Virgin and photo-degraded microplastics induce the activation of human vascular smooth muscle cells by Elisa Persiani, Antonella Cecchettini, Sofia Amato, Elisa Ceccherini, Ilaria Gisone, Agnese Sgalippa, Chiara Ippolito, Valter Castelvetro, Tommaso Lomonaco, Federico Vozzi

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Uterine Smooth Muscle Tumors of Unknown Malignant Potential (STUMP): A Dilemma for Gynecologists and Pathologists by Derman Başaran, Nejat Özgül, İlker Selçuk, Gökhan Boyraz, İbrahim Kulaç, Alp Usubütün, Kunter Yüce, Sinan Beksaç

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Leiomyoma of the palatine tonsil - report of a rare and unusual tumor at this site by Andleeb Abrari, Aarti Tyagi, Urmi Mukherjee

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Myofibrillogenesis Regulator-1 in Smooth Muscle Cells Modulates Inflammation Signaling Pathways via Regulating ROCK1 Ubiquitination and Degradation to Impact Aortic Dissection by Yin H, Li X, Lu D, Zhao X, Yang Z, Wang Z, Xu F, Chen Y, Li C

“…Furthermore, it was observed that overexpression of MR-1 and ROCK1 facilitated smooth muscle cell phenotypic transformation and augmented matrix metalloproteinase release in in vitro settings through inflammatory pathway activation. …”
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Mural cell dysfunction contributes to diastolic heart failure by promoting endothelial dysfunction and vessel remodelling by Mandy O. J. Grootaert, Alessandra Pasut, Jana Raman, Steven J. Simmonds, Bram Callewaert, Ümare Col, Mieke Dewerchin, Peter Carmeliet, Stephane Heymans, Elizabeth A. V. Jones

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The relaxant effect of Tamsulosin in the vascular reactivity of goat isolated renal artery by Aveen Muhsin Asaad, Ismail Salih Ibraheem Kakey

Subjects: “…Tamsulosin, Smooth muscles relaxation, Renal artery, Channel blockers.…”
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Value of alpha smooth muscle actin (αSMA) and inducible nitric oxide synthase (iNOS) in oral squamous cell carcinoma (OSCC): An immunohistochemical approach to tumor stroma categorization and clinicopathological parameters by Heba E.M. Youssef, Basant Hamdy AbouZaid

“…Cancer-associated fibroblasts (CAFs) are the most abundant component of tumor stroma that can direct tumorigenesis. Alpha smooth muscle actin (α-SMA) expression by stromal CAFs is linked to higher aggressive tumor behavior and poor prognosis. …”
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Autoimmune Hepatitis in Children: The Current State of the Problem by G. V. Volynets, A. I. Khavkin, T. A. Skvortsova, V. V. Matkash

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Three-dimensional ultrastructural analysis of human skin with the arrector pili muscle interacting with the hair follicle epithelium by Tomonobu Ezure, Kyoichi Matsuzaki, Hidetoshi Urakubo, Nobuhiko Ohno

“…Additionally, the dense nerve network running through and along arrector pili muscle fibers rarely penetrates the connective tissues between smooth muscle fibers and epithelial cells. Furthermore, in the observation area, no individual smooth muscle fibers formed adhesion structures with the epithelial cells of the hair follicle, ending in the dermal extracellular matrix near the epithelial cells. …”
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A novel case of left atrial and right lung mass turned out to be unconventional metastasis of uterine leiomyosarcoma with a review of literature by Tarang Patel, Priyanka Aswal, Ashish Jakhetiya, Virendrakumar Meena, Arun Pandey

“…Uterine leiomyosarcoma (ULMS) is a rare malignancy arising from the myometrial smooth muscle wall, and cardiac metastases are extremely rare. …”
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A Rare Case of Solitary Palatal Myofibroma in a Young Pediatric Patient by Tulika Wakhloo, Gosla Reddy, Ashi Chug, Arvind Kumar

“…The objective should be to differentiate benign versus malignant spindle cell lesions of smooth muscle, nerve tissue, fibrocytic, and histiocytic origin. …”
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Acetylcholine in irritable bowel syndrome pathogenesis and the role of cholineblockers by Yu. O. Shulpekova

“…Experimental data allow to assume, that «subclinical inflammation» within intestinal wall at IBS, disturbances of peristaltic activity and hyperalgesia, are related to altered response of immune and smooth-muscle cells to acetylcholine stimulation.Conclusion. …”
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BCL6 (B-cell lymphoma 6) expression in adenomyosis, leiomyomas and normal myometrium. by Loreta Canivilo Salas, Bruna Mielczarski, Raquel Camara Rivero, João Sabino Lahogue da Cunha Filho, Ricardo Francalacci Savaris

“…These findings suggest that BCL6 plays a role in the pathogenesis of leiomyomas, potentially contributing to abnormal smooth muscle cell proliferation. The study highlights the utility of automated immunohistochemistry and deep learning techniques in quantifying protein expression and classifying uterine pathologies. …”
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Pathology of the Gastrointestinal Tract in Patients with Primary Hyperparathyroidism by I. A. Baranova, A. V. Baranov

“…Hyperparathyroidism has been shown to cause smooth muscle atony with specific upper and lower GI symptoms such as nausea, heartburn and constipation. …”
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CircXYLT1 suppresses oxidative stress and promotes vascular remodeling in aging mice carotid artery injury model of atherosclerosis via PTBP1 by Gang Li, Donghui Li, Yajing Li, Bingqi Liu

“…Knockdown of CircXYLT1 increased oxidative stress and reduced antioxidant protein expression (SOD, GPX), while overexpression led to decreased oxidative damage and enhanced vascular smooth muscle cell (VSMC) proliferation. Mechanistically, CircXYLT1 interacted with PTBP1, reducing its nuclear localization and modulating downstream chemokine signaling pathways. …”
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Predicting oxytocin binding dynamics in receptor genetic variants through computational modeling by Preeti Dubey, Yingye Fang, K. Lionel Tukei, Shobhan Kuila, Xinming Liu, Annika Sahota, Antonina I. Frolova, Erin L. Reinl, Manasi Malik, Sarah K. England, Princess I. Imoukhuede

“…To address this, we developed a mathematical model examining the effects of five OXT receptor (OXTR) variants (V45L, P108A, L206V, V281M, and E339K) on OXT–OXTR binding dynamics in human embryonic kidney cells (HEK293T) and myometrial smooth muscle cells. The model was parameterized using experimentally derived, cell-specific OXTR surface localization measurements and literature-reported OXT-OXTR-binding kinetics. …”
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Vasorelaxant effects and its mechanisms of the rhizome of Acorus gramineus on isolated rat thoracic aorta by Jueon Lee, Sujin Shin, Junkyu Park, Ho-Young Choi, Kyungjin Lee

“…The findings suggested that the mechanism of this effect was independent of endothelial cells and was associated with vascular smooth muscle cells (VSMC). Since vasodilatory mechanisms associated with VSMC are predominantly influenced by K+ and Ca2+ channels, we explored various channels, including calcium-activated K+, voltage-dependent (delayed rectifier) K+, ATP-sensitive K+, inwardly rectifying K+, receptor-operated Ca2+ (ROCC), and voltage-dependent Ca2+ channels (VDCC). …”
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Gene therapy by hepatocyte growth factor results in regression of experimental liver fibrosis by N. A. Dzhoyashvili, N. I. Kalinina, I. B. Beloglazova, Z. I. Tsokolayeva, P. I. Makarevich, Yu. L. Perov, Ye. V. Parfenova, V. A. Tkachuk

“…After obtaining liver tissue samples, histological study was carried out, and by real time polymerase chain reaction (RT-PCR) contents of mPNA of liver fibrosis-associated genes were analyzed: transforming growth factor β1 (TGF-β1), collagen 1α1 (Coll1α1), matrix metalloproteinase-13 (ММР-13), tissue inhibitor of matrix metalloproteinase (TIMP-1) and smooth-muscle actin α (α-SMA). A blood was extracted for assessment of liver enzymes activity (AST and ALT). …”
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Pathogenic and therapeutic role of bile acids at reflux-gastritis by T. L. Lapina, I. M. Kartavenko, V. T. Ivashkin

“…Reflux-gastritis is chemical type gastritis, morphologically manifested by foveolar hyperplasia, edema, proliferation of smooth-muscle fibres of lamina propria, insignificant chronic inflammation. …”
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CB-MNCs@ CS/HEC/GP promote wound healing in aged murine pressure ulcer model by Zhi-cheng Yang, He Lin, Guo-jun Liu, Hui Pan, Jun-lu Zhu, Xiao-hong Zhang, Feng Gao, Zhong Wang, Zhi-hao Wang

“…Further investigation revealed that CB-MNCs@CS/HEC/GP exerted therapeutic effects by promoting changes in cell types, including fibroblasts, endothelial cells, keratinocytes, and smooth muscle cells. Conclusion CB-MNCs@CS/HEC/GP enhanced the delivery efficiency of CB-MNCs, preserved the cell viability, and contributed to pressure ulcer wound healing. …”
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