Genome data based deep learning identified new genes predicting pharmacological treatment response of attention deficit hyperactivity disorder by Yilu Zhao, Zhao Fu, Eric J. Barnett, Ning Wang, Kangfuxi Zhang, Xuping Gao, Xiangyu Zheng, Junbin Tian, Hui Zhang, XueTong Ding, Shaoxian Li, Shuyu Li, Qingjiu Cao, Suhua Chang, Yufeng Wang, Stephen V. Faraone, Li Yang

“…Based on genotype data of medication-naïve patients with ADHD who received pharmacological treatments for 12 weeks, the current study performed GWAS using the percentage changes in ADHD-RS score as phenotype. …”
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Impact de l’évaluation de la sédation sur la durée de ventilation mécanique en réanimation pédiatrique [Impact of sedation assessment on duration of mechanical ventilation in pedia... by Zakaria Zoheir Addou, Nabil Tabet Aoul, Abdessamad DALI ALI Dali-Ali

“…All children under 15 years of age who were ventilated and sedated for 24 hours or more were included in the study. …”
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Heterogeneous clinical phenotypes of sporadic early-onset Alzheimer’s disease: a neuropsychological data-driven approach by Deepti Putcha, Yuta Katsumi, Alexandra Touroutoglou, Ani Eloyan, Alexander Taurone, Maryanne Thangarajah, Paul Aisen, Jeffrey L. Dage, Tatiana Foroud, Clifford R. Jack, Joel H. Kramer, Kelly N. H. Nudelman, Rema Raman, Prashanthi Vemuri, Alireza Atri, Gregory S. Day, Ranjan Duara, Neill R. Graff-Radford, Ian M. Grant, Lawrence S. Honig, Erik C. B. Johnson, David T. Jones, Joseph C. Masdeu, Mario F. Mendez, Erik Musiek, Chiadi U. Onyike, Meghan Riddle, Emily Rogalski, Stephen Salloway, Sharon Sha, R. Scott Turner, Thomas S. Wingo, David A. Wolk, Kyle Womack, Maria C. Carrillo, Gil D. Rabinovici, Bradford C. Dickerson, Liana G. Apostolova, Dustin B. Hammers, the LEADS Consortium

“…The APOE ɛ4 genotype was enriched in the Amnestic Predominant group, who were also rated as least impaired. Cortical thickness analysis validated these clinical phenotypes with dissociations in atrophy patterns observed between the Dysexecutive and Amnestic Predominant groups. …”
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Editorial by Ann-Kristin Kölln, Antony Mason, Maria Lenk, Jörg Tremmel, Markus Rutsche

“…The first prize of the Intergenerational Justice Prize 2017/18 was awarded to Mona Lena Krook and Mary K. Nugent who contribute to this debate by arguing that lowering the eligibility age to run for office leads to better representation of the youngest and next-youngest cohorts in parliament. …”
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Artificial intelligence: a useful tool in active tuberculosis screening among vulnerable groups in Romania - advantages and limitations by Beatrice Mahler, Beatrice Mahler, Beatrice Mahler, Alexandru Stoichiță, Alexandru Stoichiță, Alexandru Stoichiță, Dragoș Băiceanu, Dragoș Băiceanu, Traian-Constantin Panciu, Traian-Constantin Panciu, Dragoș Dendrino, Dragoș Dendrino, Mihaela Mihai, Mihaela Mihai, Raluca Bobocea, Elmira Ibraim, Elmira Ibraim, Mara Bălteanu, Mara Bălteanu, Oana Popescu, Oana Popescu, Mădălina Oana Burecu, Mădălina Oana Burecu, Ioana Mădălina Moșteanu, Ioana Mădălina Moșteanu, Vanessa Veronese, Radu Matache, Radu Matache, Ioana Munteanu, Ioana Munteanu, Ioana Munteanu, Cristina Popa, Cristina Popa, Justina Antonela Dragomir, Justina Antonela Dragomir, Justina Antonela Dragomir

“…ROC curve analysis indicates an AUC of 0.923 (95% CI:0.893–0.947; significance level p < 0.0001) which shows that the test has a high capacity to accurately detect individuals with TB and also to rule out those who do not have the disease, with sensitivity 87.1, specificity 91.6 and criterion >0.3585.ConclusionOur study brings to the fore the significance of integrating AI software X-vision with bacteriological diagnosis in detecting TB among vulnerable groups in Romania. …”
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Clinical Utility of Combined Tissue and Plasma Next-Generation Sequencing in Patients With Advanced, Treatment-Naïve NSCLC by Helena Bote-de Cabo, MD, Marco Siringo, MD, Esther Conde, MD, PhD, Susana Hernández, PhD, Fernando López-Ríos, MD, PhD, Alicia Castelo-Loureiro, MD, Esther García-Lorenzo, MD, Javier Baena, MD-PhD, Mercedes Herrera, MD, Ana Belén Enguita, MD, Yolanda Ruano, PhD, Jon Zugazagoitia, MD, PhD, Luis Paz-Ares, MD, PhD

“…Methods: We retrospectively collected clinical and genomic data from 275 patients with treatment-naïve advanced NSCLC who had undergone plasma-based NGS at diagnosis in our institution. …”
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Multiple intracerebral hematomas during SEEG recording and intradural hemorrhage after spinal tap: A case report prompting more research on collagen IV gene mutation and oral nicot... by Markus Leitinger, Serena Broggi, Mathias Spendel, Gudrun Kalss, Ivan Petrović, Herbert Krainz, Fabio Rossini, Julia Höfler, Andreea Toma, Giorgi Kuchukhidze, Matthias Mauritz, Kai‐Nicolas Poppert, Bernardo Crespo‐Pimentel, Pilar Bosque‐Varela, Anna Pleyers, Patricia Ganger, Dieter Kotzot, Davor Lessel, Christoph J. Griessenauer, Eugen Trinka

“…We present a 20+ year‐old man with drug‐resistant epilepsy who underwent stereo‐EEG with 17 depth electrodes. …”
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Mental health disorder symptom changes among public safety personnel after emotional resilience skills training by R.N. Carleton, S. Sauer-Zavala, T.A. Teckchandani, K.Q. Maguire, L. Jamshidi, R.E. Shields, T.O. Afifi, J. Nisbet, K.L. Andrews, S.H. Stewart, A.J. Fletcher, R. Martin, R.S. MacPhee, J.C. MacDermid, T.M. Keane, A. Brunet, M. McCarron, L.M. Lix, N.A. Jones, G.P. Krätzig, J.P. Neary, G. Anderson, R. Ricciardelli, H. Cramm, J. Sareen, G.J.G. Asmundson

“…Methods: A 16-month longitudinal design engaged serving PSP (n = 119; 34 % female; firefighters, municipal police, paramedics, public safety communicators) who completed PSP-delivered ERST. Participants were assessed for symptoms of PTSIs, including but not limited to PTSD, at pre- and post-training, and 1-year follow-up using self-report measures and clinical interviews. …”
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Editorial by Jörg Tremmel, Maria Lenk, Antony Mason, Markus Rutsche

“…There are already a handful of indices which are, if recorded repeatedly, usable for measuring the changes in quality-of-life circumstances over time, and thus the “position” of succeeding generations in the course of history. Jamie McQuilkin, who is the winner of the 2016/17 Demography Prize, derives an additional index from national statistics in the opening article of this second part of the IGJR double issue on “Measuring Intergenerational Justice for Public Policy”. …”
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Julius Kruopis – the pioneer of applied statistics in Lithuania by Vilijandas Bagdonavičius, Vydas Čekanavičius, Rūta Levulienė, Pranas Vaitkus

“…Kruopis instilled his passion for mathematics and its applications not only in students but also in his children, who both graduated from the Faculty of Mathematics and Informatics. …”
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Relationship between physical activity level, leisure sedentary time, and frailty among residents aged 30 – 79 years in Wuzhong district, Suzhou city: a baseline surveillance data... by Xikang FAN, Jiang HUA, Jian SU, Hao YU, Yan LU, Yujie HUA, Jianrong JIN, Pei PEI, Dianjianyi SUN, Canqing YU, Jun LYU, Jinyi ZHOU, Ran TAO

“…MethodsData were collected from 53 269 residents aged 30 – 79 years in Wuzhong district, Suzhou city, who participated in the baseline survey of the China Kadoorie Biobank (CKB) from November 2004 to January 2008. …”
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Use of a specialized peptide-based enteral formula containing medium-chain triglycerides for enteral tube feeding in children with cerebral palsy and previous tube feeding intolera... by Aydan Kansu, Gunsel Kutluk, Gonul Caltepe, Cigdem Arikan, Nafiye Urganci, Gokhan Tumgor, Aysel Yuce, Ceyda Tuna Kirsaclioglu, Arzu Meltem Demir, Fatma Demirbas, Merve Usta, Sibel Yavuz, Duygu Demirtas Guner, Ersin Gumus, Buket Dalgic, Yasar Dogan, Nelgin Gerenli, Halil Kocamaz, Fulya Gulerman, Elif Sag, Aysugul Alptekin Sarioglu, Neslihan Eksi Bozbulut, Demet Teker Duztas, Hatice Altug Demirol, Coskun Celtik, Olcay Gungor, Kaan Demiroren, Aysen Uncuoglu Aydogan, Ozlem Bekem, Zeynep Arslan, Murat Cakir, Arzu Ekici, Nihal Uyar Aksu, Cigdem Ecevit, Simge Erdogan

“…This study aimed to evaluate the utility of enteral tube feeding via specialized peptide-based formula containing MCTs in children with CP in terms of gastrointestinal intolerance, anthropometrics, defecation characteristics and parental satisfaction with enteral formula.MethodsChildren with CP who received enteral tube feeding via specialized peptide-based formula containing MCTs were included in this prospective observational study. …”
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Comparable outcomes after busulfan- or treosulfan-based conditioning for allo-HSCT in children with ALL: results of FORUM by Krzysztof Kalwak, Laura M. Moser, Ulrike Pötschger, Peter Bader, Katharina Kleinschmidt, Roland Meisel, Jean-Hugues Dalle, Akif Yesilipek, Adriana Balduzzi, Gergely Krivan, Evgenios Goussetis, Raquel Staciuk, Petr Sedlacek, Herbert Pichler, Peter Svec, Melissa Gabriel, Tayfun Güngör, Ernest Bilic, Jochen Buechner, Marleen Renard, Kim Vettenranta, Marianne Ifversen, Cristina Diaz-de-Heredia, Jerry Stein, Jacek Toporski, Marc Bierings, Christina Peters, Marc Ansari, Franco Locatelli

“…Abstract: The superiority of total body irradiation (TBI)–based vs chemotherapy conditioning for allogeneic hematopoietic stem cell transplantation (allo-HSCT) in children with acute lymphoblastic leukemia (ALL) has been established in the international, prospective phase-3 FORUM study, randomizing 417 patients aged 4-18 years in complete remission (CR), who received allo-HSCT from HLA-matched sibling or unrelated donors. …”
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Penerapan Importance Performance Analysis (IPA) pada Evaluasi Keberlanjutan Penggunaan e-filing untuk Pelaporan Pajak Perorangan by Imelda Saluza, Dewi Sartika

“…According to study findings from 2017, there were already 22% of taxpayers (Wajib Pajak) in Palembang who did not file individual tax returns in 2017. …”
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Two-year trajectory of functional recovery and quality of life in post-intensive care syndrome: a multicenter prospective observational study on mechanically ventilated patients wi... by Junji Hatakeyama, Kensuke Nakamura, Shigeaki Inoue, Keibun Liu, Kazuma Yamakawa, Takeshi Nishida, Shinichiro Ohshimo, Satoru Hashimoto, Naoki Kanda, Shotaro Aso, Shinya Suganuma, Shuhei Maruyama, Yoshitaka Ogata, Akira Takasu, Daisuke Kawakami, Hiroaki Shimizu, Katsura Hayakawa, Takeshi Yoshida, Taku Oshima, Tatsuya Fuchigami, Hironori Yawata, Kyoji Oe, Akira Kawauchi, Hidehiro Yamagata, Masahiro Harada, Yuichi Sato, Tomoyuki Nakamura, Kei Sugiki, Takahiro Hakozaki, Satoru Beppu, Masaki Anraku, Noboru Kato, Tomomi Iwashita, Hiroshi Kamijo, Yuichiro Kitagawa, Michio Nagashima, Hirona Nishimaki, Kentaro Tokuda, Osamu Nishida

“…This multicenter prospective study investigated the 2-year trajectory of PICS and its components as well as factors contributing to deterioration or recovery in mechanically ventilated patients with coronavirus disease 2019 (COVID-19), and also attempted to identify possible countermeasures. Methods Patients who survived COVID-19 requiring mechanical ventilation completed questionnaires on the Barthel index, Short-Memory Questionnaire, Hospital Anxiety and Depression Scale, and EuroQol 5 dimensions 5-level every six months over a two-year period. …”
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Characteristics of adherent and non-adherent patients with hypertension in a Norwegian cross-sectional study by Eirik Olsen, Lene V. Halvorsen, Stine Rognstad, Arleen Aune, Karl Marius Brobak, Ola Undrum Bergland, Vibeke N. Kjær, Knut Liestøl, Marit D. Solbu, Rune Mo, Eva Gerdts, Morten Rostrup, Sverre E. Kjeldsen, Aud Høieggen, Mimi S. Opdal, Anne Cecilie K. Larstorp, Camilla L. Søraas

“…Among these, n = 79 (6.9%) patients were identified as non-adherent, and n = 1,072 (93.1%) patients were identified as adherent by pharmacologists who reviewed the drug concentrations in blood in relation to self-reported prescribed medications. …”
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AI-based tumor-infiltrating lymphocyte scoring system for assessing HCC prognosis in patients undergoing liver resection by Zhiyang Chen, Tingting Xie, Shuting Chen, Zhenhui Li, Su Yao, Xuanjun Lu, Wenfeng He, Chao Tang, Dacheng Yang, Shaohua Li, Feng Shi, Huan Lin, Zipei Li, Anant Madabhushi, Xiangtian Zhao, Zaiyi Liu, Cheng Lu

“…In this study, CD8+ TILs were identified as an independent prognostic factor for overall survival in patients with hepatocellular carcinoma who undergoing liver resection. Therefore, ATLS-8, a novel digital biomarker based on whole-slide image-level CD8+ TILs, could play an important role in the prognostic assessment of patients with HCC and could be integrated into clinicopathological models to participate in the decision-making and prognostic assessment of patients. …”
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IGJR issue 1/2018 by IF and FRFG

“…The double edition will have the additional help of Professor Pieter Vanhuysse, University of Southern Denmark, who will be serving as a guest editor. Submission requirements Submissions will be accepted until 1 February 2018. …”
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Cervical cancer screening: Impact of collection technique on human papillomavirus detection and genotyping by Alisa P. Young, Mutiya Olorunfemi, Leigh Morrison, Scott A. Kelley, Anna Laurie, Anna McEvoy, Jill Schneiderhan, Julie Prussack, Marie Claire O'Dwyer, Pamela Rockwell, Philip Zazove, Jonathan Gabison, Jane Chargot, Kristina Gallagher, Ananda Sen, Dongru Chen, Elizabeth A. Haro, Emma A. Butcher, Martha L. Alves, Christelle El Khoury, Melinda L. Dendrinos, Nicole Brashear, Roger Smith, Richard W. Lieberman, Natalie Saunders, Elizabeth Campbell, Heather M. Walline, Diane M. Harper

“…Methods: Participants recruited in 2020–2022 included 97 colposcopy attendees and 96 routine primary care screening attendees aged 30–65, who agreed to self-sample before their clinically scheduled speculum-based exam. …”
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Call for Papers: How attractive are political parties and trade unions to young people? by IF and FRFG

“…The 2/2018 and 1/2019 double edition will have the additional help of Professor Ann-Kristin Kölln, University of Aarhus, who will be serving as guest editor. The topic of the 2/2018 and 1/2019 double issue will be: “How attractive are political parties and trade unions to young people?” …”
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