Diagnostics and treatment of chronic constipation in adults: clinical guidelines of the Russian gastroenterological association by V. T. Ivashkin, I. V. Mayev, A. A. Sheptulin, A. S. Trukhmanov, Ye. A. Poluektova, Ye. K. Baranskaya, O. S. Shifrin, T. L. Lapina, M. F. Osipenko, V. I. Simanenkov, I. B. Khlynov

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Outcomes of total hip replacement in adults with septic arthritis of the native hip joint: A systematic review by Teddy Cheong, Surya Varma Selvakumar, Ryan Kwang Jin Goh, Ing How Moo

“…Re-infection rate and various functional outcomes, measured in terms of the Harris Hip Score (HHS), Visual Analogue Scale (VAS), Merle D'Aubigne and Postel (MAP), Western Ontario, McMaster Universities Arthritis Index (WOMAC) Short Form 12-Item (SF-12) scores, were analyzed. …”
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Impact of Small-Scale Businesses on Provision of Employment to Informal Labor Force in Kabale Municipality. by Uwibanze, Frank

“…It is about 142 kilometers (88 mi) southwest of Mbarara, the largest city in the Western Region of Uganda. The study employed both exploratory and descriptive study design. …”
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LRP11 promotes stem-like T cells via MAPK13-mediated TCF1 phosphorylation, enhancing anti-PD1 immunotherapy by Zhishui Chen, Gang Chen, Li Chen, Xiangli Zhao, Lingjuan Sun, Zhibo Ma, Xiaosheng Tan, Yuhao Tu, Jingzeng Wang, Peixiang Lan

“…Molecular interactions and TCF1 status were examined using Western blotting. Moreover, we employed RNA sequencing to investigate the effects of LDL stimulation and MAPK13 inhibition in CD8+ T cells.Results By using a tumor-bearing mouse model, we found that LDL-induced tumor-infiltrating TCF1+PD1+CD8+ T cells. …”
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iPSC-derived exosomes as amphotericin B carriers: a promising approach to combat cryptococcal meningitis by Jingyu Zhao, Jingyu Zhao, Wei Fang, Yangjie Gao, Jiquan Chen, Guizhen Wang, Julin Gu

“…Purity was confirmed by Western blotting for markers CD9, CD63, and TSG101. …”
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Hypothermia regulates mitophagy and apoptosis via PINK1/Parkin-VDAC 3 signaling pathway during oxygen-glucose deprivation/recovery injury by Luying Zhang, Song Yang, Hao Cui, Chenchen Hang, Xingsheng Wang, Le An, Zhenyu Shan, Zhen Liang, Rui Shao, Ziren Tang

“…Expression of mitophagy-related proteins (Cleaved PINK1, Parkin, SQSTM1/p62, Beclin-1, LC3B II/LC3B I), apoptosis-related proteins (Bcl-2, Cytochrome C, caspase-3, cleaved caspase3) and VDAC3 were assessed using western blot analysis and quantitative real-time PCR. …”
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How efficient are specialized public health services in China? A data envelopment analysis and geographically weighted regression approach by Qian Bai, Qian Bai, Lieyu Huang, Yan Guo, Xin Xu, Zhouyixin Zhang, Yuan Wang, Hao Chen, Ying Bian, Ying Bian

“…Besides, substantial geographic variations were observed, with the eastern region exhibiting greater levels of technical and pure technical efficiency. Contrarily, the western region appeared to perform better in terms of scale efficiency. …”
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Evaluation of Ecosystem Services and Tradeoff and Synergy in the Alpine and Canyon Region of Southwest China Based on Multi-source Geographic Data by LIU Jing, XIANG Jiayi, ZHANG Donghai, LAN Mengyao, GUAN Yinghui

“…These synergies were mainly located in the southeastern Tibetan alpine canyon ecological maintenance zone and the eastern Tibetan-western Sichuan alpine canyon ecological maintenance and water retention zone. …”
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Effect of trilaciclib administered before chemotherapy in patients with extensive-stage small-cell lung cancer: A pooled analysis of four randomized studies by Ying Liu, Lin Wu, Dingzhi Huang, Qiming Wang, Chen Yang, Li Zhou, Shuguang Sun, Xiaomei Jiang, Ying Cheng

“…Approach taken, including aspects such as the sample size: This pooled analysis included one study in China and three studies in western countries, and the overall sample size was 325. …”
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Mechanism of melanoma suppression by Prosopis juliflora derived alkaloids: Apoptosis induction and signaling pathway inhibition by Jasoda Choudhari, Snehal K. Nimal, Shridhar Chougule, Trupti Shinde, N.R. Dhatrak, Gopal C. Kundu, Rajesh N. Gacche

“…Mechanistic study of PJLME-AF was explored using ROS generation assay, apoptosis assays (Annexin V) assay, western blot (apoptotic protein, EMT markers, stem cell markers and signalling pathways), qPCR. …”
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NUAK1 acts as a novel regulator of PD-L1 via activating GSK-3β/β-catenin pathway in hepatocellular carcinoma by Chao-Yan Yao, Hang-Tian Tao, Jin-Jin He, Feng-Yi Zhu, Cui-Qing Xie, Yu-Na Cheng, Ji-Qin Li, Zhuang-Zhuang Liu, Chun-Yu Hou, Xue-Li Liu, Yong-Li Fan, Dong Fang, Xin-Rui Lv

“…HCC cell lines were used to validate the role of NUAK1 in regulating the transcription of PD-L1, the diethylnitrosamine-induced HCC model was established and the expression levels of NUAK1 and PD-L1 proteins in the rat livers were detected. Western blotting, immunofluorescence, real time PCR, and immunohistochemical staining were used to investigate the underlying mechanisms by which NUAK1 regulates PD-L1 expression in hepatocellular carcinoma. …”
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Cerebral Cortical Activity During Academic Stress Amongst Undergraduate Medical Students at Kampala International University (Uganda) by Mujinya, Regan, Kalange, Muhamudu, Ochieng, Juma John, Ninsiima, Herbert Izo, Eze, Ejike Daniel, Afodun, Adam Moyosore, Nabirumbi, Ritah, Sulaiman, Sheu Oluwadare, Kairania, Emmanuel, Echoru, Isaac, Okpanachi, Alfred Omachonu, Matama, Kevin, Asiimwe, Oscar Hilary, Nambuya, Grace, Usman, Ibe Michael, Obado, Osuwat Lawrence, Zirintunda, Gerald, Ssempijja, Fred, Nansunga, Miriam, Matovu, Henry, Ayikobua, Emmanuel Tiyo, Nganda, Ponsiano Ernest, Onanyang, David, Ekou, Justine, Musinguzi, Simon Peter, Ssimbwa, Godfrey, Keneth Iceland, Kasozi

“…Methods: This was a cross-sectional study conducted among preclinical (n = 88) and clinical (n = 96) undergraduate medical students at Kampala International University Western Campus. A standard Perceived Stress Scale (PSS) was used to categorize stress into low, moderate, and severe while the ability to cope with stress was categorized into below average, average, above average, and superior stresscoper (SS). …”
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Barriers and facilitators to data-based decision making in Australian early childhood education and care: A qualitative study by Shauna Sherker, Karen Villanueva, Ruth Beatson, Caitlin M. Macmillan, Wan Yi Lee, Olivia Hilton, Carly Molloy, Sharon Goldfeld

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Waste ceramic powder for sustainable concrete production as supplementary cementitious material by Yasin Onuralp Özkılıç, Yasin Onuralp Özkılıç, Alireza Bahrami, Yusuf Güzel, Ali Sinan Soğancı, Memduh Karalar, Essam Althaqafi, Ali İhsan Çelik, Özer Zeybek, P. Jagadesh

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Clinical characteristics, metastasis patterns, and treatment outcomes of HER2-low breast cancer by Maria Elena Lacruz, Saskia Thies, Andrea Schmidt-Pokrzywniak, Ian Wittenberg, Tobias Engler, Fabian Reinwald, Monika Klinkhammer-Schalke, Sylke Ruth Zeissig, Bianca Franke, Kerstin Weitmann, Atanas Ignatov

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Acceptance of artificial intelligence clinical assistant decision support system to prevent and control venous thromboembolism among healthcare workers: an extend Unified Theory of... by Jingxian Wang, Yun Zhou, Yun Zhou, Kai Tan, Zhigang Yu, You Li

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Modern Approaches to <i>H. pylori</i> Eradication Therapy in Adults (Literature Review and Resolution of Experts Council) by V. Т. Ivashkin, A. I. Ulyanin, I. V. Mayev, R. S. Kozlov, M. A. Livzan, S. R. Abdulkhakov, O. P. Alekseyeva, S. A. Alekseyenko, D. S. Bordin, N. N. Dekhnich, N. V. Korochyanskaya, T. L. Lapina, E. A. Poluektova, V. I. Simanenkov, A. S. Trukhmanov, I. B. Khlynov, V. V. Tsukanov, A. A. Sheptulin

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GelMA@LNP/AST Promotes eNOS-Dependent Angiogenesis Through Autophagy Activation for the Treatment of Hind Limb Ischemia by Lai L, Wu H, Peng L, Zhang Z, Wu X, Zheng S, Su Z, Chu H

“…The changes in angiogenesis markers, autophagy markers, and eNOS levels were detected using qPCR and Western blotting. 3-MA was used to assess the role of autophagy in the activation of eNOS mediated by AST and its subsequent angiogenic effects.Results: GelMA@LNP/AST significantly promoted blood flow recovery in mice with hind limb ischemia. …”
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FoxA1 knockdown promotes BMSC osteogenesis in part by activating the ERK1/2 signaling pathway and preventing ovariectomy-induced bone loss by Lijun Li, Renjin Lin, Yang Xu, Lingdi Li, Zhijun Pan, Jian Huang

“…Immunohistochemical and western blot techniques were used to identify and measure protein expression. …”
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Vincristine Regulates C/EBP-&beta;/TGF-&beta;1 to Promote A1 Astrocyte Polarization and Induce Neuropathic Pain by Chen Y, Tang G, Lu J, Tang S, Xiong X, Chen C, Pei L, Shi J

“…Pain threshold of rats was measured by thermal withdrawal latency (TWL) and mechanical withdrawal threshold (MWT), Elisa was used to detect the expression level of inflammatory factors, qRT PCR and Western blotting were used to detect astrocyte polarization markers, C/EBP-β, TGF-β 1, p-smad2 and p-smad3.Results: Following Vincristine administration, the TWL and MWT of rats exhibited a decrease. …”
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