A truncated pre-F protein mRNA vaccine elicits an enhanced immune response and protection against respiratory syncytial virus by Min Lin, Yifan Yin, Xiaomeng Zhao, Chen Wang, Xueqing Zhu, Letao Zhan, Li Chen, Siling Wang, Xue Lin, Jun Zhang, Ningshao Xia, Zizheng Zheng

“…In this study, we explored an mRNA vaccine based on a modified pre-F protein called LC2DM-lipid nanoparticle (LC2DM-LNP). …”
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Adipose tissue-derived microRNA-450a-5p induces type 2 diabetes mellitus by downregulating DUSP10 by Jiaojiao Zhu, Yanting Hou, Wei Yu, Jingzhou Wang, Xiaolong Chu, Xueting Zhang, Huai Pang, Dingling Ma, Yihan Tang, Menghuan Li, Chenggang Yuan, Jianxin Xie, Cuizhe Wang, Jun Zhang

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Liver macrophage-derived exosomal miRNA-342-3p promotes liver fibrosis by inhibiting HPCAL1 in stellate cells by Wenshuai Li, Lirong Chen, Qi Zhou, Tiansheng Huang, Wanwei Zheng, Feifei Luo, Zhong Guang Luo, Jun Zhang, Jie Liu

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Circular RNA encoded by PPARG in the peripheral blood and a lipopolysaccharide-induced cardiomyocyte inflammation model is identified as a marker of fulminant myocarditis by Shasha Huang, Shumin He, Fei Xiao, Yang Zhou, Su Lyu

“…Methods Peripheral blood was collected from 5 children with FM and 5 sex- and age-matched healthy controls; total RNA was extracted from each sample, and the extracted RNA from each group was pooled. …”
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Single-cell profiling reveals a reduced epithelial defense system, decreased immune responses and the immune regulatory roles of different fibroblast subpopulations in chronic atro... by Lin Lin, Tingxuan Huang, Lizhi Li, Yang Lin, Feng Chen, Ziyi Zheng, Jie Zhou, Yizhe Wang, Weihao You, Yujie Duan, Yawen An, Shiwei He, Weimin Ye

Subjects: “…Single-cell RNA sequencing (scRNA-seq)…”
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WGCNA and integrative network analysis identify CHRNA5 and CTLA4 as potential therapeutic targets against angiosarcoma by Trishla Bhatnagar, Madiha Haider, Mohd Yasir Khan, Mohammad Zahid Ashraf

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A CRISPR-Cas12a-based universal rapid scrub typhus diagnostic method targeting 16S rRNA of Orientia tsutsugamushi. by Bum Ju Park, Sang Taek Heo, Misun Kim, Jeong Rae Yoo, Eun Jin Bae, Su Yeon Kang, Sunghoon Park, Kyeo Re Han, Keun Hwa Lee, Jae Myun Lee, Hyeyoung Lee, Yoon-Jae Song

“…Here, we developed a CRISPR-Cas12a-based diagnostic method targeting the bacterial 16S rRNA to detect O. tsutsugamushi infection of all known genotypes. …”
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Single cell RNA sequencing reveals human tooth type identity and guides in vitro hiPSC derived odontoblast differentiation (iOB) by Sesha Hanson-Drury, Sesha Hanson-Drury, Sesha Hanson-Drury, Anjali P. Patni, Anjali P. Patni, Anjali P. Patni, Anjali P. Patni, Deborah L. Lee, Deborah L. Lee, Deborah L. Lee, Ammar Alghadeer, Ammar Alghadeer, Ammar Alghadeer, Ammar Alghadeer, Yan Ting Zhao, Yan Ting Zhao, Yan Ting Zhao, Devon Duron Ehnes, Devon Duron Ehnes, Devon Duron Ehnes, Vivian N. Vo, Vivian N. Vo, Vivian N. Vo, Sydney Y. Kim, Sydney Y. Kim, Druthi Jithendra, Druthi Jithendra, Ashish Phal, Ashish Phal, Ashish Phal, Natasha I. Edman, Natasha I. Edman, Natasha I. Edman, Natasha I. Edman, Thomas Schlichthaerle, Thomas Schlichthaerle, David Baker, David Baker, David Baker, Jessica E. Young, Jessica E. Young, Julie Mathieu, Julie Mathieu, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker, Hannele Ruohola-Baker

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Antisynthetase syndrome with anti-glycyl tRNA synthetase antibodies in a patient with axial spondyloarthritis treated with tumor necrosis factor-α inhibitors by Maria Iacovantuono, Chiara Bonini, Ernesto Di Biase, Vinicio Magliacani, Gian Domenico Sebastiani

“…Our case is the first to emphasize the coexistence of ASSD with anti-glycyl tRNA synthetase antibodies and ax-SpA, reminding us of the possible, although rare, adverse effects on the lungs with TNF-α inhibitors. …”
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Transcriptome atlases of rat brain regions and their adaptation to diabetes resolution following gastrectomy in the Goto-Kakizaki rat by François Brial, Aurélie Le Lay, Claude Rouch, Edouard Henrion, Mathieu Bourgey, Guillaume Bourque, Mark Lathrop, Christophe Magnan, Dominique Gauguier

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Long non-coding RNAs modulate glutathione metabolism gene expression and tolerance to Pb stress in root tissue of endophyte-infected rice seedling by He-Fei Sun, Xin-Nan Wang, Ya-Nan Li, Lan-Lan Wang, Yue-Ying Li, Lian-Ju Ma, Xue-Mei Li

Subjects: “…LncRNA…”
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In vivo production of engineered ACE2 decoy protects lungs from SARS-CoV-2 infection by Yuta Suzuki, Takayuki Miyazaki, Yoko Ida, Tatsuya Suzuki, Yumi Itoh, Shuto Nakao, Keita Kondo, Kenji Kubara, Keisuke Nishioka, Hiroki Muto, Ryuji Watari, Toshifumi Hirayama, Dai Kakiuchi, Shinya Sato, Satoshi Inoue, Yoshifumi Uemoto, Yohei Mukai, Atsushi Hoshino, Toru Okamoto, Junji Matsui

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CircHIPK2 recruits SRSF1 to increase TXNIP mRNA stability and promotes autophagy-dependent ferroptosis and apoptosis in myocardial ischemia-reperfusion injury by Zhu Zhang, Jinqi Hao, Qinghong Qiao, Junting Song, Yanqin Yu

“…TXNIP mRNA stability was dertermined by actinomycin D. …”
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LncRNA PVT1 links estrogen receptor alpha and the polycomb repressive complex 2 in suppression of pro-apoptotic genes in hormone-responsive breast cancer by Viola Melone, Domenico Palumbo, Luigi Palo, Noemi Brusco, Annamaria Salvati, Antonietta Tarallo, Giorgio Giurato, Francesca Rizzo, Giovanni Nassa, Alessandro Weisz, Roberta Tarallo

“…Abstract RNA-based therapeutics highlighted novel approaches to target either coding or noncoding molecules for multiple diseases treatment. …”
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Revealing the core suppression effects of various Di (2-ethylhexyl) phthalate exposure on early meiosis progression in postnatal male mice via single-cell RNA sequencing by Baoquan Han, Lei Hua, Shuai Yu, Wei Ge, Cong Huang, Yu Tian, Chunxiao Li, Jiamao Yan, Tian Qiao, Jiachen Guo, Dongliang Lu, Bin Wang, Diya Cai, Yunqi Zhang, Shaolin Liang, Jianjuan Zhao, Qi Hou, Wei Shen, Zhongyi Sun

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Cost Impact Model of a Novel Multi-mRNA Host Response Assay for Diagnosis and Risk Assessment of Acute Respiratory Tract Infections and Sepsis in the Emergency Department by John E. Schneider, Jonathan Romanowsky, Philipp Schuetz, Ivana Stojanovic, Henry K. Cheng, Oliver Liesenfeld, Ljubomir Buturovic, Timothy E. Sweeney

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Co-modulation of a circular form of PCDH11Y during neuroendocrine differentiation of prostate cancer by Giovanni Pecoraro, Ilaria Leone, Silvia Nuzzo, Santiago Negueruela, Giovanni Smaldone, Lorena Buono

Subjects: “…circRNA…”
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Integration of single-cell and bulk RNA-sequencing data to construct and validate a signature based on NK cell marker genes to predict immunotherapy response and prognosis in colorectal cancer by Xiaoyu Qin, Wenjuan Xu, Jinxiu Wu, Ming Li

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MiR-18a-LncRNA NONRATG-022419 pairs targeted PRG-1 regulates diabetic induced cognitive impairment by regulating NGF\BDNF-Trkb signaling pathway by Qiong Xiang, Hu Lin, Jia-Sheng Tao, Chuan-Jun Fu, Li-Ni Liu, Jing Deng, Xian-Hui Li

“…Methods Combined Single-cell RNA sequencing (scRNA-seq) and RNA transcriptome analysis, the distinct sub-populations, functional heterogeneity as well as potential enriched signaling pathways of hippocampal cells could be elucidated. …”
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Long non-coding RNA MIR4435-2HG modulates pancreatic cancer stem cells and chemosensitivity to gemcitabine by targeting the miR-1252-5p/STAT1 by Baocheng Xie, Peishan Wu, Hongyu Liu, XiangDi Yang, Linxuan Huang

“…The role of miR-1252-5p as a competing endogenous RNA was also explored. Overexpression of MIR4435-2HG significantly enhanced CSC self-renewal and tumorigenic potential, whereas silencing MIR4435-2HG notably diminished these properties. …”
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