KLF5 promotes esophageal squamous cell carcinoma radioresistance by targeting the Keap1-Nrf2 pathway by Yang Wang, Yue-ying Yang, Abulajiang Kamili, Dilimulati Aishanjiang, Yi Liu

“…KLF5/Keap1 regulates the effects of ESCC on in vivo radiotherapy. Conclusion KLF5 promotes ESCC radioresistance by inhibiting Keap1 transcription and activating the Nrf2 pathway.…”
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Effect of “Time To Surgery” on the Endometrial Cancer Prognosis by Engin Celik, Harika Yumru Celiksoy, Hamdullah Sozen, Hale Goksever Celik, Semen Onder, Mehmet Yavuz Salihoglu, Samet Topuz

“…STUDY DESIGN: Patients who were diagnosed with epithelial type endometrial cancer and did not receive preoperative chemotherapy, radiotherapy, or hormonal therapy were included in the study. …”
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Bidirectional regulation of reactive oxygen species for radiosensitization in nasopharyngeal carcinoma by Jie Chen, Chengyu Feng, Yufei Lan, Xiangtian Chen, Zhengqi Peng, Zihan Huang, Ruiqing Wang, Wenxin Zhang, Yingying Ye, Zhilei Mao, Dongyue Pan, Lihua Yang

“…Abstract Radiotherapy (RT) is the primary treatment modality for nasopharyngeal carcinoma (NPC). …”
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Erratum to ‘Should post-operative stereotactic radiosurgery be the standard of care in Craniopharyngioma patients?’ [World Neurosurgery: X (22C) (2024) 100327] by Saurabh Gupta, Deepak Agrawal, Shweta Kedia, Shashank Sharad Kale

“…Consecutive surgically treated craniopharyngioma patients between 2018 and 2019, who did not receive any post-operative radiotherapy constituted the control group. The clinical, and radiological outcomes were compared between the two groups. …”
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Multimodal treatment with Neoadjuvant chemotherapy for eyelid and periocular sebaceous gland carcinoma: Long-term outcomes by Vijitha S. Vempuluru, Anshika Luthra, Vijay Anand Reddy Palkonda, Swathi Kaliki

“…Three months after NACT, two patients underwent excisional biopsy of residual tumor, all 3 underwent external beam radiotherapy to the orbit and adjuvant systemic chemotherapy, and 1 with lymph node metastasis at presentation received EBRT to the lymph node area. …”
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Real-World Treatment Patterns in Men with Castration- Resistant Prostate Cancer Receiving Docetaxel by Keith L. Davis, Benjamin Gutierrez, Teresa Zyczynski, James A. Kaye

“…Other non-chemotherapy treatments used with docetaxel were hormonal therapy (22.8%), radiotherapy (17.3%), and surgery (4.1%). Most patients (75%) received ≥4 docetaxel cycles, half received ≥6 cycles, 25% received ≥8 cycles and 10% received ≥10 cycles. …”
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Swallowing-related muscle inflammation and fibrosis induced by a single dose of radiation exposure in mice by Shuntaro Soejima, Chia-Hsien Wu, Haruna Matsuse, Mariko Terakado, Shinji Okano, Tsuyoshi Inoue, Yoshihiko Kumai

“…Abstract Background Although radiotherapy is commonly used to treat head and neck cancer, it may lead to radiation-associated dysphagia (RAD). …”
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EMA/CO Combination Chemotheraphy in Gestational Trophoblastic Neoplasia: Update of Our Results by Tolga Taşçı, Işın Üreyen, Günsu Kimyon, Alper Karalök, Sevgi Koç, M. Faruk Köse, Gökhan Tulunay, Taner Turan

“…Adjuvant surgery and radiotherapy were used in selected patients. Response and effects of the prognostic factors to the response rate were analyzed. …”
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Psychosocial distress, perceived need and utilization of psycho- social support services in patients in the early phase after the first cancer diagnosis by Hannah Zingler, Diana Steinmann, Jochen Ernst, Ute Goerling, Myriel Hermann, Beate Hornemann, Anja Mehnert-Theuerkauf, Tanja Zimmermann

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Diagnosis and treatment of thyroblastoma: a case report and review of literature by Xiting Chen, Xiting Chen, Lijuan Xiong, Lijuan Xiong, Hongling Liu, Haoqiang Wang, Donghai Cheng, Wei Wang, Wenyuan He, Bo Xie, Juan Zhou

“…The patient’s progression-free survival (PFS) reached 15 months following the administration of BEP chemotherapy in conjunction with local radiotherapy. The patient ultimately died of cardiac arrest resulting from the progression of the cancer thrombus to the right atrium and right ventricle.ConclusionAlthough thyroblastoma has been treated as a separate entity with its distinctive morphologic and molecular characteristics, its clinicopathological features, diagnosis and treatment methods and prognosis remain poorly understood, which requires more accumulated clinical case data to provide basis for the correct diagnosis and treatment in the future.…”
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Automatic cervical lymph nodes detection and segmentation in heterogeneous computed tomography images using deep transfer learning by Wenjun Liao, Xiangde Luo, Lu Li, Jinfeng Xu, Yuan He, Hui Huang, Shichuan Zhang

“…No significant sensitivity difference was found between contrast-enhanced and unenhanced CT images (p = 0.502) or repeated CT images (p = 0.815) during adaptive radiotherapy. The model’s segmentation accuracy was comparable to that of experienced oncologists. …”
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Synergistic strategies for glioblastoma treatment: CRISPR-based multigene editing combined with immune checkpoint blockade by Xiaolin Liu, Xiao Liu, Xiaonan Luo, Maorong Zhu, Nannan Liu, Juan Li, Qi Zhang, Cheng Zou, Yuxin Wu, Zhengcong Cao, Shuangxin Ma, Weizhong Wang, Guangzhao Yang, Jintao Gu, Wei Liu, Meng Li, Anan Yin, Yalong He, Wei Lin

“…Abstract Glioblastoma (GBM) is a primary brain tumor known for its high levels of aggressiveness and resistance to current treatments such as radiotherapy and chemotherapy. As a result, there is a pressing need for innovative therapeutic approaches to combat GBM. …”
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Breast cancer patients with a pre-existing mental illness are less likely to receive guideline-recommended cancer treatment: A systematic review and meta-analysis by Katie Elliott, Emily Haworth, Iakov Bolnykh, R. Hamish McAllister-Williams, Alastair Greystoke, Adam Todd, Linda Sharp

“…Meta-analysis revealed that patients with mental illnesses were significantly less likely to receive guideline-recommended treatments (OR = 0.78, 95 % CI 0.72–0.83, N = 5), chemotherapy (OR = 0.56, 95 % CI 0.34–0.78, N = 6), or radiotherapy (OR = 0.79, 95 % CI 0.66–0.93, N = 5). They were also significantly more likely to undergo mastectomy instead of breast-conserving surgery (OR = 1.38, 95 % CI 1.24–1.52, N = 4). …”
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Personalized treatment strategies for breast adenoid cystic carcinoma: A machine learning approach by Sakhr Alshwayyat, Mahmoud Bashar Abu Al Hawa, Mustafa Alshwayyat, Tala Abdulsalam Alshwayyat, Siya sawan, Ghaith Heilat, Hanan M. Hammouri, Sara Mheid, Batool Al Shweiat, Hamdah Hanifa

“…The 5-year overall survival (OS) rates were highest for surgery + radiotherapy (RT) (94.9 %) and lowest for surgery + chemotherapy (CTX) + RT (80.1 %). …”
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Exploiting somatic oncogenic driver alterations in a patient with Li-Fraumeni syndrome– paving the path towards precision medicine: a case report by Carolin Seeling, Sonja Dahlum, Ralf Marienfeld, Vera Jan, Brigitte Rack, Uwe Gerstenmaier, Ambros J. Beer, Regine Mayer-Steinacker, Wolfgang Thaiss, Thomas F. E. Barth, Thomas Seufferlein, Nadine T. Gaisa, Stephan Stilgenbauer, Wolfgang Janni, Reiner Siebert, Hartmut Döhner, Verena I. Gaidzik

“…Due to impaired DNA damage repair, conventional cytotoxic therapies or radiotherapy should be avoided whenever feasible to mitigate the high incidence of treatment-related secondary malignancies in these patients. …”
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MicroRNA-541-3p/Rac2 signaling bridges radiation-induced lung injury and repair by Jiandong Zhang, Lei Ma, Limin He, Quanxiao Xu, Yan Ding, Lidong Wang

“…Background: While radiation-induced lung injury decreases quality of life and suppresses efficacy of radiotherapy, to date, the relationship between radiation-induced lung injury and repair remains unclear. …”
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Overweight and obesity among adolescents: health-conscious behaviours, acceptance, and the health behaviours of their parents by Anna Lewandowska, Grzegorz Rudzki, Tomasz Lewandowski, Anna Bartosiewicz, Michał Próchnicki, Aleksandra Stryjkowska-Góra, Barbara Laskowska, Małgorzata Sierpińska, Sławomir Rudzki, Sergii Pavlov

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Comprehensive analysis of peripheral dose in electron beam therapy with a Varian TrueBeam Linac by Kapil Dev Maharaj, Mahsheed Sabet, Joshua Dass, Mounir Ibrahim, Talat Mahmood, Pejman Rowshanfarzad

“…Conclusions: This study highlights the importance of considering peripheral doses in electron radiotherapy. It is important to note the impact on healthy tissues beyond the treatment area to ensure patient safety and prevent the long-term side effects of treatment. …”
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En plaque meningioma of the temporal bone: A systematic review on the imaging and management of a rare tumor by Arianna Burato, Giuseppe Maruccio, Livio Presutti, Ignacio Javier Fernandez, Gabriele Molteni, Giulia Molinari

“…Forty-four percent of patients were sent to definitive surgical treatment, 44 % to follow-up while 8 % received radiotherapy. Conclusions: Meningioma en plaque (MEP) is a rare tumour, particularly when it originates within the temporal bone. …”
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Development of delayed pulmonary toxicities and transcriptional changes in pre-existing interstitial lung disease mice after partial thoracic irradiation by Jiamei Fu, Xinglong Liu, Yuchuan Zhou, Shengnan Zhao, Liang Zeng, Yan Pan, Jianghong Zhang, Kevin M. Prise, Chunlin Shao, Yaping Xu

“…Abstract Background Lung cancer patients with comorbid interstitial lung disease (LC-ILD) have an increased risk of developing severe or even fatal radiation pneumonitis after thoracic radiotherapy. However, the underlying mechanisms of its pathogenesis are still inconclusive. …”
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