Prucalopride in treatment of functional chronic constipation by A. A. Sheptulin

“…It is important, that the agent has no cardiotoxic effect and does not increase the length of Q–T interval.Conclusion. Prucalopride can be recommended for treatment of functional chronic constipation, first of all – in women, resistant to laxatives.…”
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Analysis of long noncoding gene expression and its interactions with protein-coding genes in vascular endothelial cells in keloids by Yunxiang Luo, Zi Ye, Yi Li, Chau Wei Wong, Shuqia Xu, Yu Deng, Zhicheng Su, Xueqing Li, Yingxiong Huang, Bing Han

“…Magnetic Sorting of VECs and qRT-PCR were used to verify these bioinformatic results. …”
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Genome wide identification of Dof transcription factors in Carmine radish reveals RsDof33 role in cadmium stress and anthocyanin biosynthesis by Caiming Gou, Jia Li, Bo Chen, Guoting Cheng, Zhangfei Zheng, Hua Peng, Ahmed H. El-Sappah

“…Cd stress-induced RsDof expression patterns were studied using an RNA-seq atlas and qRT-PCR. The majority of RsDofs were tissue-specific and Cd-sensitive. …”
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Functional analysis of heterozygous variants in the SALL1 gene in 2 children with Townes-Brocks syndrome with FSGS by Rong Liang, Bixia Zheng, Chunli Wang, Sanlong Zhao, Wei Zhou, Ying Chen, Ruochen Che

“…The expression level of variant c.3175 C > T(p.Q1059X) in podocytes showed a significant decrease compared to that of the wild-type (P < 0.05), whereas variant c.694 C > T(p.Q232X) was markedly upregulated (P < 0.01). …”
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Identification of prognostic biomarker of non-small cell lung cancer based on mitochondrial permeability transition-driven necrosis-related genes and determination of anti-tumor ef... by Zhifei Ma, Wen Chen, Aiping Zhang, Xiaokang Shen, Lin Zheng

“…Expression levels of MPTDN-related biomarkers were detected using RT-qPCR in NSCLC tissues and cells. Moreover, the biological function of ARL14 in NSLCL was verified in vitro. …”
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Using computer modeling to find new LRRK2 inhibitors for parkinson’s disease by María C. García, Sebastián A. Cuesta, José R. Mora, Jose L. Paz, Yovani Marrero-Ponce, Frank Alexis, Edgar A. Márquez

“…The best ensemble model showed exceptional predictive performance, with five-fold cross-validation and external validation metrics exceeding 0.8 (Q2cv = 0.864 and Q2ext = 0.873). The DrugBank screening resulted in three promising drugs—triamterene, phenazopyridine, and CRA_1801—with predicted pIC50 values greater than 7, warranting further investigation as novel PD treatments. …”
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Rational design of novel phenol ether derivatives as non-covalent proteasome inhibitors through 3D-QSAR, molecular docking and ADMET prediction by Miao Yuan, Hanwen Ji, Fengxin Sun, Qiang Chen, Ping Cheng

“…Results: In this study, the structure-activity relationship (SAR) of a series of non-covalent proteasome inhibitors were studied and the optimal comparative molecular field analysis (CoMFA; Q2 = 0.574, r2 = 0.999, r2pred = 0.755) and comparative molecular similarity indices analysis (CoMSIA)-SEHA (Q2 = 0.584, r2 = 0.989, r2pred = 0.921) models were obtained. …”
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Endoplasmic reticulum stress-related CLIP4 plays a procarcinogenic role in hepatocellular carcinoma: an integrated analysis by Anqi Wang, Sitong Yan, Weijia Jiang, Xiang Chen, Yuhan Huang, Xiangyu Zu, Xiao Du, Lulu Fan, Jiatao Liu, Guoping Sun

“…RNA-seq, immunohistochemistry, western blotting, and RT-qPCR were used to verify the effect of ERS on CLIP4 expression. …”
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Cerebellar lipid dysregulation in SCA3: A comparative study in patients and mice by Alexandra F. Putka, Varshasnata Mohanty, Stephanie M. Cologna, Hayley S. McLoughlin

“…Lipid downregulation was recapitulated in early- to mid-stage mouse models of SCA3, including transgenic YACQ84 and Knock-in Q300 mice. End-stage Knock-in Q300 mice displayed a progressive reduction in lipid content, highlighting targets that could benefit from early therapeutic intervention. …”
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Trichinella spiralis excretory/secretory proteins mediated larval invasion via inducing gut epithelial apoptosis and barrier disruption. by Qi Qi Lu, Wen Wen Zheng, Zhao Yu Zhang, Pei Kun Cong, Xin Guo, Yao Zhang, Xin Zhuo Zhang, Shao Rong Long, Ruo Dan Liu, Zhong Quan Wang, Jing Cui

“…The results of trans-epithelial electrical resistance (TEER) and FITC-dextran showed that IIL ESP decreased the TEER, increased FITC-dextran flux in Caco-2 monolayer. qPCR, Western blot and immunofluorescence test (IFT) showed that IIL ESP decreased the mRNA and protein expression of TJs (ZO-1, E-cad, Occludin and Claudin-1). …”
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Molecular characterization of a rare TP63 variant associated with split-hand/split-foot malformation 4 and incomplete penetrance: disruption of the p63-Dlx signaling pathway by Jianlong Zhuang, Yanqing Li, Yu’e Chen, Hegan Zhang, Shufen Liu, Manman Hu, Chunnuan Chen

“…Whole exome sequencing (WES) was utilized to investigate sequence variants, while RNA sequencing assessed differentially expressed genes, with findings confirmed through quantitative PCR (qPCR). Results Karyotype analysis and CMA revealed no chromosomal abnormalities in the family. …”
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Association between pan-immune-inflammation value and coronary heart disease in elderly population: a cross-sectional study by Ruicong Ma, Jinyi Ren, Xianmei Chen, Xia Li, Ying Zhao, Yanchun Ding

“…In the logistic regression model, PIV was positively related to CHD [Q4 vs. Q1, OR = 1.23 (1.03–1.48, P &lt; 0.001)]. …”
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Associations between nutrient intake and osteoarthritis based on NHANES 1999 to 2018 cross sectional study by Xiaofeng Lv, Xinmin Deng, Rui Lai, Shanshan Liu, Zihao Zou, Xuechun Dai, Yalan Luo, Jian Luo, Ying Li

“…Compared with participants in the lowest quartile (Q1), those in the highest quartile (Q4) of dietary fiber, folic acid, and nicotinic acid intake had 27%, 28%, and 33% lower odds of having OA, respectively, after adjusting for potential confounding factors. …”
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Erbin Regulates Tissue Factors Through Ras/Raf Pathway in Coagulation Disorders in Sepsis by Yang C, Lei C, Jing G, Xia Y, Zhou H, Wu D, Zuo J, Gong H, Wang X, Dong Y, Aidebaike D, Wu X, Song X

“…The protein and mRNA expression level were detected by Western blot and qPCR. Pearson linear correlation analysis was used to analyze the correlation between the inflammation index and the coagulation function index.Results: We confirmed that the Erbin is involved in the regulation of coagulation function by macrophages and plays a role in the coagulation disorder of sepsis. …”
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Optimization of Harvesting Fish Return From Norongoza Pond in Mwanjari Ward Southern Division Kabale Municipality. by Nuwaha, Louis

“…F(x, y) and G(x, y) were redefined to reflect a prey-predator model relationship that is x' = x(Q- ax + by) +h,(t,x) and y' = y(bx- cy + ) + ht,y). …”
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Um teste direto da teoria de renda permanente: o caso brasileiro by Fábio Augusto Reis Gomes

“…Para mensurar esta relação, foi estimado um modelo ARIMA (p,1,q) para a renda corrente e, como resultado, foi possível verificar se as revisões de consumo e renda permanente se assemelham. …”
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La desigualdad económica y la estructura de oportunidades políticas durante las protestas de octubre de 2019 en Ecuador by Pablo Velasco Oña

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Inquiry into the Conceptual Dimensions of Project Portfolio Management by Pedro Bruno de Souza, Jorge Carneiro, Rodrigo Bandeira-de-Mello

“…This study addresses this gap by employing a q ualitative approach to uncover managerial perceptions about what is encompassed by project portfolio management and how the this construct should be evaluated. …”
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Hamiltonian simulation of minimal holographic sparsified SYK model by Raghav G. Jha

“…The circuit complexity for Hamiltonian simulation of the sparsified SYK model with N Majorana fermions and q=4 (quartic interactions), which retains holographic features (referred to as ‘minimal holographic sparsified SYK’) with k≪N3/24 (where k is the total number of interaction terms times 1/N) using the second-order Trotter method and Jordan-Wigner encoding is found to be O˜(kαN3/2log⁡N(Jt)3/2ε−1/2) where t is the simulation time, ε is the desired error in the implementation of the unitary U=exp⁡(−iHt) measured by the operator norm, J is the disorder strength, and constant α<1. …”
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Assessing hemorrhagic risks in combination therapy: implications of angiogenesis inhibitors and immune checkpoint inhibitors by Yuhui Yang, Yuhui Yang, Yuhui Yang, Pingping Long, Pingping Long, Ying Tuo, Ying Tuo, Xiaoxiao Wang

“…ObjectiveThis study aims to evaluate the hemorrhage risk in solid tumor patients receiving angiogenesis inhibitors (AGIs), immune checkpoint inhibitors (ICIs), and their combination using the FDA Adverse Event Reporting System (FAERS) database.MethodsData from Q1 2011 to Q4 2023 were extracted from the FAERS database for solid tumor patients treated with AGIs, ICIs, or their combination. …”
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