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Clinical Guidelines of the Russian Gastroenterological Association on the Diagnostics and Treatment of Eosinophilic Esophagitis
Published 2019-01-01“…The diagnostic criterion is the eosinophilic infiltration of the esophageal mucosa with an eosinophil density of ≥ 15 per high power field (×400) in at least one of the biopsy specimens (about 60 eosinophils in 1 mm2). Total IgE levels, peripheral blood eosinophilia and skin allergy tests are considered to be additional diagnostic means. …”
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242
Co-Optimization of Power Delivery Network Design for 3-D Heterogeneous Integration of RRAM-Based Compute In-Memory Accelerators
Published 2025-01-01“…For ResNet architectures in 3-D integration, we demonstrate that peripheral TSV placement provides an optimal balance between interconnect complexity and performance, achieving IR-drop below 10% of <inline-formula> <tex-math notation="LaTeX">$V_{\text {DD}}$ </tex-math></inline-formula> while maintaining high classification accuracy.…”
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243
Tradition and Development of Lithuanian Terminology
Published 2024-03-01“…Due to Lithuania’s socio-cultural circumstances—such as the prevalence of science in international languages, the absence of a standardised public Lithuanian language, occupation, and its peripheral status within the empire—terminology primarily relied on the spoken folk language, lacking a structured scientific foundation. …”
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244
A novel platform for engineered AAV-based vaccines
Published 2025-03-01“…Moreover, the AAV.RBDs were able to trigger RBD-specific cellular immune responses in peripheral human lymphocytes. In conclusion, this novel AAV-based next-generation vaccine platform allows for the presentation of large antigenic sequences to elicit strong and specific immune responses. …”
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245
Long-term results of antiviral therapy in patients with chronic hepatitis C with sustained virologic response
Published 2013-09-01“…In 114 patients RNA HCV and DNA HBV in blood serum and peripheral mononuclear blood cells were studied by polymerase chain reaction (PCR) with fluorescent hybridization detection in «real time» mode (sensitivity of 10 IU/ml for HCV and 5 IU/ml for HBV).Results. …”
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246
The dual anti-inflammatory and anticoagulant effects of Jianpi Huashi Tongluo prescription on Rheumatoid Arthritis through inhibiting the activation of the PI3K/AKT signaling pathw...
Published 2025-02-01“…Lastly, a co-culture system of RA patient-derived peripheral blood mononuclear cells (RA-PBMCs) and vascular endothelial cells (VECs) was established to mimic the in vivo microenvironment, and the anti-inflammatory and anticoagulant mechanisms of XFC were validated in vitro.ResultsData mining analysis revealed abnormally elevated levels of inflammatory and coagulation markers such as fibrinogen (FBG), erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (Hs-CRP), and rheumatoid factor (RF) in RA patients (p < 0.001), and emphasized the close correlation between XFC treatment and the improvement of these markers including Hs-CRP, ESR, and RF (confidence >60% and lift >1). …”
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247
Association of Serum Irisin With Severity and Prognosis in Patients With Coronavirus Disease 2019: A Prospective Cohort Study
Published 2025-02-01“…The aim of this study was to assess the relationships of serum irisin with the severity and prognosis of COVID-19.Methods: A total of 328 COVID-19 patients were recruited. Peripheral blood samples were collected. The level of serum irisin was determined by ELISA. …”
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248
CX3CR1+ age-associated CD4+ T cells contribute to synovial inflammation in late-onset rheumatoid arthritis
Published 2025-02-01“…This study aimed to examine the involvement of cytotoxic T cells in LORA. Methods Fresh peripheral blood samples were collected from 78 treatment-naïve active RA patients, 12 with difficult-to-treat RA, and 16 healthy controls. …”
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249
Water–rock interaction in the geothermal systems related to post-collision zone volcanism: A case study based on multivariate statistical analysis from the Kavak geothermal field (...
Published 2023-12-01“…The Kavak thermal waters are meteoric in origin and peripheral waters (Ca–Na–HCO$_{3}$) in the geothermal system related to the orogenic volcanism. …”
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250
Platelet-derived HMGB1 induces NETosis, exacerbating brain damage in the photothrombotic stroke model
Published 2025-02-01“…Concomitant with this, peripheral neutrophils isolated following PTS exhibited progressive NETosis, particularly intravascular NETosis. …”
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251
Exploration of pulse wave analysis under reactive hyperemia and close to an arteriovenous fistula: a comparative analysis
Published 2025-02-01“…Methods Subjects underwent local peripheral tonometric pulse wave analysis with the SphygmoCor® device and duplex sonography to assess flow velocity (peak Vmax and diastolic Vdiast) under physiological conditions. …”
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252
Remote Continuous Microinjury-Triggered Cytokines Facilitate Severe Diabetic Foot Ulcer Healing via the Ras/Raf/MEK/ERK Pathway
Published 2025-02-01“…These changes were in parallel with the expression of TGF-β 1, PDGF-BB, and VEGF in the foot wounds and the frequency of EPCs in both bone marrow and peripheral circulation, which implied that the secreted TGF-β 1, PDGF-BB, and VEGF promote proliferation and migration of EPCs to the foot wounds. …”
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253
Phenylalanine-derived β-lactam TRPM8 antagonists: revisiting configuration and new benzoyl derivatives
Published 2025-01-01“…The pharmacological activity in vivo was studied on a mice model of oxaliplatin-induced peripheral neuropathy. Results: For OtBu derivatives, a 3S,4S-configuration was preferred, while compounds with 2'R chiral centers show higher selectivity for TRPM8 versus transient receptor potential vanilloid, subtype 1 (TRPV1) than their 2'S-counterparts. …”
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254
Systemic delivery of AAV5, AAV8, and AAV9 packaging a C5-12-microdystrophin-FLAG expression cassette in non-human primates
Published 2025-03-01“…The C5-12 promoter was highly selective for heart and skeletal muscles, when compared to off-target tissues such as peripheral blood mononuclear cells, lung, liver, and kidney. …”
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255
Targeting HVEM-GPT2 axis: a novel approach to T cell activation and metabolic reprogramming in non-small cell lung cancer therapy
Published 2025-02-01“…In addition, animal experiments revealed the importance of HVEM in maintaining activated peripheral immunity and inflamed local tumor microenvironment. …”
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256
Magnesium in pain control - mechanisms of action in perioperative pain, neuropathic pain and migraine
Published 2025-02-01“…Evidence suggests that magnesium supplementation can reduce opioid use, counteract central and peripheral sensitization, and potentially prevent migraine attacks, highlighting its potential as an effective adjuvant in pain management strategies. …”
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257
TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa in patients with advanced solid tumors: a first-in-human, phase 1, dose-escalation trial
Published 2025-02-01“…Anti-TIGIT mode-of-action-related pharmacodynamic effects were observed in peripheral blood and in tumor tissue. RDEs were 1600 mg every 2 weeks or 2400 mg every 3 weeks for M6223 monotherapy and 1600+1200 mg every 2 weeks for M6223+BA.Conclusions M6223±BA had a manageable safety profile, with RDEs defined for both monotherapy and combination therapy. …”
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258
T cell immune senescence is associated with frailty and sarcopenia in lung transplant candidates
Published 2025-02-01“…Immune phenotyping was performed using multichannel flow cytometry of peripheral blood mononuclear cells (PBMC) in a total of 26 lung transplant candidates. …”
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259
Cord Direct Antiglobulin Test for Predicting the Need for Phototherapy in Neonates with ABO Incompatibility: A Prospective Cohort Study
Published 2025-02-01“…Serum bilirubin levels, complete blood counts with peripheral smear analysis and reticulocyte counts were performed on day 3 or earlier, as clinically indicated. …”
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260
Small intestinal bacterial overgrowth syndrome and systemic inflammation in pathogenesis of hemodynamic changes at liver cirrhosis
Published 2018-08-01“…Lactulose hydrogen breath test, serum level of C-reactive protein and cardiac ultrasound with simultaneous blood pressure (BP) and heart rate measurement, estimation of basic hemodynamic scores: mean blood pressure (MBP), cardiac output (CO), total peripheral vascular resistance (TPVR) were investigated in all patients. …”
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