Rasoul Baradaran Hassanzadeh, Mehdi Zeynali

“…Future research should explore and assess the optimization of stock return forecasting in other significant industries like pharmaceuticals, electricity, steam, hot water supply, etc. to compare and evaluate their outcomes alongside the findings of this study.…”
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Phase II trial of nab-paclitaxel plus ramucirumab in combination with nivolumab for unresectable advanced or recurrent gastric cancer after progression on first-line treatment incl... by Hidekazu Hirano, Naoki Takahashi, Yusuke Amanuma, Nobumi Suzuki, Daisuke Takahari, Takeshi Kawakami, Chie Kudo-Saito, Kengo Nagashima, Narikazu Boku, Ken Kato, Hirokazu Shoji

“…Methods The PADDLE trial, which is sponsored by Ono Pharmaceutical, is an investigator-initiated, multicenter, open-label, single-arm, prospective phase II trial conducted at six institutions in Japan. …”
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Metabolite profile and antioxidant activities of Trikatu, black pepper, Javanese long pepper, and red ginger essential oils by Dewa Ayu Ika Pramitha, Tati Herlina, Iman Permana Maksum, Ari Hardianto, Abd. Wahid Rizaldi Akili, Jalifah Latip

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Internet-based cognitive–behavioural therapy for insomnia (ICBT-i): a meta-analysis of randomised controlled trials by Jia Chen, Juan Liu, Yuan-yuan Ye, Ni-ka Chen, Ling Lin, Ya-zhen Liu, Ying Lang, Xun-jun Li, Xin-ju Yang, Xiao-jiang Jiang

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Phytochemical study and evaluation of the antidiabetic and antihyperglycemic activities of the fruit extracts of Physalis peruviana L. (Solanaceae) by Damien S.T. Tshibangu, Fortune S. Kavugho, Carlos N. Kabengele, Adrien T. Masunda, Gédéon N. Bongo, Giresse N. Kasiama, Domaine T. Mwanangombo, Clément L. Inkoto, Clément M. Mbadiko, Benjamin Z. Gbolo, Désiré M. Musuyu, Dorothée D. Tshilanda, Jean Paul K.N. Ngbolua, Pius T. Mpiana

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The relationship between vision status and its influencing factors among primary and secondary school students: The masking effect of physical activity level and the moderating eff... by Jiyan Xu, Yanjun Li, Siyuan Ma, Shimeng Dai, Weiwei Xu, Mengjiao Sang, Kaijie Feng

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Lutein and inflammation: a comprehensive review of its mechanisms of action by Paradentavida Prathyusha, Geetha Viswanathan, Anjilikal Tomy Tomcy, Ponnamparambil P. Binitha, Smitha V. Bava, Edakkadath R. Sindhu

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Shift from chronic to episodic migraine frequency in a long-term phase 3 study of galcanezumab by Hans-Christoph Diener, Kathleen A. Day, Sarah Lipsius, Sheena K. Aurora, Nada A. Hindiyeh, Holland C. Detke

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Efficacy of non-invasive ventilation and oxygen therapy on immunocompromised patients with acute hypoxaemic respiratory failure: protocol for a systematic review and meta-analysis... by Juhong Shi, Gang Liu, Meng Wang, Tao Wang, Yi Li, Yi Yang, Xuezhong Yu, Huadong Zhu, Yong Ma, Zongru Li, Lixi Zhang, Kun He, Jianqiang He

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Amebicidal and Antiadhesion Activities of Knema retusa Extract Against Acanthamoeba triangularis T4 Genotype on Contact Lenses and Modeling Simulation of Its Main Compound, E2N, Ag... by Watcharapong Mitsuwan, Imran Sama-ae, Suthinee Sangkanu, Dhrubo Ahmed Khan, Partha Biswas, Md. Nazmul Hasan, Julalak Chuprom, Tajudeen O. Jimoh, Christophe Wiart, Masyitah Binti Zulkipli, Nor Hayati Abdullah, Maria de Lourdes Pereira, Sonia M. Rodrigues Oliveira, Shanmuga Sundar Saravanabhavan, Polrat Wilairatana, Tooba Mahboob, Veeranoot Nissapatorn

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